Oliver Smithies

Publications

• Transforming Growth Factor β1 and Diabetic Nephropathy
  American Journal of Physiology. Renal Physiology. Dec, 2015  |   Pubmed ID: 26719364
• A Conversation with Oliver Smithies
  The Journal of Clinical Investigation. Nov, 2015  |   Pubmed ID: 26524588
• The Whole of a Scientific Career: an Interview with Oliver Smithies
  PLoS Genetics. May, 2015  |   Pubmed ID: 26020970
• Low TGFβ1 Expression Prevents and High Expression Exacerbates Diabetic Nephropathy in Mice
  Proceedings of the National Academy of Sciences of the United States of America. May, 2015  |   Pubmed ID: 25902541
• Endothelin-1 Critically Influences Cardiac Function Via Superoxide-MMP9 Cascade
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015  |   Pubmed ID: 25848038
• A Conversation with Oliver Smithies
  Annual Review of Physiology. 2015  |   Pubmed ID: 25668016
• Transforming Growth Factor Beta1 and Aldosterone
  Current Opinion in Nephrology and Hypertension. Mar, 2015  |   Pubmed ID: 25587902
• The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure
  Current Hypertension Reviews. 2014  |   Pubmed ID: 25801626
• Stable Oligomeric Clusters of Gold Nanoparticles: Preparation, Size Distribution, Derivatization, and Physical and Biological Properties
  Langmuir : the ACS Journal of Surfaces and Colloids. Nov, 2014  |   Pubmed ID: 25317930
• Colour Blindness: Still Too Many Red-green Figures
  Nature. Jun, 2014  |   Pubmed ID: 24943948
• The Smooth Muscle-selective RhoGAP GRAF3 is a Critical Regulator of Vascular Tone and Hypertension
  Nature Communications. 2013  |   Pubmed ID: 24335996
• Primary Aldosteronism and Impaired Natriuresis in Mice Underexpressing TGFβ1
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013  |   Pubmed ID: 23503843
• Null Mutations at the P66 and Bradykinin 2 Receptor Loci Induce Divergent Phenotypes in the Diabetic Kidney
  American Journal of Physiology. Renal Physiology. Dec, 2012  |   Pubmed ID: 23019230
• Distribution of Histone3 Lysine 4 Trimethylation at T3-responsive Loci in the Heart During Reversible Changes in Gene Expression
  Gene Expression. 2012  |   Pubmed ID: 22783727
• How It All Began: a Personal History of Gel Electrophoresis
  Methods in Molecular Biology (Clifton, N.J.). 2012  |   Pubmed ID: 22585472
• The Kallikrein-kinin System in Diabetic Nephropathy
  Kidney International. Apr, 2012  |   Pubmed ID: 22318421
• ENOS Deficiency Acts Through Endothelin to Aggravate SFlt-1-induced Pre-eclampsia-like Phenotype
  Journal of the American Society of Nephrology : JASN. Apr, 2012  |   Pubmed ID: 22282588
• Quantification of Myocyte Chemotaxis: a Role for FAK in Regulating Directional Motility
  Methods in Molecular Biology (Clifton, N.J.). 2012  |   Pubmed ID: 22222526
• The Kallikrein-kinin System and Oxidative Stress
  Current Opinion in Nephrology and Hypertension. Jan, 2012  |   Pubmed ID: 22048723
• β-MyHC and Cardiac Hypertrophy: Size Does Matter
  Circulation Research. Sep, 2011  |   Pubmed ID: 21885833
• Mitochondrial DNA Polymerase Editing Mutation, PolgD257A, Reduces the Diabetic Phenotype of Akita Male Mice by Suppressing Appetite
  Proceedings of the National Academy of Sciences of the United States of America. May, 2011  |   Pubmed ID: 21555558
• A Modest Decrease in Endothelial NOS in Mice Comparable to That Associated with Human NOS3 Variants Exacerbates Diabetic Nephropathy
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011  |   Pubmed ID: 21245338
• Therapeutic Benefits in Thalassemic Mice Transplanted with Long-term-cultured Bone Marrow Cells
  Experimental Hematology. Mar, 2011  |   Pubmed ID: 21184801
• Reversible Epigenetic Modifications of the Two Cardiac Myosin Heavy Chain Genes During Changes in Expression
  Gene Expression. 2010  |   Pubmed ID: 21526716
• Science Brick by Brick
  Nature. Oct, 2010  |   Pubmed ID: 20944621
