Maarten Merkx Laboratory of Chemical Biology Institute of Complex Molecular Systems (ICMS) Biography Publications Institution JoVE Articles Maarten Merkx has not added a biography. If you are Maarten Merkx and would like to personalize this page please email our Author Liaison for assistance. Publications Inhibition of Human Copper Trafficking by a Small Molecule Significantly Attenuates Cancer Cell Proliferation Nature Chemistry. Dec, 2015 | Pubmed ID: 26587712 EZinCh-2: A Versatile, Genetically Encoded FRET Sensor for Cytosolic and Intraorganelle Zn(2+) Imaging ACS Chemical Biology. Sep, 2015 | Pubmed ID: 26151333 Efficient Synthesis of Peptide and Protein Functionalized Pyrrole-Imidazole Polyamides Using Native Chemical Ligation International Journal of Molecular Sciences. 2015 | Pubmed ID: 26053396 Antibody Activation Using DNA-based Logic Gates Angewandte Chemie (International Ed. in English). Feb, 2015 | Pubmed ID: 25573528 DNA-directed Control of Enzyme-inhibitor Complex Formation: a Modular Approach to Reversibly Switch Enzyme Activity ACS Synthetic Biology. May, 2015 | Pubmed ID: 25216042 Genetically-encoded FRET-based Sensors for Monitoring Zn(2+) in Living Cells Metallomics : Integrated Biometal Science. Feb, 2015 | Pubmed ID: 25156481 Colorful Protein-based Fluorescent Probes for Collagen Imaging PloS One. 2014 | Pubmed ID: 25490719 Treatment Outcome of Alcohol Use Disorder Outpatients with or Without Medically Assisted Detoxification Journal of Studies on Alcohol and Drugs. Nov, 2014 | Pubmed ID: 25343657 Quantifying Stickiness: Thermodynamic Characterization of Intramolecular Domain Interactions to Guide the Design of Förster Resonance Energy Transfer Sensors Biochemistry. Oct, 2014 | Pubmed ID: 25216081 Mitochondrial and ER-targeted ECALWY Probes Reveal High Levels of Free Zn2+ ACS Chemical Biology. Sep, 2014 | Pubmed ID: 25011072 Engineering Genetically Encoded FRET Sensors Sensors (Basel, Switzerland). 2014 | Pubmed ID: 24991940 Dynamic Imaging of Cytosolic Zinc in Arabidopsis Roots Combining FRET Sensors and RootChip Technology The New Phytologist. Apr, 2014 | Pubmed ID: 24372442 MagFRET: the First Genetically Encoded Fluorescent Mg2+ Sensor PloS One. 2013 | Pubmed ID: 24312622 No Washing, Less Waiting: Engineering Biomolecular Reporters for Single-step Antibody Detection in Solution Organic & Biomolecular Chemistry. Nov, 2013 | Pubmed ID: 24091607 Rational Design of FRET Sensor Proteins Based on Mutually Exclusive Domain Interactions Biochemical Society Transactions. Oct, 2013 | Pubmed ID: 24059509 Robust Red FRET Sensors Using Self-associating Fluorescent Domains ACS Chemical Biology. Oct, 2013 | Pubmed ID: 23962156 Switchable Reporter Enzymes Based on Mutually Exclusive Domain Interactions Allow Antibody Detection Directly in Solution ACS Chemical Biology. Oct, 2013 | Pubmed ID: 23941162 Non Contrast-enhanced MRA Versus Ultrasound Blood Vessel Assessment to Determine the Choice of Hemodialysis Vascular Access The Journal of Vascular Access. Oct-Dec, 2013 | Pubmed ID: 23817956 The Benefit of Non Contrast-enhanced Magnetic Resonance Angiography for Predicting Vascular Access Surgery Outcome: a Computer Model Perspective PloS One. 2013 | Pubmed ID: 23390490 Supramolecular Control of Enzyme Activity Through Cucurbit[8]uril-mediated Dimerization Angewandte Chemie (International Ed. in English). Mar, 2013 | Pubmed ID: 23355250 Predictive Validity of Treatment Allocation Guidelines on Drinking Outcome in Alcohol-dependent Patients Addictive Behaviors. Mar, 2013 | Pubmed ID: 23254220 Tuning the Metal Binding Site Specificity of a Fluorescent Sensor Protein: from Copper to Zinc and Back Dalton Transactions (Cambridge, England : 2003). Mar, 2013 | Pubmed ID: 23076326 Monitoring Bile Acid Transport in Single Living Cells Using a Genetically Encoded Förster Resonance Energy Transfer Sensor Hepatology (Baltimore, Md.). Feb, 2013 | Pubmed ID: 22899095 Accuracy and Precision of Vessel Area Assessment: Manual Versus Automatic Lumen Delineation Based on Full-width at Half-maximum Journal of Magnetic Resonance Imaging : JMRI. Nov, 2012 | Pubmed ID: 22826150 Calculation of Transition Dipole Moment in Fluorescent Proteins--towards Efficient Energy Transfer Physical Chemistry Chemical Physics : PCCP. Mar, 2012 | Pubmed ID: 22331099 Colorful Calcium Sensors Chembiochem : a European Journal of Chemical Biology. Feb, 2012 | Pubmed ID: 22234942 In Vivo Characterization of a New Abdominal Aortic Aneurysm Mouse Model with Conventional and Molecular Magnetic Resonance Imaging Journal of the American College of Cardiology. Dec, 2011 | Pubmed ID: 22133853 Reengineering of a Fluorescent Zinc Sensor Protein Yields the First Genetically Encoded Cadmium Probe Chemical Communications (Cambridge, England). Nov, 2011 | Pubmed ID: 21986860 Semi-synthesis of a Protease-activatable Collagen Targeting Probe Chemical Communications (Cambridge, England). Jul, 2011 | Pubmed ID: 21691626 Chemoselective Protein and Peptide Immobilization on Biosensor Surfaces Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21674345 NMR Characterization of a Cu(I)-bound Peptide Model of Copper Metallochaperones: Insights on the Role of Methionine Chemical Communications (Cambridge, England). Jun, 2011 | Pubmed ID: 21552638 Choline Dendrimers As Generic Scaffolds for the Non-covalent Synthesis of Multivalent Protein Assemblies Chemical Communications (Cambridge, England). Jun, 2011 | Pubmed ID: 21512694 From Phage Display to Dendrimer Display: Insights into Multivalent Binding Journal of the American Chemical Society. May, 2011 | Pubmed ID: 21473586 Engineering Protein Switches: Sensors, Regulators, and Spare Parts for Biology and Biotechnology Chembiochem : a European Journal of Chemical Biology. Feb, 2011 | Pubmed ID: 21271630 Dendrimer Display of Tumor-homing Peptides Bioconjugate Chemistry. Mar, 2011 | Pubmed ID: 21261269 Guidelines for Allocating Outpatient Alcohol Abusers to Levels of Care: Predictive Validity Addictive Behaviors. Jun, 2011 | Pubmed ID: 21236585 The Binding of CNA35 Contrast Agents to Collagen Fibrils Chemical Communications (Cambridge, England). Feb, 2011 | Pubmed ID: 21088778 Collagen Targeting Using Multivalent Protein-functionalized Dendrimers Bioorganic & Medicinal Chemistry. Feb, 2011 | Pubmed ID: 20724168 Antibody Detection by Using a FRET-based Protein Conformational Switch Chembiochem : a European Journal of Chemical Biology. Nov, 2010 | Pubmed ID: 20928879 Protease-activatable Collagen Targeting Based on Protein Cyclization Chembiochem : a European Journal of Chemical Biology. Aug, 2010 | Pubmed ID: 20589824 Exchange Kinetics of Protein-functionalized Micelles and Liposomes Studied by Förster Resonance Energy Transfer Bioconjugate Chemistry. May, 2010 | Pubmed ID: 20397687 Genetically Encoded FRET Sensors to Monitor Intracellular Zn2+ Homeostasis Nature Methods. Oct, 2009 | Pubmed ID: 19718032 High-affinity Peptide-based Collagen Targeting Using Synthetic Phage Mimics: from Phage Display to Dendrimer Display Journal of the American Chemical Society. Aug, 2009 | Pubmed ID: 19642697 Efficient, Chemoselective Synthesis of Immunomicelles Using Single-domain Antibodies with a C-terminal Thioester BMC Biotechnology. 