Kevin Mills Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health University College London Biography Publications Institution JoVE Articles Kevin Mills has not added a biography. If you are Kevin Mills and would like to personalize this page please email our Author Liaison for assistance. Publications An Optimised Method for the Proteomic Profiling of Full Thickness Human Skin Biological Procedures Online. 2016 | Pubmed ID: 27445641 Regulation of Post-Golgi LH3 Trafficking is Essential for Collagen Homeostasis Nature Communications. 2016 | Pubmed ID: 27435297 The Embryological Basis of Subclinical Hypertrophic Cardiomyopathy Scientific Reports. 2016 | Pubmed ID: 27323879 A Rapid High Throughput Proteomic Method Based on Profiling of Proteolytic Free Peptides to Assess Post-delivery Degradation of Placental Tissue Placenta. Aug, 2016 | Pubmed ID: 27161200 Identification of Novel Bile Acids As Biomarkers for the Early Diagnosis of Niemann-Pick C Disease FEBS Letters. Jun, 2016 | Pubmed ID: 27139891 Global Serum Glycoform Profiling for the Investigation of Dystroglycanopathies & Congenital Disorders of Glycosylation Molecular Genetics and Metabolism Reports. Jun, 2016 | Pubmed ID: 27134828 Quantitative Proteomic Analysis of Stratum Corneum Dysfunction in Adult Chronic Atopic Dermatitis The Journal of Investigative Dermatology. Aug, 2016 | Pubmed ID: 27091361 Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells Cancer Discovery. May, 2016 | Pubmed ID: 27001151 Formate Supplementation Enhances Folate-dependent Nucleotide Biosynthesis and Prevents Spina Bifida in a Mouse Model of Folic Acid-resistant Neural Tube Defects Biochimie. Jul, 2016 | Pubmed ID: 26924399 Inositol for Prevention of Neural Tube Defects: a Pilot Randomised Controlled Trial - CORRIGENDUM The British Journal of Nutrition. May, 2016 | Pubmed ID: 26917444 Erratum To: Identification of Novel CSF Biomarkers for Neurodegeneration and Their Validation by a High-throughput Multiplexed Targeted Proteomic Assay Molecular Neurodegeneration. 2016 | Pubmed ID: 26907468 Inositol for the Prevention of Neural Tube Defects: a Pilot Randomised Controlled Trial The British Journal of Nutrition. Mar, 2016 | Pubmed ID: 26847388 Increased Cerebrospinal Fluid Soluble TREM2 Concentration in Alzheimer's Disease Molecular Neurodegeneration. 2016 | Pubmed ID: 26754172 Identification of Novel CSF Biomarkers for Neurodegeneration and Their Validation by a High-throughput Multiplexed Targeted Proteomic Assay Molecular Neurodegeneration. 2015 | Pubmed ID: 26627638 Proteomic Discovery and Development of a Multiplexed Targeted MRM-LC-MS/MS Assay for Urine Biomarkers of Extracellular Matrix Disruption in Mucopolysaccharidoses I, II, and VI Analytical Chemistry. Dec, 2015 | Pubmed ID: 26537538 Residential Segregation and Overweight/Obesity Among African-American Adults: A Critical Review Frontiers in Public Health. 2015 | Pubmed ID: 26191522 Current Applications of Biomarkers in Cardiomyopathies Expert Review of Cardiovascular Therapy. 2015 | Pubmed ID: 26106935 Pathogenic Autoantibodies from Patients with Lupus Nephritis Cause Reduced Tyrosine Phosphorylation of Podocyte Proteins, Including Tubulin Lupus Science & Medicine. 2014 | Pubmed ID: 25396061 Changes in Regulation of Human Monocyte Proteins in Response to IgG from Patients with Antiphospholipid Syndrome Blood. Dec, 2014 | Pubmed ID: 25301710 Growth Associated Protein (GAP-43): Cloning and the Development of a Sensitive ELISA for Neurological Disorders Journal of Neuroimmunology. Nov, 2014 | Pubmed ID: 25175067 Epilepsy Due to PNPO Mutations: Genotype, Environment and Treatment Affect Presentation and Outcome Brain : a Journal of Neurology. May, 2014 | Pubmed ID: 24645144 Physiological Expression of the PI3K-activating Mutation Pik3ca(H1047R) Combines with Apc Loss to Promote Development of Invasive Intestinal Adenocarcinomas in Mice The Biochemical Journal. Mar, 2014 | Pubmed ID: 24320611 Tumor Suppression: Putting P53 in Context Cell Cycle (Georgetown, Tex.). Nov, 2013 | Pubmed ID: 24131920 A DNA Break- and Phosphorylation-dependent Positive Feedback Loop Promotes Immunoglobulin Class-switch Recombination Nature Immunology. Nov, 2013 | Pubmed ID: 24097111 Thymosin β4-sulfoxide Attenuates Inflammatory Cell Infiltration and Promotes Cardiac Wound Healing Nature Communications. 