M. Juliana McElrath Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Biography Publications Institution JoVE Articles M. Juliana McElrath has not added a biography. If you are M. Juliana McElrath and would like to personalize this page please email our Author Liaison for assistance. Publications MRKAd5 HIV-1 Gag/Pol/Nef Vaccine-Induced T-Cell Responses Inadequately Predict Distance of Breakthrough HIV-1 Sequences to the Vaccine or Viral Load PloS One. 2012 | Pubmed ID: 22952672 Quantifying Ongoing HIV-1 Exposure in HIV-1-Serodiscordant Couples to Identify Individuals With Potential Host Resistance to HIV-1 The Journal of Infectious Diseases. Aug, 2012 | Pubmed ID: 22926009 A Novel HIV Vaccine Adjuvanted by IC31 Induces Robust and Persistent Humoral and Cellular Immunity PloS One. 2012 | Pubmed ID: 22848738 Is an HIV Vaccine Possible? Journal of Acquired Immune Deficiency Syndromes (1999). Aug, 2012 | Pubmed ID: 22772390 Two New Monoclonal Antibodies for Biochemical and Flow Cytometric Analyses of Human Interferon Regulatory Factor-3 Activation, Turnover, and Depletion Methods (San Diego, Calif.). Jun, 2012 | Pubmed ID: 22705311 Vpu-Deficient HIV Strains Stimulate Innate Immune Signaling Responses in Target Cells Journal of Virology. Aug, 2012 | Pubmed ID: 22647704 Optimization and Qualification of a Multiplex Bead Array to Assess Cytokine and Chemokine Production by Vaccine-specific Cells Journal of Immunological Methods. Aug, 2012 | Pubmed ID: 22626638 Vpu Mediates Depletion of Interferon Regulatory Factor 3 During HIV Infection by a Lysosome-Dependent Mechanism Journal of Virology. Aug, 2012 | Pubmed ID: 22593165 Decreased Pre-existing Ad5 Capsid and Ad35 Neutralizing Antibodies Increase HIV-1 Infection Risk in the Step Trial Independent of Vaccination PloS One. 2012 | Pubmed ID: 22496775 Immune-correlates Analysis of an HIV-1 Vaccine Efficacy Trial The New England Journal of Medicine. Apr, 2012 | Pubmed ID: 22475592 Human Adenovirus-specific T Cells Modulate HIV-specific T Cell Responses to an Ad5-vectored HIV-1 Vaccine The Journal of Clinical Investigation. Jan, 2012 | Pubmed ID: 22201684 Profiling Immunity to HIV Vaccines with Systems Biology Current Opinion in HIV and AIDS. Jan, 2012 | Pubmed ID: 22134340 Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure PloS One. 2011 | Pubmed ID: 22174851 Vaginal Langerhans Cells Nonproductively Transporting HIV-1 Mediate Infection of T Cells Journal of Virology. Dec, 2011 | Pubmed ID: 21976645 Timing of Plasmid Cytokine (IL-2/Ig) Administration Affects HIV-1 Vaccine Immunogenicity in HIV-seronegative Subjects The Journal of Infectious Diseases. Nov, 2011 | Pubmed ID: 21940420 Safety and Immunogenicity of an HIV Adenoviral Vector Boost After DNA Plasmid Vaccine Prime by Route of Administration: a Randomized Clinical Trial PloS One. 2011 | Pubmed ID: 21931737 A Phase IIA Randomized Clinical Trial of a Multiclade HIV-1 DNA Prime Followed by a Multiclade RAd5 HIV-1 Vaccine Boost in Healthy Adults (HVTN204) PloS One. 2011 | Pubmed ID: 21857901 HIV-DNA Priming Alters T Cell Responses to HIV-adenovirus Vaccine Even when Responses to DNA Are Undetectable Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21844392 Protective HIV-specific CD8+ T Cells Evade Treg Cell Suppression Nature Medicine. Aug, 2011 | Pubmed ID: 21765403 Host Genetic Polymorphisms Associated with Innate Immune Factors and HIV-1 Current Opinion in HIV and AIDS. Sep, 2011 | Pubmed ID: 21734565 Vaccine-induced HIV-specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-specific Regions of HIV-1 Journal of Acquired Immune Deficiency Syndromes (1999). Nov, 2011 | Pubmed ID: 21709567 Mapping HIV-1 Vaccine Induced T-cell Responses: