Philippe Froguel Genomics Faculty of Medicine Imperial College London Biography Publications Institution JoVE Articles Philippe Froguel has not added a biography. If you are Philippe Froguel and would like to personalize this page please email our Author Liaison for assistance. Publications Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women Than in Men The Journal of Clinical Endocrinology and Metabolism. Dec, 2012 | Pubmed ID: 23264395 Genome-wide Association Analyses Identify 18 New Loci Associated with Serum Urate Concentrations Nature Genetics. Dec, 2012 | Pubmed ID: 23263486 Seventy-five Genetic Loci Influencing the Human Red Blood Cell Nature. Dec, 2012 | Pubmed ID: 23222517 Estimation of Newborn Risk for Child or Adolescent Obesity: Lessons from Longitudinal Birth Cohorts PloS One. 2012 | Pubmed ID: 23209618 New Loci Associated with Birth Weight Identify Genetic Links Between Intrauterine Growth and Adult Height and Metabolism Nature Genetics. Dec, 2012 | Pubmed ID: 23202124 Response to Comment On: Marquez Et Al. Low-frequency Variants in HMGA1 Are Not Associated with Type 2 Diabetes Risk. Diabetes 2012;61:524-530 Diabetes. Sep, 2012 | Pubmed ID: 22923658 Large-scale Association Analyses Identify New Loci Influencing Glycemic Traits and Provide Insight into the Underlying Biological Pathways Nature Genetics. Aug, 2012 | Pubmed ID: 22885924 Large-scale Association Analysis Provides Insights into the Genetic Architecture and Pathophysiology of Type 2 Diabetes Nature Genetics. Aug, 2012 | Pubmed ID: 22885922 Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-fat Diet-fed Mice Through Lymphocyte-dependent and Independent Mechanisms PloS One. 2012 | Pubmed ID: 22768283 Dynamic Hydroxymethylation of Deoxyribonucleic Acid Marks Differentiation-associated Enhancers Nucleic Acids Research. Sep, 2012 | Pubmed ID: 22730288 Whole-exome Sequencing and High Throughput Genotyping Identified KCNJ11 As the Thirteenth MODY Gene PloS One. 2012 | Pubmed ID: 22701567 Impact of Common Variation in Bone-related Genes on Type 2 Diabetes and Related Traits Diabetes. Aug, 2012 | Pubmed ID: 22698912 Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases PLoS Genetics. May, 2012 | Pubmed ID: 22693455 The Interplay of Variants Near LEKR and CCNL1 and Social Stress in Relation to Birth Size PloS One. 2012 | Pubmed ID: 22685556 Glucose-dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity PloS One. 2012 | Pubmed ID: 22606236 Novel Association Approach for Variable Number Tandem Repeats (VNTRs) Identifies DOCK5 As a Susceptibility Gene for Severe Obesity Human Molecular Genetics. Aug, 2012 | Pubmed ID: 22595969 Tryptophan Metabolism Activation by Indoleamine 2,3-dioxygenase in Adipose Tissue of Obese Women: an Attempt to Maintain Immune Homeostasis and Vascular Tone American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2012 | Pubmed ID: 22592557 A Genome-wide Approach Accounting for Body Mass Index Identifies Genetic Variants Influencing Fasting Glycemic Traits and Insulin Resistance Nature Genetics. 2012 | Pubmed ID: 22581228 The Lessons of Early-onset Monogenic Diabetes for the Understanding of Diabetes Pathogenesis Best Practice & Research. Clinical Endocrinology & Metabolism. Apr, 2012 | Pubmed ID: 22498247 A Genome-wide Association Meta-analysis Identifies New Childhood Obesity Loci Nature Genetics. Apr, 2012 | Pubmed ID: 22484627 Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: a Multi-ethnic Meta-analysis of 45,891 Individuals PLoS Genetics. Mar, 2012 | Pubmed ID: 22479202 High Prevalence of Leptin and Melanocortin-4 Receptor Gene Mutations in Children with Severe Obesity from Pakistani Consanguineous Families Molecular Genetics and Metabolism. May, 2012 | Pubmed ID: 22463805 Loss-of-function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population Obesity (Silver Spring, Md.). Nov, 2012 | Pubmed ID: 22447289 No Interactions Between Previously Associated 2-hour Glucose Gene Variants and Physical Activity or BMI on 2-hour Glucose Levels Diabetes. May, 2012 | Pubmed ID: 22415877 KLHL3 Mutations Cause Familial Hyperkalemic Hypertension by Impairing Ion Transport in the Distal Nephron Nature Genetics. Apr, 2012 | Pubmed ID: 22406640 A Genome-wide Association Study Identifies Rs2000999 