2013 | Pubmed ID: 23820300 A New Method for the Rapid Diagnosis of Protein N-linked Congenital Disorders of Glycosylation Journal of Proteome Research. Jul, 2013 | Pubmed ID: 23742123 Coenzyme Q10 Quantification in Muscle, Fibroblasts and Cerebrospinal Fluid by Liquid Chromatography/tandem Mass Spectrometry Using a Novel Deuterated Internal Standard Rapid Communications in Mass Spectrometry : RCM. May, 2013 | Pubmed ID: 23592193 Attenuating Homologous Recombination Stimulates an AID-induced Antileukemic Effect The Journal of Experimental Medicine. May, 2013 | Pubmed ID: 23589568 Progression in Multiple Sclerosis is Associated with Low Endogenous NCAM Journal of Neurochemistry. Jun, 2013 | Pubmed ID: 23495921 The Identification of New Biomarkers for Identifying and Monitoring Kidney Disease and Their Translation into a Rapid Mass Spectrometry-based Test: Evidence of Presymptomatic Kidney Disease in Pediatric Fabry and Type-I Diabetic Patients Journal of Proteome Research. May, 2013 | Pubmed ID: 23464927 Urinary Conjugated α-tocopheronolactone--a Biomarker of Oxidative Stress in Children with Type 1 Diabetes Free Radical Biology & Medicine. Feb, 2013 | Pubmed ID: 23108104 Measurement of Plasma B6 Vitamer Profiles in Children with Inborn Errors of Vitamin B6 Metabolism Using an LC-MS/MS Method Journal of Inherited Metabolic Disease. Jan, 2013 | Pubmed ID: 22576361 Reference Measurement Procedures for Alzheimer's Disease Cerebrospinal Fluid Biomarkers: Definitions and Approaches with Focus on Amyloid β42 Biomarkers in Medicine. Aug, 2012 | Pubmed ID: 22917143 Activation-induced Cytidine Deaminase-initiated Off-target DNA Breaks Are Detected and Resolved During S Phase Journal of Immunology (Baltimore, Md. : 1950). Sep, 2012 | Pubmed ID: 22826323 The Identification of a New Role for LEKTI in the Skin: The Use of Protein 'bait' Arrays to Detect Defective Trafficking of Dermcidin in the Skin of Patients with Netherton Syndrome Journal of Proteomics. Jul, 2012 | Pubmed ID: 22588119 The Development of a Peptide SRM-based Tandem Mass Spectrometry Assay for Prenatal Screening of Down Syndrome Journal of Proteomics. Jun, 2012 | Pubmed ID: 22543281 Identification of New Biomarkers for Down's Syndrome in Maternal Plasma Journal of Proteomics. May, 2012 | Pubmed ID: 22456345 Comparison of Two Dimension-Reduction Methods for Network Simulation Models Journal of Research of the National Institute of Standards and Technology. Sep-Oct, 2011 | Pubmed ID: 26989599 2D DIGE Analysis of Maternal Plasma for Potential Biomarkers of Down Syndrome Proteome Science. 2011 | Pubmed ID: 21929753 Quantitative Analysis of Myo-inositol in Urine, Blood and Nutritional Supplements by High-performance Liquid Chromatography Tandem Mass Spectrometry Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Sep, 2011 | Pubmed ID: 21856255 Rhabdomyosarcomas in Aging A/J Mice PloS One. 2011 | Pubmed ID: 21853140 Brain Lipid-binding Protein: a Marker of Differentiation in Neuroblastic Tumors Journal of Pediatric Surgery. Jun, 2011 | Pubmed ID: 21683222 Scalp Stratum Corneum Histamine Levels: Novel Sampling Method Reveals Association with Itch Resolution in Dandruff/seborrhoeic Dermatitis Treatment Acta Dermato-venereologica. Jun, 2011 | Pubmed ID: 21336476 Epidermal Changes Associated with Symptomatic Resolution of Dandruff: Biomarkers of Scalp Health International Journal of Dermatology. Jan, 2011 | Pubmed ID: 21182510 Nuclear Positioning, Higher-order Folding, and Gene Expression of Mmu15 Sequences Are Refractory to Chromosomal Translocation Chromosoma. Feb, 2011 | Pubmed ID: 20703494 ARTEMIS Stabilizes the Genome and Modulates Proliferative Responses in Multipotent Mesenchymal Cells BMC Biology. 