2009 | Pubmed ID: 19619333 Noncovalent Synthesis of Protein Dendrimers Chemistry (Weinheim an Der Bergstrasse, Germany). Sep, 2009 | Pubmed ID: 19609988 Feasibility and Validity of Low-budget Telephonic Follow-up Interviews in Routine Outcome Monitoring of Substance Abuse Treatment Addiction (Abingdon, England). Jul, 2009 | Pubmed ID: 19563559 Collagen Targeting Using Protein-functionalized Micelles: the Strength of Multiple Weak Interactions Journal of the American Chemical Society. Jun, 2009 | Pubmed ID: 19469576 Efficient and Chemoselective Surface Immobilization of Proteins by Using Aniline-catalyzed Oxime Chemistry Chembiochem : a European Journal of Chemical Biology. Mar, 2009 | Pubmed ID: 19241407 Multivalent Choline Dendrimers As Potent Inhibitors of Pneumococcal Cell-wall Hydrolysis Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19115336 Two-photon Microscopy on Vital Carotid Arteries: Imaging the Relationship Between Collagen and Inflammatory Cells in Atherosclerotic Plaques Journal of Biomedical Optics. Jul-Aug, 2008 | Pubmed ID: 19021350 One-step Refolding and Purification of Disulfide-containing Proteins with a C-terminal MESNA Thioester BMC Biotechnology. 2008 | Pubmed ID: 18828922 Biomechanical Properties of Abdominal Aortic Aneurysms Assessed by Simultaneously Measured Pressure and Volume Changes in Humans Journal of Vascular Surgery. Dec, 2008 | Pubmed ID: 18771885 His-tags As Zn(II) Binding Motifs in a Protein-based Fluorescent Sensor Protein Engineering, Design & Selection : PEDS. Aug, 2008 | Pubmed ID: 18502789 Mapping Preferred Sites for Fluorescent Labeling by Combining Fluorescence and MS Analysis of Tryptic CNA35 Protein Digests Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Mar, 2008 | Pubmed ID: 18272440 Ratiometric Detection of Zn(II) Using Chelating Fluorescent Protein Chimeras Journal of Molecular Biology. Nov, 2007 | Pubmed ID: 17936298 Site-specific Protein and Peptide Immobilization on a Biosensor Surface by Pulsed Native Chemical Ligation Chembiochem : a European Journal of Chemical Biology. Oct, 2007 | Pubmed ID: 17763488 Branched KLVFF Tetramers Strongly Potentiate Inhibition of Beta-amyloid Aggregation Chembiochem : a European Journal of Chemical Biology. Oct, 2007 | Pubmed ID: 17763487 Imaging Collagen in Intact Viable Healthy and Atherosclerotic Arteries Using Fluorescently Labeled CNA35 and Two-photon Laser Scanning Microscopy Molecular Imaging. Jul-Aug, 2007 | Pubmed ID: 17711780 Human Copper Transporter 2 is Localized in Late Endosomes and Lysosomes and Facilitates Cellular Copper Uptake The Biochemical Journal. Oct, 2007 | Pubmed ID: 17617060 High Resolution Imaging of Collagen Organisation and Synthesis Using a Versatile Collagen Specific Probe Journal of Structural Biology. Sep, 2007 | Pubmed ID: 17572104 Ligand-induced Monomerization of Allochromatium Vinosum Cytochrome C' Studied Using Native Mass Spectrometry and Fluorescence Resonance Energy Transfer Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Aug, 2007 | Pubmed ID: 17546467 Enhanced Sensitivity of FRET-based Protease Sensors by Redesign of the GFP Dimerization Interface Chembiochem : a European Journal of Chemical Biology. Jul, 2007 | Pubmed ID: 17525917 Evidence for Heme Release in Layer-by-layer Assemblies of Myoglobin and Polystyrenesulfonate on Pyrolitic Graphite Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Aug, 2007 | Pubmed ID: 17410384 Variation of Linker Length in Ratiometric Fluorescent Sensor Proteins Allows Rational Tuning of Zn(II) Affinity in the Picomolar to Femtomolar Range Journal of the American Chemical Society. Mar, 2007 | Pubmed ID: 17335212 Reorganization of Immobilized Horse and Yeast Cytochrome C Induced by PH Changes or Nitric Oxide Binding Langmuir : the ACS Journal of Surfaces and Colloids. Mar, 