As a Strong Genetic Determinant of Circulating Haptoglobin Levels PloS One. 2012 | Pubmed ID: 22403646 Multicohort Genomewide Association Study Reveals a New Signal of Protection Against HIV-1 Acquisition The Journal of Infectious Diseases. Feb, 2012 | Pubmed ID: 22362864 Dysfunction of Lipid Sensor GPR120 Leads to Obesity in Both Mouse and Human Nature. Mar, 2012 | Pubmed ID: 22343897 Common Variants Near TARDBP and EGR2 Are Associated with Susceptibility to Ewing Sarcoma Nature Genetics. Mar, 2012 | Pubmed ID: 22327514 Rare MTNR1B Variants Impairing Melatonin Receptor 1B Function Contribute to Type 2 Diabetes Nature Genetics. Mar, 2012 | Pubmed ID: 22286214 A Genome-wide Association Search for Type 2 Diabetes Genes in African Americans PloS One. 2012 | Pubmed ID: 22238593 Clinical and Metabolic Features of Adult-onset Diabetes Caused by ABCC8 Mutations Diabetes Care. Feb, 2012 | Pubmed ID: 22210575 Low-frequency Variants in HMGA1 Are Not Associated with Type 2 Diabetes Risk Diabetes. Feb, 2012 | Pubmed ID: 22210315 Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity Diabetes. Feb, 2012 | Pubmed ID: 22210313 ITIH-5 Expression in Human Adipose Tissue is Increased in Obesity Obesity (Silver Spring, Md.). Apr, 2012 | Pubmed ID: 21852814 Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels with Severe Obesity Obesity (Silver Spring, Md.). Jan, 2012 | Pubmed ID: 21760635 Common Variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 Show Evidence of Association with Adult Obesity in the Greek Population Obesity (Silver Spring, Md.). Feb, 2012 | Pubmed ID: 21720444 New Gene Functions in Megakaryopoiesis and Platelet Formation Nature. Dec, 2011 | Pubmed ID: 22139419 Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: a Meta-analysis of 218,166 Adults and 19,268 Children PLoS Medicine. Nov, 2011 | Pubmed ID: 22069379 Human Mutation Within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 22065581 Genome-wide Association Study Identifies Loci Influencing Concentrations of Liver Enzymes in Plasma Nature Genetics. Nov, 2011 | Pubmed ID: 22001757 Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene PloS One. 2011 | Pubmed ID: 21980470 Effects of Genetic Susceptibility for Type 2 Diabetes on the Evolution of Glucose Homeostasis Traits Before and After Diabetes Diagnosis: Data from the D.E.S.I.R. Study Diabetes. Oct, 2011 | Pubmed ID: 21911746 Mirror Extreme BMI Phenotypes Associated with Gene Dosage at the Chromosome 16p11.2 Locus Nature. Oct, 2011 | Pubmed ID: 21881559 Genome-wide Association Study in Individuals of South Asian Ancestry Identifies Six New Type 2 Diabetes Susceptibility Loci Nature Genetics. Oct, 2011 | Pubmed ID: 21874001 Genome-wide Association Identifies Nine Common Variants Associated with Fasting Proinsulin Levels and Provides New Insights into the Pathophysiology of Type 2 Diabetes Diabetes. Oct, 2011 | Pubmed ID: 21873549 Characterization of the Human SLC30A8 Promoter and Intronic Enhancer Journal of Molecular Endocrinology. Dec, 2011 | Pubmed ID: 21798992 Systems Medicine and Integrated Care to Combat Chronic Noncommunicable Diseases Genome Medicine. 2011 | Pubmed ID: 21745417 Accurate Single-nucleotide Polymorphism Allele Assignment in Trisomic or Duplicated Regions by Using a Single Base-extension Assay with MALDI-TOF Mass Spectrometry Clinical Chemistry. Aug, 2011 | Pubmed ID: 21677093 Disruption of a Novel Kruppel-like Transcription Factor P300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the C.-331 INS Mutation Found in Neonatal Diabetes Mellitus The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21592955 FamCNV: Copy Number Variant Association for Quantitative Traits in Families Bioinformatics (Oxford, England). Jul, 2011 | Pubmed ID: 21546396 Association of Genetic Loci with Glucose Levels in Childhood and Adolescence: a Meta-analysis of over 6,000 Children Diabetes. Jun, 2011 | Pubmed ID: 21515849 Chromosome 19p13.3 Deletion in a Patient with Macrocephaly, Obesity, Mental Retardation, and Behavior Problems American Journal of Medical Genetics. Part A. May, 2011 | Pubmed ID: 21465662 Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway The Journal of Biological Chemistry. May, 2011 | Pubmed ID: 21454707 Investigation of the HIN200 Locus in UK SLE Families Identifies Novel Copy Number Variants Annals of Human Genetics. May, 2011 | Pubmed ID: 21401563 Bio-Repository of DNA in Stroke (BRAINS): a Study Protocol BMC Medical Genetics. 