Lorne Zinman Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre University of Toronto Biography Publications Institution JoVE Articles Lorne Zinman has not added a biography. If you are Lorne Zinman and would like to personalize this page please email our Author Liaison for assistance. Publications Genome-wide Analyses Identify KIF5A As a Novel ALS Gene Neuron. Mar, 2018 | Pubmed ID: 29566793 Clinical Reasoning: A 42-year-old Man with Unilateral Leg Weakness Neurology. Mar, 2018 | Pubmed ID: 29555890 Downregulation of Exosomal MiR-204-5p and MiR-632 As a Biomarker for FTD: a GENFI Study Journal of Neurology, Neurosurgery, and Psychiatry. Feb, 2018 | Pubmed ID: 29434051 Motor Unit Number Index and Neurophysiological Index As Candidate Biomarkers of Presymptomatic Motor Neuron Loss in Amyotrophic Lateral Sclerosis Muscle & Nerve. Jan, 2018 | Pubmed ID: 29381812 Unaffected Mosaiccase: RNA Foci, Dipeptide Proteins, but Upregulated C9orf72 Expression Neurology. Jan, 2018 | Pubmed ID: 29282338 Loss of CHCHD10-CHCHD2 Complexes Required for Respiration Underlies the Pathogenicity of a CHCHD10 Mutation in ALS Human Molecular Genetics. Jan, 2018 | Pubmed ID: 29121267 Clinical and Neuropathological Features of ALS/FTD with TIA1 Mutations Acta Neuropathologica Communications. Dec, 2017 | Pubmed ID: 29216908 Neuroleptics As Therapeutic Compounds Stabilizing Neuromuscular Transmission in Amyotrophic Lateral Sclerosis JCI Insight. Nov, 2017 | Pubmed ID: 29202456 Dysregulation of Chromatin Remodelling Complexes in Amyotrophic Lateral Sclerosis Human Molecular Genetics. Nov, 2017 | Pubmed ID: 28973294 TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics Neuron. Aug, 2017 | Pubmed ID: 28817800 Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI) Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28671116 DNA Methylation Age-acceleration is Associated with Disease Duration and Age at Onset in C9orf72 Patients Acta Neuropathologica. Aug, 2017 | Pubmed ID: 28439722 Speech Movement Measures As Markers of Bulbar Disease in Amyotrophic Lateral Sclerosis Journal of Speech, Language, and Hearing Research : JSLHR. Oct, 2016 | Pubmed ID: 27679842 Physician-assisted Death: A Canada-wide Survey of ALS Health Care Providers Neurology. Sep, 2016 | Pubmed ID: 27178703 Genetic and Epigenetic Study of ALS-discordant Identical Twins with Double Mutations in SOD1 and ARHGEF28 Journal of Neurology, Neurosurgery, and Psychiatry. 11, 2016 | Pubmed ID: 27154192 Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems PloS One. 2016 | Pubmed ID: 27148967 C9orf72 Isoforms in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration Brain Research. 09, 2016 | Pubmed ID: 27134035 Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) PloS One. 2016 | Pubmed ID: 26789001 MTHFSD and DDX58 Are Novel RNA-binding Proteins Abnormally Regulated in Amyotrophic Lateral Sclerosis Brain : a Journal of Neurology. Jan, 2016 | Pubmed ID: 26525917 Isoform-specific Antibodies Reveal Distinct Subcellular Localizations of C9orf72 in Amyotrophic Lateral Sclerosis Annals of Neurology. Oct, 2015 | Pubmed ID: 26174152 Jump from Pre-mutation to Pathologic Expansion in C9orf72 American Journal of Human Genetics. Jun, 2015 | Pubmed ID: 26004200 Mutation Analysis of CHCHD10 in Different Neurodegenerative Diseases Brain : a Journal of Neurology. Sep, 2015 | Pubmed ID: 25833818 Low Molecular Weight Species of TDP-43 Generated by Abnormal Splicing Form Inclusions in Amyotrophic Lateral Sclerosis and Result in Motor Neuron Death Acta Neuropathologica. Jul, 2015 | Pubmed ID: 25788357 The C9orf72 Repeat Expansion Itself is Methylated in ALS and FTLD Patients Acta Neuropathologica. May, 2015 | Pubmed ID: 25716178 Electrical Impedance Myography in the Evaluation of the Tongue Musculature in Amyotrophic Lateral Sclerosis Muscle & Nerve. Oct, 2015 | Pubmed ID: 25580728 Mutation Analysis of Patients with Neurodegenerative Disorders Using NeuroX Array Neurobiology of Aging. Jan, 2015 | Pubmed ID: 25174650 Identical Twins with the C9orf72 Repeat Expansion Are Discordant for ALS Neurology. Oct, 2014 | Pubmed ID: 25209579 Economic Burden of Amyotrophic Lateral Sclerosis: a Canadian Study of Out-of-pocket Expenses Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Sep, 2014 | Pubmed ID: 25025935 Hypermethylation of the CpG-island Near the C9orf72 G₄C₂-repeat Expansion in FTLD Patients