Morten A. Karsdal Nordic Bioscience Biography Publications Institution JoVE Articles Morten A. Karsdal has not added a biography. If you are Morten A. Karsdal and would like to personalize this page please email our Author Liaison for assistance. Publications Biochemical Markers in Osteoarthritis with Lessons Learned from Osteoporosis Clinical and Experimental Rheumatology. Sep-Oct, 2019 | Pubmed ID: 31621570 Associations Between Biomarkers of Bone and Cartilage Turnover, Gender, Pain Categories and Radiographic Severity in Knee Osteoarthritis Arthritis Research & Therapy. Sep, 2019 | Pubmed ID: 31481084 Clinical Relevance of Collagen Protein Degradation Markers C3M and C4M in the Serum of Breast Cancer Patients Treated with Neoadjuvant Therapy in the GeparQuinto Trial Cancers. Aug, 2019 | Pubmed ID: 31443252 Improvement of Non-invasive Markers of NAFLD from an Individualised, Web-based Exercise Program Alimentary Pharmacology & Therapeutics. Oct, 2019 | Pubmed ID: 31342533 Mechanisms of Vascular Permeability and Remodeling Associated with Hemarthrosis in Factor VIII-deficient Mice Journal of Thrombosis and Haemostasis : JTH. Jul, 2019 | Pubmed ID: 31301687 Biomarkers of Collagen Synthesis Predict Progression in the PROFILE Idiopathic Pulmonary Fibrosis Cohort Respiratory Research. Jul, 2019 | Pubmed ID: 31299951 Circulating Levels of PRO-C3 Reflect Liver Fibrosis and Liver Function in HIV Positive Patients Receiving Modern CART PloS One. 2019 | Pubmed ID: 31295293 A Dual Amylin and Calcitonin Receptor Agonist Inhibits Pain Behavior and Reduces Cartilage Pathology in an Osteoarthritis Rat Model Osteoarthritis and Cartilage. Sep, 2019 | Pubmed ID: 31176015 Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass The Journal of Clinical Endocrinology and Metabolism. May, 2019 | Pubmed ID: 31120518 Serum Tau Fragments As Predictors of Death or Poor Neurological Outcome After Out-of-hospital Cardiac Arrest Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Sep, 2019 | Pubmed ID: 31017476 The Message from the Matrix-should We Listen More Closely? Journal of Thoracic Disease. Mar, 2019 | Pubmed ID: 30997184 Tissue Metabolite of Type I Collagen, C1M, and CRP Predicts Structural Progression of Rheumatoid Arthritis BMC Rheumatology. 2019 | Pubmed ID: 30886991 Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography Hepatology (Baltimore, Md.). Jul, 2019 | Pubmed ID: 30859582 Matrix Metalloprotease Generated Fragments of Type VI Collagen Have Serum Biomarker Potential in Cancer - A Proof of Concept Study Translational Oncology. May, 2019 | Pubmed ID: 30856553 A Marker of Type VI Collagen Formation (PRO-C6) is Associated with Higher Arterial Stiffness in Type 1 Diabetes Acta Diabetologica. 06, 2019 | Pubmed ID: 30852680 Biochemical and Histological Characterisation of an Experimental Rodent Model of Non-alcoholic Steatohepatitis - Effects of a Peroxisome Proliferator-activated Receptor Gamma (PPAR-γ) Agonist and a Glucagon-like Peptide-1 Analogue Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Mar, 2019 | Pubmed ID: 30841472 GPDPLQ-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in Vitro Scientific Reports. Feb, 2019 | Pubmed ID: 30816326 Combining Naproxen and a Dual Amylin and Calcitonin Receptor Agonist Improves Pain and Structural Outcomes in the Collagen-induced Arthritis Rat Model Arthritis Research & Therapy. Feb, 2019 | Pubmed ID: 30795801 Enhanced Processing of Von Willebrand Factor Reflects Disease Severity and Discriminates Severe Portal Hypertension in Cirrhosis European Journal of Gastroenterology & Hepatology. Aug, 2019 | Pubmed ID: 30768435 Serological Biomarker Profiles of Rapidly Progressive Osteoarthritis in Tanezumab-treated Patients Osteoarthritis and Cartilage. Mar, 2019 | Pubmed ID: 30576794 Citrullinated Vimentin and Biglycan Protein Fingerprints As Candidate Serological Biomarkers for Disease Activity in Systemic Sclerosis: a Pilot Study Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. May, 2019 | Pubmed ID: 30457356 Effect of NGM282, an FGF19 Analogue, in Primary Sclerosing Cholangitis: A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Trial Journal of Hepatology. Mar, 2019 | Pubmed ID: 30414864 Assessment of Liver Fibrosis Progression and Regression by a Serological Collagen Turnover Profile American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2019 | Pubmed ID: 30160980 Tofacitinib and TPCA-1 Exert Chondroprotective Effects on Extracellular Matrix Turnover in Bovine Articular Cartilage Ex Vivo Biochemical Pharmacology. Jul, 2019 | Pubmed ID: 30059674 ADAPT: An Algorithm Incorporating PRO-C3 Accurately Identifies Patients With NAFLD and Advanced Fibrosis Hepatology (Baltimore, Md.). Mar, 2019 | Pubmed ID: 30014517 Protein Biomarkers Associated with Pain Mechanisms in Osteoarthritis Journal of Proteomics. 