2011 | Pubmed ID: 21366918 TCF7L2 Splice Variants Have Distinct Effects on Beta-cell Turnover and Function Human Molecular Genetics. May, 2011 | Pubmed ID: 21357677 Childhood Obesity is Associated with Shorter Leukocyte Telomere Length The Journal of Clinical Endocrinology and Metabolism. May, 2011 | Pubmed ID: 21349907 Familial Mild Hyperglycemia Associated with a Novel ABCC8-V84I Mutation Within Three Generations Pediatric Diabetes. May, 2011 | Pubmed ID: 21214702 Screening Low-frequency SNPS from Genome-wide Association Study Reveals a New Risk Allele for Progression to AIDS Journal of Acquired Immune Deficiency Syndromes (1999). Mar, 2011 | Pubmed ID: 21107268 Lack of Association of CD36 SNPs with Early Onset Obesity: a Meta-analysis in 9,973 European Subjects Obesity (Silver Spring, Md.). Apr, 2011 | Pubmed ID: 20966904 Expression of the Selenoprotein S (SELS) Gene in Subcutaneous Adipose Tissue and SELS Genotype Are Associated with Metabolic Risk Factors Metabolism: Clinical and Experimental. Jan, 2011 | Pubmed ID: 20619427 Investigation of Mendelian Forms of Obesity Holds out the Prospect of Personalized Medicine Annals of the New York Academy of Sciences. Dec, 2010 | Pubmed ID: 21175686 Molecular Diagnosis of Neonatal Diabetes Mellitus Using Next-generation Sequencing of the Whole Exome PloS One. 2010 | Pubmed ID: 21049026 Association Analyses of 249,796 Individuals Reveal 18 New Loci Associated with Body Mass Index Nature Genetics. Nov, 2010 | Pubmed ID: 20935630 Meta-analysis Identifies 13 New Loci Associated with Waist-hip Ratio and Reveals Sexual Dimorphism in the Genetic Basis of Fat Distribution Nature Genetics. Nov, 2010 | Pubmed ID: 20935629 Common Variants at 10 Genomic Loci Influence Hemoglobin Aâ‚(C) Levels Via Glycemic and Nonglycemic Pathways Diabetes. Dec, 2010 | Pubmed ID: 20858683 A Genome-wide Association Study in the Japanese Population Identifies Susceptibility Loci for Type 2 Diabetes at UBE2E2 and C2CD4A-C2CD4B Nature Genetics. Oct, 2010 | Pubmed ID: 20818381 The Emerging Genetics of Type 2 Diabetes Trends in Molecular Medicine. Sep, 2010 | Pubmed ID: 20728409 Evaluation of A2BP1 As an Obesity Gene Diabetes. Nov, 2010 | Pubmed ID: 20724578 Multiple-cohort Genetic Association Study Reveals CXCR6 As a New Chemokine Receptor Involved in Long-term Nonprogression to AIDS The Journal of Infectious Diseases. Sep, 2010 | Pubmed ID: 20704485 Genetic and Functional Assessment of the Role of the Rs13431652-A and Rs573225-A Alleles in the G6PC2 Promoter That Are Strongly Associated with Elevated Fasting Glucose Levels Diabetes. Oct, 2010 | Pubmed ID: 20622168 Twelve Type 2 Diabetes Susceptibility Loci Identified Through Large-scale Association Analysis Nature Genetics. Jul, 2010 | Pubmed ID: 20581827 CnvHap: an Integrative Population and Haplotype-based Multiplatform Model of SNPs and CNVs Nature Methods. Jul, 2010 | Pubmed ID: 20512141 Two New Loci for Body-weight Regulation Identified in a Joint Analysis of Genome-wide Association Studies for Early-onset Extreme Obesity in French and German Study Groups PLoS Genetics. Apr, 2010 | Pubmed ID: 20421936 Variants in ADCY5 and Near CCNL1 Are Associated with Fetal Growth and Birth Weight Nature Genetics. May, 2010 | Pubmed ID: 20372150 Evidence for Leptin Receptor Isoforms Heteromerization at the Cell Surface FEBS Letters. Jun, 2010 | Pubmed ID: 20347812 Inflammatory Role of Toll-like Receptors in Human and Murine Adipose Tissue Mediators of Inflammation. 