Martin Hirst

Publications

• Fate Mapping of Human Glioblastoma Reveals an Invariant Stem Cell Hierarchy
  Nature. Sep, 2017  |   Pubmed ID: 28854171
• The [PSI +] Yeast Prion Does Not Wildly Affect Proteome Composition Whereas Selective Pressure Exerted on [PSI +] Cells Can Promote Aneuploidy
  Scientific Reports. Aug, 2017  |   Pubmed ID: 28814753
• Characterization of the Human Thyroid Epigenome
  The Journal of Endocrinology. Nov, 2017  |   Pubmed ID: 28808080
• Vitamin C Induces Specific Demethylation of H3K9me2 in Mouse Embryonic Stem Cells Via Kdm3a/b
  Epigenetics & Chromatin. 2017  |   Pubmed ID: 28706564
• Increasing Quality, Throughput and Speed of Sample Preparation for Strand-specific Messenger RNA Sequencing
  BMC Genomics. Jul, 2017  |   Pubmed ID: 28679365
• Whole-genome Analysis Reveals Unexpected Dynamics of Mutant Subclone Development in a Patient with JAK2-V617F-positive Chronic Myeloid Leukemia
  Experimental Hematology. Sep, 2017  |   Pubmed ID: 28602946
• Automated High Throughput Nucleic Acid Purification from Formalin-fixed Paraffin-embedded Tissue Samples for Next Generation Sequence Analysis
  PloS One. 2017  |   Pubmed ID: 28570594
• Draft Genome Sequence of the Pelagic Photoferrotroph Chlorobium Phaeoferrooxidans
  Genome Announcements. Mar, 2017  |   Pubmed ID: 28360175
• Atrophin Controls Developmental Signaling Pathways Via Interactions with Trithorax-like
  ELife. Mar, 2017  |   Pubmed ID: 28327288
• SnapShot: Epigenomic Assays
  Cell. Nov, 2016  |   Pubmed ID: 27863253
• The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
  Cell. Nov, 2016  |   Pubmed ID: 27863232
• Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility
  Cell Reports. Nov, 2016  |   Pubmed ID: 27851972
• Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks
  Cell Reports. Nov, 2016  |   Pubmed ID: 27851968
• Robust High-performance Nanoliter-volume Single-cell Multiple Displacement Amplification on Planar Substrates
  Proceedings of the National Academy of Sciences of the United States of America. 07, 2016  |   Pubmed ID: 27412862
• Putative BRAF Activating Fusion in a Medullary Thyroid Cancer
  Cold Spring Harbor Molecular Case Studies. Mar, 2016  |   Pubmed ID: 27148585
• Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways
  Cancer Cell. Mar, 2016  |   Pubmed ID: 26977886
• The Genomic and Transcriptomic Landscape of Anaplastic Thyroid Cancer: Implications for Therapy
  BMC Cancer. Dec, 2015  |   Pubmed ID: 26680454
• Barcoding Reveals Complex Clonal Dynamics of De Novo Transformed Human Mammary Cells
  Nature. Dec, 2015  |   Pubmed ID: 26633636
• MEF2B Mutations in Non-Hodgkin Lymphoma Dysregulate Cell Migration by Decreasing MEF2B Target Gene Activation
  Nature Communications. Aug, 2015  |   Pubmed ID: 26245647
• Epigenome Data Release: a Participant-centered Approach to Privacy Protection
  Genome Biology. Jul, 2015  |   Pubmed ID: 26185018
• Integrative Analysis of 111 Reference Human Epigenomes
  Nature. Feb, 2015  |   Pubmed ID: 25693563
• Multifocal Endometriotic Lesions Associated with Cancer Are Clonal and Carry a High Mutation Burden
  The Journal of Pathology. Jun, 2015  |   Pubmed ID: 25692284
• Intermediate DNA Methylation is a Conserved Signature of Genome Regulation
  Nature Communications. 2015  |   Pubmed ID: 25691127
• Epigenetic and Transcriptional Determinants of the Human Breast
  Nature Communications. Feb, 2015  |   Pubmed ID: 25690954
• Loss of the Notch Effector RBPJ Promotes Tumorigenesis
  The Journal of Experimental Medicine. Jan, 2015  |   Pubmed ID: 25512468
• DNA Barcoding Reveals Diverse Growth Kinetics of Human Breast Tumour Subclones in Serially Passaged Xenografts
  Nature Communications. Dec, 2014  |   Pubmed ID: 25532760
• Regulatory Network Decoded from Epigenomes of Surface Ectoderm-derived Cell Types
  Nature Communications. Nov, 2014  |   Pubmed ID: 25421844
