Lorne Zinman Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre University of Toronto Biography Publications Institution JoVE Articles Lorne Zinman has not added a biography. If you are Lorne Zinman and would like to personalize this page please email our Author Liaison for assistance. Publications Genome-wide Analyses Identify KIF5A As a Novel ALS Gene Neuron. Mar, 2018 | Pubmed ID: 29566793 Clinical Reasoning: A 42-year-old Man with Unilateral Leg Weakness Neurology. Mar, 2018 | Pubmed ID: 29555890 Downregulation of Exosomal MiR-204-5p and MiR-632 As a Biomarker for FTD: a GENFI Study Journal of Neurology, Neurosurgery, and Psychiatry. Feb, 2018 | Pubmed ID: 29434051 Motor Unit Number Index and Neurophysiological Index As Candidate Biomarkers of Presymptomatic Motor Neuron Loss in Amyotrophic Lateral Sclerosis Muscle & Nerve. Jan, 2018 | Pubmed ID: 29381812 Unaffected Mosaiccase: RNA Foci, Dipeptide Proteins, but Upregulated C9orf72 Expression Neurology. Jan, 2018 | Pubmed ID: 29282338 Loss of CHCHD10-CHCHD2 Complexes Required for Respiration Underlies the Pathogenicity of a CHCHD10 Mutation in ALS Human Molecular Genetics. Jan, 2018 | Pubmed ID: 29121267 Clinical and Neuropathological Features of ALS/FTD with TIA1 Mutations Acta Neuropathologica Communications. Dec, 2017 | Pubmed ID: 29216908 Neuroleptics As Therapeutic Compounds Stabilizing Neuromuscular Transmission in Amyotrophic Lateral Sclerosis JCI Insight. Nov, 2017 | Pubmed ID: 29202456 Dysregulation of Chromatin Remodelling Complexes in Amyotrophic Lateral Sclerosis Human Molecular Genetics. Nov, 2017 | Pubmed ID: 28973294 TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics Neuron. Aug, 2017 | Pubmed ID: 28817800 Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI) Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28671116 DNA Methylation Age-acceleration is Associated with Disease Duration and Age at Onset in C9orf72 Patients Acta Neuropathologica. Aug, 2017 | Pubmed ID: 28439722 Speech Movement Measures As Markers of Bulbar Disease in Amyotrophic Lateral Sclerosis Journal of Speech, Language, and Hearing Research : JSLHR. Oct, 2016 | Pubmed ID: 27679842 Physician-assisted Death: A Canada-wide Survey of ALS Health Care Providers Neurology. Sep, 2016 | Pubmed ID: 27178703 Genetic and Epigenetic Study of ALS-discordant Identical Twins with Double Mutations in SOD1 and ARHGEF28 Journal of Neurology, Neurosurgery, and Psychiatry. 11, 2016 | Pubmed ID: 27154192 Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems PloS One. 2016 | Pubmed ID: 27148967 C9orf72 Isoforms in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration Brain Research. 09, 2016 | Pubmed ID: 27134035 Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) PloS One. 2016 | Pubmed ID: 26789001 MTHFSD and DDX58 Are Novel RNA-binding Proteins Abnormally Regulated in Amyotrophic Lateral Sclerosis Brain : a Journal of Neurology. Jan, 2016 | Pubmed ID: 26525917 Isoform-specific Antibodies Reveal Distinct Subcellular Localizations of C9orf72 in Amyotrophic Lateral Sclerosis Annals of Neurology. Oct, 2015 | Pubmed ID: 26174152 Jump from Pre-mutation to Pathologic Expansion in C9orf72 American Journal of Human Genetics. Jun, 2015 | Pubmed ID: 26004200 Mutation Analysis of CHCHD10 in Different Neurodegenerative Diseases Brain : a Journal of Neurology. Sep, 2015 | Pubmed ID: 25833818 Low Molecular Weight Species of TDP-43 Generated by Abnormal Splicing Form Inclusions in Amyotrophic Lateral Sclerosis and Result in Motor Neuron Death Acta Neuropathologica. Jul, 2015 | Pubmed ID: 25788357 The C9orf72 Repeat Expansion Itself is Methylated in ALS and FTLD Patients Acta Neuropathologica. May, 2015 | Pubmed ID: 25716178 Electrical Impedance Myography in the Evaluation of the Tongue Musculature in Amyotrophic Lateral Sclerosis Muscle & Nerve. Oct, 2015 | Pubmed ID: 25580728 Mutation Analysis of Patients with Neurodegenerative Disorders Using NeuroX Array Neurobiology of Aging. Jan, 2015 | Pubmed ID: 25174650 Identical Twins with the C9orf72 Repeat Expansion Are Discordant for ALS Neurology. Oct, 2014 | Pubmed ID: 25209579 Economic Burden of Amyotrophic Lateral Sclerosis: a Canadian Study of Out-of-pocket Expenses Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Sep, 2014 | Pubmed ID: 25025935 Hypermethylation of the CpG-island Near the C9orf72 G₄C₂-repeat Expansion in FTLD Patients Human Molecular Genetics. Nov, 2014 | Pubmed