Michael T. Lewis Department of Molecular and Cellular Biology Baylor College of Medicine Biography Publications Institution JoVE Articles Michael T. Lewis has not added a biography. If you are Michael T. Lewis and would like to personalize this page please email our Author Liaison for assistance. Publications Landscape Analysis of Adjacent Gene Rearrangements Reveals BCL2L14-ETV6 Gene Fusions in More Aggressive Triple-negative Breast Cancer Proceedings of the National Academy of Sciences of the United States of America. May, 2020 | Pubmed ID: 32321829 A CTC-Cluster-Specific Signature Derived from OMICS Analysis of Patient-Derived Xenograft Tumors Predicts Outcomes in Basal-Like Breast Cancer Journal of Clinical Medicine. 10, 2019 | Pubmed ID: 31652963 The Altered Transcriptome and DNA Methylation Profiles of Docetaxel Resistance in Breast Cancer PDX Models Molecular Cancer Research : MCR. 10, 2019 | Pubmed ID: 31320385 S100a4-Cre-mediated Deletion of Patched1 Causes Hypogonadotropic Hypogonadism: Role of Pituitary Hematopoietic Cells in Endocrine Regulation JCI Insight. Jul, 2019 | Pubmed ID: 31265437 Chromosome 12p Amplification in Triple-Negative/Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity Cancer Research. 08, 2019 | Pubmed ID: 31213465 Circulating Tumor Cell Investigation in Breast Cancer Patient-derived Xenograft Models by Automated Immunofluorescence Staining, Image Acquisition, and Single Cell Retrieval and Analysis BMC Cancer. Mar, 2019 | Pubmed ID: 30871481 Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes Cancer Research. 01, 2019 | Pubmed ID: 30401712 C/EBPδ Links IL-6 and HIF-1 Signaling to Promote Breast Cancer Stem Cell-associated Phenotypes Oncogene. 05, 2019 | Pubmed ID: 30262865 Publisher Correction: EMT Cells Increase Breast Cancer Metastasis Via Paracrine GLI Activation in Neighbouring Tumour Cells Nature Communications. 11, 2018 | Pubmed ID: 30420638 Differentiation-state Plasticity is a Targetable Resistance Mechanism in Basal-like Breast Cancer Nature Communications. 09, 2018 | Pubmed ID: 30232459 The Chick Chorioallantoic Membrane (CAM) As a Versatile Patient-derived Xenograft (PDX) Platform for Precision Medicine and Preclinical Research American Journal of Cancer Research. 2018 | Pubmed ID: 30210932 GpGrouper: A Peptide Grouping Algorithm for Gene-Centric Inference and Quantitation of Bottom-Up Proteomics Data Molecular & Cellular Proteomics : MCP. 11, 2018 | Pubmed ID: 30093420 Combinatorial Inhibition of PTPN12-regulated Receptors Leads to a Broadly Effective Therapeutic Strategy in Triple-negative Breast Cancer Nature Medicine. 05, 2018 | Pubmed ID: 29578538 Pharmacological Targeting of MYC-regulated IRE1/XBP1 Pathway Suppresses MYC-driven Breast Cancer The Journal of Clinical Investigation. 04, 2018 | Pubmed ID: 29480818 TEM8/ANTXR1-Specific CAR T Cells As a Targeted Therapy for Triple-Negative Breast Cancer Cancer Research. 01, 2018 | Pubmed ID: 29183891 PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models Cancer Research. 11, 2017 | Pubmed ID: 29092942 New Paradigms for the Hedgehog Signaling Network in Mammary Gland Development and Breast Cancer Biochimica Et Biophysica Acta. Reviews on Cancer. Aug, 2017 | Pubmed ID: 28624497 EMT Cells Increase Breast Cancer Metastasis Via Paracrine GLI Activation in Neighbouring Tumour Cells Nature Communications. 06, 2017 | Pubmed ID: 28604738 Carbon Nanotube Capsules Enhance the in Vivo Efficacy of Cisplatin Acta Biomaterialia. 08, 2017 | Pubmed ID: 28465075 Mutual Regulation of Tumour Vessel Normalization and Immunostimulatory Reprogramming Nature. 04, 2017 | Pubmed ID: 28371798 Epithelial and Non-epithelial Play Opposing Roles to Regulate Proliferation and Morphogenesis of the Mouse Mammary Gland Development (Cambridge, England). 04, 2017 | Pubmed ID: 28275010 The Terminal End Bud: the Little Engine That Could Journal of Mammary Gland Biology and Neoplasia. 06, 2017 | Pubmed ID: 28168376 Patient-derived Xenograft (PDX) Models in Basic and Translational Breast Cancer Research Cancer Metastasis Reviews. 12, 2016 | Pubmed ID: 28025748 The Pursuit of Truth in the Company of Friends : In Memorium: Charles W. Daniel Journal of Mammary Gland Biology and Neoplasia. 12, 2016 | Pubmed ID: 27889858 Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 Through Poly-ubiquitination PLoS Genetics. 