Human Molecular Genetics. Nov, 2014 | Pubmed ID: 24908669 Venous Thromboembolism in Amyotrophic Lateral Sclerosis: a Prospective Study Neurology. May, 2014 | Pubmed ID: 24727309 Mutations in the Matrin 3 Gene Cause Familial Amyotrophic Lateral Sclerosis Nature Neuroscience. May, 2014 | Pubmed ID: 24686783 Speech in ALS: Longitudinal Changes in Lips and Jaw Movements and Vowel Acoustics Journal of Medical Speech-language Pathology. Mar, 2013 | Pubmed ID: 27453680 Bulbar and Speech Motor Assessment in ALS: Challenges and Future Directions Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Jul, 2013 | Pubmed ID: 23898888 Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion American Journal of Human Genetics. Jun, 2013 | Pubmed ID: 23731538 Mortality Associated with Periodic Limb Movements During Sleep in Amyotrophic Lateral Sclerosis Patients Einstein (Sao Paulo, Brazil). Oct-Dec, 2012 | Pubmed ID: 23386081 Enhancing Clinical Trials in Neurodegenerative Disorders: Lessons from Amyotrophic Lateral Sclerosis Current Opinion in Neurology. Dec, 2012 | Pubmed ID: 23160423 Indagine Di C9orf72 in 4 Patologie Neurodegenerative Archives of Neurology. Sep, 2012 | Pubmed ID: 22964832 Tongue Movements and Their Acoustic Consequences in Amyotrophic Lateral Sclerosis Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP). 2012 | Pubmed ID: 22555651 Un'espansione Di Ripetizione Hexanucleotide in C9ORF72 è Che La Causa Del Cromosoma 9 P 21 - Collegato FTD-ALS Neuron. Oct, 2011 | Pubmed ID: 21944779 Miopatia Paraspinale Con Romanzo Scheggia-come Aggregati Compatti Di Filamenti Sottili Muscle & Nerve. Jul, 2011 | Pubmed ID: 21660984 Eterogeneità Patologica Nella Sclerosi Laterale Amiotrofica Con Mutazioni FUS: Due Modelli Distinti Di Correlazione Con La Gravità Della Malattia E Mutazione Acta Neuropathologica. Jul, 2011 | Pubmed ID: 21604077 Obiettivi Emergenti E Trattamenti Nella Sclerosi Laterale Amiotrofica Lancet Neurology. May, 2011 | Pubmed ID: 21511200 Obiettivi Di RNA Di TDP-43 Identificato Da UV-CLIP Sono Liberalizzati in ALS Molecular and Cellular Neurosciences. Jul, 2011 | Pubmed ID: 21421050 Firme Biochimiche Distinte Caratterizzano Desmina Isoforma Espressione in Lesioni Traumatiche Neuronale E Malattia Del Motoneurone Journal of Neurochemistry. Aug, 2010 | Pubmed ID: 20533992 Sicurezza Ed Efficacia Del Litio in Combinazione Con Riluzolo Per Il Trattamento Della Sclerosi Laterale Amiotrofica: Un Trial Randomizzato, in Doppio-cieco, Placebo-controllato Lancet Neurology. May, 2010 | Pubmed ID: 20363190 Ventilazione Non Invasiva Per Pazienti Canadesi Con ALS: Abbiamo Il Consenso? The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. Jan, 2010 | Pubmed ID: 20169767 Sclerosi Laterale Amiotrofica è Una Malattia Non-amiloide in Cui Vasto Misfolding Di SOD1 è Unico Per La Forma Familiare Acta Neuropathologica. Mar, 2010 | Pubmed ID: 20111867 Cinematica Di Progressione Della Malattia in ALS Bulbare Journal of Communication Disorders. Jan-Feb, 2010 | Pubmed ID: 19683250 Sicurezza Della Vaccinazione Contro L'influenza in Pazienti Affetti Da Miastenia Grave: Uno Studio Population-based Muscle & Nerve. Dec, 2009 | Pubmed ID: 19902540 Mancanza Di Prove Del Monomero/denatura Superossido Dismutasi-1 Sporadica Della Sclerosi Laterale Amiotrofica Annals of Neurology. Jul, 2009 | Pubmed ID: 19670443 Sono Statine Farmaci Sicuri in Pazienti Con SLA? Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. Aug, 2008 | Pubmed ID: 18608105 Trattamento IVIG Per Miastenia Gravis: Efficacia, Limiti E Nuove Strategie Terapeutiche Annals of the New York Academy of Sciences. 2008 | Pubmed ID: 18567877 Misure Di Outcome Terapeutico Surrogato in Pazienti Affetti Da Miastenia Grave Muscle & Nerve. Feb, 2008 | Pubmed ID: 17918748 Studi Genetici Di GRN E IFT74 Nella Sclerosi Laterale Amiotrofica Neurobiology of Aging. Aug, 2008 | Pubmed ID: 17383054 Prove Che TDP-43 Non è La Destinazione Principale Ubiquitarie Entro Le Inclusioni Patologiche Della Sclerosi Laterale Amiotrofica Journal of Neuropathology and Experimental Neurology. Dec, 2007 | Pubmed ID: 18090923 Immunoglobulina IV in Pazienti Affetti Da Miastenia Grave: Uno Studio Randomizzato Controllato Neurology. Mar, 2007 | Pubmed ID: 17353471 Sensibilità Di Ripetitiva Stimolazione Nervo Facciale Nei Pazienti Affetti Da Miastenia Grave Muscle & Nerve. May, 2006 | Pubmed ID: 16421884 