Nico van Rooijen Department of Molecular Biology Vrije Universiteit Amsterdam Biography Publications Institution JoVE Articles Nico van Rooijen has not added a biography. If you are Nico van Rooijen and would like to personalize this page please email our Author Liaison for assistance. Publications Cell Reports. Jul, 2012 | Pubmed ID: 22840403 CD11c(+)/CD11b(+) Cells Are Critical for Organic Dust-elicited Murine Lung Inflammation American Journal of Respiratory Cell and Molecular Biology. Jul, 2012 | Pubmed ID: 22822029 Monocytes Control Second-phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury American Journal of Respiratory and Critical Care Medicine. Jul, 2012 | Pubmed ID: 22822022 The American Journal of Pathology. Jul, 2012 | Pubmed ID: 22770665 PloS One. 2012 | Pubmed ID: 22768201 The EMBO Journal. 2012 | Pubmed ID: 22760164 Annals of Neurology. Jun, 2012 | Pubmed ID: 22718543 Nanomedicine (London, England). Jun, 2012 | Pubmed ID: 22709345 Combined Fiber Modifications Both to Target α(v)β(6) and Detarget the Coxsackievirus-adenovirus Receptor Improve Virus Toxicity Profiles in Vivo but Fail to Improve Antitumoral Efficacy Relative to Adenovirus Serotype 5 Human Gene Therapy. Jun, 2012 | Pubmed ID: 22708837 Inflammatory Ly-6C(hi) Monocytes Play an Important Role in the Development of Severe Transplant Arteriosclerosis in Hyperlipidemic Recipients Atherosclerosis. May, 2012 | Pubmed ID: 22704806 Naïve CD8 T Cell Activation by Liver Bone Marrow-derived Cells Leads to a "neglected" IL-2low Bimhigh Phenotype, Poor CTL Function and Cell Death Journal of Hepatology. May, 2012 | Pubmed ID: 22659099 Journal of Neuroinflammation. May, 2012 | Pubmed ID: 22651847 Journal of Controlled Release : Official Journal of the Controlled Release Society. May, 2012 | Pubmed ID: 22626939 The American Journal of Pathology. Jul, 2012 | Pubmed ID: 22613023 Cutting Edge: LPS-induced Emergency Myelopoiesis Depends on TLR4-expressing Nonhematopoietic Cells Journal of Immunology (Baltimore, Md. : 1950). Jun, 2012 | Pubmed ID: 22586037 The Journal of Experimental Medicine. Jun, 2012 | Pubmed ID: 22565824 The Journal of Infectious Diseases. Jul, 2012 | Pubmed ID: 22517912 PloS One. 2012 | Pubmed ID: 22514719 Investigative Ophthalmology & Visual Science. May, 2012 | Pubmed ID: 22511631 The EMBO Journal. May, 2012 | Pubmed ID: 22505026 Gut. Apr, 2012 | Pubmed ID: 22490516 A Targeted Complement-dependent Strategy to Improve the Outcome of MAb Therapy, and Characterization in a Murine Model of Metastatic Cancer Blood. Jun, 2012 | Pubmed ID: 22442351 American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2012 | Pubmed ID: 22442158 Host Genetics and Chlamydia Disease: Prediction and Validation of Disease Severity Mechanisms PloS One. 2012 | Pubmed ID: 22438999 Cancer Immunology, Immunotherapy : CII. Mar, 2012 | Pubmed ID: 22392192 Macrophage-derived Wnt Opposes Notch Signaling to Specify Hepatic Progenitor Cell Fate in Chronic Liver Disease Nature Medicine. Apr, 2012 | Pubmed ID: 22388089 Neuropharmacology. Jun, 2012 | Pubmed ID: 22361233 Science Translational Medicine. Feb, 2012 | Pubmed ID: 22323829 Journal of Neuropathology and Experimental Neurology. Mar, 2012 | Pubmed ID: 22318123 Journal of Neuroinflammation. 