Martin Biel Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy Ludwig-Maximilians-Universität München Biography Publications Institution JoVE Articles Martin Biel has not added a biography. If you are Martin Biel and would like to personalize this page please email our Author Liaison for assistance. Publications CAMP-dependent Regulation of HCN4 Controls the Tonic Entrainment Process in Sinoatrial Node Pacemaker Cells Nature Communications. 11, 2020 | Pubmed ID: 33144559 A Gene Therapy for Inherited Blindness Using DCas9-VPR-mediated Transcriptional Activation Science Advances. Aug, 2020 | Pubmed ID: 32875106 Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of MRNA Splicing for a Deep Intronic CLRN1 Mutation Molecular Therapy. Nucleic Acids. Sep, 2020 | Pubmed ID: 32841912 TPC1 Deficiency or Blockade Augments Systemic Anaphylaxis and Mast Cell Activity Proceedings of the National Academy of Sciences of the United States of America. 07, 2020 | Pubmed ID: 32661165 Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial JAMA Ophthalmology. 06, 2020 | Pubmed ID: 32352493 Neuropathic and CAMP-induced Pain Behavior is Ameliorated in Mice Lacking CNGB1 Neuropharmacology. 07, 2020 | Pubmed ID: 32272140 Enigmatic Rhodopsin Mutation Creates an Exceptionally Strong Splice Acceptor Site Human Molecular Genetics. 01, 2020 | Pubmed ID: 31816042 Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes Journal of Pharmaceutical Sciences. 01, 2020 | Pubmed ID: 31639391 Advancing Gene Therapy for PDE6A Retinitis Pigmentosa Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 31884596 HCN3 Ion Channels: Roles in Sensory Neuronal Excitability and Pain The Journal of Physiology. 09, 2019 | Pubmed ID: 31290157 Abolishing CAMP Sensitivity in HCN2 Pacemaker Channels Induces Generalized Seizures JCI Insight. 05, 2019 | Pubmed ID: 31045576 The Protein Interaction Networks of Mucolipins and Two-pore Channels Biochimica Et Biophysica Acta. Molecular Cell Research. 07, 2019 | Pubmed ID: 30395881 Optimized Subretinal Injection Technique for Gene Therapy Approaches Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30324458 In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30324456 Accessory Heterozygous Mutations in Cone Photoreceptor CNGA3 Exacerbate CNG Channel-associated Retinopathy The Journal of Clinical Investigation. 12, 2018 | Pubmed ID: 30418171 Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of RAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial Human Gene Therapy. Clinical Development. 09, 2018 | Pubmed ID: 30187779 Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients Investigative Ophthalmology & Visual Science. 04, 2018 | Pubmed ID: 29677353 Hif1a Inactivation Rescues Photoreceptor Degeneration Induced by a Chronic Hypoxia-like Stress Cell Death and Differentiation. 12, 2018 | Pubmed ID: 29666476 Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy International Journal of Molecular Sciences. Mar, 2018 | Pubmed ID: 29518895 Endolysosomal Cation Channels and Cancer-A Link with Great Potential Pharmaceuticals (Basel, Switzerland). Jan, 2018 | Pubmed ID: 29303993 Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa Frontiers in Immunology. 2017 | Pubmed ID: 29354133 Gene Therapy Successfully Delays Degeneration in a Mouse Model of -Linked Retinitis Pigmentosa (RP43) Human Gene Therapy. Dec, 2017 | Pubmed ID: 29212391 Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Toward Treating Human -Retinitis Pigmentosa Human Gene Therapy. Dec, 2017 | Pubmed ID: 29212382 Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates Investigative Ophthalmology & Visual Science. 11, 2017 | Pubmed ID: 29117317 Abstracts from the 8th International Conference on CGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017 BMC Pharmacology & Toxicology. Oct, 2017 | Pubmed ID: 29035170 AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2017 | Pubmed ID: 28970046 TPC2 Polymorphisms Associated with a Hair Pigmentation Phenotype in Humans Result in Gain of Channel Function by Independent Mechanisms Proceedings of the National Academy of Sciences of the United States of America. 