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In JoVE (1)
Other Publications (3)
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Articles by Lauren LaCount in JoVE
FMRI İnsan Beyninin izlenmesi Akupunktur Etkileri
Kathleen K. S. Hui1, Vitaly Napadow1, Jing Liu1, Ming Li1, Ovidiu Marina1,2, Erika E. Nixon1, Joshua D. Claunch1, Lauren LaCount1, Tara Sporko1, Kenneth K. Kwong1
1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 2William Beaumont Hospital
FMRI ve fizyolojik izleme, merkezi ve periferik sinir sistemi üzerinde Akupunktur etkilerini incelemek amacıyla kullanılır. Akupunktur muhtemelen periferik sinir sistemi, otonom etkisi ile ilgili olarak, nörolojik aktivite modüle, varsayılan mod ağ ile büyük bir örtüşme ile, limbik-paralimbik-neokortikal ağ harekete geçirir.
Other articles by Lauren LaCount on PubMed
NeuroImage. Sep, 2009 | Pubmed ID: 19500677
Acupuncture-induced sensations have historically been associated with clinical efficacy. These sensations are atypical, arising from sub-dermal receptors, and their neural encoding is not well known. In this fMRI study, subjects were stimulated at acupoint PC-6, while rating sensation with a custom-built, MR-compatible potentiometer. Separate runs included real (ACUP) and sham (SHAM) acupuncture, the latter characterized by non-insertive, cutaneous stimulation. FMRI data analysis was guided by the on-line rating timeseries, thereby localizing brain correlates of acupuncture sensation. Sensation ratings correlated with stimulation more (p<0.001) for SHAM (r=0.63) than for ACUP (r=0.32). ACUP induced stronger and more varied sensations with significant persistence into no-stimulation blocks, leading to more run-time spent rating low and moderate sensations compared to SHAM. ACUP sensation correlated with activation in regions associated with sensorimotor (SII, insula) and cognitive (dorsomedial prefrontal cortex (dmPFC)) processing, and deactivation in default-mode network (DMN) regions (posterior cingulate, precuneus). Compared to SHAM, ACUP yielded greater activity in both anterior and posterior dmPFC and dlPFC. In contrast, SHAM produced greater activation in sensorimotor (SI, SII, insula) and greater deactivation in DMN regions. Thus, brain encoding of ACUP sensation (more persistent and varied, leading to increased cognitive load) demonstrated greater activity in both cognitive/evaluative (posterior dmPFC) and emotional/interoceptive (anterior dmPFC) cortical regions. Increased cognitive load and dmPFC activity may be a salient component of acupuncture analgesia--sensations focus attention and accentuate bodily awareness, contributing to enhanced top-down modulation of any nociceptive afference and central pain networks. Hence, acupuncture may function as a somatosensory-guided mind-body therapy.
Arthritis and Rheumatism. Aug, 2010 | Pubmed ID: 20506181
Fibromyalgia (FM) is considered to be the prototypical central chronic pain syndrome and is associated with widespread pain that fluctuates spontaneously. Multiple studies have demonstrated altered brain activity in these patients. The objective of this study was to investigate the degree of connectivity between multiple brain networks in patients with FM, as well as how activity in these networks correlates with the level of spontaneous pain.
Aviation, Space, and Environmental Medicine. Apr, 2011 | Pubmed ID: 21485400
Nausea is a commonly occurring symptom typified by epigastric discomfort with urge to vomit. The relationship between autonomic nervous system (ANS) outflow and increasing nausea perception is not fully understood.