2010 | Pubmed ID: 20339530 MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans Diabetes. Jun, 2010 | Pubmed ID: 20200315 Concordance of Two Multiple Analytical Approaches Demonstrate That Interaction Between BMI and ADIPOQ Haplotypes is a Determinant of LDL Cholesterol in a General French Population Journal of Human Genetics. Apr, 2010 | Pubmed ID: 20186155 Meta-analysis and Functional Effects of the SLC30A8 Rs13266634 Polymorphism on Isolated Human Pancreatic Islets Molecular Genetics and Metabolism. May, 2010 | Pubmed ID: 20138556 Study of TNFalpha -308G/A and IL6 -174G/C Polymorphisms in Type 2 Diabetes and Obesity Risk in the Tunisian Population Clinical Biochemistry. Apr, 2010 | Pubmed ID: 20132806 New Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Type 2 Diabetes Risk Nature Genetics. Feb, 2010 | Pubmed ID: 20081858 Genetic Variation in GIPR Influences the Glucose and Insulin Responses to an Oral Glucose Challenge Nature Genetics. Feb, 2010 | Pubmed ID: 20081857 Analysis of the SIM1 Contribution to Polygenic Obesity in the French Population Obesity (Silver Spring, Md.). Aug, 2010 | Pubmed ID: 20075856 TCF7L2 Rs7903146-macronutrient Interaction in Obese Individuals' Responses to a 10-wk Randomized Hypoenergetic Diet The American Journal of Clinical Nutrition. Feb, 2010 | Pubmed ID: 20032493 Genome-wide Association Study Identifies Five Loci Associated with Lung Function Nature Genetics. Jan, 2010 | Pubmed ID: 20010834 Insulin Gene Mutations Resulting in Early-onset Diabetes: Marked Differences in Clinical Presentation, Metabolic Status, and Pathogenic Effect Through Endoplasmic Reticulum Retention Diabetes. Mar, 2010 | Pubmed ID: 20007936 Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY) Diabetes Care. Feb, 2010 | Pubmed ID: 19903754 Early Detrimental Metabolic Outcomes of Rs17300539-A Allele of ADIPOQ Gene Despite Higher Adiponectinemia Obesity (Silver Spring, Md.). Jul, 2010 | Pubmed ID: 19893502 Obesity-related Polymorphisms and Their Associations with the Ability to Regulate Fat Oxidation in Obese Europeans: the NUGENOB Study Obesity (Silver Spring, Md.). Jul, 2010 | Pubmed ID: 19876004 Prevalence of Loss-of-function FTO Mutations in Lean and Obese Individuals Diabetes. Jan, 2010 | Pubmed ID: 19833892 Monogenic Forms of Diabetes Mellitus: an Update EndocrinologÃa Y Nutrición : órgano De La Sociedad Española De EndocrinologÃa Y Nutrición. Dec, 2009 | Pubmed ID: 20629227 Monogenic Forms of Diabetes Mellitus: an Update Endocrinologia Y Nutricion : Organo De La Sociedad Espanola De Endocrinologia Y Nutricion. Dec, 2009 | Pubmed ID: 20542223 PLCL1 Rs7595412 Variation is Not Associated with Hip Bone Size Variation in Postmenopausal Danish Women BMC Medical Genetics. 2009 | Pubmed ID: 20030815 [Inputs from the Genetics of Fasting Glucose: Lessons for Diabetes] Médecine Sciences : M/S. Nov, 2009 | Pubmed ID: 19951660 Meta-analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? PLoS Genetics. Oct, 2009 | Pubmed ID: 19851442 MODY7 Gene, KLF11, is a Novel P300-dependent Regulator of Pdx-1 (MODY4) Transcription in Pancreatic Islet Beta Cells The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19843526 Genomewide Association Study of a Rapid Progression Cohort Identifies New Susceptibility Alleles for AIDS (ANRS Genomewide Association Study 03) The Journal of Infectious Diseases. Oct, 2009 | Pubmed ID: 19754311 Genetic Variant Near IRS1 is Associated with Type 2 Diabetes, Insulin Resistance and Hyperinsulinemia Nature Genetics. Oct, 2009 | Pubmed ID: 19734900 Genetic Variant in HK1 is Associated with a Proanemic State and A1C but Not Other Glycemic Control-related Traits Diabetes. Nov, 2009 | Pubmed ID: 19651813 Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians Diabetes. Nov, 2009 | Pubmed ID: 19651812 Tenomodulin is Highly Expressed in Adipose Tissue, Increased in Obesity, and Down-regulated During Diet-induced Weight Loss The Journal of Clinical Endocrinology and Metabolism. Oct, 2009 | Pubmed ID: 19602561 Genetic Loci Associated with C-reactive Protein Levels and Risk of Coronary Heart Disease JAMA : the Journal of the American Medical Association. Jul, 2009 | Pubmed ID: 19567438 Loss-of-function Mutation in the Dioxygenase-encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations American Journal of Human Genetics. Jul, 2009 | Pubmed ID: 19559399 Improved Donor/acceptor BRET Couples for Monitoring Beta-arrestin Recruitment to G Protein-coupled Receptors Biotechnology Journal. Sep, 2009 | Pubmed ID: 19557797 Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-associated Variants Diabetes. Sep, 2009 | Pubmed ID: 19542200 The Genetic Contribution to Non-syndromic Human Obesity Nature Reviews. Genetics. Jul, 2009 | Pubmed ID: 19506576 A Deletion of the HBII-85 Class of Small Nucleolar RNAs (snoRNAs) is Associated with Hyperphagia, Obesity and