• Heterogeneous Myocyte Enhancer Factor-2 (Mef2) Activation in Myocytes Predicts Focal Scarring in Hypertrophic Cardiomyopathy
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010  |   Pubmed ID: 20923879
• Genetically Determined Angiotensin Converting Enzyme Level and Myocardial Tolerance to Ischemia
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2010  |   Pubmed ID: 20667972
• Loss of Bradykinin Signaling Does Not Accelerate the Development of Cardiac Dysfunction in Type 1 Diabetic Akita Mice
  Endocrinology. Aug, 2010  |   Pubmed ID: 20501666
• Lack of Both Bradykinin B1 and B2 Receptors Enhances Nephropathy, Neuropathy, and Bone Mineral Loss in Akita Diabetic Mice
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010  |   Pubmed ID: 20479236
• Normal Development of Mice Deficient in Beta 2M, MHC Class I Proteins, and CD8+ T Cells. 1990
  Journal of Immunology (Baltimore, Md. : 1950). May, 2010  |   Pubmed ID: 20410496
• Genetic Variations in Peroxisome Proliferator-activated Receptor Gamma Expression Affect Blood Pressure
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009  |   Pubmed ID: 19884495
• Influence of Natriuretic Peptide Receptor-1 on Survival and Cardiac Hypertrophy During Development
  Biochimica Et Biophysica Acta. Dec, 2009  |   Pubmed ID: 19782130
• Mouse Models of Diabetic Nephropathy
  Journal of the American Society of Nephrology : JASN. Dec, 2009  |   Pubmed ID: 19729434
• Restoration of Podocyte Structure and Improvement of Chronic Renal Disease in Transgenic Mice Overexpressing Renin
  PloS One. 2009  |   Pubmed ID: 19696925
• Decreased Beta-adrenergic Responsiveness Following Hypertrophy Occurs Only in Cardiomyocytes That Also Re-express Beta-myosin Heavy Chain
  European Journal of Heart Failure. Jul, 2009  |   Pubmed ID: 19553396
• Gender-dependent Survival of Allogeneic Trophoblast Stem Cells in Liver
  Cell Transplantation. 2009  |   Pubmed ID: 19523327
• The Kallikrein-kinin System in Health and in Diseases of the Kidney
  Kidney International. May, 2009  |   Pubmed ID: 19190676
• RNA Repair Restores Hemoglobin Expression in IVS2-654 Thalassemic Mice
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2009  |   Pubmed ID: 19164558
• Tea with Dr Oliver Smithies, 2007 Nobel Laureate in Physiology and Medicine. Interview by Dr. Anthony Viera
  Journal of Clinical Hypertension (Greenwich, Conn.). Aug, 2008  |   Pubmed ID: 18772647
• Discordant On/off Switching of Gene Expression in Myocytes During Cardiac Hypertrophy in Vivo
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008  |   Pubmed ID: 18755891
• Turning Pages (Nobel Lecture)
  Chembiochem : a European Journal of Chemical Biology. Jun, 2008  |   Pubmed ID: 18543237
• Tissue-specific Regulation of ACE/ACE2 and AT1/AT2 Receptor Gene Expression by Oestrogen in Apolipoprotein E/oestrogen Receptor-alpha Knock-out Mice
  Experimental Physiology. May, 2008  |   Pubmed ID: 18192335
• Salt-sensitive Blood Pressure in Mice with Increased Expression of Aldosterone Synthase
  Hypertension. Jan, 2008  |   Pubmed ID: 18039983
• Conditional Deletion of Focal Adhesion Kinase Leads to Defects in Ventricular Septation and Outflow Tract Alignment
  Molecular and Cellular Biology. Aug, 2007  |   Pubmed ID: 17526730
• Receptor Activity-modifying Proteins 2 and 3 Have Distinct Physiological Functions from Embryogenesis to Old Age
  The Journal of Biological Chemistry. Jun, 2007  |   Pubmed ID: 17470425
• Bradykinin B1 and B2 Receptors Both Have Protective Roles in Renal Ischemia/reperfusion Injury
  Proceedings of the National Academy of Sciences of the United States of America. May, 2007  |   Pubmed ID: 17452647
• Early Cardiac Hypertrophy in Mice with Impaired Calmodulin Regulation of Cardiac Muscle Ca Release Channel
  The Journal of Clinical Investigation. May, 2007  |   Pubmed ID: 17431507