• A Transgenic Mouse Model Demonstrating the Oncogenic Role of Mutations in the Polycomb-group Gene EZH2 in Lymphomagenesis
  Blood. Jun, 2014  |   Pubmed ID: 24802772
• Draft Genome Sequences of Six Rhodobacter Capsulatus Strains, YW1, YW2, B6, Y262, R121, and DE442
  Genome Announcements. Feb, 2014  |   Pubmed ID: 24526637
• Clonal Analysis Via Barcoding Reveals Diverse Growth and Differentiation of Transplanted Mouse and Human Mammary Stem Cells
  Cell Stem Cell. Feb, 2014  |   Pubmed ID: 24440600
• Regulatory Variation: an Emerging Vantage Point for Cancer Biology
  Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Jan-Feb, 2014  |   Pubmed ID: 24254976
• Complete Bordetella Avium, Bordetella Hinzii and Bordetella Trematum Lipid A Structures and Genomic Sequence Analyses of the Loci Involved in Their Modifications
  Innate Immunity. Aug, 2014  |   Pubmed ID: 24127384
• A Clinically Validated Diagnostic Second-generation Sequencing Assay for Detection of Hereditary BRCA1 and BRCA2 Mutations
  The Journal of Molecular Diagnostics : JMD. Nov, 2013  |   Pubmed ID: 24094589
• Analysis of the Clonal Growth and Differentiation Dynamics of Primitive Barcoded Human Cord Blood Cells in NSG Mice
  Blood. Oct, 2013  |   Pubmed ID: 24030380
• Vitamin C Induces Tet-dependent DNA Demethylation and a Blastocyst-like State in ES Cells
  Nature. Aug, 2013  |   Pubmed ID: 23812591
• Estimating Absolute Methylation Levels at Single CpG Resolution from Methylation Enrichment and Restriction Enzyme Sequencing Methods
  Genome Research. Jun, 2013  |   Pubmed ID: 23804401
• Functional DNA Methylation Differences Between Tissues, Cell Types, and Across Individuals Discovered Using the M&M Algorithm
  Genome Research. Jun, 2013  |   Pubmed ID: 23804400
• DNA Hypomethylation Within Specific Transposable Element Families Associates with Tissue-specific Enhancer Landscape
  Nature Genetics. Jul, 2013  |   Pubmed ID: 23708189
• Epigenomics: Sequencing the Methylome
  Methods in Molecular Biology (Clifton, N.J.). 2013  |   Pubmed ID: 23412782
• The Genetic Landscape of High-risk Neuroblastoma
  Nature Genetics. Mar, 2013  |   Pubmed ID: 23334666
• DNA Template Strand Sequencing of Single-cells Maps Genomic Rearrangements at High Resolution
  Nature Methods. Nov, 2012  |   Pubmed ID: 23042453
• Spark: a Navigational Paradigm for Genomic Data Exploration
  Genome Research. Nov, 2012  |   Pubmed ID: 22960372
• Mutation Discovery in Regions of Segmental Cancer Genome Amplifications with CoNAn-SNV: a Mixture Model for Next Generation Sequencing of Tumors
  PloS One. 2012  |   Pubmed ID: 22916110
• Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-risk Acute Lymphoblastic Leukemia
  Cancer Cell. Aug, 2012  |   Pubmed ID: 22897847
• Use of Mutation Profiles to Refine the Classification of Endometrial Carcinomas
  The Journal of Pathology. Sep, 2012  |   Pubmed ID: 22653804
• Integrative Analysis of Genome-wide Loss of Heterozygosity and Monoallelic Expression at Nucleotide Resolution Reveals Disrupted Pathways in Triple-negative Breast Cancer
  Genome Research. Oct, 2012  |   Pubmed ID: 22637570
• The Clonal and Mutational Evolution Spectrum of Primary Triple-negative Breast Cancers
  Nature. Apr, 2012  |   Pubmed ID: 22495314
• Integrated Genome and Transcriptome Sequencing Identifies a Novel Form of Hybrid and Aggressive Prostate Cancer
  The Journal of Pathology. May, 2012  |   Pubmed ID: 22294438
• JointSNVMix: a Probabilistic Model for Accurate Detection of Somatic Mutations in Normal/tumour Paired Next-generation Sequencing Data
  Bioinformatics (Oxford, England). Apr, 2012  |   Pubmed ID: 22285562
• Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenosine Phosphorylase, an Exploitable Tumor Target
  Molecular Cancer Therapeutics. Mar, 2012  |   Pubmed ID: 22252602
• Feature-based Classifiers for Somatic Mutation Detection in Tumour-normal Paired Sequencing Data
  Bioinformatics (Oxford, England). Jan, 2012  |   Pubmed ID: 22084253