01, 2019 | Pubmed ID: 29704569 A Novel High Sensitivity Type II Collagen Blood-Based Biomarker, PRO-C2, for Assessment of Cartilage Formation International Journal of Molecular Sciences. Nov, 2018 | Pubmed ID: 30404167 Serum Type XVI Collagen is Associated with Colorectal Cancer and Ulcerative Colitis Indicating a Pathological Role in Gastrointestinal Disorders Cancer Medicine. 09, 2018 | Pubmed ID: 30030909 High Turnover of Extracellular Matrix Reflected by Specific Protein Fragments Measured in Serum is Associated with Poor Outcomes in Two Metastatic Breast Cancer Cohorts International Journal of Cancer. 12, 2018 | Pubmed ID: 29923614 A Serological Biomarker of Versican Degradation is Associated with Mortality Following Acute Exacerbations of Idiopathic Interstitial Pneumonia Respiratory Research. 05, 2018 | Pubmed ID: 29728109 Translational Biomarkers and Ex Vivo Models of Joint Tissues As a Tool for Drug Development in Rheumatoid Arthritis Arthritis & Rheumatology (Hoboken, N.J.). 09, 2018 | Pubmed ID: 29669391 Higher Collagen VI Formation Is Associated With All-Cause Mortality in Patients With Type 2 Diabetes and Microalbuminuria Diabetes Care. 07, 2018 | Pubmed ID: 29643059 Osteoclasts Degrade Bone and Cartilage Knee Joint Compartments Through Different Resorption Processes Arthritis Research & Therapy. 04, 2018 | Pubmed ID: 29636095 Assessment of Extracellular Matrix-related Biomarkers in Patients with Lower Extremity Artery Disease Journal of Vascular Surgery. 10, 2018 | Pubmed ID: 29615349 Age-related Collagen Turnover of the Interstitial Matrix and Basement Membrane: Implications of Age- and Sex-dependent Remodeling of the Extracellular Matrix PloS One. 2018 | Pubmed ID: 29596429 Development of a Neo-Epitope Specific Assay for Serological Assessment of Type VII Collagen Turnover and Its Relevance in Fibroproliferative Disorders Assay and Drug Development Technologies. Feb/Mar, 2018 | Pubmed ID: 29493258 IL-6 Receptor Inhibition Modulates Type III Collagen and C-reactive Protein Degradation in Rheumatoid Arthritis Patients with an Inadequate Response to Anti-tumour Necrosis Factor Therapy: Analysis of Connective Tissue Turnover in the Tocilizumab RADIATE Study Clinical and Experimental Rheumatology. Jul-Aug, 2018 | Pubmed ID: 29465346 Acute Decompensation Boosts Hepatic Collagen Type III Deposition and Deteriorates Experimental and Human Cirrhosis Hepatology Communications. 02, 2018 | Pubmed ID: 29404528 Identification of Pain Categories Associated with Change in Pain in Patients Receiving Placebo: Data from Two Phase 3 Randomized Clinical Trials in Symptomatic Knee Osteoarthritis BMC Musculoskeletal Disorders. 01, 2018 | Pubmed ID: 29343266 Blockade of GM-CSF Pathway Induced Sustained Suppression of Myeloid and T Cell Activities in Rheumatoid Arthritis Rheumatology (Oxford, England). 01, 2018 | Pubmed ID: 29069507 Quantification of Altered Tissue Turnover in a Liquid Biopsy: a Proposed Precision Medicine Tool to Assess Chronic Inflammation and Desmoplasia Associated with a Pro-cancerous Niche and Response to Immuno-therapeutic Anti-tumor Modalities Cancer Immunology, Immunotherapy : CII. 01, 2018 | Pubmed ID: 29022089 Sprifermin (rhFGF18) Modulates Extracellular Matrix Turnover in Cartilage Explants Ex Vivo Journal of Translational Medicine. Dec, 2017 | Pubmed ID: 29233174 Erratum: Preventive Effects of Kudzu Root on Bone Loss and Cartilage Degradation in Ovariectomized Rats American Journal of Translational Research. 2017 | Pubmed ID: 29218115 Biomarkers of Collagen Turnover Are Related to Annual Change in FEV in Patients with Chronic Obstructive Pulmonary Disease Within the ECLIPSE Study BMC Pulmonary Medicine. Dec, 2017 | Pubmed ID: 29202744 Safety, Tolerability, and Pharmacodynamics of an Anti-interleukin-1α/β Dual Variable Domain Immunoglobulin in Patients with Osteoarthritis of the Knee: a Randomized Phase 1 Study Osteoarthritis and Cartilage. 12, 2017 | Pubmed ID: 28964890 Sprifermin (rhFGF18) Enables Proliferation of Chondrocytes Producing a Hyaline Cartilage Matrix Osteoarthritis and Cartilage. 11, 2017 | Pubmed ID: 28823647 Preventive Effects of Kudzu Root on Bone Loss and Cartilage Degradation in Ovariectomized Rats [corrected] American Journal of Translational Research. 