Bias Towards Less-conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study PloS One. 2011 | Pubmed ID: 21695251 Demographic Processes Affect HIV-1 Evolution in Primary Infection Before the Onset of Selective Processes Journal of Virology. Aug, 2011 | Pubmed ID: 21593162 Pre-existing Adenovirus Immunity Modifies a Complex Mixed Th1 and Th2 Cytokine Response to an Ad5/HIV-1 Vaccine Candidate in Humans PloS One. 2011 | Pubmed ID: 21533229 Priming CD8+ T Cells with Dendritic Cells Matured Using TLR4 and TLR7/8 Ligands Together Enhances Generation of CD8+ T Cells Retaining CD28 Blood. Jun, 2011 | Pubmed ID: 21493800 A Trimeric, V2-deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers The Journal of Infectious Diseases. Apr, 2011 | Pubmed ID: 21451004 Association Between Peripheral γδ T-cell Profile and Disease Progression in Individuals Infected with HIV-1 or HIV-2 in West Africa Journal of Acquired Immune Deficiency Syndromes (1999). Jun, 2011 | Pubmed ID: 21423026 Trivalent Adenovirus Type 5 HIV Recombinant Vaccine Primes for Modest Cytotoxic Capacity That is Greatest in Humans with Protective HLA Class I Alleles PLoS Pathogens. Feb, 2011 | Pubmed ID: 21383976 Genetic Impact of Vaccination on Breakthrough HIV-1 Sequences from the STEP Trial Nature Medicine. Mar, 2011 | Pubmed ID: 21358627 Standing Guard at the Mucosa Immunity. Feb, 2011 | Pubmed ID: 21349427 Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection PloS One. 2011 | Pubmed ID: 21283794 Host Genetic Determinants of T Cell Responses to the MRKAd5 HIV-1 Gag/pol/nef Vaccine in the Step Trial The Journal of Infectious Diseases. Mar, 2011 | Pubmed ID: 21278214 A Phase I Trial of Preventive HIV Vaccination with Heterologous Poxviral-vectors Containing Matching HIV-1 Inserts in Healthy HIV-uninfected Subjects Vaccine. Feb, 2011 | Pubmed ID: 21216311 Serological Immunity to Adenovirus Serotype 5 is Not Associated with Risk of HIV Infection: a Case-control Study AIDS (London, England). Jan, 2011 | Pubmed ID: 21150554 Equivalence of ELISpot Assays Demonstrated Between Major HIV Network Laboratories PloS One. 2010 | Pubmed ID: 21179404 Profiles of Human Serum Antibody Responses Elicited by Three Leading HIV Vaccines Focusing on the Induction of Env-specific Antibodies PloS One. 2010 | Pubmed ID: 21085486 The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation Science (New York, N.Y.). Dec, 2010 | Pubmed ID: 21051598 Safety and Immunogenicity of a Replication-defective Adenovirus Type 5 HIV Vaccine in Ad5-seronegative Persons: a Randomized Clinical Trial (HVTN 054) PloS One. 2010 | Pubmed ID: 21048953 Induction of Immunity to Human Immunodeficiency Virus Type-1 by Vaccination Immunity. Oct, 2010 | Pubmed ID: 21029964 Immune Responses to HIV Vaccines and Potential Impact on Control of Acute HIV-1 Infection The Journal of Infectious Diseases. Oct, 2010 | Pubmed ID: 20846040 Immunization with Cocktail of HIV-derived Peptides in Montanide ISA-51 is Immunogenic, but Causes Sterile Abscesses and Unacceptable Reactogenicity PloS One. 2010 | Pubmed ID: 20706632 Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells Through Expression of APOBEC3A Isoforms The Journal of Biological Chemistry. Sep, 2010 | Pubmed ID: 20615867 HIV Vaccines: Mosaic Approach to Virus Diversity Nature Medicine. Mar, 2010 | Pubmed ID: 20208511 In Situ Detection of Gag-specific CD8+ Cells in the GI Tract of SIV Infected Rhesus Macaques Retrovirology. 