Hypogonadism Human Molecular Genetics. Sep, 2009 | Pubmed ID: 19498035 Common Variation in SIM1 is Reproducibly Associated with BMI in Pima Indians Diabetes. Jul, 2009 | Pubmed ID: 19401419 Breakthroughs in Monogenic Diabetes Genetics: from Pediatric Forms to Young Adulthood Diabetes Pediatric Endocrinology Reviews : PER. Mar, 2009 | Pubmed ID: 19396026 Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q Diabetes. Jul, 2009 | Pubmed ID: 19389826 The T-381C SNP in BNP Gene May Be Modestly Associated with Type 2 Diabetes: an Updated Meta-analysis in 49 279 Subjects Human Molecular Genetics. Jul, 2009 | Pubmed ID: 19377085 Contribution of Type 2 Diabetes Associated Loci in the Arabic Population from Tunisia: a Case-control Study BMC Medical Genetics. 2009 | Pubmed ID: 19368707 Regulation of Carboxylesterase 1 (CES1) in Human Adipose Tissue Biochemical and Biophysical Research Communications. May, 2009 | Pubmed ID: 19332024 G-allele of Intronic Rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-stimulated Insulin Release: Studies Involving 19,605 Europeans Diabetes. Jun, 2009 | Pubmed ID: 19324940 A Rare Variant in the Visfatin Gene (NAMPT/PBEF1) is Associated with Protection from Obesity Obesity (Silver Spring, Md.). Aug, 2009 | Pubmed ID: 19300429 Functional and Genetic Analysis in Type 2 Diabetes of Liver X Receptor Alleles--a Cohort Study BMC Medical Genetics. 2009 | Pubmed ID: 19292929 ALK7 Expression is Specific for Adipose Tissue, Reduced in Obesity and Correlates to Factors Implicated in Metabolic Disease Biochemical and Biophysical Research Communications. May, 2009 | Pubmed ID: 19275893 Combined Effects of MC4R and FTO Common Genetic Variants on Obesity in European General Populations Journal of Molecular Medicine (Berlin, Germany). May, 2009 | Pubmed ID: 19255736 Evaluating the Association of Common APOA2 Variants with Type 2 Diabetes BMC Medical Genetics. 2009 | Pubmed ID: 19216768 Identification of Susceptibility Genes for Complex Diseases Using Pooling-based Genome-wide Association Scans Human Genetics. Apr, 2009 | Pubmed ID: 19184112 Association Studies on Ghrelin and Ghrelin Receptor Gene Polymorphisms with Obesity Obesity (Silver Spring, Md.). Apr, 2009 | Pubmed ID: 19165163 Genome-wide Association Study for Early-onset and Morbid Adult Obesity Identifies Three New Risk Loci in European Populations Nature Genetics. Feb, 2009 | Pubmed ID: 19151714 Smallness for Gestational Age Interacts with High Mobility Group A2 Gene Genetic Variation to Modulate Height European Journal of Endocrinology / European Federation of Endocrine Societies. Apr, 2009 | Pubmed ID: 19139030 Genomewide Association Study of an AIDS-nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02) The Journal of Infectious Diseases. Feb, 2009 | Pubmed ID: 19115949 A Variant Near MTNR1B is Associated with Increased Fasting Plasma Glucose Levels and Type 2 Diabetes Risk Nature Genetics. Jan, 2009 | Pubmed ID: 19060909 The Q121 Variant of ENPP1 May Protect from Childhood Overweight/obesity in the Italian Population Obesity (Silver Spring, Md.). Jan, 2009 | Pubmed ID: 18948963 Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population Obesity Facts. 2008 | Pubmed ID: 20054193 Is Obesity Our Genetic Legacy? The Journal of Clinical Endocrinology and Metabolism. Nov, 2008 | Pubmed ID: 18987270 Estrogen Receptor Alpha Gene Variants Associate with Type 2 Diabetes and Fasting Plasma Glucose Pharmacogenetics and Genomics. Nov, 2008 | Pubmed ID: 18854778 Small Deletion Variants Have Stable Breakpoints Commonly Associated with Alu Elements PloS One. 2008 | Pubmed ID: 18769679 The Power of the Extreme in Elucidating Obesity The New England Journal of Medicine. Aug, 2008 | Pubmed ID: 18753645 The FTO Gene is Associated with Adulthood Obesity in the Mexican Population Obesity (Silver Spring, Md.). Oct, 2008 | Pubmed ID: 18719664 Predicting Diabetes: Clinical, Biological, and Genetic Approaches: Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Diabetes Care. Oct, 2008 | Pubmed ID: 18689695 Common Nonsynonymous Variants in PCSK1 Confer Risk of Obesity Nature Genetics. Aug, 2008 | Pubmed ID: 18604207 Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-dependent Penetrance in Multigenerational Pedigrees Diabetes. Sep, 2008 | Pubmed ID: 18559663 The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population Diabetes. Aug, 2008 | Pubmed ID: 18556336 Genetic Analysis of Kruppel-like Zinc Finger 11 Variants in 5864 Danish Individuals: Potential Effect on Insulin Resistance and Modified Signal Transducer and Activator of Transcription-3 Binding by Promoter Variant -1659G>C The Journal of Clinical Endocrinology and Metabolism. Aug, 2008 | Pubmed ID: 18505768 The Genetic Susceptibility to Type 2 Diabetes May Be Modulated by Obesity Status: Implications for Association Studies BMC Medical Genetics. 