2017 | Pubmed ID: 28804568 High Resolution Molecular and Histological Analysis of Renal Disease Progression in ZSF1 Fa/faCP Rats, a Model of Type 2 Diabetic Nephropathy PloS One. 2017 | Pubmed ID: 28746409 The Good and the Bad Collagens of Fibrosis - Their Role in Signaling and Organ Function Advanced Drug Delivery Reviews. 11, 2017 | Pubmed ID: 28736303 Unique Insight into Microenvironmental Changes in Colorectal Cancer: Assessment of Matrix Metalloprotease-mediated Molecular Changes in Human Colorectal Tumor Tissue and Corresponding Non-neoplastic Adjacent Tissue Oncology Letters. May, 2017 | Pubmed ID: 28529592 Modifiable Risk Factors Promoting Neurodegeneration is Associated with Two Novel Brain Degradation Markers Measured in Serum Neurochemistry International. Sep, 2017 | Pubmed ID: 28499950 The Dual Amylin- and Calcitonin-Receptor Agonist KBP-042 Works As Adjunct to Metformin on Fasting Hyperglycemia and HbA1c in a Rat Model of Type 2 Diabetes The Journal of Pharmacology and Experimental Therapeutics. 07, 2017 | Pubmed ID: 28438778 Serum Endotrophin, a Type VI Collagen Cleavage Product, is Associated with Increased Mortality in Chronic Kidney Disease PloS One. 2017 | Pubmed ID: 28403201 Metabolic Syndrome, Insulin Resistance, and Cognitive Dysfunction: Does Your Metabolic Profile Affect Your Brain? Diabetes. Jul, 2017 | Pubmed ID: 28389469 Biomarker of Extracellular Matrix Remodelling C1M and Proinflammatory Cytokine Interleukin 6 Are Related to Synovitis and Pain in End-stage Knee Osteoarthritis Patients Pain. 07, 2017 | Pubmed ID: 28333699 Nidogen-1 Degraded by Cathepsin S Can Be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer Neoplasia (New York, N.Y.). 04, 2017 | Pubmed ID: 28282545 Weight Change and Risk of Hyperglycaemia in Elderly Women Aging Clinical and Experimental Research. Mar, 2017 | Pubmed ID: 28265973 Serum Endotrophin Identifies Optimal Responders to PPARγ Agonists in Type 2 Diabetes Diabetologia. Jan, 2017 | Pubmed ID: 27631136 Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD Chest. Jan, 2017 | Pubmed ID: 27575358 Fibrogenesis Assessed by Serological Type III Collagen Formation Identifies Patients with Progressive Liver Fibrosis and Responders to a Potential Antifibrotic Therapy American Journal of Physiology. Gastrointestinal and Liver Physiology. 12, 2016 | Pubmed ID: 27765759 High Levels of Biomarkers of Collagen Remodeling Are Associated with Increased Mortality in COPD - Results from the ECLIPSE Study Respiratory Research. 10, 2016 | Pubmed ID: 27716343 Characterization of Serological Neo-epitope Biomarkers Reflecting Collagen Remodeling in Clinically Stable Chronic Obstructive Pulmonary Disease Clinical Biochemistry. Oct, 2016 | Pubmed ID: 27614218 Metabolic Syndrome and Subsequent Risk of Type 2 Diabetes and Cardiovascular Disease in Elderly Women: Challenging the Current Definition Medicine. Sep, 2016 | Pubmed ID: 27603394 A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy and Safety of Oral Salmon Calcitonin in the Treatment of Osteoporosis in Postmenopausal Women Taking Calcium and Vitamin D Bone. 10, 2016 | Pubmed ID: 27462009 Precision-Cut Kidney Slices As a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis Biomarker Insights. 2016 | Pubmed ID: 27257368 Intercritical Circulating Levels of Neo-epitopes Reflecting Matrixmetalloprotease-driven Degradation As Markers of Gout and Frequent Gout Attacks Rheumatology (Oxford, England). 09, 2016 | Pubmed ID: 27256715 Abdominal Wall Hernias-A Local Manifestation of Systemically Impaired Quality of the Extracellular Matrix Surgery. 07, 2016 | Pubmed ID: 27085685 Association Between Biomarkers of Tissue Inflammation and Progression of Osteoarthritis: Evidence from the Rotterdam Study Cohort Arthritis Research & Therapy. Apr, 2016 | Pubmed ID: 27039382 Early Changes in Blood-based Joint Tissue Destruction Biomarkers Are Predictive of Response to Tocilizumab in the LITHE Study Arthritis Research & Therapy. Jan, 2016 | Pubmed ID: 26787505 Turnover of Type III Collagen Reflects Disease Severity and is Associated with Progression and Microinflammation in Patients with IgA Nephropathy Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Mar, 2016 | Pubmed ID: 26311218 Collagen and Tissue Turnover As a Function of Age: Implications for Fibrosis Journal of Hepatology. Jan, 2016 | Pubmed ID: 26307398 Serum Cartilage Oligomeric Matrix Protein and Development of Radiographic and Painful Knee Osteoarthritis. A Community-based Cohort of Middle-aged Women Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 2015 | Pubmed ID: 26848781 Collagen Type III and VI