05, 2016 | Pubmed ID: 27195754 Oncogenic MTOR Signalling Recruits Myeloid-derived Suppressor Cells to Promote Tumour Initiation Nature Cell Biology. Jun, 2016 | Pubmed ID: 27183469 A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics Within the Terminal End Bud PLoS Computational Biology. Apr, 2016 | Pubmed ID: 27115287 Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer Cell Reports. Mar, 2016 | Pubmed ID: 26923594 An Essential Role for Gα(i2) in Smoothened-stimulated Epithelial Cell Proliferation in the Mammary Gland Science Signaling. Sep, 2015 | Pubmed ID: 26373672 Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion Via JAK2 Activation Cell Reports. Jul, 2015 | Pubmed ID: 26166574 Identifying and Targeting Tumor-initiating Cells in the Treatment of Breast Cancer Endocrine-related Cancer. Jun, 2015 | Pubmed ID: 25876646 Patient-derived Xenograft Models of Breast Cancer and Their Predictive Power Breast Cancer Research : BCR. Feb, 2015 | Pubmed ID: 25849559 Circulating and Disseminated Tumor Cells from Breast Cancer Patient-derived Xenograft-bearing Mice As a Novel Model to Study Metastasis Breast Cancer Research : BCR. 2015 | Pubmed ID: 25572662 Drug-repositioning Screening Identified Piperlongumine As a Direct STAT3 Inhibitor with Potent Activity Against Breast Cancer Oncogene. Mar, 2015 | Pubmed ID: 24681959 STAT3 Signaling is Activated Preferentially in Tumor-initiating Cells in Claudin-low Models of Human Breast Cancer Stem Cells (Dayton, Ohio). Oct, 2014 | Pubmed ID: 24891218 Wnt-responsive Cancer Stem Cells Are Located Close to Distorted Blood Vessels and Not in Hypoxic Regions in a P53-null Mouse Model of Human Breast Cancer Stem Cells Translational Medicine. Jul, 2014 | Pubmed ID: 24797826 Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy Journal of Biomolecular Screening. Jul, 2014 | Pubmed ID: 24525869 A Dosage-dependent Pleiotropic Role of Dicer in Prostate Cancer Growth and Metastasis Oncogene. Jun, 2014 | Pubmed ID: 23851498 Establishment of Patient-Derived Xenograft (PDX) Models of Human Breast Cancer Current Protocols in Mouse Biology. Mar, 2013 | Pubmed ID: 26069021 Three-dimensional Vasculature Reconstruction of Tumour Microenvironment Via Local Clustering and Classification Interface Focus. Aug, 2013 | Pubmed ID: 24511379 Cancer Stem Cell Markers Are Enriched in Normal Tissue Adjacent to Triple Negative Breast Cancer and Inversely Correlated with DNA Repair Deficiency Breast Cancer Research : BCR. 2013 | Pubmed ID: 24008095 A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-derived Human Breast Cancer Xenograft Models Cancer Research. Aug, 2013 | Pubmed ID: 23737486 Paracrine Wnt Signaling Both Promotes and Inhibits Human Breast Tumor Growth Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23559372 Separation by Cell Size Enriches for Mammary Stem Cell Repopulation Activity Stem Cells Translational Medicine. Mar, 2013 | Pubmed ID: 23408103 Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-initiating Cells and Improves Recurrence Free Survival in a Human-xenograft Model PloS One. 2012 | Pubmed ID: 22879872 A Mystery Wrapped in an Enigma: Matrigel Enhancement of Mammary Cell Growth and Morphogenesis Journal of Mammary Gland Biology and Neoplasia. Jun, 2012 | Pubmed ID: 22581302 Cisplatin@US-tube Carbon Nanocapsules for Enhanced Chemotherapeutic Delivery Biomaterials. Feb, 2012 | Pubmed ID: 22078812 Integrative Physical Oncology Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Jan-Feb, 2012 | Pubmed ID: 21853537 ID4 Regulates Mammary Gland Development by Suppressing P38MAPK Activity Development (Cambridge, England). Dec, 2011 | Pubmed ID: 22069192 Dicer-mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2011 | Pubmed ID: 21878538 Altered Differentiation and Paracrine Stimulation of Mammary Epithelial Cell Proliferation by Conditionally Activated Smoothened Developmental Biology. Apr, 2011 | Pubmed ID: 21276786 High IGF-IR Activity in Triple-negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2011 | Pubmed ID: 21177763 Cancer Stem Cell, Niche and EGFR Decide Tumor Development and Treatment Response: A Bio-computational Simulation Study Journal of Theoretical Biology. Jan, 2011 | Pubmed ID: 20969880 Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-cadherin in Normal and Malignant Breast Cells PloS One. 2010 | Pubmed ID: 20808935 Characterizing Cancer Cells with Cancer Stem Cell-like Features in 293T Human Embryonic Kidney Cells Molecular Cancer. Jul, 2010 | Pubmed ID: 20615238 Hedgehog Signaling in the Normal and