2012 | Pubmed ID: 22293457 Infection and Immunity. Apr, 2012 | Pubmed ID: 22290146 Vascular Endothelial Growth Factor-induced Skin Carcinogenesis Depends on Recruitment and Alternative Activation of Macrophages The Journal of Pathology. May, 2012 | Pubmed ID: 22262122 The B-cell Superantigen Finegoldia Magna Protein L Causes Pulmonary Inflammation by a Mechanism Dependent on MyD88 but Not B Cells or Immunoglobulins Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. Feb, 2012 | Pubmed ID: 22249932 An Essential Role for TH2-type Responses in Limiting Acute Tissue Damage During Experimental Helminth Infection Nature Medicine. Feb, 2012 | Pubmed ID: 22245779 Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions Circulation. Jan, 2012 | Pubmed ID: 22144566 Blood. Mar, 2012 | Pubmed ID: 22138510 Nature Immunology. Jan, 2012 | Pubmed ID: 22101728 Microglial Depletion Using Intrahippocampal Injection of Liposome-encapsulated Clodronate in Prolonged Hypothermic Cardiac Arrest in Rats Resuscitation. Apr, 2012 | Pubmed ID: 21970817 Immunobiology. May, 2012 | Pubmed ID: 21798616 Tissue Tropism and Target Cells of NSs-deleted Rift Valley Fever Virus in Live Immunodeficient Mice PLoS Neglected Tropical Diseases. Dec, 2011 | Pubmed ID: 22163058 Effects of Ischemia on Lung Macrophages PloS One. 2011 | Pubmed ID: 22110592 PLoS Pathogens. Nov, 2011 | Pubmed ID: 22102816 Herpesvirus Entry Mediator Regulates Hypoxia-inducible Factor-1α and Erythropoiesis in Mice The Journal of Clinical Investigation. Dec, 2011 | Pubmed ID: 22080867 Investigative Ophthalmology & Visual Science. 2011 | Pubmed ID: 22039242 The Journal of Experimental Medicine. Nov, 2011 | Pubmed ID: 22025304 Hepatocyte Entry Leads to Degradation of Autoreactive CD8 T Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21933957 Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-induced Obese Mice PloS One. 2011 | Pubmed ID: 21931688 Blood. Nov, 2011 | Pubmed ID: 21926352 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2011 | Pubmed ID: 21873555 The American Journal of Pathology. Oct, 2011 | Pubmed ID: 21854752 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21813778 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21795597 Chlamydia Psittaci Genetic Variants Differ in Virulence by Modulation of Host Immunity The Journal of Infectious Diseases. Aug, 2011 | Pubmed ID: 21791668 Neuroscience Letters. Sep, 2011 | Pubmed ID: 21782894 Control of TH17 Cells Occurs in the Small Intestine Nature. Jul, 2011 | Pubmed ID: 21765430 Cell-type-specific Type I Interferon Antagonism Influences Organ Tropism of Murine Coronavirus Journal of Virology. Oct, 2011 | Pubmed ID: 21752905 CLEC-2 Signaling Via Syk in Myeloid Cells Can Regulate Inflammatory Responses European Journal of Immunology. Oct, 2011 | Pubmed ID: 21728173 FEMS Immunology and Medical Microbiology. Oct, 2011 | Pubmed ID: 21707780 The American Journal of Pathology. Jul, 2011 | Pubmed ID: 21703402 SHIP-deficient, Alternatively Activated Macrophages Protect Mice During DSS-induced Colitis Journal of Leukocyte Biology. Sep, 2011 | Pubmed ID: 21685246 Ly6Chi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis American Journal of Respiratory and Critical Care Medicine. Sep, 2011 | Pubmed ID: 21680953 Journal of Autoimmunity. Nov, 2011 | Pubmed ID: 21665436 Journal of Neurotrauma. Sep, 2011 | Pubmed ID: 21657851 Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Nov, 2011 | Pubmed ID: 21655971 PLoS Pathogens. Jun, 2011 | Pubmed ID: 21655107 In Vivo Invasion of Head and Neck Squamous Cell Carcinoma Cells Does Not Require Macrophages The American Journal of Pathology. Jun, 2011 | Pubmed ID: 21641405 Microbes and Infection / Institut Pasteur. Oct, 2011 | Pubmed ID: 21635963 European Journal of Immunology. Sep, 2011 | Pubmed ID: 21630252 The Journal of Allergy and Clinical Immunology. Jun, 2011 | Pubmed ID: 21624619 Biochemical Pharmacology. Aug, 2011 | Pubmed ID: 21570957 Science (New York, N.Y.). Jun, 2011 | Pubmed ID: 21566158 Pretransplant CSF-1 Therapy Expands Recipient Macrophages and Ameliorates GVHD After Allogeneic Hematopoietic Cell Transplantation The Journal of Experimental Medicine. May, 2011 | Pubmed ID: 21536742 Cell Transplantation. Apr, 2011 | Pubmed ID: 21535911 Journal of Applied Physiology (Bethesda, Md. : 1985). Jul, 2011 | Pubmed ID: 21512145 The Journal of Clinical Investigation. May, 2011 | Pubmed ID: 21505265 PLoS Pathogens. Mar, 2011 | Pubmed ID: 21445234 Blood. May, 2011 | Pubmed ID: 21444914 The Journal of Clinical Investigation. Apr, 2011 | Pubmed ID: 21436586 Blood. Apr, 2011 | Pubmed ID: 21389319 Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Jun, 2011 | Pubmed ID: 21352081 Osteal Macrophages Promote in Vivo Intramembranous Bone Healing in a Mouse Tibial Injury Model Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jul, 2011 | Pubmed ID: 21305607 The Journal of Experimental Medicine. Feb, 2011 | Pubmed ID: 21282381 PloS One. 2011 | Pubmed ID: 21267073 Journal of Immunology (Baltimore, Md. : 1950). Feb, 2011 | Pubmed ID: 21248252 Rapid Host Defense Against Aspergillus Fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype PloS One. 2011 | Pubmed ID: 21246055 Journal of Immunology (Baltimore, Md. : 1950). Feb, 2011 | Pubmed ID: 21239712 Macrophage IL-12p70 Signaling Prevents HSV-1-induced CNS Autoimmunity Triggered by Autoaggressive CD4+ Tregs Investigative Ophthalmology & Visual Science. Apr, 2011 | Pubmed ID: 21220560 Microenvironmental Control of Malignancy Exerted by RNASET2, a Widely Conserved Extracellular RNase Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21189302 Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21187388 Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Influenza A: Fc Receptors and Alveolar Macrophages Mediate Protection Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21169548 Journal of Immunotherapy (Hagerstown, Md. : 1997). Jan, 2011 | Pubmed ID: 21150715 Journal of Hepatology. Apr, 2011 | Pubmed ID: 21129806 Connective Tissue Research. Jun, 2011 | Pubmed ID: 21117894 Critical Roles of Macrophages in the Formation of Intracranial Aneurysm Stroke; a Journal of Cerebral Circulation. Jan, 2011 | Pubmed ID: 21106959 Gastroenterology. Feb, 2011 | Pubmed ID: 21070778 Blood. Jan, 2011 | Pubmed ID: 21059897 Investigative Ophthalmology & Visual Science. Mar, 2011 | Pubmed ID: 21051720 The International Journal of Biochemistry & Cell Biology. Jan, 2011 | Pubmed ID: 21044893 American Journal of Respiratory Cell and Molecular Biology. Jul, 2011 | Pubmed ID: 20813992 Experimental Neurology. Jul, 2011 | Pubmed ID: 20338167 Hippocampus. Feb, 2011 | Pubmed ID: 20082289 PloS One. 2010 | Pubmed ID: 21203444 Experimental Biology and Medicine (Maywood, N.J.). Dec, 2010 | Pubmed ID: 21127343 Cell Metabolism. Dec, 2010 | Pubmed ID: 21109192 Contrasting Roles of Macrophages and Dendritic Cells in Controlling Initial Pulmonary Brucella Infection European Journal of Immunology. Dec, 2010 | Pubmed ID: 21108467 LXR Promotes the Maximal Egress of Monocyte-derived Cells from Mouse Aortic Plaques During Atherosclerosis Regression The Journal of Clinical Investigation. Dec, 2010 | Pubmed ID: 21041949 Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21041641 PLoS Pathogens. 2010 | Pubmed ID: 20949078 Interleukin-6 Signaling in Liver-parenchymal Cells Suppresses Hepatic Inflammation and Improves Systemic Insulin Action Cell Metabolism. Sep, 2010 | Pubmed ID: 20816090 PloS One. 2010 | Pubmed ID: 20808850 Vaccine. Nov, 2010 | Pubmed ID: 20800700 Unique Requirements for Reactivation of Virus-specific Memory B Lymphocytes Journal of Immunology (Baltimore, Md. : 1950). Oct, 2010 | Pubmed ID: 20739675 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2010 | Pubmed ID: 20720208 Blood. Dec, 2010 | Pubmed ID: 20713966 In Aged Mice, Outgrowth of Intraocular Melanoma Depends on Proangiogenic M2-type Macrophages Journal of Immunology (Baltimore, Md. : 1950). Sep, 2010 | Pubmed ID: 20713886 Molecular Vision. 2010 | Pubmed ID: 20664704 Malaria Journal. 