Turnover in Response to Long-Term Immobilization PloS One. 2015 | Pubmed ID: 26641456 Markers of Collagen Remodeling Detect Clinically Significant Fibrosis in Chronic Hepatitis C Patients PloS One. 2015 | Pubmed ID: 26406331 Accelerated Extracellular Matrix Turnover During Exacerbations of COPD Respiratory Research. Jun, 2015 | Pubmed ID: 26062683 KBP-042 Improves Bodyweight and Glucose Homeostasis with Indices of Increased Insulin Sensitivity Irrespective of Route of Administration European Journal of Pharmacology. Sep, 2015 | Pubmed ID: 26027795 Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 MAb, Anifrolumab, in Adult Patients with Systemic Sclerosis The Journal of Investigative Dermatology. Oct, 2015 | Pubmed ID: 25993119 Serological Assessment of Neutrophil Elastase Activity on Elastin During Lung ECM Remodeling BMC Pulmonary Medicine. May, 2015 | Pubmed ID: 25935650 Call for Standardized Definitions of Osteoarthritis and Risk Stratification for Clinical Trials and Clinical Use Osteoarthritis and Cartilage. Aug, 2015 | Pubmed ID: 25865392 Clinical Drug Development Using Dynamic Biomarkers to Enable Personalized Health Care in COPD Chest. Jul, 2015 | Pubmed ID: 25856563 Serum and Urine Markers of Collagen Degradation Reflect Renal Fibrosis in Experimental Kidney Diseases Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jul, 2015 | Pubmed ID: 25784725 Longitudinal Change in Collagen Degradation Biomarkers in Idiopathic Pulmonary Fibrosis: an Analysis from the Prospective, Multicentre PROFILE Study The Lancet. Respiratory Medicine. Jun, 2015 | Pubmed ID: 25770676 Novel Insights into the Function and Dynamics of Extracellular Matrix in Liver Fibrosis American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2015 | Pubmed ID: 25767261 Pro-C5, a Marker of True Type V Collagen Formation and Fibrillation, Correlates with Portal Hypertension in Patients with Alcoholic Cirrhosis Scandinavian Journal of Gastroenterology. May, 2015 | Pubmed ID: 25639675 The Collagen Turnover Profile is Altered in Patients with Inguinal and Incisional Hernia Surgery. Feb, 2015 | Pubmed ID: 25616945 Biological Relevance of Citrullinations: Diagnostic, Prognostic and Therapeutic Options Autoimmunity. Mar, 2015 | Pubmed ID: 25520183 Plasma Pro-C3 (N-terminal Type III Collagen Propeptide) Predicts Fibrosis Progression in Patients with Chronic Hepatitis C Liver International : Official Journal of the International Association for the Study of the Liver. Feb, 2015 | Pubmed ID: 25308921 Association of Versican Turnover with All-cause Mortality in Patients on Haemodialysis PloS One. 2014 | Pubmed ID: 25354390 PRO-C3-levels in Patients with HIV/HCV-Co-infection Reflect Fibrosis Stage and Degree of Portal Hypertension PloS One. 2014 | Pubmed ID: 25265505 Serological Biomarkers of Joint Tissue Turnover Predict Tocilizumab Response at Baseline Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases. Sep, 2014 | Pubmed ID: 25160020 Biomarkers of Cartilage and Surrounding Joint Tissue Biomarkers in Medicine. 2014 | Pubmed ID: 25123039 Serum Biomarkers Reflecting Specific Tumor Tissue Remodeling Processes Are Valuable Diagnostic Tools for Lung Cancer Cancer Medicine. Oct, 2014 | Pubmed ID: 25044252 Alpha C-telopeptide of Type I Collagen is Associated with Subchondral Bone Turnover and Predicts Progression of Joint Space Narrowing and Osteophytes in Osteoarthritis Arthritis & Rheumatology (Hoboken, N.J.). Sep, 2014 | Pubmed ID: 24909851 Oral Salmon Calcitonin Enhances Insulin Action and Glucose Metabolism in Diet-induced Obese Streptozotocin-diabetic Rats European Journal of Pharmacology. Aug, 2014 | Pubmed ID: 24858364 A Comparison of Osteoclast-rich and Osteoclast-poor Osteopetrosis in Adult Mice Sheds Light on the Role of the Osteoclast in Coupling Bone Resorption and Bone Formation Calcified Tissue International. Jul, 2014 | Pubmed ID: 24838599 A Novel Oral Dual Amylin and Calcitonin Receptor Agonist (KBP-042) Exerts Antiobesity and Antidiabetic Effects in Rats American Journal of Physiology. Endocrinology and Metabolism. Jul, 2014 | Pubmed ID: 24801386 Mammographic Texture Resemblance Generalizes As an Independent Risk Factor for Breast Cancer Breast Cancer Research : BCR. Apr, 2014 | Pubmed ID: 24713478 The Active Form of MMP-3 is a Marker of Synovial Inflammation and Cartilage Turnover in Inflammatory Joint Diseases BMC Musculoskeletal Disorders. Mar, 2014 | Pubmed ID: 24641725 Decline in Calcitonin Receptor Expression in Osteocytes with Age The Journal of Endocrinology. May, 2014 | Pubmed ID: 24516262 Rheumatoid