Neoplastic Mammary Gland Current Drug Targets. Sep, 2010 | Pubmed ID: 20545610 Activation of Erk by Sonic Hedgehog Independent of Canonical Hedgehog Signalling The International Journal of Biochemistry & Cell Biology. Sep, 2010 | Pubmed ID: 20451654 Constitutive Activation of Smoothened Leads to Female Infertility and Altered Uterine Differentiation in the Mouse Biology of Reproduction. May, 2010 | Pubmed ID: 20130264 Androgen Receptor Overexpression Induces Tamoxifen Resistance in Human Breast Cancer Cells Breast Cancer Research and Treatment. May, 2010 | Pubmed ID: 19533338 Decreased TGFbeta Signaling and Increased COX2 Expression in High Risk Women with Increased Mammographic Breast Density Breast Cancer Research and Treatment. Jan, 2010 | Pubmed ID: 19241157 Methods in Mammary Gland Biology and Breast Cancer Research: an Update Journal of Mammary Gland Biology and Neoplasia. Dec, 2009 | Pubmed ID: 19949842 Methods for Preparing Fluorescent and Neutral Red-stained Whole Mounts of Mouse Mammary Glands Journal of Mammary Gland Biology and Neoplasia. Dec, 2009 | Pubmed ID: 19936989 Residual Breast Cancers After Conventional Therapy Display Mesenchymal As Well As Tumor-initiating Features Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19666588 Pygo2 Expands Mammary Progenitor Cells by Facilitating Histone H3 K4 Methylation The Journal of Cell Biology. Jun, 2009 | Pubmed ID: 19487454 Ptch1 is Required Locally for Mammary Gland Morphogenesis and Systemically for Ductal Elongation Development (Cambridge, England). May, 2009 | Pubmed ID: 19297414 Scaffold Attachment Factor B1 (SAFB1) Heterozygosity Does Not Influence Wnt-1 or DMBA-induced Tumorigenesis Molecular Cancer. Mar, 2009 | Pubmed ID: 19267898 Cyclopamine Inhibition of Human Breast Cancer Cell Growth Independent of Smoothened (Smo) Breast Cancer Research and Treatment. Jun, 2009 | Pubmed ID: 18563554 Faith, Heresy and the Cancer Stem Cell Hypothesis Future Oncology (London, England). Oct, 2008 | Pubmed ID: 18922113 Evidence That an Early Pregnancy Causes a Persistent Decrease in the Number of Functional Mammary Epithelial Stem Cells--implications for Pregnancy-induced Protection Against Breast Cancer Stem Cells (Dayton, Ohio). Dec, 2008 | Pubmed ID: 18787212 Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy Journal of the National Cancer Institute. May, 2008 | Pubmed ID: 18445819 Constitutively Active Type I Insulin-like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and is Accompanied by an Epithelial-to-mesenchymal Transition Mediated by NF-kappaB and Snail Molecular and Cellular Biology. Apr, 2007 | Pubmed ID: 17296734 Constitutive Activation of Smoothened (SMO) in Mammary Glands of Transgenic Mice Leads to Increased Proliferation, Altered Differentiation and Ductal Dysplasia Development (Cambridge, England). Mar, 2007 | Pubmed ID: 17287253 The Hedgehog Signaling Network, Mammary Stem Cells, and Breast Cancer: Connections and Controversies Ernst Schering Foundation Symposium Proceedings. 2006 | Pubmed ID: 17939302 Introduction of Oncogenes into Mammary Glands in Vivo with an Avian Retroviral Vector Initiates and Promotes Carcinogenesis in Mouse Models Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17090666 Patterns of Resistance and Incomplete Response to Docetaxel by Gene Expression Profiling in Breast Cancer Patients Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2005 | Pubmed ID: 15718313 Next Stop, the Twilight Zone: Hedgehog Network Regulation of Mammary Gland Development Journal of Mammary Gland Biology and Neoplasia. Apr, 2004 | Pubmed ID: 15300011 स्तन कैंसर के लिए प्रीक्लिनिकल मॉडल के रूप में स्तन ट्यूमर का आर्थोटोपिक प्रत्यारोपण Xiangdong Lv*1,2,3, Lacey E. Dobrolecki*1,2,3, Yao Ding1,2,3, Jeffrey M. Rosen1,2,3, Michael T. Lewis1,2,3, Xi Chen1,2,3 1Department of Molecular and Cellular Biology, Baylor College of Medicine, 2Lester and Sue Smith Breast Center, Baylor College of Medicine, 3Dan L. Duncan Cancer Center, Baylor College of Medicine JoVE 61173 Cancer Research
स्तन कैंसर के लिए प्रीक्लिनिकल मॉडल के रूप में स्तन ट्यूमर का आर्थोटोपिक प्रत्यारोपण Xiangdong Lv*1,2,3, Lacey E. Dobrolecki*1,2,3, Yao Ding1,2,3, Jeffrey M. Rosen1,2,3, Michael T. Lewis1,2,3, Xi Chen1,2,3 1Department of Molecular and Cellular Biology, Baylor College of Medicine, 2Lester and Sue Smith Breast Center, Baylor College of Medicine, 3Dan L. Duncan Cancer Center, Baylor College of Medicine JoVE 61173 Cancer Research