2010 | Pubmed ID: 20618960 Blood. Oct, 2010 | Pubmed ID: 20610817 Journal of Neuroimmunology. Sep, 2010 | Pubmed ID: 20599280 Journal of Neurochemistry. Sep, 2010 | Pubmed ID: 20584104 Hepatology (Baltimore, Md.). Jul, 2010 | Pubmed ID: 20578253 Monocytic Suppressive Cells Mediate Cardiovascular Transplantation Tolerance in Mice The Journal of Clinical Investigation. Jul, 2010 | Pubmed ID: 20551515 Hypertension. Aug, 2010 | Pubmed ID: 20547967 International Journal of Medical Microbiology : IJMM. Nov, 2010 | Pubmed ID: 20547100 Transplantation. Jun, 2010 | Pubmed ID: 20535850 Journal of Leukocyte Biology. Sep, 2010 | Pubmed ID: 20534703 Critical Role of Airway Macrophages in Modulating Disease Severity During Influenza Virus Infection of Mice Journal of Virology. Aug, 2010 | Pubmed ID: 20504924 MAbs. Jul, 2010 | Pubmed ID: 20495353 Prolonged Antigen Presentation is Required for Optimal CD8+ T Cell Responses Against Malaria Liver Stage Parasites PLoS Pathogens. May, 2010 | Pubmed ID: 20463809 Murine Kupffer Cells Are Protective in Total Hepatic Ischemia/reperfusion Injury with Bowel Congestion Through IL-10 Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20400698 Nature Immunology. Apr, 2010 | Pubmed ID: 20228797 Nature Immunology. Apr, 2010 | Pubmed ID: 20228796 The Journal of Experimental Medicine. Mar, 2010 | Pubmed ID: 20212069 A Protease-dependent Mechanism for Initiating T-dependent B Cell Responses to Large Particulate Antigens Journal of Immunology (Baltimore, Md. : 1950). Apr, 2010 | Pubmed ID: 20208013 Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jun, 2010 | Pubmed ID: 20200508 Investigative Ophthalmology & Visual Science. Jul, 2010 | Pubmed ID: 20181837 Neuron. Jan, 2010 | Pubmed ID: 20152116 Blockade of Tumor Necrosis Factor Alpha Signaling in Tumor-associated Macrophages As a Radiosensitizing Strategy Cancer Research. Feb, 2010 | Pubmed ID: 20145121 Hypertension. Mar, 2010 | Pubmed ID: 20142563 Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Aug, 2010 | Pubmed ID: 20135679 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133703 Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20072882 Hepatology (Baltimore, Md.). Feb, 2010 | Pubmed ID: 20054868 International Journal for Parasitology. May, 2010 | Pubmed ID: 20045000 Gastroenterology. Apr, 2010 | Pubmed ID: 20044996 Hepatology (Baltimore, Md.). Jan, 2010 | Pubmed ID: 20034047 Journal of Virology. Apr, 2010 | Pubmed ID: 20032173 The American Journal of Pathology. Jan, 2010 | Pubmed ID: 20008135 Journal of Immunotherapy (Hagerstown, Md. : 1997). Jan, 2010 | Pubmed ID: 19952960 IL-33 Shifts Macrophage Polarization, Promoting Resistance Against Pseudomonas Aeruginosa Keratitis Investigative Ophthalmology & Visual Science. Mar, 2010 | Pubmed ID: 19892870 American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2010 | Pubmed ID: 19875703 Journal of Immunology (Baltimore, Md. : 1950). Dec, 2009 | Pubmed ID: 19923456 The Journal of Clinical Investigation. Dec, 2009 | Pubmed ID: 19907079 Archivum Immunologiae Et Therapiae Experimentalis. Nov-Dec, 2009 | Pubmed ID: 19885646 PLoS Pathogens. Oct, 2009 | Pubmed ID: 19851468 Journal of Immunology (Baltimore, Md. : 1950). Nov, 2009 | Pubmed ID: 19841166 The American Journal of Pathology. Nov, 2009 | Pubmed ID: 19808647 The American Journal of Pathology. Nov, 2009 | Pubmed ID: 19808642 Inescapable Need for Neutrophils As Mediators of Cellular Innate Immunity to Acute Pseudomonas Aeruginosa Pneumonia Infection and Immunity. Dec, 2009 | Pubmed ID: 19805527 Antiglioma Immunological Memory in Response to Conditional Cytotoxic/immune-stimulatory Gene Therapy: Humoral and Cellular Immunity Lead to Tumor Regression Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2009 | Pubmed ID: 19789315 A Novel Animal Model of Borrelia Recurrentis Louse-borne Relapsing Fever Borreliosis Using Immunodeficient Mice PLoS Neglected Tropical Diseases. 