Arthritis: a Case for Personalized Health Care? Arthritis Care & Research. Sep, 2014 | Pubmed ID: 24470057 Effect of Tocilizumab Combined with Methotrexate on Circulating Biomarkers of Synovium, Cartilage, and Bone in the LITHE Study Seminars in Arthritis and Rheumatism. Feb, 2014 | Pubmed ID: 23932312 The Future of Blood-based Biomarkers for Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jan, 2014 | Pubmed ID: 23850333 Osteoclast-derived Coupling Factors in Bone Remodeling Calcified Tissue International. Jan, 2014 | Pubmed ID: 23700149 Extracellular Matrix Specific Protein Fingerprints Measured in Serum Can Separate Pancreatic Cancer Patients from Healthy Controls BMC Cancer. Nov, 2013 | Pubmed ID: 24261855 Osteoclasts Are Not Crucial for Hematopoietic Stem Cell Maintenance in Adult Mice Haematologica. Dec, 2013 | Pubmed ID: 24097632 Association of Systemic Collagen Type IV Formation with Survival Among Patients Undergoing Hemodialysis PloS One. 2013 | Pubmed ID: 23990924 Serological Identification of Fast Progressors of Structural Damage with Rheumatoid Arthritis Arthritis Research & Therapy. Aug, 2013 | Pubmed ID: 23945134 Type VI Collagen Turnover-related Peptides-novel Serological Biomarkers of Muscle Mass and Anabolic Response to Loading in Young Men Journal of Cachexia, Sarcopenia and Muscle. Dec, 2013 | Pubmed ID: 23943593 Musculoskeletal Ageing and Primary Prevention Best Practice & Research. Clinical Obstetrics & Gynaecology. Oct, 2013 | Pubmed ID: 23891483 Acute Myocardial Infarction and Pulmonary Diseases Result in Two Different Degradation Profiles of Elastin As Quantified by Two Novel ELISAs PloS One. 2013 | Pubmed ID: 23805173 Oral Salmon Calcitonin Protects Against Impaired Fasting Glycemia, Glucose Intolerance, and Obesity Induced by High-fat Diet and Ovariectomy in Rats Menopause (New York, N.Y.). Jul, 2013 | Pubmed ID: 23793169 Quantification of "end Products" of Tissue Destruction in Inflammation May Reflect Convergence of Cytokine and Signaling Pathways -- Implications for Modern Clinical Chemistry Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Aug, 2013 | Pubmed ID: 23721060 An Enzyme-generated Fragment of Tau Measured in Serum Shows an Inverse Correlation to Cognitive Function PloS One. 2013 | Pubmed ID: 23717682 The Neo-epitope Specific PRO-C3 ELISA Measures True Formation of Type III Collagen Associated with Liver and Muscle Parameters American Journal of Translational Research. 2013 | Pubmed ID: 23634241 Role of Hormones in Cartilage and Joint Metabolism: Understanding an Unhealthy Metabolic Phenotype in Osteoarthritis Menopause (New York, N.Y.). May, 2013 | Pubmed ID: 23615651 A MMP Derived Versican Neo-epitope is Elevated in Plasma from Patients with Atherosclerotic Heart Disease International Journal of Clinical and Experimental Medicine. 2013 | Pubmed ID: 23573348 Atherofibrosis - a Unique and Common Process of the Disease Pathogenesis of Atherosclerosis and Fibrosis - Lessons for Biomarker Development American Journal of Translational Research. 2013 | Pubmed ID: 23390561 Circulating Protein Fragments of Cartilage and Connective Tissue Degradation Are Diagnostic and Prognostic Markers of Rheumatoid Arthritis and Ankylosing Spondylitis PloS One. 2013 | Pubmed ID: 23365672 Circulating Citrullinated Vimentin Fragments Reflect Disease Burden in Ankylosing Spondylitis and Have Prognostic Capacity for Radiographic Progression Arthritis and Rheumatism. Apr, 2013 | Pubmed ID: 23280360 Protein Fingerprinting of the Extracellular Matrix Remodelling in a Rat Model of Liver Fibrosis--a Serological Evaluation Liver International : Official Journal of the International Association for the Study of the Liver. Mar, 2013 | Pubmed ID: 23279004 Bringing Cancer Serological Diagnosis to a New Level: Focusing on HER2, Protein Ectodomain Shedding and Neoepitope Technology Future Oncology (London, England). Jan, 2013 | Pubmed ID: 23252562 Extracellular Matrix Remodeling: the Common Denominator in Connective Tissue Diseases. Possibilities for Evaluation and Current Understanding of the Matrix As More Than a Passive Architecture, but a Key Player in Tissue Failure Assay and Drug Development Technologies. Mar, 2013 | Pubmed ID: 23046407 Serological Muscle Loss Biomarkers: an Overview of Current Concepts and Future Possibilities Journal of Cachexia, Sarcopenia and Muscle. Mar, 2013 | Pubmed ID: 22996343 Future Detection and Monitoring of Diabetes May Entail Analysis of Both β-cell Function and Volume: How Markers of β-cell Loss May Assist Journal of Translational Medicine. Oct, 2012 | Pubmed ID: 23110768 Serological Investigation of the Collagen Degradation Profile of Patients with Chronic Obstructive Pulmonary Disease or Idiopathic Pulmonary Fibrosis Biomarker Insights. 