Nicola L. Jones Cell Biology Hospital for Sick Children Biography Publications Institution JoVE Articles Nicola L. Jones has not added a biography. If you are Nicola L. Jones and would like to personalize this page please email our Author Liaison for assistance. Publications Under the Radar: Strategies Used by to Evade Host Responses Annual Review of Physiology. 02, 2022 | Pubmed ID: 34672717 High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in IPSC-Derived Human Intestinal Organoids Cells. 12, 2021 | Pubmed ID: 34943927 Vitamin D Deficiency Enhances Expression of Autophagy-regulating MiR-142-3p in Mouse and "involved" IBD Patient Intestinal Tissues American Journal of Physiology. Gastrointestinal and Liver Physiology. 08, 2021 | Pubmed ID: 34159811 Helicobacter Pylori Infection Gastroenterology Clinics of North America. 06, 2021 | Pubmed ID: 34024441 Development of the Patient-oriented Research Curriculum in Child Health (PORCCH) Research Involvement and Engagement. May, 2021 | Pubmed ID: 33971980 2019 Harry Shwachman Award: Dr Anne M. Griffiths, MD, FRCPC Journal of Pediatric Gastroenterology and Nutrition. 04, 2020 | Pubmed ID: 31880672 MCOLN1/TRPML1 Inhibition - a Novel Strategy Used by to Escape Autophagic Killing and Antibiotic Eradication Therapy Autophagy. 01, 2020 | Pubmed ID: 31599196 VacA Generates a Protective Intracellular Reservoir for Helicobacter Pylori That is Eliminated by Activation of the Lysosomal Calcium Channel TRPML1 Nature Microbiology. 08, 2019 | Pubmed ID: 31110360 VacA Promotes CagA Accumulation in Gastric Epithelial Cells During Helicobacter Pylori Infection Scientific Reports. 01, 2019 | Pubmed ID: 30631092 Protein Kinase C δ Signaling is Required for Dietary Prebiotic-induced Strengthening of Intestinal Epithelial Barrier Function Scientific Reports. 01, 2017 | Pubmed ID: 28098206 The Toronto Consensus for the Treatment of Helicobacter Pylori Infection in Adults Gastroenterology. Jul, 2016 | Pubmed ID: 27102658 Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the MiRNA Silencing Pathway Inflammatory Bowel Diseases. Dec, 2015 | Pubmed ID: 26332312 Helicobacter Pylori Inhibits Dendritic Cell Maturation Via Interleukin-10-mediated Activation of the Signal Transducer and Activator of Transcription 3 Pathway Journal of Innate Immunity. 2015 | Pubmed ID: 25412627 What is the Best Regimen for Helicobacter Pylori Eradication in Canadian Arctic Aboriginals? Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. Dec, 2013 | Pubmed ID: 24340311 Modulation of Autophagy by Helicobacter Pylori and Its Role in Gastric Carcinogenesis Trends in Microbiology. Nov, 2013 | Pubmed ID: 24156875 Cell Culture Assays to Evaluate Bacterial Toxicity and Virulence Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 23015494 Cell Culture-based Assays to Test for Bacterial Adherence and Internalization Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 23015493 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy Autophagy. Apr, 2012 | Pubmed ID: 22966490 Crohn Disease ATG16L1 Polymorphism Increases Susceptibility to Infection with Helicobacter Pylori in Humans Autophagy. Sep, 2012 | Pubmed ID: 22885761 Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter Pylori Infection in Humans Gastroenterology. May, 2012 | Pubmed ID: 22333951 Helicobacter Pylori in First Nations and Recent Immigrant Populations in Canada Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. Feb, 2012 | Pubmed ID: 22312609 Helicobacter Pylori and Immigrant Health CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Jan, 2012 | Pubmed ID: 22232338 Autophagy: a Primer for the Gastroenterologist/hepatologist Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. Dec, 2011 | Pubmed ID: 22175057 Helicobacter Pylori Treatment in the Hospital Setting: a Potential Model for Developing Quality Improvement Initiatives to Prevent Missed Test Results Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. Oct, 2011 | Pubmed ID: 22059157 Helicobacter Pylori Activates Calpain Via Toll-like Receptor 2 to Disrupt Adherens Junctions in Human Gastric Epithelial Cells Infection and Immunity. Oct, 2011 | Pubmed ID: 21825064 Detergent-resistant Microdomains Mediate Activation of Host Cell Signaling in Response to Attaching-effacing Bacteria Laboratory Investigation; a Journal of Technical Methods and Pathology. Feb, 2010 | Pubmed ID: 19997063 Methods to Monitor Autophagy in H. Pylori Vacuolating Cytotoxin A (VacA)-treated