2008 | Pubmed ID: 18498634 Post Genome-wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-gene Interaction and High Predictive Value PloS One. 2008 | Pubmed ID: 18461161 Common Variants Near MC4R Are Associated with Fat Mass, Weight and Risk of Obesity Nature Genetics. Jun, 2008 | Pubmed ID: 18454148 Common Genetic Variation Near MC4R is Associated with Waist Circumference and Insulin Resistance Nature Genetics. Jun, 2008 | Pubmed ID: 18454146 A Polymorphism Within the G6PC2 Gene is Associated with Fasting Plasma Glucose Levels Science (New York, N.Y.). May, 2008 | Pubmed ID: 18451265 Inflammation is Associated with a Decrease of Lipogenic Factors in Omental Fat in Women American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2008 | Pubmed ID: 18448614 TCF7L2 Genetic Defect and Type 2 Diabetes Current Diabetes Reports. Apr, 2008 | Pubmed ID: 18445358 Monogenic Diabetes in the Young, Pharmacogenetics and Relevance to Multifactorial Forms of Type 2 Diabetes Endocrine Reviews. May, 2008 | Pubmed ID: 18436708 Evaluation of the Association of IGF2BP2 Variants with Type 2 Diabetes in French Caucasians Diabetes. Jul, 2008 | Pubmed ID: 18430866 Long-term Follow-up of Oral Glucose Tolerance Test-derived Glucose Tolerance and Insulin Secretion and Insulin Sensitivity Indexes in Subjects with Glucokinase Mutations (MODY2) Diabetes Care. Jul, 2008 | Pubmed ID: 18411240 Preferential Reciprocal Transfer of Paternal/maternal DLK1 Alleles to Obese Children: First Evidence of Polar Overdominance in Humans European Journal of Human Genetics : EJHG. Sep, 2008 | Pubmed ID: 18398438 INS VNTR is Not Associated with Childhood Obesity in 1,023 Families: a Family-based Study Obesity (Silver Spring, Md.). Jun, 2008 | Pubmed ID: 18388898 Endocannabinoid Receptor 1 Gene Variations Increase Risk for Obesity and Modulate Body Mass Index in European Populations Human Molecular Genetics. Jul, 2008 | Pubmed ID: 18375449 A Rare Mutation in ABCC8/SUR1 Leading to Altered ATP-sensitive K+ Channel Activity and Beta-cell Glucose Sensing is Associated with Type 2 Diabetes in Adults Diabetes. Jun, 2008 | Pubmed ID: 18346985 Genome-wide Association Scans Identified CTNNBL1 As a Novel Gene for Obesity Human Molecular Genetics. Jun, 2008 | Pubmed ID: 18325910 R125W Coding Variant in TBC1D1 Confers Risk for Familial Obesity and Contributes to Linkage on Chromosome 4p14 in the French Population Human Molecular Genetics. Jun, 2008 | Pubmed ID: 18325908 Evaluating the Association of Common PBX1 Variants with Type 2 Diabetes BMC Medical Genetics. 2008 | Pubmed ID: 18312624 Neonatal Hyperglycaemia and Abnormal Development of the Pancreas Best Practice & Research. Clinical Endocrinology & Metabolism. Feb, 2008 | Pubmed ID: 18279778 Effects of TCF7L2 Polymorphisms on Obesity in European Populations Obesity (Silver Spring, Md.). Feb, 2008 | Pubmed ID: 18239663 Analysis of Novel Risk Loci for Type 2 Diabetes in a General French Population: the D.E.S.I.R. Study Journal of Molecular Medicine (Berlin, Germany). Mar, 2008 | Pubmed ID: 18210030 Heterozygous Missense Mutations in the Insulin Gene Are Linked to Permanent Diabetes Appearing in the Neonatal Period or in Early Infancy: a Report from the French ND (Neonatal Diabetes) Study Group Diabetes. Apr, 2008 | Pubmed ID: 18171712 Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study Diabetes. Jan, 2008 | Pubmed ID: 17977958 Association Analysis Indicates That a Variant GATA-binding Site in the PIK3CB Promoter is a Cis-acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children Diabetes. Feb, 2008 | Pubmed ID: 17977952 A Single-nucleotide Polymorphism in the P110beta Gene Promoter is Associated with Partial Protection