2012 | Pubmed ID: 23012495 Molecular Serum Markers of Liver Fibrosis Biomarker Insights. 2012 | Pubmed ID: 22872786 Measurement of MMP-9 and -12 Degraded Elastin (ELM) Provides Unique Information on Lung Tissue Degradation BMC Pulmonary Medicine. Jul, 2012 | Pubmed ID: 22818364 Clinical Evaluation of a Matrix Metalloproteinase-12 Cleaved Fragment of Titin As a Cardiovascular Serological Biomarker Journal of Translational Medicine. Jul, 2012 | Pubmed ID: 22768802 A Specific Subtype of Osteoclasts Secretes Factors Inducing Nodule Formation by Osteoblasts Bone. Sep, 2012 | Pubmed ID: 22722081 Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women International Journal of Biomedical Imaging. 2012 | Pubmed ID: 22719751 Novel Cardiac-specific Biomarkers and the Cardiovascular Continuum Biomarker Insights. 2012 | Pubmed ID: 22577298 IL-6 Receptor Inhibition Positively Modulates Bone Balance in Rheumatoid Arthritis Patients with an Inadequate Response to Anti-tumor Necrosis Factor Therapy: Biochemical Marker Analysis of Bone Metabolism in the Tocilizumab RADIATE Study (NCT00106522) Seminars in Arthritis and Rheumatism. Oct, 2012 | Pubmed ID: 22397953 Enzyme-linked Immunosorbent Serum Assay Specific for the 7S Domain of Collagen Type IV (P4NP 7S): A Marker Related to the Extracellular Matrix Remodeling During Liver Fibrogenesis Hepatology Research : the Official Journal of the Japan Society of Hepatology. May, 2012 | Pubmed ID: 22221767 Generation of Human Osteoclasts from Peripheral Blood Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22130928 Ankylosing Spondylitis is Characterized by an Increased Turnover of Several Different Metalloproteinase-derived Collagen Species: a Cross-sectional Study Rheumatology International. Nov, 2012 | Pubmed ID: 22086471 Tumor Necrosis Factor-α and Receptor Activator of Nuclear Factor-κB Ligand Augment Human Macrophage Foam-cell Destruction of Extracellular Matrix Through Protease-mediated Processes Assay and Drug Development Technologies. Feb, 2012 | Pubmed ID: 22053710 A Comparison of Strontium Ranelate and PTH(1-84) Expert Review of Endocrinology & Metabolism. Mar, 2011 | Pubmed ID: 30290441 Diagnosis of Osteoarthritis by Cartilage Surface Smoothness Quantified Automatically from Knee MRI Cartilage. Jan, 2011 | Pubmed ID: 26069569 Molecular Serum and Urine Marker Repertoire Supporting Clinical Research on Joint Diseases Best Practice & Research. Clinical Rheumatology. Dec, 2011 | Pubmed ID: 22265266 Abdominal Aortic Calcification Quantified by the Morphological Atherosclerotic Calcification Distribution (MACD) Index is Associated with Features of the Metabolic Syndrome BMC Cardiovascular Disorders. Dec, 2011 | Pubmed ID: 22185588 Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-functional V-ATPase in Osteoclasts Leads to Increased Bone Strength PloS One. 2011 | Pubmed ID: 22087326 Identification of the Calcitonin Receptor in Osteoarthritic Chondrocytes BMC Research Notes. Oct, 2011 | Pubmed ID: 21996094 Assessment of Proteolytic Degradation of the Basement Membrane: a Fragment of Type IV Collagen As a Biochemical Marker for Liver Fibrosis Fibrogenesis & Tissue Repair. Oct, 2011 | Pubmed ID: 21970406 Glucocorticoids Exert Context-dependent Effects on Cells of the Joint in Vitro Steroids. Dec, 2011 | Pubmed ID: 21855558 Circulating CO3-610, a Degradation Product of Collagen III, Closely Reflects Liver Collagen and Portal Pressure in Rats with Fibrosis Fibrogenesis & Tissue Repair. Aug, 2011 | Pubmed ID: 21813019 Immunological Detection of the Type V Collagen Propeptide Fragment, PVCP-1230, in Connective Tissue Remodeling Associated with Liver Fibrosis Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Aug, 2011 | Pubmed ID: 21612338 Development and Validation of an Enzyme-linked Immunosorbent Assay for the Quantification of a Specific MMP-9 Mediated Degradation Fragment of Type III Collagen--A Novel Biomarker of Atherosclerotic Plaque Remodeling Clinical Biochemistry. Jul, 2011 | Pubmed ID: 21549691 Biochemical Markers of Ongoing Joint Damage in Rheumatoid Arthritis--current and Future Applications, Limitations and Opportunities Arthritis Research & Therapy. Apr, 2011 | Pubmed ID: 21539724 Measurement of CO3-610, a Potential Liver Biomarker Derived from Matrix Metalloproteinase-9 Degradation of Collagen Type Iii, in a Rat Model of Reversible Carbon-tetrachloride-induced