2010 | Pubmed ID: 20979627 Widespread Genomic Breaks Generated by Activation-induced Cytidine Deaminase Are Prevented by Homologous Recombination Nature Immunology. Sep, 2010 | Pubmed ID: 20657597 Genotypic and Phenotypic Spectrum of Pyridoxine-dependent Epilepsy (ALDH7A1 Deficiency) Brain : a Journal of Neurology. Jul, 2010 | Pubmed ID: 20554659 New Role for LEKTI in Skin Barrier Formation: Label-free Quantitative Proteomic Identification of Caspase 14 As a Novel Target for the Protease Inhibitor LEKTI Journal of Proteome Research. Aug, 2010 | Pubmed ID: 20533828 A Novel Method for the Direct Measurement of Urinary Conjugated Metabolites of Alpha-tocopherol and Its Use in Diabetes Molecular Nutrition & Food Research. May, 2010 | Pubmed ID: 20169581 Global Changes in Processing of MRNA 3' Untranslated Regions Characterize Clinically Distinct Cancer Subtypes Cancer Research. Dec, 2009 | Pubmed ID: 19934316 Engraftment, Differentiation, and Functional Benefits of Autologous Cardiosphere-derived Cells in Porcine Ischemic Cardiomyopathy Circulation. Sep, 2009 | Pubmed ID: 19738142 Aging in Inbred Strains of Mice: Study Design and Interim Report on Median Lifespans and Circulating IGF1 Levels Aging Cell. Jun, 2009 | Pubmed ID: 19627267 Colocalization of Somatic and Meiotic Double Strand Breaks Near the Myc Oncogene on Mouse Chromosome 15 Genes, Chromosomes & Cancer. Oct, 2009 | Pubmed ID: 19603522 Complex Oncogenic Translocations with Gene Amplification Are Initiated by Specific DNA Breaks in Lymphocytes Cancer Research. May, 2009 | Pubmed ID: 19435904 Gb(3)/creatinine Biomarkers for Fabry Disease: Issues to Consider Molecular Genetics and Metabolism. Jul, 2009 | Pubmed ID: 19428279 Discovery of a New Biomarker for the Mucopolysaccharidoses (MPS), Dipeptidyl Peptidase IV (DPP-IV; CD26), by SELDI-TOF Mass Spectrometry Molecular Genetics and Metabolism. Apr, 2009 | Pubmed ID: 19153055 SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression During Aging Cell. Nov, 2008 | Pubmed ID: 19041753 Abnormal Sympathetic Innervation of Viable Myocardium and the Substrate of Ventricular Tachycardia After Myocardial Infarction Journal of the American College of Cardiology. Jun, 2008 | Pubmed ID: 18534275 Treatment of Fabry Disease with Different Dosing Regimens of Agalsidase: Effects on Antibody Formation and GL-3 Molecular Genetics and Metabolism. Jul, 2008 | Pubmed ID: 18424138 Homologous Recombination is Necessary for Normal Lymphocyte Development Molecular and Cellular Biology. Apr, 2008 | Pubmed ID: 18212067 Chromosome Neighborhood Composition Determines Translocation Outcomes After Exposure to High-dose Radiation in Primary Cells Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 2007 | Pubmed ID: 18060570 Dynamic Clustered Distribution of Hemagglutinin Resolved at 40 Nm in Living Cell Membranes Discriminates Between Raft Theories Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17959773 Simulating Timescale Dynamics of Network Traffic Using Homogeneous Modeling Journal of Research of the National Institute of Standards and Technology. 