2007 | Pubmed ID: 17319704 Protein-liposome Conjugates Using Cysteine-lipids and Native Chemical Ligation Bioconjugate Chemistry. Mar-Apr, 2007 | Pubmed ID: 17315942 Allocation of Substance Use Disorder Patients to Appropriate Levels of Care: Feasibility of Matching Guidelines in Routine Practice in Dutch Treatment Centres Addiction (Abingdon, England). Mar, 2007 | Pubmed ID: 17298655 Electron Transfer and Ligand Binding to Cytochrome C' Immobilized on Self-assembled Monolayers Langmuir : the ACS Journal of Surfaces and Colloids. Jan, 2007 | Pubmed ID: 17209627 Quantitative Understanding of the Energy Transfer Between Fluorescent Proteins Connected Via Flexible Peptide Linkers Biochemistry. Nov, 2006 | Pubmed ID: 17073440 Ratiometric Fluorescent Sensor Proteins with Subnanomolar Affinity for Zn(II) Based on Copper Chaperone Domains Journal of the American Chemical Society. Aug, 2006 | Pubmed ID: 16910670 Fluorescently Labeled Collagen Binding Proteins Allow Specific Visualization of Collagen in Tissues and Live Cell Culture Analytical Biochemistry. Mar, 2006 | Pubmed ID: 16476406 Heme Release in Myoglobin-DDAB Films and Its Role in Electrochemical NO Reduction Journal of the American Chemical Society. Nov, 2005 | Pubmed ID: 16287313 Multivalent Peptide and Protein Dendrimers Using Native Chemical Ligation Angewandte Chemie (International Ed. in English). Aug, 2005 | Pubmed ID: 16007714 Electrochemical Reduction of NO by Hemin Adsorbed at Pyrolitic Graphite Journal of the American Chemical Society. May, 2005 | Pubmed ID: 15898809 Successful Recombinant Production of Allochromatium Vinosum Cytochrome C' Requires Coexpression of Cmm Genes in Heme-rich Escherichia Coli JCB712 Biochemical and Biophysical Research Communications. Feb, 2005 | Pubmed ID: 15649399 Preparation and X-ray Structures of Metal-free, Dicobalt and Dimanganese Forms of Soluble Methane Monooxygenase Hydroxylase from Methylococcus Capsulatus (Bath) Biochemistry. Dec, 2004 | Pubmed ID: 15610020 Copper-dependent Protein-protein Interactions Studied by Yeast Two-hybrid Analysis Biochemical and Biophysical Research Communications. Oct, 2004 | Pubmed ID: 15381069 Determination by X-ray Absorption Spectroscopy of the Fe-Fe Separation in the Oxidized Form of the Hydroxylase of Methane Monooxygenase Alone and in the Presence of MMOD Inorganic Chemistry. Jul, 2004 | Pubmed ID: 15257585 Why OrfY? Characterization of MMOD, a Long Overlooked Component of the Soluble Methane Monooxygenase from Methylococcus Capsulatus (Bath) The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11709550 Dioxygen Activation and Methane Hydroxylation by Soluble Methane Monooxygenase: A Tale of Two Irons and Three Proteins A List of Abbreviations Can Be Found in Section 7 Angewandte Chemie (International Ed. in English). Aug, 2001 | Pubmed ID: 11500872 Cover Picture Angewandte Chemie (International Ed. in English). Aug, 2001 | Pubmed ID: 11500870 ניטור בזמן אמת של תאיים חומצות מרה Dynamics שימוש חומצות מרה חיישן מבוסס סריג גנטי מקודד Sandra Van de Wiel1, Maarten Merkx2,3, Stan Van de Graaf1 1Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, 2Laboratory of Chemical Biology, Institute of Complex Molecular Systems (ICMS), 3Department of Biomedical Engineering, Eindhoven University of Technology Bioengineering
ניטור בזמן אמת של תאיים חומצות מרה Dynamics שימוש חומצות מרה חיישן מבוסס סריג גנטי מקודד Sandra Van de Wiel1, Maarten Merkx2,3, Stan Van de Graaf1 1Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, 2Laboratory of Chemical Biology, Institute of Complex Molecular Systems (ICMS), 3Department of Biomedical Engineering, Eindhoven University of Technology Bioengineering