2009 | Pubmed ID: 19787030 Journal of Immunology (Baltimore, Md. : 1950). Oct, 2009 | Pubmed ID: 19734227 Breast Cancer Research : BCR. 2009 | Pubmed ID: 19706193 Biochimica Et Biophysica Acta. Nov, 2009 | Pubmed ID: 19699298 The American Journal of Pathology. Sep, 2009 | Pubmed ID: 19644016 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2009 | Pubmed ID: 19641138 European Journal of Immunology. Oct, 2009 | Pubmed ID: 19637226 CD47 is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells Cell. Jul, 2009 | Pubmed ID: 19632179 CD47 is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis Cell. Jul, 2009 | Pubmed ID: 19632178 Essential Role for Neutrophils but Not Alveolar Macrophages at Early Time Points Following Aspergillus Fumigatus Infection The Journal of Infectious Diseases. Aug, 2009 | Pubmed ID: 19591573 Infection and Immunity. Sep, 2009 | Pubmed ID: 19581396 Virology. Aug, 2009 | Pubmed ID: 19540545 Journal of Hepatology. Aug, 2009 | Pubmed ID: 19501931 Journal of Immunotherapy (Hagerstown, Md. : 1997). Jul-Aug, 2009 | Pubmed ID: 19483647 MHC Class II-dependent Basophil-CD4+ T Cell Interactions Promote T(H)2 Cytokine-dependent Immunity Nature Immunology. Jul, 2009 | Pubmed ID: 19465906 PLoS Pathogens. May, 2009 | Pubmed ID: 19461878 Journal of Leukocyte Biology. Sep, 2009 | Pubmed ID: 19458267 Hepatology (Baltimore, Md.). Jul, 2009 | Pubmed ID: 19441102 Basic Research in Cardiology. Nov, 2009 | Pubmed ID: 19437062 Blood. Jul, 2009 | Pubmed ID: 19429866 Cornea. Jun, 2009 | Pubmed ID: 19421039 Journal of Leukocyte Biology. Aug, 2009 | Pubmed ID: 19414540 Nature Medicine. May, 2009 | Pubmed ID: 19412173 Journal of Neuroscience Methods. Jun, 2009 | Pubmed ID: 19393692 Toxicology and Applied Pharmacology. Apr, 2009 | Pubmed ID: 19371622 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2009 | Pubmed ID: 19321792 The EGF/CSF-1 Paracrine Invasion Loop Can Be Triggered by Heregulin Beta1 and CXCL12 Cancer Research. Apr, 2009 | Pubmed ID: 19293185 Blood. Jun, 2009 | Pubmed ID: 19273835 Fate of Endothelialized Modular Constructs Implanted in an Omental Pouch in Nude Rats Tissue Engineering. Part A. Oct, 2009 | Pubmed ID: 19265460 Epilysin (MMP-28) Restrains Early Macrophage Recruitment in Pseudomonas Aeruginosa Pneumonia Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19265166 Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19234214 Blood. Apr, 2009 | Pubmed ID: 19234141 Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2009 | Pubmed ID: 19223863 American Journal of Respiratory and Critical Care Medicine. May, 2009 | Pubmed ID: 19218195 Innate Immunity. Feb, 2009 | Pubmed ID: 19201820 Neoplasia (New York, N.Y.). Feb, 2009 | Pubmed ID: 19177202 Journal of Cardiovascular Pharmacology and Therapeutics. Mar, 2009 | Pubmed ID: 19168432 Hepatology (Baltimore, Md.). Apr, 2009 | Pubmed ID: 19133650 Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2009 | Pubmed ID: 19127252 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2009 | Pubmed ID: 19124759 और चूहे में मैक्रोफेज की कमी पुनर्गठन Shelley B. Weisser1, Nico van Rooijen2, Laura M. Sly3 1Department of Graduate Studies, University of British Columbia, 2Department of Molecular Biology, Vrije Universiteit Amsterdam, 3Department of Pediatrics, University of British Columbia JoVE 4105 Immunology and Infection
और चूहे में मैक्रोफेज की कमी पुनर्गठन Shelley B. Weisser1, Nico van Rooijen2, Laura M. Sly3 1Department of Graduate Studies, University of British Columbia, 2Department of Molecular Biology, Vrije Universiteit Amsterdam, 3Department of Pediatrics, University of British Columbia JoVE 4105 Immunology and Infection