2006 | Pubmed ID: 27274931 Integrity of the Methylation Cycle is Essential for Mammalian Neural Tube Closure Birth Defects Research. Part A, Clinical and Molecular Teratology. Jul, 2006 | Pubmed ID: 16933307 Quantitative Analysis of S-adenosylmethionine and S-adenosylhomocysteine in Neurulation-stage Mouse Embryos by Liquid Chromatography Tandem Mass Spectrometry Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Nov, 2006 | Pubmed ID: 16890031 XRCC4 P53 불충분 한 쥐 안에 재발 Translocations와 Medulloblastomas를 표시 하지 않습니다 Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16670198 Diagnosis of Congenital Disorders of Glycosylation Type-I Using Protein Chip Technology Proteomics. Apr, 2006 | Pubmed ID: 16552784 53BP1 and P53 Synergize to Suppress Genomic Instability and Lymphomagenesis Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16492765 Genomic 불안정성 및 포유류 Sirt6의 부재에서 노화 같은 표현 형 Cell. Jan, 2006 | Pubmed ID: 16439206 Determination of Coenzyme Q10 Status in Blood Mononuclear Cells, Skeletal Muscle, and Plasma by HPLC with Di-propoxy-coenzyme Q10 As an Internal Standard Clinical Chemistry. Dec, 2005 | Pubmed ID: 16306103 Non-invasive Screening Method for Fabry Disease by Measuring Globotriaosylceramide in Whole Urine Samples Using Tandem Mass Spectrometry Molecular Genetics and Metabolism. Jul, 2005 | Pubmed ID: 15979031 The Synthesis of Internal Standards for the Quantitative Determination of Sphingolipids by Tandem Mass Spectrometry Rapid Communications in Mass Spectrometry : RCM. 2005 | Pubmed ID: 15909321 Monitoring the Clinical and Biochemical Response to Enzyme Replacement Therapy in Three Children with Fabry Disease European Journal of Pediatrics. Oct, 2004 | Pubmed ID: 15243806 Collaboration of Homologous Recombination and Nonhomologous End-joining Factors for the Survival and Integrity of Mice and Cells Genes & Development. Jun, 2004 | Pubmed ID: 15175261 Rad54 and DNA Ligase IV Cooperate to Maintain Mammalian Chromatid Stability Genes & Development. Jun, 2004 | Pubmed ID: 15175260 The Role of DNA Breaks in Genomic Instability and Tumorigenesis Immunological Reviews. Aug, 2003 | Pubmed ID: 12846809 The Underglycosylation of Plasma Alpha 1-antitrypsin in Congenital Disorders of Glycosylation Type I is Not Random Glycobiology. Feb, 2003 | Pubmed ID: 12626422 Exploring Collective Dynamics in Communication Networks Journal of Research of the National Institute of Standards and Technology. 2002 | Pubmed ID: 27446726 Fourth Ventricular CART Reduces Food and Water Intake and Produces a Conditioned Taste Aversion in Rats Behavioral Neuroscience. Oct, 2002 | Pubmed ID: 12369811 Unrepaired DNA Breaks in P53-deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations Cell. Jun, 2002 | Pubmed ID: 12110179 Synthesis of Novel Internal Standards for the Quantitative Determination of Plasma Ceramide Trihexoside in Fabry Disease by Tandem Mass Spectrometry FEBS Letters. Mar, 2002 | Pubmed ID: 11943216 높은 처리량, 멀티 플렉스 및 대상 단백체 CSF 분석은 퇴행성 신경 바이오 마커 및 아포 지단백 E 이소 상태를 정량화하기 Wendy E. Heywood*1, Anna Baud*1, Emily Bliss1, Ernestas Sirka1, Jonathan M. Schott2, Henrik Zetterberg3, Daniela Galimberti4, Neil J. Sebire5, Kevin Mills1 1Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health, University College London, 2Dementia Research Centre, Institute of Neurology, University College London, 3Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, 4Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, 5Great Ormond Street Hospital for Children, University College London JoVE 54541 Medicine
높은 처리량, 멀티 플렉스 및 대상 단백체 CSF 분석은 퇴행성 신경 바이오 마커 및 아포 지단백 E 이소 상태를 정량화하기 Wendy E. Heywood*1, Anna Baud*1, Emily Bliss1, Ernestas Sirka1, Jonathan M. Schott2, Henrik Zetterberg3, Daniela Galimberti4, Neil J. Sebire5, Kevin Mills1 1Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health, University College London, 2Dementia Research Centre, Institute of Neurology, University College London, 3Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, 4Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, 5Great Ormond Street Hospital for Children, University College London JoVE 54541 Medicine