10, 2017 | Pubmed ID: 28923947 Protein Kinase A Regulates Inflammatory Pain Sensitization by Modulating HCN2 Channel Activity in Nociceptive Sensory Neurons Pain. Oct, 2017 | Pubmed ID: 28767511 Small Molecules for Early Endosome-Specific Patch Clamping Cell Chemical Biology. Jul, 2017 | Pubmed ID: 28732201 Patch-clamp Technique to Characterize Ion Channels in Enlarged Individual Endolysosomes Nature Protocols. Aug, 2017 | Pubmed ID: 28726848 Photopharmacological Control of Bipolar Cells Restores Visual Function in Blind Mice The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28581442 Peripherin-2 and Rom-1 Have Opposing Effects on Rod Outer Segment Targeting of Retinitis Pigmentosa-linked Peripherin-2 Mutants Scientific Reports. 05, 2017 | Pubmed ID: 28539581 Endoplasmic Reticulum (ER) Ca-channel Activity Contributes to ER Stress and Cone Death in Cyclic Nucleotide-gated Channel Deficiency The Journal of Biological Chemistry. 07, 2017 | Pubmed ID: 28495882 From Mucolipidosis Type IV to Ebola: TRPML and Two-pore Channels at the Crossroads of Endo-lysosomal Trafficking and Disease Cell Calcium. 11, 2017 | Pubmed ID: 28457591 Recombinant Tandem of Pore-domains in a Weakly Inward Rectifying K Channel 2 (TWIK2) Forms Active Lysosomal Channels Scientific Reports. 04, 2017 | Pubmed ID: 28381826 Mosaic Synaptopathy and Functional Defects in Cav1.4 Heterozygous Mice and Human Carriers of CSNB2 Human Molecular Genetics. Jan, 2017 | Pubmed ID: 28365780 Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion After Cone Precursor Transplantation Molecular Therapy : the Journal of the American Society of Gene Therapy. 03, 2017 | Pubmed ID: 28143742 Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells Cancer Research. 03, 2017 | Pubmed ID: 28108508 Gene Therapy for Achromatopsia The Journal of Gene Medicine. Mar, 2017 | Pubmed ID: 28095637 Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response Investigative Ophthalmology & Visual Science. 05, 2016 | Pubmed ID: 27152964 Peripherin-2 Differentially Interacts with Cone Opsins in Outer Segments of Cone Photoreceptors Human Molecular Genetics. Mar, 2016 | Pubmed ID: 27033727 HCN1 Channels Enhance Rod System Responsivity in the Retina Under Conditions of Light Exposure PloS One. 2016 | Pubmed ID: 26807953 In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in MRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors PLoS Genetics. Jan, 2016 | Pubmed ID: 26796962 Loss of HCN1 Enhances Disease Progression in Mouse Models of CNG Channel-linked Retinitis Pigmentosa and Achromatopsia Human Molecular Genetics. Mar, 2016 | Pubmed ID: 26740549 Comprehensive Multilevel in Vivo and in Vitro Analysis of Heart Rate Fluctuations in Mice by ECG Telemetry and Electrophysiology Nature Protocols. Jan, 2016 | Pubmed ID: 26658468 Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated Via Its C-Terminal PDZ Binding Motif PloS One. 2015 | Pubmed ID: 26352593 Retinitis Pigmentosa: Impact of Different Pde6a Point Mutations on the Disease Phenotype Human Molecular Genetics. Oct, 2015 | Pubmed ID: 26188004 CGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26124274 Electroretinographic Assessment of Rod- and Cone-mediated Bipolar Cell Pathways Using Flicker Stimuli in Mice Scientific Reports. Jun, 2015 | Pubmed ID: 26029863 Expression of Ca²⁺-permeable Two-pore Channels Rescues NAADP Signalling in TPC-deficient Cells The EMBO Journal. Jul, 2015 | Pubmed ID: 25872774 Vitreal Delivery of AAV Vectored Cnga3 Restores Cone Function in CNGA3-/-/Nrl-/- Mice, an All-cone Model of CNGA3 Achromatopsia Human Molecular Genetics. Jul, 2015 | Pubmed ID: 25855802 TET3 is Recruited by REST for Context-specific Hydroxymethylation and Induction of Gene Expression Cell Reports. Apr, 2015 | Pubmed ID: 25843715 Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments Anesthesiology. May, 2015 | Pubmed ID: 25782754 Ebola Virus. Two-pore Channels Control Ebola Virus Host Cell Entry and Are Drug Targets for Disease Treatment Science (New York, N.Y.). Feb, 2015 | Pubmed ID: 25722412 Retinal Gene Delivery by Adeno-associated Virus (AAV) Vectors: Strategies and Applications