Cells Autophagy. Jan, 2010 | Pubmed ID: 19875940 Autophagy As an Emerging Dimension to Adaptive and Innate Immunity Seminars in Immunology. Aug, 2009 | Pubmed ID: 19502083 Effect of Helicobacter Pylori's Vacuolating Cytotoxin on the Autophagy Pathway in Gastric Epithelial Cells Autophagy. Apr, 2009 | Pubmed ID: 19164948 Helicobacter Pylori Cytotoxin-associated Gene A Activates the Signal Transducer and Activator of Transcription 3 Pathway in Vitro and in Vivo Cancer Research. Jan, 2009 | Pubmed ID: 19147578 Autophagy: Healthy Eating and Self-digestion for Gastroenterologists Journal of Pediatric Gastroenterology and Nutrition. May, 2008 | Pubmed ID: 18493203 Oral Vaccination Against Helicobacter Pylori Infection is Not Effective in Mice with Fas Ligand Deficiency Digestive Diseases and Sciences. Dec, 2005 | Pubmed ID: 16416178 Pediatric Gastrointestinal Diseases: Are Drugs the Answer? Current Opinion in Pharmacology. Dec, 2005 | Pubmed ID: 16199203 Canadian Helicobacter Study Group Consensus Conference: Update on the Approach to Helicobacter Pylori Infection in Children and Adolescents--an Evidence-based Evaluation Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. Jul, 2005 | Pubmed ID: 16010300 Amelioration of the Effects of Citrobacter Rodentium Infection in Mice by Pretreatment with Probiotics The Journal of Infectious Diseases. Jun, 2005 | Pubmed ID: 15897997 A Review of Current Guidelines for the Management of Helicobacter Pylori Infection in Children and Adolescents Paediatrics & Child Health. Dec, 2004 | Pubmed ID: 19688080 Helicobacter Pylori Infection and Gastric Cancer: Host, Bug, Environment, or All Three? Current Gastroenterology Reports. Dec, 2004 | Pubmed ID: 15527671 Probiotics Reduce Bacterial Colonization and Gastric Inflammation in H. Pylori-infected Mice Digestive Diseases and Sciences. Aug, 2004 | Pubmed ID: 15387328 Helicobacter Pylori Induces Apoptosis of Macrophages in Association with Alterations in the Mitochondrial Pathway Infection and Immunity. May, 2004 | Pubmed ID: 15102801 Helicobacter Pylori Disrupts STAT1-mediated Gamma Interferon-induced Signal Transduction in Epithelial Cells Infection and Immunity. Jan, 2004 | Pubmed ID: 14688135 Fascination with Bacteria-triggered Cell Death: the Significance of Fas-mediated Apoptosis During Bacterial Infection in Vivo Microbes and Infection. Oct, 2003 | Pubmed ID: 14554257 Helicobacter Pylori Infection Interferes with Epithelial Stat6-mediated Interleukin-4 Signal Transduction Independent of CagA, CagE, or VacA Journal of Immunology (Baltimore, Md. : 1950). Aug, 2003 | Pubmed ID: 12902508 Helicobacter Pylori Strains Expressing the Vacuolating Cytotoxin Interrupt Phagosome Maturation in Macrophages by Recruiting and Retaining TACO (coronin 1) Protein Cellular Microbiology. Jan, 2003 | Pubmed ID: 12542468 Detection of Shiga Toxin-mediated Programmed Cell Death and Delineation of Death-signaling Pathways Methods in Molecular Medicine. 2003 | Pubmed ID: 12375433 Escherichia Coli Shiga-like Toxins Induce Apoptosis and Cleavage of Poly(ADP-ribose) Polymerase Via in Vitro Activation of Caspases Infection and Immunity. Aug, 2002 | Pubmed ID: 12117981 Enhanced Disease Severity in Helicobacter Pylori-infected Mice Deficient in Fas Signaling Infection and Immunity. May, 2002 | Pubmed ID: 11953400 Helicobacter Pylori Induces Gastric Epithelial Cell Apoptosis in Association with Increased Fas Receptor Expression Infection and Immunity. Aug, 1999 | Pubmed ID: 10417197 A Fluorescence-Based Assay of Membrane Potential for High-Throughput Functional Study of Two Endogenous Ion Channels in Two Epithelial Cell Lines Sunny Xia1,3, Michelle Di Paola3, Nicola L. Jones2,4,5, Christine E. Bear1,3,5 1Molecular Medicine, Hospital for Sick Children, 2Cell Biology, Hospital for Sick Children, 3Department of Physiology, University of Toronto, 4Department of Paediatrics, University of Toronto, 5Department of Biochemistry, University of Toronto JoVE 63528 Biology
A Fluorescence-Based Assay of Membrane Potential for High-Throughput Functional Study of Two Endogenous Ion Channels in Two Epithelial Cell Lines Sunny Xia1,3, Michelle Di Paola3, Nicola L. Jones2,4,5, Christine E. Bear1,3,5 1Molecular Medicine, Hospital for Sick Children, 2Cell Biology, Hospital for Sick Children, 3Department of Physiology, University of Toronto, 4Department of Paediatrics, University of Toronto, 5Department of Biochemistry, University of Toronto JoVE 63528 Biology