• Adrenomedullin Gene Expression Differences in Mice Do Not Affect Blood Pressure but Modulate Hypertension-induced Pathology in Males
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007  |   Pubmed ID: 17360661
• Npr1-regulated Gene Pathways Contributing to Cardiac Hypertrophy and Fibrosis
  Journal of Molecular Endocrinology. Feb, 2007  |   Pubmed ID: 17293444
• Angiotensin II Causes Hypertension and Cardiac Hypertrophy Through Its Receptors in the Kidney
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006  |   Pubmed ID: 17090678
• Disturbed Homeostasis in Sodium-restricted Mice Heterozygous and Homozygous for Aldosterone Synthase Gene Disruption
  Hypertension. Dec, 2006  |   Pubmed ID: 17075030
• Fibrosis, Not Cell Size, Delineates Beta-myosin Heavy Chain Reexpression During Cardiac Hypertrophy and Normal Aging in Vivo
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006  |   Pubmed ID: 17068123
• Reduced Maternal Expression of Adrenomedullin Disrupts Fertility, Placentation, and Fetal Growth in Mice
  The Journal of Clinical Investigation. Oct, 2006  |   Pubmed ID: 16981008
• Apop-1, a Novel Protein Inducing Cyclophilin D-dependent but Bax/Bak-related Channel-independent Apoptosis
  The Journal of Biological Chemistry. Aug, 2006  |   Pubmed ID: 16782708
• A DNA Insulator Prevents Repression of a Targeted X-linked Transgene but Not Its Random or Imprinted X Inactivation
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006  |   Pubmed ID: 16777957
• Intermittent Pressure Overload Triggers Hypertrophy-independent Cardiac Dysfunction and Vascular Rarefaction
  The Journal of Clinical Investigation. Jun, 2006  |   Pubmed ID: 16741575
• Senescence-associated Phenotypes in Akita Diabetic Mice Are Enhanced by Absence of Bradykinin B2 Receptors
  The Journal of Clinical Investigation. May, 2006  |   Pubmed ID: 16604193
• Amino Acids As Modulators of Endothelium-derived Nitric Oxide
  American Journal of Physiology. Renal Physiology. Aug, 2006  |   Pubmed ID: 16571593
• Hydrops Fetalis, Cardiovascular Defects, and Embryonic Lethality in Mice Lacking the Calcitonin Receptor-like Receptor Gene
  Molecular and Cellular Biology. Apr, 2006  |   Pubmed ID: 16537897
• Kidney Function in Mice Lacking Aldosterone
  American Journal of Physiology. Renal Physiology. Jan, 2006  |   Pubmed ID: 16118390
• Isolating Gene-corrected Stem Cells Without Drug Selection
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005  |   Pubmed ID: 16258059
• An Improved Technique for Tail-cuff Blood Pressure Measurements with Dark-tailed Mice
  Contemporary Topics in Laboratory Animal Science / American Association for Laboratory Animal Science. Sep, 2005  |   Pubmed ID: 16138782
• An Interview With... Oliver Smithies [interviewed by Magdalena Skipper]
  Nature Reviews. Genetics. May, 2005  |   Pubmed ID: 15880879
• Many Little Things: One Geneticist's View of Complex Diseases
  Nature Reviews. Genetics. May, 2005  |   Pubmed ID: 15861211
• Distinct Roles for the Kidney and Systemic Tissues in Blood Pressure Regulation by the Renin-angiotensin System
  The Journal of Clinical Investigation. Apr, 2005  |   Pubmed ID: 15841186
• Increased Susceptibility to Heart Failure in Response to Volume Overload in Mice Lacking Natriuretic Peptide Receptor-A Gene
  Cardiovascular Research. Apr, 2005  |   Pubmed ID: 15769452
• Homeostatic Responses in the Adrenal Cortex to the Absence of Aldosterone in Mice
  Endocrinology. Jun, 2005  |   Pubmed ID: 15731365
• Correction of Factor IX Deficiency in Mice by Embryonic Stem Cells Differentiated in Vitro
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005  |   Pubmed ID: 15699326
• Lifelong Genetic Minipumps
  Physiological Genomics. Jan, 2005  |   Pubmed ID: 15585607
• Ren1c Homozygous Null Mice Are Hypotensive and Polyuric, but Heterozygotes Are Indistinguishable from Wild-type
  Journal of the American Society of Nephrology : JASN. Jan, 2005  |   Pubmed ID: 15563565