Fibrosis Biomarker Insights. Mar, 2011 | Pubmed ID: 21499440 Measurement of Matrix Metalloproteinase 9-mediated Collagen Type III Degradation Fragment As a Marker of Skin Fibrosis BMC Dermatology. Mar, 2011 | Pubmed ID: 21447148 A Microarray Analysis of Full Depth Knee Cartilage of Ovariectomized Rats BMC Research Notes. Mar, 2011 | Pubmed ID: 21406075 Efficacy and Safety of the PPARγ Partial Agonist Balaglitazone Compared with Pioglitazone and Placebo: a Phase III, Randomized, Parallel-group Study in Patients with Type 2 Diabetes on Stable Insulin Therapy Diabetes/metabolism Research and Reviews. May, 2011 | Pubmed ID: 21328517 Enzyme-linked Immunosorbent Assay (ELISAs) for Metalloproteinase Derived Type II Collagen Neoepitope, CIIM--increased Serum CIIM in Subjects with Severe Radiographic Osteoarthritis Clinical Biochemistry. Apr, 2011 | Pubmed ID: 21223960 Distribution, Size, Shape, Growth Potential and Extent of Abdominal Aortic Calcified Deposits Predict Mortality in Postmenopausal Women BMC Cardiovascular Disorders. Nov, 2010 | Pubmed ID: 21067610 Screening of Protein Kinase Inhibitors Identifies PKC Inhibitors As Inhibitors of Osteoclastic Acid Secretion and Bone Resorption BMC Musculoskeletal Disorders. Oct, 2010 | Pubmed ID: 20977756 Matrix Metalloproteinase-9-mediated Type III Collagen Degradation As a Novel Serological Biochemical Marker for Liver Fibrogenesis Liver International : Official Journal of the International Association for the Study of the Liver. Oct, 2010 | Pubmed ID: 20666994 Macrophage-mediated Proteolytic Remodeling of the Extracellular Matrix in Atherosclerosis Results in Neoepitopes: a Potential New Class of Biochemical Markers Assay and Drug Development Technologies. Oct, 2010 | Pubmed ID: 20662734 Alterations in Osteoclast Function and Phenotype Induced by Different Inhibitors of Bone Resorption--implications for Osteoclast Quality BMC Musculoskeletal Disorders. Jun, 2010 | Pubmed ID: 20515459 Human Macrophage Foam Cells Degrade Atherosclerotic Plaques Through Cathepsin K Mediated Processes BMC Cardiovascular Disorders. Apr, 2010 | Pubmed ID: 20409295 Investigation of the Direct Effects of Salmon Calcitonin on Human Osteoarthritic Chondrocytes BMC Musculoskeletal Disorders. Apr, 2010 | Pubmed ID: 20367884 Application of Biochemical Markers in Development of Drugs for Treatment of Osteoarthritis Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Feb, 2010 | Pubmed ID: 20085489 Which Elements Are Involved in Reversible and Irreversible Cartilage Degradation in Osteoarthritis? Rheumatology International. Feb, 2010 | Pubmed ID: 19816688 Investigations of Inter- and Intraindividual Relationships Between Exposure to Oral Salmon Calcitonin and a Surrogate Marker of Pharmacodynamic Efficacy European Journal of Clinical Pharmacology. Jan, 2010 | Pubmed ID: 19813008 Biochemical Markers of Joint Tissue Turnover Assay and Drug Development Technologies. Feb, 2010 | Pubmed ID: 19715454 PLCL1 Rs7595412 Variation is Not Associated with Hip Bone Size Variation in Postmenopausal Danish Women BMC Medical Genetics. 2009 | Pubmed ID: 20030815 Suppression of MMP Activity in Bovine Cartilage Explants Cultures Has Little if Any Effect on the Release of Aggrecanase-derived Aggrecan Fragments BMC Research Notes. Dec, 2009 | Pubmed ID: 20021645 Identification of Progressors in Osteoarthritis by Combining Biochemical and MRI-based Markers Arthritis Research & Therapy. 2009 | Pubmed ID: 19630944 A Comparison of Glycemic Control, Water Retention, and Musculoskeletal Effects of Balaglitazone and Pioglitazone in Diet-induced Obese Rats European Journal of Pharmacology. Aug, 2009 | Pubmed ID: 19595686 Influence of Food Intake on the Bioavailability and Efficacy of Oral Calcitonin British Journal of Clinical Pharmacology. Apr, 2009 | Pubmed ID: 19371314 Local Communication on and Within Bone Controls Bone Remodeling Bone. Jun, 2009 | Pubmed ID: 19345750 A Pharmacokinetic and Pharmacodynamic Comparison of Synthetic and Recombinant Oral Salmon Calcitonin Journal of Clinical Pharmacology. Feb, 2009 | Pubmed ID: 19179298 Characterization of Acid Flux in Osteoclasts from Patients Harboring a G215R Mutation in ClC-7 Biochemical and Biophysical Research Communications. Jan, 2009 | Pubmed ID: 19070589 Characterization of the Bone Phenotype in ClC-7-deficient Mice Calcified Tissue International. Dec, 2008 | Pubmed ID: 18958510 Ion Transporters Involved in Acidification of the Resorption Lacuna in Osteoclasts Calcified Tissue International. Sep, 2008 | Pubmed ID: 18787885 Optimizing Bioavailability of Oral Administration of Small Peptides Through Pharmacokinetic and Pharmacodynamic Parameters: the Effect of Water and Timing of Meal Intake on Oral Delivery of Salmon Calcitonin BMC Clinical Pharmacology. Sep, 2008 | Pubmed ID: 18782439 The Disease Modifying Osteoarthritis Drug (DMOAD): Is It in the Horizon? Pharmacological Research. Jul, 2008 | Pubmed ID: 18590824 Does Increased Local Bone Resorption Secondary to Breast and Prostate Cancer Result in Increased Cartilage Degradation? BMC Cancer. Jun, 2008 | Pubmed ID: 18588674 Cartilage Degradation is Fully Reversible in the Presence of Aggrecanase but Not Matrix Metalloproteinase Activity Arthritis Research & Therapy. 