Piruthivi Sukumar

Publications

• Cixutumumab Reveals a Critical Role for IGF-1 in Adipose and Hepatic Tissue Remodelling During the Development of Diet-induced Obesity
  Adipocyte. Dec, 2022  |   Pubmed ID: 35734881
• Elevated ATP, Cytokines and Potential Microglial Inflammation Distinguish Exfoliation Glaucoma from Exfoliation Syndrome
  Cytokine. Mar, 2022  |   Pubmed ID: 35074716
• Endothelial Piezo1 Sustains Muscle Capillary Density and Contributes to Physical Activity
  The Journal of Clinical Investigation. Mar, 2022  |   Pubmed ID: 35025768
• Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine
  Annual Review of Pharmacology and Toxicology. Jan, 2022  |   Pubmed ID: 34499525
• Author Correction: Elevated Dimethylarginine, ATP, Cytokines, Metabolic Remodeling Involving Tryptophan Metabolism and Potential Microglial Inflammation Characterize Primary Open Angle Glaucoma
  Scientific Reports. Sep, 2021  |   Pubmed ID: 34480064
• Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling
  Endocrinology. Nov, 2021  |   Pubmed ID: 34460911
• Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat
  Circulation Research. Sep, 2021  |   Pubmed ID: 34420367
• Elevated Dimethylarginine, ATP, Cytokines, Metabolic Remodeling Involving Tryptophan Metabolism and Potential Microglial Inflammation Characterize Primary Open Angle Glaucoma
  Scientific Reports. May, 2021  |   Pubmed ID: 33963197
• Endothelial IGF-1 Receptor Mediates Crosstalk with the Gut Wall to Regulate Microbiota in Obesity
  EMBO Reports. May, 2021  |   Pubmed ID: 33934497
• Kv1.3 Voltage-gated Potassium Channels Link Cellular Respiration to Proliferation Through a Non-conducting Mechanism
  Cell Death & Disease. Apr, 2021  |   Pubmed ID: 33828089
• Systems Analysis of Avascular Necrosis of Femoral Head Using Integrative Data Analysis and Literature Mining Delineates Pathways Associated with Disease
  Scientific Reports. Oct, 2020  |   Pubmed ID: 33093559
• Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy
  Journal of the American Heart Association. Sep, 2020  |   Pubmed ID: 32892688
• Orai-1 and Orai-2 Regulate Oral Cancer Cell Migration and Colonisation by Suppressing Akt/mTOR/NF-κB Signalling
  Life Sciences. Nov, 2020  |   Pubmed ID: 32882268
• Divergent Effects of Genetic and Pharmacological Inhibition of Nox2 NADPH Oxidase on Insulin Resistance-related Vascular Damage
  American Journal of Physiology. Cell Physiology. Jul, 2020  |   Pubmed ID: 32401607
• Piezo1 Channel Activation Mimics High Glucose As a Stimulator of Insulin Release
  Scientific Reports. Nov, 2019  |   Pubmed ID: 31727906
• Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice
  Endocrinology. Aug, 2018  |   Pubmed ID: 29796592
• Piezo1 Channels Sense Whole Body Physical Activity to Reset Cardiovascular Homeostasis and Enhance Performance
  Nature Communications. 08, 2017  |   Pubmed ID: 28839146
• Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance
  Diabetes. Nov, 2017  |   Pubmed ID: 28830894
• Disaggregation of Amylin Aggregate by Novel Conformationally Restricted Aminobenzoic Acid Containing α/β and α/γ Hybrid Peptidomimetics
  Scientific Reports. Jan, 2017  |   Pubmed ID: 28054630
• Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop
  Circulation Research. Mar, 2017  |   Pubmed ID: 27920123
• Haploinsufficiency of the Insulin-like Growth Factor-1 Receptor Enhances Endothelial Repair and Favorably Modifies Angiogenic Progenitor Cell Phenotype
  Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2014  |   Pubmed ID: 25012136
• Restoring Akt1 Activity in Outgrowth Endothelial Cells from South Asian Men Rescues Vascular Reparative Potential
  Stem Cells (Dayton, Ohio). Oct, 2014  |   Pubmed ID: 24916783
• Response to Comment On: Sukumar Et Al. Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance-related Endothelial Cell Dysfunction. Diabetes 2013;62:2130-2134
  Diabetes. Dec, 2013  |   Pubmed ID: 24264411
• Endothelium-specific Insulin Resistance Leads to Accelerated Atherosclerosis in Areas with Disturbed Flow Patterns: a Role for Reactive Oxygen Species
  Atherosclerosis. Sep, 2013  |   Pubmed ID: 23958265
• Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance-related Endothelial Cell Dysfunction
  Diabetes. Jun, 2013  |   Pubmed ID: 23349484
• Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-targeted IGF-1 Receptor Transgenic Mice
  Diabetes. Sep, 2012  |   Pubmed ID: 22733797
• Constitutively Active TRPC Channels of Adipocytes Confer a Mechanism for Sensing Dietary Fatty Acids and Regulating Adiponectin
  Circulation Research. Jul, 2012  |   Pubmed ID: 22668831
• Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis
  Diabetes. Apr, 2012  |   Pubmed ID: 22357965
• The Insulin-like Growth Factor-1 Receptor is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium
  Diabetes. Aug, 2011  |   Pubmed ID: 21677284
• Rapid and Contrasting Effects of Rosiglitazone on Transient Receptor Potential TRPM3 and TRPC5 Channels
  Molecular Pharmacology. Jun, 2011  |   Pubmed ID: 21406603
• Insulin Resistance Impairs Circulating Angiogenic Progenitor Cell Function and Delays Endothelial Regeneration
  Diabetes. Apr, 2011  |   Pubmed ID: 21317296
• Potent Suppression of Vascular Smooth Muscle Cell Migration and Human Neointimal Hyperplasia by KV1.3 Channel Blockers
  Cardiovascular Research. Feb, 2011  |   Pubmed ID: 20884640
• TRPM3 Channel Stimulated by Pregnenolone Sulphate in Synovial Fibroblasts and Negatively Coupled to Hyaluronan
  BMC Musculoskeletal Disorders. Jun, 2010  |   Pubmed ID: 20525329
• Nitric Oxide Lacks Direct Effect on TRPC5 Channels but Suppresses Endogenous TRPC5-containing Channels in Endothelial Cells
  Pflugers Archiv : European Journal of Physiology. Jun, 2010  |   Pubmed ID: 20390293
• Pregnenolone Sulphate- and Cholesterol-regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction
  Circulation Research. May, 2010  |   Pubmed ID: 20360246
• Stimulation of TRPC5 Cationic Channels by Low Micromolar Concentrations of Lead Ions (Pb2+)
  Biochemical and Biophysical Research Communications. Feb, 2010  |   Pubmed ID: 20100462
• Robotic Multiwell Planar Patch-clamp for Native and Primary Mammalian Cells
  Nature Protocols. 2009  |   Pubmed ID: 19197268
• Interactions, Functions, and Independence of Plasma Membrane STIM1 and TRPC1 in Vascular Smooth Muscle Cells
  Circulation Research. Oct, 2008  |   Pubmed ID: 18802022
• TRPC Channel Activation by Extracellular Thioredoxin
  Nature. Jan, 2008  |   Pubmed ID: 18172497
• Channel Regulation by Extracellular Redox Protein
  Channels (Austin, Tex.). 2007  |   Pubmed ID: 18690048
• A Sphingosine-1-phosphate-activated Calcium Channel Controlling Vascular Smooth Muscle Cell Motility
  Circulation Research. Jun, 2006  |   Pubmed ID: 16675717
• Downregulated REST Transcription Factor is a Switch Enabling Critical Potassium Channel Expression and Cell Proliferation
  Molecular Cell. Oct, 2005  |   Pubmed ID: 16209944