• Concurrent CIC Mutations, IDH Mutations, and 1p/19q Loss Distinguish Oligodendrogliomas from Other Cancers
  The Journal of Pathology. Jan, 2012  |   Pubmed ID: 22072542
• Retrotransposon-induced Heterochromatin Spreading in the Mouse Revealed by Insertional Polymorphisms
  PLoS Genetics. Sep, 2011  |   Pubmed ID: 21980304
• Frequent Mutation of Histone-modifying Genes in Non-Hodgkin Lymphoma
  Nature. Aug, 2011  |   Pubmed ID: 21796119
• Using Next-generation Sequencing for the Diagnosis of Rare Disorders: a Family with Retinitis Pigmentosa and Skeletal Abnormalities
  The Journal of Pathology. Sep, 2011  |   Pubmed ID: 21792934
• Cell of Origin in AML: Susceptibility to MN1-induced Transformation is Regulated by the MEIS1/AbdB-like HOX Protein Complex
  Cancer Cell. Jul, 2011  |   Pubmed ID: 21741595
• DeFuse: an Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data
  PLoS Computational Biology. May, 2011  |   Pubmed ID: 21625565
• DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in MESCs
  Cell Stem Cell. Jun, 2011  |   Pubmed ID: 21624812
• Genome and Transcriptome Analyses of the Mountain Pine Beetle-fungal Symbiont Grosmannia Clavigera, a Lodgepole Pine Pathogen
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011  |   Pubmed ID: 21262841
• Next Generation Sequencing Based Approaches to Epigenomics
  Briefings in Functional Genomics. Dec, 2010  |   Pubmed ID: 21266347
• ARID1A Mutations in Endometriosis-associated Ovarian Carcinomas
  The New England Journal of Medicine. Oct, 2010  |   Pubmed ID: 20942669
• System-level Analysis of Neuroblastoma Tumor-initiating Cells Implicates AURKB As a Novel Drug Target for Neuroblastoma
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2010  |   Pubmed ID: 20651058
• Locus Co-occupancy, Nucleosome Positioning, and H3K4me1 Regulate the Functionality of FOXA2-, HNF4A-, and PDX1-bound Loci in Islets and Liver
  Genome Research. Aug, 2010  |   Pubmed ID: 20551221
• Whole-genome Profiling of Mutagenesis in Caenorhabditis Elegans
  Genetics. Jun, 2010  |   Pubmed ID: 20439774
• Digital Gene Expression by Tag Sequencing on the Illumina Genome Analyzer
  Current Protocols in Human Genetics. Apr, 2010  |   Pubmed ID: 20373513
• SNVMix: Predicting Single Nucleotide Variants from Next-generation Sequencing of Tumors
  Bioinformatics (Oxford, England). Mar, 2010  |   Pubmed ID: 20130035
• Somatic Mutations Altering EZH2 (Tyr641) in Follicular and Diffuse Large B-cell Lymphomas of Germinal-center Origin
  Nature Genetics. Feb, 2010  |   Pubmed ID: 20081860
• De Novo Genome Sequence Assembly of a Filamentous Fungus Using Sanger, 454 and Illumina Sequence Data
  Genome Biology. 2009  |   Pubmed ID: 19747388
• ELT-2 is the Predominant Transcription Factor Controlling Differentiation and Function of the C. Elegans Intestine, from Embryo to Adult
  Developmental Biology. Mar, 2009  |   Pubmed ID: 19111532
• In-depth Characterization of the MicroRNA Transcriptome in a Leukemia Progression Model
  Genome Research. Nov, 2008  |   Pubmed ID: 18849523
• Transcriptome Analysis for Caenorhabditis Elegans Based on Novel Expressed Sequence Tags
  BMC Biology. Jul, 2008  |   Pubmed ID: 18611272
• A Mouse Atlas of Gene Expression: Large-scale Digital Gene-expression Profiles from Precisely Defined Developing C57BL/6J Mouse Tissues and Cells
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005  |   Pubmed ID: 16352711
• Novel Avian Influenza H7N3 Strain Outbreak, British Columbia
  Emerging Infectious Diseases. Dec, 2004  |   Pubmed ID: 15663859
• Isolation and Identification of L-dopa Decarboxylase As a Protein That Binds to and Enhances Transcriptional Activity of the Androgen Receptor Using the Repressed Transactivator Yeast Two-hybrid System
  The Biochemical Journal. Oct, 2003  |   Pubmed ID: 12864730
• A Two-hybrid System for Transactivator Bait Proteins
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2001  |   Pubmed ID: 11447261