2010 | Pubmed ID: 20158906 Virus-specific CD8+ T-cell Responses Better Define HIV Disease Progression Than HLA Genotype Journal of Virology. May, 2010 | Pubmed ID: 20147397 Ex Vivo Comparison of Microbicide Efficacies for Preventing HIV-1 Genomic Integration in Intraepithelial Vaginal Cells Antimicrobial Agents and Chemotherapy. Feb, 2010 | Pubmed ID: 19949052 Differential Specificity and Immunogenicity of Adenovirus Type 5 Neutralizing Antibodies Elicited by Natural Infection or Immunization Journal of Virology. Jan, 2010 | Pubmed ID: 19846512 Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-lymphocyte Responses The Journal of Infectious Diseases. Dec, 2009 | Pubmed ID: 19909083 Polymorphisms in Toll-like Receptor 4 and Toll-like Receptor 9 Influence Viral Load in a Seroincident Cohort of HIV-1-infected Individuals AIDS (London, England). Nov, 2009 | Pubmed ID: 19855253 Preinfection Human Immunodeficiency Virus (HIV)-specific Cytotoxic T Lymphocytes Failed to Prevent HIV Type 1 Infection from Strains Genetically Unrelated to Viruses in Long-term Exposed Partners Journal of Virology. Oct, 2009 | Pubmed ID: 19706711 Human Immunodeficiency Virus Type 1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses Within Infected Cells Journal of Virology. Oct, 2009 | Pubmed ID: 19706707 Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response PLoS Pathogens. Apr, 2009 | Pubmed ID: 19343217 Post-step Modifications for Research on HIV Vaccines AIDS (London, England). Jan, 2009 | Pubmed ID: 19050380 Safety and Immunogenicity of a CTL Multiepitope Peptide Vaccine for HIV with or Without GM-CSF in a Phase I Trial Vaccine. Jan, 2009 | Pubmed ID: 18996425 T Cell Responses Generated by HIV Vaccines in Clinical Trials Current Opinion in HIV and AIDS. May, 2008 | Pubmed ID: 19372993 HIV-1 Vaccine-induced Immunity in the Test-of-concept Step Study: a Case-cohort Analysis Lancet. Nov, 2008 | Pubmed ID: 19012957 Efficacy Assessment of a Cell-mediated Immunity HIV-1 Vaccine (the Step Study): a Double-blind, Randomised, Placebo-controlled, Test-of-concept Trial Lancet. Nov, 2008 | Pubmed ID: 19012954 Impaired Viral Entry Cannot Explain Reduced CD4+ T Cell Susceptibility to HIV Type 1 in Certain Highly Exposed Individuals AIDS Research and Human Retroviruses. Nov, 2008 | Pubmed ID: 19000021 Development of an Automated Analysis System for Data from Flow Cytometric Intracellular Cytokine Staining Assays from Clinical Vaccine Trials Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Sep, 2008 | Pubmed ID: 18615598 Setting the Stage: Host Invasion by HIV Nature Reviews. Immunology. Jun, 2008 | Pubmed ID: 18469831 Novel Cytotoxic T-lymphocyte Escape Mutation by a Three-amino-acid Insertion in the Human Immunodeficiency Virus Type 1 P6Pol and P6Gag Late Domain Associated with Drug Resistance Journal of Virology. Jan, 2008 | Pubmed ID: 17942528 A Framework for Assessing Immunological Correlates of Protection in Vaccine Trials The Journal of Infectious Diseases. Nov, 2007 | Pubmed ID: 17922394 Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-lymphocyte Epitopes: Fitness-balanced Escape Journal of Virology. Nov, 2007 | Pubmed ID: 17728222 Role of Human Immunodeficiency Virus (HIV)-specific T-cell Immunity in Control of Dual HIV-1 and HIV-2 Infection Journal of Virology. Sep, 2007 | Pubmed ID: 17582003 Optimization and Validation of an 8-color Intracellular Cytokine Staining (ICS) Assay to Quantify Antigen-specific T Cells Induced by Vaccination Journal of Immunological Methods. May, 2007 | Pubmed ID: 17451739 Macaques Infected with a CCR5-tropic Simian/human Immunodeficiency Virus (SHIV) Develop Broadly Reactive Anti-HIV Neutralizing Antibodies Journal of Virology. Jun, 2007 | Pubmed ID: 17392364 Defining Blood Processing Parameters for Optimal Detection of Cryopreserved Antigen-specific Responses for HIV Vaccine Trials Journal of Immunological Methods. Apr, 2007 | Pubmed ID: 17382342 Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection Journal of Virology. May, 2007 | Pubmed ID: 17329342 Initial Events in Establishing Vaginal Entry and Infection by Human Immunodeficiency Virus Type-1 Immunity. Feb, 2007 | Pubmed ID: 17306567 Comprehensive Epitope Analysis of Cross-clade Gag-specific T-cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic Vaccine. Jan, 2007 | Pubmed ID: 17112643 Phase 2 Study of an HIV-1 Canarypox Vaccine (vCP1452) Alone and in Combination with Rgp120: Negative Results Fail to Trigger a Phase 3 Correlates Trial Journal of Acquired Immune Deficiency Syndromes (1999). Feb, 2007 | Pubmed ID: 17106277 Durable HIV-1 Antibody and T-cell Responses Elicited by an Adjuvanted Multi-protein Recombinant Vaccine in Uninfected Human Volunteers Vaccine. Jan, 2007 | Pubmed ID: 17049679 Preservation of T Cell Proliferation Restricted by Protective HLA Alleles is Critical for Immune Control of HIV-1 Infection Journal of Immunology (Baltimore, Md. : 1950). Nov, 2006 | Pubmed ID: 17082660 Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-specific T-cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection Journal of Virology. Oct, 2006 | Pubmed ID: 16973582 Selection on the Human Immunodeficiency Virus Type 1 Proteome Following Primary Infection Journal of Virology. Oct, 2006 | Pubmed ID: 16973556 Abacavir Hypersensitivity Reaction in Primary HIV Infection AIDS (London, England). Jun, 2006 | Pubmed ID: 16816555 Genetic Association of the Antiviral Restriction Factor TRIM5alpha with Human Immunodeficiency Virus Type 1 Infection Journal of Virology. Mar, 2006 | Pubmed ID: 16474153 Repeat-region Polymorphisms in the Gene for the Dendritic Cell-specific Intercellular Adhesion Molecule-3-grabbing Nonintegrin-related Molecule: Effects on HIV-1 Susceptibility The Journal of Infectious Diseases. Mar, 2006 | Pubmed ID: 16453266 CD4+ T Cell Receptor Repertoire Perturbations in HIV-1 Infection: Association with Plasma Viremia and Disease Progression Clinical Immunology (Orlando, Fla.). Apr, 2006 | Pubmed ID: 16403675 Combined Effect of CCR5-Delta32 Heterozygosity and the CCR5 Promoter Polymorphism -2459 A/G on CCR5 Expression and Resistance to Human Immunodeficiency Virus Type 1 Transmission Journal of Virology. Sep, 2005 | Pubmed ID: 16140745 High-dose Recombinant Canarypox Vaccine Expressing HIV-1 Protein, in Seronegative Human Subjects The Journal of Infectious Diseases. Oct, 2005 | Pubmed ID: 16136469 Most DC-SIGNR Transcripts at Mucosal HIV Transmission Sites Are Alternatively Spliced Isoforms European Journal of Human Genetics : EJHG. Jun, 2005 | Pubmed ID: 15812562 Demographic Factors That Influence the Neutralizing Antibody Response in Recipients of Recombinant HIV-1 Gp120 Vaccines The Journal of Infectious Diseases. Dec, 2004 | Pubmed ID: 15529261 Correlation Between Interferon- Gamma Secretion and Cytotoxicity, in Virus-specific Memory T Cells The Journal of Infectious Diseases. Nov, 2004 | Pubmed ID: 15478077 Effect of Adjunct Hydroxyurea on Helper T Cell Immunity in HIV Type 1-infected Patients with Virological Suppression AIDS Research and Human Retroviruses. Aug, 2004 | Pubmed ID: 15320983 Analysis of Genetic Polymorphisms in CCR5, CCR2, Stromal Cell-derived Factor-1, RANTES, and Dendritic Cell-specific Intercellular Adhesion Molecule-3-grabbing Nonintegrin in Seronegative Individuals Repeatedly Exposed to HIV-1 The Journal of Infectious Diseases. Sep, 2004 | Pubmed ID: 15319853 Breakthrough Infections During Phase 1 and 2 Prime-boost HIV-1 Vaccine Trials with Canarypox Vectors (ALVAC) and Booster Dose of Recombinant Gp120 or Gp160 The Journal of Infectious Diseases. Sep, 2004 | Pubmed ID: 15295694 Absence of Immunodominant Anti-Gag