Philipp Koch Institute of Reconstructive Neurobiology University of Bonn Biography Publications Institution JoVE Articles Philipp Koch has not added a biography. If you are Philipp Koch and would like to personalize this page please email our Author Liaison for assistance. Publications In Vitro Segregation and Isolation of Human Pluripotent Stem Cell-derived Neural Crest Cells Methods (San Diego, Calif.). Oct, 2017 | Pubmed ID: 29037816 A Little Bit of Guidance: Mini Brains on Their Route to Adolescence Cell Stem Cell. Aug, 2017 | Pubmed ID: 28777940 The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for P3 Peptides Cell Reports. Jun, 2017 | Pubmed ID: 28591569 An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome Cell Reports. Apr, 2017 | Pubmed ID: 28380362 Whole-brain 3D Mapping of Human Neural Transplant Innervation Nature Communications. Jan, 2017 | Pubmed ID: 28102196 MTSS1 is Epigenetically Regulated in Glioma Cells and Inhibits Glioma Cell Motility Translational Oncology. Feb, 2017 | Pubmed ID: 27988423 Specific Triazine Herbicides Induce Amyloid-β42 Production Journal of Alzheimer's Disease : JAD. Sep, 2016 | Pubmed ID: 27589520 Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein Cell Reports. Mar, 2016 | Pubmed ID: 26923602 Phosphorylation of the Amyloid β-peptide at Ser26 Stabilizes Oligomeric Assembly and Increases Neurotoxicity Acta Neuropathologica. Apr, 2016 | Pubmed ID: 26898910 Direct Conversion Provides Old Neurons from Aged Donor's Skin Cell Stem Cell. Dec, 2015 | Pubmed ID: 26637936 Arylsulfatase A Overexpressing Human IPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2015 | Pubmed ID: 26061647 Human Induced Pluripotent Stem Cells Improve Recovery in Stroke-injured Aged Rats Restorative Neurology and Neuroscience. 2014 | Pubmed ID: 24916776 Auto-attraction of Neural Precursors and Their Neuronal Progeny Impairs Neuronal Migration Nature Neuroscience. Jan, 2014 | Pubmed ID: 24241396 APP Processing in Human Pluripotent Stem Cell-derived Neurons is Resistant to NSAID-based γ-secretase Modulation Stem Cell Reports. 2013 | Pubmed ID: 24371804 Anticancer Effects of Niclosamide in Human Glioblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23908450 Leveling Waddington: the Emergence of Direct Programming and the Loss of Cell Fate Hierarchies Nature Reviews. Molecular Cell Biology. Apr, 2013 | Pubmed ID: 23847783 MicroRNA-based Promotion of Human Neuronal Differentiation and Subtype Specification PloS One. 2013 | Pubmed ID: 23527072 Embryonic Stem Cell-based Modeling of Tau Pathology in Human Neurons The American Journal of Pathology. May, 2013 | Pubmed ID: 23499461 Leveling Waddington: the Emergence of Direct Programming and the Loss of Cell Fate Hierarchies Nature Reviews. Molecular Cell Biology. Apr, 2013 | Pubmed ID: 23486282 Targeting the Cytosolic Innate Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma Stem Cells (Dayton, Ohio). Jun, 2013 | Pubmed ID: 23390110 Functional Neuronal Cells Generated by Human Parthenogenetic Stem Cells PloS One. 2012 | Pubmed ID: 22880113 Presenilin-1 L166P Mutant Human Pluripotent Stem Cell-derived Neurons Exhibit Partial Loss of γ-secretase Activity in Endogenous Amyloid-β Generation The American Journal of Pathology. Jun, 2012 | Pubmed ID: 22510327 Small Molecules Enable Highly Efficient Neuronal Conversion of Human Fibroblasts Nature Methods. Jun, 2012 | Pubmed ID: 22484851 Capture of Neuroepithelial-like Stem Cells from Pluripotent Stem Cells Provides a Versatile System for in Vitro Production of Human Neurons PloS One. 2012 | Pubmed ID: 22272239 Human Embryonic Stem Cell-derived Neurons Establish Region-specific, Long-range Projections in the Adult Brain Cellular and Molecular Life Sciences : CMLS. Feb, 2012 | Pubmed ID: 21779868 Excitation-induced Ataxin-3 Aggregation in Neurons from Patients with Machado-Joseph Disease Nature. Nov, 2011 | Pubmed ID: 22113611 A Novel Human High-risk Ependymoma Stem Cell Model Reveals the Differentiation-inducing Potential of the Histone Deacetylase Inhibitor Vorinostat Acta Neuropathologica. Nov, 2011 | Pubmed ID: 21863243 Notchの阻害は、ヒト胚性幹細胞由来神経幹細胞における遅延G1 / S期遷移にシグナルを送ると、in Vitroおよびin Vivoで神経分化を加速 Stem Cells (Dayton, Ohio). May, 2010 | Pubmed ID: 20235098 Laser-assisted Photoablation of Human Pluripotent Stem Cells from Differentiating Cultures Stem Cell Reviews. Jun, 2010 | Pubmed ID: 20186504 Emerging Concepts in Neural Stem Cell Research: Autologous Repair and Cell-based Disease Modelling The Lancet. Neurology. Sep, 2009 | Pubmed ID: 19679274 A Rosette-type, Self-renewing Human ES Cell-derived Neural Stem Cell with Potential for in Vitro Instruction and Synaptic Integration Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19218428 Lineage Selection of Functional and Cryopreservable Human Embryonic Stem Cell-derived Neurons Stem Cells (Dayton, Ohio). Jul, 2008 | Pubmed ID: 18420830 Nucleofection of Human Embryonic Stem Cells Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18370194 Transduction of Human Embryonic Stem Cells by Ecotropic Retroviral Vectors Nucleic Acids Research. 2006 | Pubmed ID: 16998181 細胞透過性Creリコンビナーゼにより誘導されるヒト胚性幹細胞における部位特異的組換え Nature Methods. Jun, 2006 | Pubmed ID: 16721380 Nucleofection of Human Embryonic Stem Cells Stem Cells and Development. Aug, 2005 | Pubmed ID: 16137226 標準化され、再現性のある前脳型人間から脳オルガノイドの生成誘導多能性幹細胞 Olivia Krefft*1, Ammar Jabali*1, Vira Iefremova1, Philipp Koch1,2,3, Julia Ladewig1 1Institute of Reconstructive Neurobiology, University of Bonn, 2Central Institute of Mental Health, University of Heidelberg/Medical Faculty Mannheim, 3Hector Institute for Translational Brain Research (HITBR gGmbH) JoVE 56768 Developmental Biology
標準化され、再現性のある前脳型人間から脳オルガノイドの生成誘導多能性幹細胞 Olivia Krefft*1, Ammar Jabali*1, Vira Iefremova1, Philipp Koch1,2,3, Julia Ladewig1 1Institute of Reconstructive Neurobiology, University of Bonn, 2Central Institute of Mental Health, University of Heidelberg/Medical Faculty Mannheim, 3Hector Institute for Translational Brain Research (HITBR gGmbH) JoVE 56768 Developmental Biology