Articles by Rainer Meyer in JoVE

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion

JoVE 3896 7/17/2012

Se-Chan Kim¹, Olaf Boehm¹, Rainer Meyer², Andreas Hoeft¹, Pascal Knüfermann¹, Georg Baumgarten¹

¹Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany, ²Institute of Physiology, University of Bonn, Germany

Surgical trauma induces an inflammatory response. Cytokines and endogenous ligands are known to modulate myocardial infarct size following ischemia and reperfusion. We present a modified closed-chest model of murine ischemia and reperfusion using hanging weights to minimize effects of thoracotomy.