P17 (SL9) Responses Among Gag CTL-positive, HIV-uninfected Vaccine Recipients Expressing the HLA-A*0201 Allele Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004 | Pubmed ID: 15265949 Statistical Considerations for the Design and Analysis of the ELISpot Assay in HIV-1 Vaccine Trials Journal of Immunological Methods. May, 2004 | Pubmed ID: 15183082 Comparison of Systemic and Mucosal Delivery of 2 Canarypox Virus Vaccines Expressing Either HIV-1 Genes or the Gene for Rabies Virus G Protein The Journal of Infectious Diseases. Apr, 2004 | Pubmed ID: 15031791 Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease The Journal of Infectious Diseases. Feb, 2004 | Pubmed ID: 14745710 Incomplete Immune Reconstitution After Initiation of Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus-infected Patients with Severe CD4+ Cell Depletion The Journal of Infectious Diseases. Dec, 2003 | Pubmed ID: 14673757 Broadly Increased Sensitivity to Cytotoxic T Lymphocytes Resulting from Nef Epitope Escape Mutations Journal of Immunology (Baltimore, Md. : 1950). Oct, 2003 | Pubmed ID: 14530319 Evolution of CD8+ T Cell Immunity and Viral Escape Following Acute HIV-1 Infection Journal of Immunology (Baltimore, Md. : 1950). Oct, 2003 | Pubmed ID: 14500685 Hepatitis C Virus-specific Cytolytic T Cell Responses After Antiviral Therapy Clinical Immunology (Orlando, Fla.). Sep, 2003 | Pubmed ID: 14499244 Most Highly Exposed Seronegative Men Lack HIV-1-specific, IFN-gamma-secreting T Cells Journal of Immunology (Baltimore, Md. : 1950). Sep, 2003 | Pubmed ID: 12928421 HIV-1 Vaccination Administered Intramuscularly Can Induce Both Systemic and Mucosal T Cell Immunity in HIV-1-uninfected Individuals Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003 | Pubmed ID: 12847284 Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-specific Gamma Interferon-secreting CD8+ T Cells in Primary HIV-1 Infection Journal of Virology. Jun, 2003 | Pubmed ID: 12768006 Persistence of Extraordinarily Low Levels of Genetically Homogeneous Human Immunodeficiency Virus Type 1 in Exposed Seronegative Individuals Journal of Virology. Jun, 2003 | Pubmed ID: 12743268 Moving to Human Immunodeficiency Virus Type 1 Vaccine Efficacy Trials: Defining T Cell Responses As Potential Correlates of Immunity The Journal of Infectious Diseases. Jan, 2003 | Pubmed ID: 12552447 Early Induction and Maintenance of Env-specific T-helper Cells Following Human Immunodeficiency Virus Type 1 Infection Journal of Virology. Feb, 2003 | Pubmed ID: 12552005 Progress in the Development of a Preventive HIV-1 Vaccine Clinics in Laboratory Medicine. Dec, 2002 | Pubmed ID: 12489290 Safety and Immunogenicity of a High-titered Canarypox Vaccine in Combination with Rgp120 in a Diverse Population of HIV-1-uninfected Adults: AIDS Vaccine Evaluation Group Protocol 022A Journal of Acquired Immune Deficiency Syndromes (1999). Mar, 2002 | Pubmed ID: 11873074 Перечень основных периферической крови популяции лейкоцитов для многоцентровых клинических испытаний с использованием полного анализа крови Фенотипирование Tiffany R. Hensley1, Austin B. Easter1, Sarah E. Gerdts1, Stephen C. De Rosa1, Antje Heit1, M. Juliana McElrath1, Erica Andersen-Nissen1 1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center JoVE 4302 Immunology and Infection
Перечень основных периферической крови популяции лейкоцитов для многоцентровых клинических испытаний с использованием полного анализа крови Фенотипирование Tiffany R. Hensley1, Austin B. Easter1, Sarah E. Gerdts1, Stephen C. De Rosa1, Antje Heit1, M. Juliana McElrath1, Erica Andersen-Nissen1 1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center JoVE 4302 Immunology and Infection