Raffreddamento Delle Soglie Di Rilevazione Nella Valutazione Del Diabetica Polineuropatia Sensoriale: Confronto Di Strumenti CASE IV E Medoc Diabetes Care. Jul, 2004 | Pubmed ID: 15220245 Bassa Intensità Laser Terapia Per I Sintomi Dolorosi Di Polineuropatia Sensitivo-motoria Diabetica: Una Prova Controllata Diabetes Care. Apr, 2004 | Pubmed ID: 15047649 Sequenziamento di nuova generazione e bioinformatica Pipeline per valutare fattori determinanti genetici della malattia costituzionale mirati Allison A. Dilliott1,2, Sali M.K. Farhan3, Mahdi Ghani4, Christine Sato4, Eric Liang5, Ming Zhang4, Adam D. McIntyre1, Henian Cao1, Lemuel Racacho6,7, John F. Robinson1, Michael J. Strong1,8, Mario Masellis9,10, Dennis E. Bulman6,7, Ekaterina Rogaeva4, Anthony Lang10,11, Carmela Tartaglia4,10, Elizabeth Finger12,13, Lorne Zinman9, John Turnbull14, Morris Freedman10,15, Rick Swartz9, Sandra E. Black9,16, Robert A. Hegele1,2 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, 3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, 4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 5School of Medicine, Faculty of Health Sciences, Queen's University, 6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 7CHEO Research Institute, Faculty of Medicine, University of Ottawa, 8Department of Clinical Neurological Sciences, Western University, 9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 10Division of Neurology, Department of Medicine, University of Toronto, 11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, 12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 13Parkwood Institute, St. Joseph's Health Care, 14Department of Medicine, Division of Neurology, McMaster University, 15Division of Neurology, Department of Medicine, Baycrest Health Sciences, 16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto JoVE 57266 Genetics Un protocollo per la valutazione completa della disfunzione bulbare nella Sclerosi Laterale Amiotrofica (SLA) Yana Yunusova1,2, Jordan R. Green3, Jun Wang3, Gary Pattee4, Lorne Zinman2,5 1Department of Speech-Language Pathology, University of Toronto, 2ALS/ MN Clinic, Sunnybrook Health Science Centre, 3Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, 4Department of Neurology, Munroe-Meyer Institute, University of Nebraska Medical Center, 5Department of Neurology, University of Toronto JoVE 2422 Medicine
Sequenziamento di nuova generazione e bioinformatica Pipeline per valutare fattori determinanti genetici della malattia costituzionale mirati Allison A. Dilliott1,2, Sali M.K. Farhan3, Mahdi Ghani4, Christine Sato4, Eric Liang5, Ming Zhang4, Adam D. McIntyre1, Henian Cao1, Lemuel Racacho6,7, John F. Robinson1, Michael J. Strong1,8, Mario Masellis9,10, Dennis E. Bulman6,7, Ekaterina Rogaeva4, Anthony Lang10,11, Carmela Tartaglia4,10, Elizabeth Finger12,13, Lorne Zinman9, John Turnbull14, Morris Freedman10,15, Rick Swartz9, Sandra E. Black9,16, Robert A. Hegele1,2 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, 3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, 4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 5School of Medicine, Faculty of Health Sciences, Queen's University, 6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 7CHEO Research Institute, Faculty of Medicine, University of Ottawa, 8Department of Clinical Neurological Sciences, Western University, 9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 10Division of Neurology, Department of Medicine, University of Toronto, 11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, 12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 13Parkwood Institute, St. Joseph's Health Care, 14Department of Medicine, Division of Neurology, McMaster University, 15Division of Neurology, Department of Medicine, Baycrest Health Sciences, 16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto JoVE 57266 Genetics
Un protocollo per la valutazione completa della disfunzione bulbare nella Sclerosi Laterale Amiotrofica (SLA) Yana Yunusova1,2, Jordan R. Green3, Jun Wang3, Gary Pattee4, Lorne Zinman2,5 1Department of Speech-Language Pathology, University of Toronto, 2ALS/ MN Clinic, Sunnybrook Health Science Centre, 3Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, 4Department of Neurology, Munroe-Meyer Institute, University of Nebraska Medical Center, 5Department of Neurology, University of Toronto JoVE 2422 Medicine