Lary C. Walker Yerkes National Primate Research Center Emory University Biography Publications Institution JoVE Articles Lary C. Walker has not added a biography. If you are Lary C. Walker and would like to personalize this page please email our Author Liaison for assistance. Publications Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy Current Pharmaceutical Design. Jan, 2012 | Pubmed ID: 22288403 The Presence of Aβ Seeds, and Not Age Per Se, is Critical to the Initiation of Aβ Deposition in the Brain Acta Neuropathologica. Jan, 2012 | Pubmed ID: 22101366 Exogenous Seeding of Cerebral β-amyloid Deposition in βAPP-transgenic Rats Journal of Neurochemistry. Mar, 2012 | Pubmed ID: 22017494 Pathogenic Protein Seeding in Alzheimer Disease and Other Neurodegenerative Disorders Annals of Neurology. Oct, 2011 | Pubmed ID: 22028219 Soluble Aβ Seeds Are Potent Inducers of Cerebral β-amyloid Deposition The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2011 | Pubmed ID: 21994365 Cerebral Amyloid-β Proteostasis is Regulated by the Membrane Transport Protein ABCC1 in Mice The Journal of Clinical Investigation. Oct, 2011 | Pubmed ID: 21881209 The Role of the ATP-binding Cassette Transporter P-glycoprotein in the Transport of β-amyloid Across the Blood-brain Barrier Current Pharmaceutical Design. 2011 | Pubmed ID: 21827406 Amyloid by Default Nature Neuroscience. Jun, 2011 | Pubmed ID: 21613991 Automated Detection of Amyloid-β-related Cortical and Subcortical Signal Changes in a Transgenic Model of Alzheimer's Disease Using High-field MRI Journal of Alzheimer's Disease : JAD. 2011 | Pubmed ID: 20966552 PIB Binding in Aged Primate Brain: Enrichment of High-affinity Sites in Humans with Alzheimer's Disease Neurobiology of Aging. Feb, 2011 | Pubmed ID: 19329226 Peripherally Applied Abeta-containing Inoculates Induce Cerebral Beta-amyloidosis Science (New York, N.Y.). Nov, 2010 | Pubmed ID: 20966215 Days to Criterion As an Indicator of Toxicity Associated with Human Alzheimer Amyloid-beta Oligomers Annals of Neurology. Aug, 2010 | Pubmed ID: 20641005 Mosaic Aging Medical Hypotheses. Jun, 2010 | Pubmed ID: 20110150 The Grandmother Effect and the Uniqueness of the Human Aging Phenotype Gerontology. 2010 | Pubmed ID: 19864883 Deficient High-affinity Binding of Pittsburgh Compound B in a Case of Alzheimer's Disease Acta Neuropathologica. Feb, 2010 | Pubmed ID: 19690877 Molecular Polymorphism of Abeta in Alzheimer's Disease Neurobiology of Aging. Apr, 2010 | Pubmed ID: 18619711 Ovarian Aging in Squirrel Monkeys (Saimiri Sciureus) Reproduction (Cambridge, England). Nov, 2009 | Pubmed ID: 19656956 Induction of Cerebral Beta-amyloidosis: Intracerebral Versus Systemic Abeta Inoculation Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19622727 Alzheimer's Disease and Blood-brain Barrier Function-Why Have Anti-beta-amyloid Therapies Failed to Prevent Dementia Progression? Neuroscience and Biobehavioral Reviews. Jul, 2009 | Pubmed ID: 19481107 The Synthesis and Structure-activity Relationship of Substituted N-phenyl Anthranilic Acid Analogs As Amyloid Aggregation Inhibitors Bioorganic & Medicinal Chemistry Letters. Feb, 2009 | Pubmed ID: 19121939 Clinico-pathologic Function of Cerebral ABC Transporters - Implications for the Pathogenesis of Alzheimer's Disease Current Alzheimer Research. Aug, 2008 | Pubmed ID: 18690837 Tauopathy with Paired Helical Filaments in an Aged Chimpanzee The Journal of Comparative Neurology. Jul, 2008 | Pubmed ID: 18481275 Long-term Hypothermia Reduces Infarct Volume in Aged Rats After Focal Ischemia Neuroscience Letters. Jun, 2008 | Pubmed ID: 18456407 Development of Transgenic Rats Producing Human Beta-amyloid Precursor Protein As a Model for Alzheimer's Disease: Transgene and Endogenous APP Genes Are Regulated Tissue-specifically BMC Neuroscience. 