2008 | Pubmed ID: 18513402 Patients with Rheumatoid Arthritis Have an Altered Circulatory Aggrecan Profile BMC Musculoskeletal Disorders. May, 2008 | Pubmed ID: 18507823 Calcitonin: a Drug of the Past or for the Future? Physiologic Inhibition of Bone Resorption While Sustaining Osteoclast Numbers Improves Bone Quality BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 2008 | Pubmed ID: 18481897 Osteoclasts Secrete Non-bone Derived Signals That Induce Bone Formation Biochemical and Biophysical Research Communications. Feb, 2008 | Pubmed ID: 18068671 Evaluation of Cartilage Damage by Measuring Collagen Degradation Products in Joint Extracts in a Traumatic Model of Osteoarthritis Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Feb, 2008 | Pubmed ID: 17852072 Calcitonin Affects Both Bone and Cartilage: a Dual Action Treatment for Osteoarthritis? Annals of the New York Academy of Sciences. Nov, 2007 | Pubmed ID: 18056043 Dissolution of the Inorganic Phase of Bone Leading to Release of Calcium Regulates Osteoclast Survival Biochemical and Biophysical Research Communications. Sep, 2007 | Pubmed ID: 17631274 Diphyllin, a Novel and Naturally Potent V-ATPase Inhibitor, Abrogates Acidification of the Osteoclastic Resorption Lacunae and Bone Resorption Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Oct, 2007 | Pubmed ID: 17576165 Are Nonresorbing Osteoclasts Sources of Bone Anabolic Activity? Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Apr, 2007 | Pubmed ID: 17227224 Effects of Ovariectomy and Estrogen Therapy on Type II Collagen Degradation and Structural Integrity of Articular Cartilage in Rats: Implications of the Time of Initiation Arthritis and Rheumatism. Aug, 2006 | Pubmed ID: 16871544 Alpha CTX As a Biomarker of Skeletal Invasion of Breast Cancer: Immunolocalization and the Load Dependency of Urinary Excretion Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jul, 2006 | Pubmed ID: 16835341 Degradation of the Organic Phase of Bone by Osteoclasts: a Secondary Role for Lysosomal Acidification Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jan, 2006 | Pubmed ID: 16355274 Osteoclasts from Patients with Autosomal Dominant Osteopetrosis Type I Caused by a T253I Mutation in Low-density Lipoprotein Receptor-related Protein 5 Are Normal in Vitro, but Have Decreased Resorption Capacity in Vivo The American Journal of Pathology. Nov, 2005 | Pubmed ID: 16251418 Acidification of the Osteoclastic Resorption Compartment Provides Insight into the Coupling of Bone Formation to Bone Resorption The American Journal of Pathology. Feb, 2005 | Pubmed ID: 15681830 The Chloride Channel Inhibitor NS3736 [corrected] Prevents Bone Resorption in Ovariectomized Rats Without Changing Bone Formation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jul, 2004 | Pubmed ID: 15176998 Characterization of Osteoclasts from Patients Harboring a G215R Mutation in ClC-7 Causing Autosomal Dominant Osteopetrosis Type II The American Journal of Pathology. May, 2004 | Pubmed ID: 15111300 Transforming Growth Factor-beta Controls Human Osteoclastogenesis Through the P38 MAPK and Regulation of RANK Expression The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12933809 Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-beta Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12226090 Ex Vivo Ткань Культура Модель хряща Ремоделирования в Bovine колено Explants Christian S. Thudium*1, Amalie Engstrom*1,2, Solveig S. Groen1, Morten A. Karsdal1, Anne-Christine Bay-Jensen1 1Nordic Bioscience, 2Department of Biomedical Sciences, University of Copenhagen JoVE 59467 Biology
Ex Vivo Ткань Культура Модель хряща Ремоделирования в Bovine колено Explants Christian S. Thudium*1, Amalie Engstrom*1,2, Solveig S. Groen1, Morten A. Karsdal1, Anne-Christine Bay-Jensen1 1Nordic Bioscience, 2Department of Biomedical Sciences, University of Copenhagen JoVE 59467 Biology