• Complementation of Replication Origin Function in Mouse Embryonic Stem Cells by Human DNA Sequences
  Genomics. Sep, 2004  |   Pubmed ID: 15498455
• Three-dimensional Diffusion Tensor Microscopy of Fixed Mouse Hearts
  Magnetic Resonance in Medicine. Sep, 2004  |   Pubmed ID: 15334561
• Diabetic Nephropathy is Markedly Enhanced in Mice Lacking the Bradykinin B2 Receptor
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004  |   Pubmed ID: 15326315
• A GammaGT-AT1A Receptor Transgene Protects Renal Cortical Structure in AT1 Receptor-deficient Mice
  Physiological Genomics. Aug, 2004  |   Pubmed ID: 15306694
• E-prostanoid-3 Receptors Mediate the Proinflammatory Actions of Prostaglandin E2 in Acute Cutaneous Inflammation
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004  |   Pubmed ID: 15240726
• Renin Cells Are Precursors for Multiple Cell Types That Switch to the Renin Phenotype when Homeostasis is Threatened
  Developmental Cell. May, 2004  |   Pubmed ID: 15130496
• Altering the Expression in Mice of Genes by Modifying Their 3' Regions
  Developmental Cell. Apr, 2004  |   Pubmed ID: 15068798
• Human Genetics, Animal Models and Computer Simulations for Studying Hypertension
  Trends in Genetics : TIG. Mar, 2004  |   Pubmed ID: 15036807
• Cardiac Hypertrophy and Sudden Death in Mice with a Genetically Clamped Renin Transgene
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004  |   Pubmed ID: 14978280
• Physiological Impact of Increased Expression of the AT1 Angiotensin Receptor
  Hypertension. Oct, 2003  |   Pubmed ID: 12963678
• Induction of Hepatic Differentiation in Embryonic Stem Cells by Co-culture with Embryonic Cardiac Mesoderm
  Surgery. Aug, 2003  |   Pubmed ID: 12947317
• Natriuretic Peptide Receptor A Mediates Renal Sodium Excretory Responses to Blood Volume Expansion
  American Journal of Physiology. Renal Physiology. Oct, 2003  |   Pubmed ID: 12824076
• Minireview: Computer Simulations of Blood Pressure Regulation by the Renin-angiotensin System
  Endocrinology. Jun, 2003  |   Pubmed ID: 12746272
• Why the Kidney Glomerulus Does Not Clog: a Gel Permeation/diffusion Hypothesis of Renal Function
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2003  |   Pubmed ID: 12655073
• Targeted Disruption of Hsp70.1 Sensitizes to Osmotic Stress
  EMBO Reports. Sep, 2002  |   Pubmed ID: 12189176
• A Genetically Clamped Renin Transgene for the Induction of Hypertension
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002  |   Pubmed ID: 12034874
• Genotype/age Interactions on Aggressive Behavior in Gonadally Intact Estrogen Receptor Beta Knockout (betaERKO) Male Mice
  Hormones and Behavior. May, 2002  |   Pubmed ID: 11971662
• Multiple Roles of Adrenomedullin Revealed by Animal Models
  Microscopy Research and Technique. Apr, 2002  |   Pubmed ID: 11921356
• Molecular Phenotyping for Analyzing Subtle Genetic Effects in Mice: Application to an Angiotensinogen Gene Titration
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002  |   Pubmed ID: 11904385
• Impaired T Cell Function in RANTES-deficient Mice
  Clinical Immunology (Orlando, Fla.). Mar, 2002  |   Pubmed ID: 11890717
• Posttranscriptional Compensation for Heterozygous Disruption of the Kidney-specific NaK2Cl Cotransporter Gene
  Journal of the American Society of Nephrology : JASN. Mar, 2002  |   Pubmed ID: 11856763
• Interactions Between Endothelial Nitric Oxide Synthase and Sex Hormones in Vascular Protection in Mice
  The Journal of Clinical Investigation. Feb, 2002  |   Pubmed ID: 11854327
• Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor Beta
  Science (New York, N.Y.). Jan, 2002  |   Pubmed ID: 11799247
• Targeted Disruption of the Gene for Natriuretic Peptide Receptor-A Worsens Hypoxia-induced Cardiac Hypertrophy
  American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2002  |   Pubmed ID: 11748047