2008 | Pubmed ID: 18302776 The Response of the Aged Brain to Stroke: Too Much, Too Soon? Current Neurovascular Research. Aug, 2007 | Pubmed ID: 17691975 MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's Amyloid-beta Peptides--implications for the Mechanisms of Abeta Clearance at the Blood-brain Barrier Brain Pathology (Zurich, Switzerland). Oct, 2007 | Pubmed ID: 17610523 Exogenous Induction of Cerebral Beta-amyloidogenesis is Governed by Agent and Host Science (New York, N.Y.). Sep, 2006 | Pubmed ID: 16990547 Inducible Proteopathies Trends in Neurosciences. Aug, 2006 | Pubmed ID: 16806508 Alzheimer Therapeutics-what After the Cholinesterase Inhibitors? Age and Ageing. Jul, 2006 | Pubmed ID: 16644763 Cerebrovascular P-glycoprotein Expression is Decreased in Creutzfeldt-Jakob Disease Acta Neuropathologica. May, 2006 | Pubmed ID: 16523342 Calcium Channel Alpha2-delta Type 1 Subunit is the Major Binding Protein for Pregabalin in Neocortex, Hippocampus, Amygdala, and Spinal Cord: an Ex Vivo Autoradiographic Study in Alpha2-delta Type 1 Genetically Modified Mice Brain Research. Feb, 2006 | Pubmed ID: 16460711 Emerging Prospects for the Disease-modifying Treatment of Alzheimer's Disease Biochemical Pharmacology. Apr, 2005 | Pubmed ID: 15763538 Proteomic Identification of the Involvement of the Mitochondrial Rieske Protein in Epilepsy Epilepsia. Mar, 2005 | Pubmed ID: 15730530 The Role of P-glycoprotein in Cerebral Amyloid Angiopathy; Implications for the Early Pathogenesis of Alzheimer's Disease Current Alzheimer Research. May, 2004 | Pubmed ID: 15975076 Aging, Gender and APOE Isotype Modulate Metabolism of Alzheimer's Abeta Peptides and F-isoprostanes in the Absence of Detectable Amyloid Deposits Journal of Neurochemistry. Aug, 2004 | Pubmed ID: 15287908 Alzheimer A Beta Vaccination of Rhesus Monkeys (Macaca Mulatta) Alzheimer Disease and Associated Disorders. Jan-Mar, 2004 | Pubmed ID: 15195463 Alzheimer's Abeta Vaccination of Rhesus Monkeys (Macaca Mulatta) Mechanisms of Ageing and Development. Feb, 2004 | Pubmed ID: 15037022 Xanthomatosis Journal of Neurosurgery. Oct, 2002 | Pubmed ID: 12405396 Deposition of Alzheimer's Beta-amyloid is Inversely Correlated with P-glycoprotein Expression in the Brains of Elderly Non-demented Humans Pharmacogenetics. Oct, 2002 | Pubmed ID: 12360104 Exogenous Induction of Cerebral Beta-amyloidosis in BetaAPP-transgenic Mice Peptides. Jul, 2002 | Pubmed ID: 12128081 Proteopathy: the Next Therapeutic Frontier? Current Opinion in Investigational Drugs (London, England : 2000). May, 2002 | Pubmed ID: 12090553 Axonopathy, Tau Abnormalities, and Dyskinesia, but No Neurofibrillary Tangles in P25-transgenic Mice The Journal of Comparative Neurology. May, 2002 | Pubmed ID: 11932941 SDS-PAGE/Immunoblot Detection of Aβ Multimers in Human Cortical Tissue Homogenates using Antigen-Epitope Retrieval Rebecca F. Rosen1, Yasushi Tomidokoro2, Jorge A. Ghiso3, Lary C. Walker1,4 1Yerkes National Primate Research Center, Emory University, 2Department of Neurology, Institute of Clinical Medicine, Tsukuba University, 3Department of Pathology, New York University School of Medicine, 4Department of Neurology, Emory University JoVE 1916 Neuroscience
SDS-PAGE/Immunoblot Detection of Aβ Multimers in Human Cortical Tissue Homogenates using Antigen-Epitope Retrieval Rebecca F. Rosen1, Yasushi Tomidokoro2, Jorge A. Ghiso3, Lary C. Walker1,4 1Yerkes National Primate Research Center, Emory University, 2Department of Neurology, Institute of Clinical Medicine, Tsukuba University, 3Department of Pathology, New York University School of Medicine, 4Department of Neurology, Emory University JoVE 1916 Neuroscience