from Insulin Resistance in Severely Obese Adolescents The Journal of Clinical Endocrinology and Metabolism. Jan, 2008 | Pubmed ID: 17971428 Lack of Association Between the Pro12Ala Polymorphism of the PPAR-gamma 2 Gene and Type 2 Diabetes Mellitus in the Qatari Consanguineous Population Acta Diabetologica. Mar, 2008 | Pubmed ID: 17805473 Silencing of OB-RGRP in Mouse Hypothalamic Arcuate Nucleus Increases Leptin Receptor Signaling and Prevents Diet-induced Obesity Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18042720 Diabetes in Very Young Children and Mutations in the Insulin-secreting Cell Potassium Channel Genes: Therapeutic Consequences Endocrine Development. 2007 | Pubmed ID: 17923772 Meta-analysis of Genome-wide Linkage Studies in BMI and Obesity Obesity (Silver Spring, Md.). Sep, 2007 | Pubmed ID: 17890495 Genetic Study of the Melanin-concentrating Hormone Receptor 2 in Childhood and Adulthood Severe Obesity The Journal of Clinical Endocrinology and Metabolism. Nov, 2007 | Pubmed ID: 17698913 Analysis of KLF Transcription Factor Family Gene Variants in Type 2 Diabetes BMC Medical Genetics. 2007 | Pubmed ID: 17688680 Type 2 Diabetes Whole-genome Association Study in Four Populations: the DiaGen Consortium American Journal of Human Genetics. Aug, 2007 | Pubmed ID: 17668382 Array CGH Analysis of Copy Number Variation Identifies 1284 New Genes Variant in Healthy White Males: Implications for Association Studies of Complex Diseases Human Molecular Genetics. Dec, 2007 | Pubmed ID: 17666407 Secretory Granule Neuroendocrine Protein 1 (SGNE1) Genetic Variation and Glucose Intolerance in Severe Childhood and Adult Obesity BMC Medical Genetics. 2007 | Pubmed ID: 17617923 TCF7L2 Rs7903146 Variant Does Not Associate with Smallness for Gestational Age in the French Population BMC Medical Genetics. 2007 | Pubmed ID: 17593304 FCGR3B Copy Number Variation is Associated with Susceptibility to Systemic, but Not Organ-specific, Autoimmunity Nature Genetics. Jun, 2007 | Pubmed ID: 17529978 Non-synonymous Polymorphisms in Melanocortin-4 Receptor Protect Against Obesity: the Two Facets of a Janus Obesity Gene Human Molecular Genetics. Aug, 2007 | Pubmed ID: 17519222 Variation in FTO Contributes to Childhood Obesity and Severe Adult Obesity Nature Genetics. Jun, 2007 | Pubmed ID: 17496892 TCF7L2 is Reproducibly Associated with Type 2 Diabetes in Various Ethnic Groups: a Global Meta-analysis Journal of Molecular Medicine (Berlin, Germany). Jul, 2007 | Pubmed ID: 17476472 Examining the Candidacy of Ghrelin As a Gene Responsible for Variation in Adult Stature in a United Kingdom Population with Type 2 Diabetes The Journal of Clinical Endocrinology and Metabolism. Jun, 2007 | Pubmed ID: 17389697 New ABCC8 Mutations in Relapsing Neonatal Diabetes and Clinical Features Diabetes. Jun, 2007 | Pubmed ID: 17389331 Coexistence in the Same Family of Both Focal and Diffuse Forms of Hyperinsulinism Diabetes Care. Jun, 2007 | Pubmed ID: 17384337 Preadipocyte Response and Impairment of Differentiation in an Inflammatory Environment Biochemical and Biophysical Research Communications. May, 2007 | Pubmed ID: 17383612 Common Variation in the LMNA Gene (encoding Lamin A/C) and Type 2 Diabetes: Association Analyses in 9,518 Subjects Diabetes. Mar, 2007 | Pubmed ID: 17327460 Activating Transcription Factor 6 (ATF6) Sequence Polymorphisms in Type 2 Diabetes and Pre-diabetic Traits Diabetes. Mar, 2007 | Pubmed ID: 17327457 A Genome-wide Association Study Identifies Novel Risk Loci for Type 2 Diabetes Nature. Feb, 2007 | Pubmed ID: 17293876 Targeted Disruption of AdipoR1 and AdipoR2 Causes Abrogation of Adiponectin Binding and Metabolic Actions Nature Medicine. Mar, 2007 | Pubmed ID: 17268472 Leptin Receptor Genotype at Gln223Arg is Associated with Body Composition, BMD, and Vertebral Fracture in Postmenopausal Danish Women Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Apr, 2007 | Pubmed ID: 17243864 Comment on "A Common Genetic Variant is Associated with Adult and Childhood Obesity" Science (New York, N.Y.). Jan, 2007 | Pubmed ID: 17218508 No Contribution of Angiotensin-converting Enzyme (ACE) Gene Variants to Severe Obesity: a Model for Comprehensive Case/control and Quantitative Cladistic Analysis of ACE in Human Diseases European Journal of Human Genetics : EJHG. Mar, 2007 | Pubmed ID: 17164796 Impact of a CART Promoter Genetic Variation on Plasma Lipid Profile in a General Population Molecular Genetics and Metabolism. Feb, 2007 | Pubmed ID: 17008116 Adiponectin, Type 2 Diabetes and the Metabolic Syndrome: Lessons from Human Genetic Studies Expert Reviews in Molecular Medicine. 