European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Sep, 2015 | Pubmed ID: 25615882 High Susceptibility to Fatty Liver Disease in Two-pore Channel 2-deficient Mice Nature Communications. Aug, 2014 | Pubmed ID: 25144390 A Small Molecule Restores Function to TRPML1 Mutant Isoforms Responsible for Mucolipidosis Type IV Nature Communications. Aug, 2014 | Pubmed ID: 25119295 Peripherin-2 Couples Rhodopsin to the CNG Channel in Outer Segments of Rod Photoreceptors Human Molecular Genetics. Nov, 2014 | Pubmed ID: 24963162 Gene Therapy Restores Vision and Delays Degeneration in the CNGB1(-/-) Mouse Model of Retinitis Pigmentosa Advances in Experimental Medicine and Biology. 2014 | Pubmed ID: 24664765 Mosaic Synaptopathy and Functional Defects in Cav1.4 Heterozygous Mice and Human Carriers of CSNB2 Human Molecular Genetics. Mar, 2014 | Pubmed ID: 24163243 CGMP Accumulation Causes Photoreceptor Degeneration in CNG Channel Deficiency: Evidence of CGMP Cytotoxicity Independently of Enhanced CNG Channel Function The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2013 | Pubmed ID: 24027293 Gene Replacement Therapy for Retinal CNG Channelopathies Molecular Genetics and Genomics : MGG. Oct, 2013 | Pubmed ID: 23861024 Loss of Cone Cyclic Nucleotide-gated Channel Leads to Alterations in Light Response Modulating System and Cellular Stress Response Pathways: a Gene Expression Profiling Study Human Molecular Genetics. Oct, 2013 | Pubmed ID: 23740940 Up-regulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 (HCN3) by Specific Interaction with K+ Channel Tetramerization Domain-containing Protein 3 (KCTD3) The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23382386 Characterization of Neurite Outgrowth and Ectopic Synaptogenesis in Response to Photoreceptor Dysfunction Cellular and Molecular Life Sciences : CMLS. May, 2013 | Pubmed ID: 23269435 Isotope-based Analysis of Modified TRNA Nucleosides Correlates Modification Density with Translational Efficiency Angewandte Chemie (International Ed. in English). Oct, 2012 | Pubmed ID: 23037940 Complex Regulation of Voltage-dependent Activation and Inactivation Properties of Retinal Voltage-gated Cav1.4 L-type Ca2+ Channels by Ca2+-binding Protein 4 (CaBP4) The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22936811 Gene Therapy Restores Vision and Delays Degeneration in the CNGB1(-/-) Mouse Model of Retinitis Pigmentosa Human Molecular Genetics. Oct, 2012 | Pubmed ID: 22802073 Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by CCMP The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22715094 Role of TRPML and Two-pore Channels in Endolysosomal Cation Homeostasis The Journal of Pharmacology and Experimental Therapeutics. Aug, 2012 | Pubmed ID: 22518024 CNGA3 Deficiency Affects Cone Synaptic Terminal Structure and Function and Leads to Secondary Rod Dysfunction and Degeneration Investigative Ophthalmology & Visual Science. Mar, 2012 | Pubmed ID: 22247469 Gene Therapy Restores Missing Cone-mediated Vision in the CNGA3-/- Mouse Model of Achromatopsia Advances in Experimental Medicine and Biology. 2012 | Pubmed ID: 22183332 The Role of HCN Channels in Ventricular Repolarization Trends in Cardiovascular Medicine. Nov, 2011 | Pubmed ID: 22902068 Exploring HCN Channels As Novel Drug Targets Nature Reviews. Drug Discovery. Nov, 2011 | Pubmed ID: 22094868 HCN3 Contributes to the Ventricular Action Potential Waveform in the Murine Heart Circulation Research. Oct, 2011 | Pubmed ID: 21903939 The CGMP-dependent Protein Kinase II Is an Inhibitory Modulator of the Hyperpolarization-activated HCN2 Channel PloS One. Feb, 2011 | Pubmed ID: 21347269 The Glutamic Acid-rich Protein is a Gating Inhibitor of Cyclic Nucleotide-gated Channels The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2011 | Pubmed ID: 21209198 Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes Science Signaling. Dec, 2010 | Pubmed ID: 21139138 An Olfactory Subsystem That Detects Carbon Disulfide and Mediates Food-related Social Learning Current Biology : CB. Aug, 2010 | Pubmed ID: 20637621 Restoration of Cone Vision in the CNGA3-/- Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 