ID: 24908669 Venous Thromboembolism in Amyotrophic Lateral Sclerosis: a Prospective Study Neurology. May, 2014 | Pubmed ID: 24727309 Mutations in the Matrin 3 Gene Cause Familial Amyotrophic Lateral Sclerosis Nature Neuroscience. May, 2014 | Pubmed ID: 24686783 Speech in ALS: Longitudinal Changes in Lips and Jaw Movements and Vowel Acoustics Journal of Medical Speech-language Pathology. Mar, 2013 | Pubmed ID: 27453680 Bulbar and Speech Motor Assessment in ALS: Challenges and Future Directions Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Jul, 2013 | Pubmed ID: 23898888 Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion American Journal of Human Genetics. Jun, 2013 | Pubmed ID: 23731538 Mortality Associated with Periodic Limb Movements During Sleep in Amyotrophic Lateral Sclerosis Patients Einstein (Sao Paulo, Brazil). Oct-Dec, 2012 | Pubmed ID: 23386081 Enhancing Clinical Trials in Neurodegenerative Disorders: Lessons from Amyotrophic Lateral Sclerosis Current Opinion in Neurology. Dec, 2012 | Pubmed ID: 23160423 Investigación De C9orf72 En 4 Enfermedades Neurodegenerativas Archives of Neurology. Sep, 2012 | Pubmed ID: 22964832 Tongue Movements and Their Acoustic Consequences in Amyotrophic Lateral Sclerosis Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP). 2012 | Pubmed ID: 22555651 Expansión De La Repetición En Hexanucleótido C9ORF72 Es La Causa Del Cromosoma 9p21-vinculado ELA-FTD Neuron. Oct, 2011 | Pubmed ID: 21944779 Miopatía Paraespinal Con La Novela Fragmento-como Agregados Compactos De Filamentos Delgados Muscle & Nerve. Jul, 2011 | Pubmed ID: 21660984 La Heterogeneidad Patológica De La Esclerosis Lateral Amiotrófica Con Mutaciones Del FUS: Dos Modelos De Correlación Con La Gravedad Y La Mutación Acta Neuropathologica. Jul, 2011 | Pubmed ID: 21604077 Objetivos Emergentes Y Tratamientos En La Esclerosis Lateral Amiotrófica Lancet Neurology. May, 2011 | Pubmed ID: 21511200 Los Objetivos De ARN De TDP-43 Identificados Por La Radiación UV-CLIP Se Encuentran Desreguladas En La ELA Molecular and Cellular Neurosciences. Jul, 2011 | Pubmed ID: 21421050 Distintas Firmas Bioquímicos Caracterizar Periferina Isoforma De Expresión Tanto En La Lesión Traumática Neuronal Y Enfermedad De La Motoneurona Journal of Neurochemistry. Aug, 2010 | Pubmed ID: 20533992 Safety and Efficacy of Lithium in Combination with Riluzole for Treatment of Amyotrophic Lateral Sclerosis: a Randomised, Double-blind, Placebo-controlled Trial Lancet Neurology. May, 2010 | Pubmed ID: 20363190 La Ventilación No Invasiva Para Los Pacientes Canadienses Con Esclerosis Lateral Amiotrófica: ¿Tenemos Un Consenso? The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. Jan, 2010 | Pubmed ID: 20169767 Esclerosis Lateral Amiotrófica Es Una Enfermedad No-amiloide En El Que Misfolding Extensivo De SOD1 Es Aplicable Sólo a La Forma Familiar Acta Neuropathologica. Mar, 2010 | Pubmed ID: 20111867 Cinemática De La Progresión De La Enfermedad En La ELA Bulbar Journal of Communication Disorders. Jan-Feb, 2010 | Pubmed ID: 19683250 Seguridad De La Vacunación Contra La Influenza En Pacientes Con Miastenia Gravis: Un Estudio De Base Poblacional Muscle & Nerve. Dec, 2009 | Pubmed ID: 19902540 La Falta De Evidencia De Monómero / Mal Plegadas Superóxido Dismutasa 1 En Esclerosis Lateral Amiotrófica Esporádica Annals of Neurology. Jul, 2009 | Pubmed ID: 19670443 ¿Son Las Estatinas Seguro En Pacientes Con Esclerosis Lateral Amiotrófica? Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. Aug, 2008 | Pubmed ID: 18608105 IgIV Tratamiento Para La Miastenia Grave: Eficacia, Limitaciones Y Nuevas Estrategias Terapéuticas Annals of the New York Academy of Sciences. 2008 | Pubmed ID: 18567877 Medidas Sustitutos Efecto Terapéutico En Pacientes Con Miastenia Gravis Muscle & Nerve. Feb, 2008 | Pubmed ID: 17918748 Los Estudios Genéticos De La GRN Y IFT74 En La Esclerosis Lateral Amiotrófica Neurobiology of Aging. Aug, 2008 | Pubmed ID: 17383054 Evidencia De Que La TDP-43 No Es El Principal Objetivo Ubiquitinated Dentro De Las Inclusiones Patológicas De La Esclerosis Lateral Amiotrófica Journal of Neuropathology and Experimental Neurology. Dec, 2007 | Pubmed ID: 18090923 Inmunoglobulina IV En Pacientes Con Miastenia Gravis: Un Ensayo Controlado Aleatorio Neurology. Mar, 2007 | Pubmed ID: 17353471 La Sensibilidad De Los Nervios Facial Repetitivo Estimulación En Pacientes Con Miastenia Gravis Muscle & Nerve. May, 2006 | Pubmed ID: 16421884 Enfriamiento Umbrales De Detección En La Evaluación De La Polineuropatía Diabética Sensorial: Comparación De Caso IV Y Los Instrumentos De Medoc Diabetes Care. Jul, 2004 | Pubmed ID: 15220245 Láser De Baja Intensidad Terapia Para Los Síntomas Dolorosos De La Polineuropatía Sensitivomotora Diabética: Un Ensayo Controlado Diabetes Care. Apr, 2004 | Pubmed ID: 15047649 Dirigida tubería de Bioinformática y secuenciación de próxima generación para evaluar determinantes genéticos de la enfermedad constitucional Allison A. Dilliott1,2, Sali M.K. Farhan3, Mahdi Ghani4, Christine Sato4, Eric Liang5, Ming Zhang4, Adam D. McIntyre1, Henian Cao1, Lemuel Racacho6,7, John F. Robinson1, Michael J. Strong1,8, Mario Masellis9,10, Dennis E. Bulman6,7, Ekaterina Rogaeva4, Anthony Lang10,11, Carmela Tartaglia4,10, Elizabeth Finger12,13, Lorne Zinman9, John Turnbull14, Morris Freedman10,15, Rick Swartz9, Sandra E. Black9,16, Robert A. Hegele1,2 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, 3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, 4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 5School of Medicine, Faculty of Health Sciences, Queen's University, 6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 7CHEO Research Institute, Faculty of Medicine, University of Ottawa, 8Department of Clinical Neurological Sciences, Western University, 9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 10Division of Neurology, Department of Medicine, University of Toronto, 11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, 12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 13Parkwood Institute, St. Joseph's Health Care, 14Department of Medicine, Division of Neurology, McMaster University, 15Division of Neurology, Department of Medicine, Baycrest Health Sciences, 16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto JoVE 57266 Genetics Un Protocolo de Evaluación Integral de la disfunción bulbar de la Esclerosis Lateral Amiotrófica (ALS) Yana Yunusova1,2, Jordan R. Green3, Jun Wang3, Gary Pattee4, Lorne Zinman2,5 1Department of Speech-Language Pathology, University of Toronto, 2ALS/ MN Clinic, Sunnybrook Health Science Centre, 3Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, 4Department of Neurology, Munroe-Meyer Institute, University of Nebraska Medical Center, 5Department of Neurology, University of Toronto JoVE 2422 Medicine
Dirigida tubería de Bioinformática y secuenciación de próxima generación para evaluar determinantes genéticos de la enfermedad constitucional Allison A. Dilliott1,2, Sali M.K. Farhan3, Mahdi Ghani4, Christine Sato4, Eric Liang5, Ming Zhang4, Adam D. McIntyre1, Henian Cao1, Lemuel Racacho6,7, John F. Robinson1, Michael J. Strong1,8, Mario Masellis9,10, Dennis E. Bulman6,7, Ekaterina Rogaeva4, Anthony Lang10,11, Carmela Tartaglia4,10, Elizabeth Finger12,13, Lorne Zinman9, John Turnbull14, Morris Freedman10,15, Rick Swartz9, Sandra E. Black9,16, Robert A. Hegele1,2 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, 3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, 4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 5School of Medicine, Faculty of Health Sciences, Queen's University, 6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 7CHEO Research Institute, Faculty of Medicine, University of Ottawa, 8Department of Clinical Neurological Sciences, Western University, 9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 10Division of Neurology, Department of Medicine, University of Toronto, 11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, 12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 13Parkwood Institute, St. Joseph's Health Care, 14Department of Medicine, Division of Neurology, McMaster University, 15Division of Neurology, Department of Medicine, Baycrest Health Sciences, 16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto JoVE 57266 Genetics
Un Protocolo de Evaluación Integral de la disfunción bulbar de la Esclerosis Lateral Amiotrófica (ALS) Yana Yunusova1,2, Jordan R. Green3, Jun Wang3, Gary Pattee4, Lorne Zinman2,5 1Department of Speech-Language Pathology, University of Toronto, 2ALS/ MN Clinic, Sunnybrook Health Science Centre, 3Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, 4Department of Neurology, Munroe-Meyer Institute, University of Nebraska Medical Center, 5Department of Neurology, University of Toronto JoVE 2422 Medicine