2006 | Pubmed ID: 17112391 Genotype-by-nutrient Interactions Assessed in European Obese Women. A Case-only Study European Journal of Nutrition. Dec, 2006 | Pubmed ID: 17080261 TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population: the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study Diabetes. Nov, 2006 | Pubmed ID: 17065361 Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human Beta-cells and Adipose Tissue and Strong Association with Type 2 Diabetes Diabetes. Oct, 2006 | Pubmed ID: 17003360 Bardet-Biedl Syndrome Gene Variants Are Associated with Both Childhood and Adult Common Obesity in French Caucasians Diabetes. Oct, 2006 | Pubmed ID: 17003356 Genetics of Obesity and the Prediction of Risk for Health Human Molecular Genetics. Oct, 2006 | Pubmed ID: 16987875 Polymorphisms in the Glucokinase-associated, Dual-specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated with Type 2 Diabetes Diabetes. Sep, 2006 | Pubmed ID: 16936214 Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples from Populations with Replicated Evidence of Linkage to Chromosome 1q Diabetes. Sep, 2006 | Pubmed ID: 16936202 Distinct Impaired Regulation of SOCS3 and Long and Short Isoforms of the Leptin Receptor in Visceral and Subcutaneous Fat of Lean and Obese Women Biochemical and Biophysical Research Communications. Oct, 2006 | Pubmed ID: 16920065 Activating Mutations in the ABCC8 Gene in Neonatal Diabetes Mellitus The New England Journal of Medicine. Aug, 2006 | Pubmed ID: 16885549 Genetic Polymorphisms and Weight Loss in Obesity: a Randomised Trial of Hypo-energetic High- Versus Low-fat Diets PLoS Clinical Trials. Jun, 2006 | Pubmed ID: 16871334 Förbättrad protokoll för laser mikrodissektion av humana pankreasöar från kirurgiska prover Dorothée Sturm1,2, Lorella Marselli3, Florian Ehehalt1,2, Daniela Richter1, Marius Distler2, Stephan Kersting1,2, Robert Grützmann2, Krister Bokvist4, Philippe Froguel5, Robin Liechti6, Anne Jörns7, Paolo Meda8, Gustavo Bruno Baretton9, Hans-Detlev Saeger2, Anke M. Schulte10, Piero Marchetti3, Michele Solimena1 1Molecular Diabetology, Paul Langerhans Institute Dresden, 2Department of GI-, Thoracic- and Vascular Surgery, University Hospital Carl Gustav Carus, University of Technology Dresden, 3Department of Endocrinology and Metabolism, Metabolic Unit University of Pisa, 4Labs DC0522, Lilly Corporate Center, 5Genomics, Faculty of Medicine Imperial College London, 6Vital-IT, SIB Swiss Institute of Bioinformatics, 7Clinical Biochemistry, Hannover Medical School, 8Cell Physiology and Metabolism, Medical School, University of Geneva, 9Department of Pathology, University Hospital Carl Gustav Carus, University of Technology Dresden, 10R&D DIAB Division / Translational Medicine, Sanofi-Aventis JoVE 50231 Medicine
Förbättrad protokoll för laser mikrodissektion av humana pankreasöar från kirurgiska prover Dorothée Sturm1,2, Lorella Marselli3, Florian Ehehalt1,2, Daniela Richter1, Marius Distler2, Stephan Kersting1,2, Robert Grützmann2, Krister Bokvist4, Philippe Froguel5, Robin Liechti6, Anne Jörns7, Paolo Meda8, Gustavo Bruno Baretton9, Hans-Detlev Saeger2, Anke M. Schulte10, Piero Marchetti3, Michele Solimena1 1Molecular Diabetology, Paul Langerhans Institute Dresden, 2Department of GI-, Thoracic- and Vascular Surgery, University Hospital Carl Gustav Carus, University of Technology Dresden, 3Department of Endocrinology and Metabolism, Metabolic Unit University of Pisa, 4Labs DC0522, Lilly Corporate Center, 5Genomics, Faculty of Medicine Imperial College London, 6Vital-IT, SIB Swiss Institute of Bioinformatics, 7Clinical Biochemistry, Hannover Medical School, 8Cell Physiology and Metabolism, Medical School, University of Geneva, 9Department of Pathology, University Hospital Carl Gustav Carus, University of Technology Dresden, 10R&D DIAB Division / Translational Medicine, Sanofi-Aventis JoVE 50231 Medicine