20628362 Grueneberg Ganglion Neurons Are Finely Tuned Cold Sensors The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2010 | Pubmed ID: 20519530 Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+ Currents in Isolated Lysosomes The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20495006 Calmodulin is a Functional Regulator of Cav1.4 L-type Ca2+ Channels The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19717559 Hyperpolarization-activated Cation Channels: from Genes to Function Physiological Reviews. Jul, 2009 | Pubmed ID: 19584315 The Two-pore Channel TPCN2 Mediates NAADP-dependent Ca(2+)-release from Lysosomal Stores Pflugers Archiv : European Journal of Physiology. Sep, 2009 | Pubmed ID: 19557428 Cyclic Nucleotide-gated Channels Handbook of Experimental Pharmacology. 2009 | Pubmed ID: 19089328 Cyclic Nucleotide-regulated Cation Channels The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19054768 Function and Dysfunction of CNG Channels: Insights from Channelopathies and Mouse Models Molecular Neurobiology. Jun, 2007 | Pubmed ID: 17917115 Contribution of the Receptor Guanylyl Cyclase GC-D to Chemosensory Function in the Olfactory Epithelium Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17724338 Switching off Calcium-dependent Inactivation in L-type Calcium Channels by an Autoinhibitory Domain Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17028172 Loss of CNGB1 Protein Leads to Olfactory Dysfunction and Subciliary Cyclic Nucleotide-gated Channel Trapping The Journal of Biological Chemistry. Nov, 2006 | Pubmed ID: 16980309 The Enhancement of HCN Channel Instantaneous Current Facilitated by Slow Deactivation is Regulated by Intracellular Chloride Concentration Pflugers Archiv : European Journal of Physiology. Sep, 2006 | Pubmed ID: 16715293 A Novel Mechanism of Modulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channels by Src Kinase The Journal of Biological Chemistry. Oct, 2005 | Pubmed ID: 16079136 The Murine HCN3 Gene Encodes a Hyperpolarization-activated Cation Channel with Slow Kinetics and Unique Response to Cyclic Nucleotides The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15923185 Impaired Opsin Targeting and Cone Photoreceptor Migration in the Retina of Mice Lacking the Cyclic Nucleotide-gated Channel CNGA3 Investigative Ophthalmology & Visual Science. Apr, 2005 | Pubmed ID: 15790924 An Arginine Residue in the Pore Region is a Key Determinant of Chloride Dependence in Cardiac Pacemaker Channels The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15644313 Impaired Channel Targeting and Retinal Degeneration in Mice Lacking the Cyclic Nucleotide-gated Channel Subunit CNGB1 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2005 | Pubmed ID: 15634774 Role of Subunit Heteromerization and N-linked Glycosylation in the Formation of Functional Hyperpolarization-activated Cyclic Nucleotide-gated Channels The Journal of Biological Chemistry. Oct, 2003 | Pubmed ID: 12928435 Molecular Cloning and Functional Characterization of a New Modulatory Cyclic Nucleotide-gated Channel Subunit from Mouse Retina The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2000 | Pubmed ID: 10662822 Implantatie van gecombineerde telemetrische ECG- en bloeddruktransmitters om spontane baroreflexgevoeligheid bij bewuste muizen te bepalen René D. Rötzer1, Verena F. Brox1, Konstantin Hennis1, Stefan B. Thalhammer1, Martin Biel1,2, Christian Wahl-Schott3, Stefanie Fenske1,2 1Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München, 2German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 3Hannover Medical School, Institute for Neurophysiology JoVE 62101 Medicine
Implantatie van gecombineerde telemetrische ECG- en bloeddruktransmitters om spontane baroreflexgevoeligheid bij bewuste muizen te bepalen René D. Rötzer1, Verena F. Brox1, Konstantin Hennis1, Stefan B. Thalhammer1, Martin Biel1,2, Christian Wahl-Schott3, Stefanie Fenske1,2 1Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München, 2German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 3Hannover Medical School, Institute for Neurophysiology JoVE 62101 Medicine