Paul C. Blainey Broad Institute Massachusetts Institute of Technology and Harvard Medical School Biography Publications Institution JoVE Articles Paul C. Blainey has not added a biography. If you are Paul C. Blainey and would like to personalize this page please email our Author Liaison for assistance. Publications Microfluidic-based Mini-metagenomics Enables Discovery of Novel Microbial Lineages from Complex Environmental Samples ELife. Jul, 2017 | Pubmed ID: 28678007 High-throughput Automated Microfluidic Sample Preparation for Accurate Microbial Genomics Nature Communications. Jan, 2017 | Pubmed ID: 28128213 Sliding on DNA: From Peptides to Small Molecules Angewandte Chemie (International Ed. in English). Nov, 2016 | Pubmed ID: 27813331 Funding: Interdisciplinary Challenges Nature Microbiology. Jul, 2016 | Pubmed ID: 27573117 Virtual Microfluidics for Digital Quantification and Single-cell Sequencing Nature Methods. Sep, 2016 | Pubmed ID: 27479330 Molecular Sled Sequences Are Common in Mammalian Proteins Nucleic Acids Research. Mar, 2016 | Pubmed ID: 26857546 Molecular Sled is an Eleven-amino Acid Vehicle Facilitating Biochemical Interactions Via Sliding Components Along DNA Nature Communications. Feb, 2016 | Pubmed ID: 26831565 A Microfluidic Platform Enabling Single-cell RNA-seq of Multigenerational Lineages Nature Communications. Jan, 2016 | Pubmed ID: 26732280 Tools for the Microbiome: Nano and Beyond ACS Nano. Jan, 2016 | Pubmed ID: 26695070 Optimal Estimation of Diffusion Coefficients from Single-particle Trajectories Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Feb, 2014 | Pubmed ID: 25353527 Laser Microdissection of the Alveolar Duct Enables Single-cell Genomic Analysis Frontiers in Oncology. 2014 | Pubmed ID: 25309876 Dissecting Genomic Diversity, One Cell at a Time Nature Methods. Jan, 2014 | Pubmed ID: 24524132 Optofluidic Cell Selection from Complex Microbial Communities for Single-genome Analysis Methods in Enzymology. 2013 | Pubmed ID: 24060116 Single-cell and Metagenomic Analyses Indicate a Fermentative and Saccharolytic Lifestyle for Members of the OP9 Lineage Nature Communications. 2013 | Pubmed ID: 23673639 The Future is Now: Single-cell Genomics of Bacteria and Archaea FEMS Microbiology Reviews. May, 2013 | Pubmed ID: 23298390 Regulation of a Viral Proteinase by a Peptide and DNA in One-dimensional Space: IV. Viral Proteinase Slides Along DNA to Locate and Process Its Substrates The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23043138 Regulation of a Viral Proteinase by a Peptide and DNA in One-dimensional Space: II. Adenovirus Proteinase is Activated in an Unusual One-dimensional Biochemical Reaction The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23043137 Regulation of a Viral Proteinase by a Peptide and DNA in One-dimensional Space: I. Binding to DNA AND to Hexon of the Precursor to Protein VI, PVI, of Human Adenovirus The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23043136 A Single-cell Genome for Thiovulum Sp Applied and Environmental Microbiology. Dec, 2012 | Pubmed ID: 23023751 Quantitative Analysis of the Human Airway Microbial Ecology Reveals a Pervasive Signature for Cystic Fibrosis Science Translational Medicine. Sep, 2012 | Pubmed ID: 23019655 Single-cell Sequencing Provides Clues About the Host Interactions of Segmented Filamentous Bacteria (SFB) Genome Research. Jun, 2012 | Pubmed ID: 22434425 Partial Genome Assembly for a Candidate Division OP11 Single Cell from an Anoxic Spring (Zodletone Spring, Oklahoma) Applied and Environmental Microbiology. Nov, 2011 | Pubmed ID: 21908640 Genome of a Low-salinity Ammonia-oxidizing Archaeon Determined by Single-cell and Metagenomic Analysis PloS One. 2011 | Pubmed ID: 21364937 Digital MDA for Enumeration of Total Nucleic Acid Contamination Nucleic Acids Research. Mar, 2011 | Pubmed ID: 21071419 Nonspecifically Bound Proteins Spin While Diffusing Along DNA Nature Structural & Molecular Biology. Dec, 2009 | Pubmed ID: 19898474 Digital PCR Provides Sensitive and Absolute Calibration for High Throughput Sequencing BMC Genomics. 2009 | Pubmed ID: 19298667 Diffusion Constant of a Nonspecifically Bound Protein Undergoing Curvilinear Motion Along DNA The Journal of Physical Chemistry. B. May, 2008 | Pubmed ID: 18321088 Multiplexed Single-molecule Assay for Enzymatic Activity on Flow-stretched DNA Nature Methods. May, 2007 | Pubmed ID: 17435763 A Base-excision DNA-repair Protein Finds Intrahelical Lesion Bases by Fast Sliding in Contact with DNA Proceedings of the National Academy of Sciences of the United States of America. Apr, 2006 | Pubmed ID: 16585517 Single-molecule Kinetics of Lambda Exonuclease Reveal Base Dependence and Dynamic Disorder Science (New York, N.Y.). Aug, 2003 | Pubmed ID: 12947199 A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA Kan Xiong1,2, Paul C. Blainey1,2 1Broad Institute, Massachusetts Institute of Technology and Harvard Medical School, 2Dept. of Biological Engineering, Massachusetts Institute of Technology JoVE 55923 Biochemistry
A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA Kan Xiong1,2, Paul C. Blainey1,2 1Broad Institute, Massachusetts Institute of Technology and Harvard Medical School, 2Dept. of Biological Engineering, Massachusetts Institute of Technology JoVE 55923 Biochemistry
