Rakesh Karmacharya Center for Genomic Medicine Massachusetts General Hospital Biography Publications Institution JoVE Articles Rakesh Karmacharya has not added a biography. If you are Rakesh Karmacharya and would like to personalize this page please email our Author Liaison for assistance. Publications The Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo): Rationale, Methods, and Baseline Characteristics Frontiers in Psychiatry. 2021 | Pubmed ID: 34234702 A Systematic Review of the Association Between Biological Markers and Environmental Stress Risk Factors for Adolescent Depression Journal of Psychiatric Research. 06, 2021 | Pubmed ID: 33857787 Comparative Transcriptomic Analysis of Cerebral Organoids and Cortical Neuron Cultures Derived from Human Induced Pluripotent Stem Cells Stem Cells and Development. Sep, 2020 | Pubmed ID: 32862797 Mental Health Units in Correctional Facilities in the United States Harvard Review of Psychiatry. Jul/Aug, 2020 | Pubmed ID: 32692089 Advances Toward Precision Medicine for Bipolar Disorder: Mechanisms & Molecules Molecular Psychiatry. Jul, 2020 | Pubmed ID: 32636474 Integrating Stem Cell-based Experiments in Clinical Research European Psychiatry : the Journal of the Association of European Psychiatrists. 06, 2020 | Pubmed ID: 32536357 Transcriptome Analysis and Functional Characterization of Cerebral Organoids in Bipolar Disorder Genome Medicine. 04, 2020 | Pubmed ID: 32306996 Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia JAMA Psychiatry. Jul, 2020 | Pubmed ID: 32186681 Synaptic Deficits in IPSC-derived Cortical Interneurons in Schizophrenia Are Mediated by NLGN2 and Rescued by N-acetylcysteine Translational Psychiatry. 11, 2019 | Pubmed ID: 31780643 Protocol for a Systematic Review of the Development of Depression Among Adolescents and Young Adults: Psychological, Biological, and Contextual Perspectives Around the World Systematic Reviews. 07, 2019 | Pubmed ID: 31325965 HDAC6 Modulates Signaling Pathways Relevant to Synaptic Biology and Neuronal Differentiation in Human Stem-Cell-Derived Neurons International Journal of Molecular Sciences. Mar, 2019 | Pubmed ID: 30935091 Identifying Depression Early in Adolescence The Lancet. Child & Adolescent Health. 04, 2019 | Pubmed ID: 30878111 Increased Synapse Elimination by Microglia in Schizophrenia Patient-derived Models of Synaptic Pruning Nature Neuroscience. 03, 2019 | Pubmed ID: 30718903 Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells ACS Chemical Biology. 08, 2017 | Pubmed ID: 28628306 Stem Cell-derived Neurons in the Development of Targeted Treatment for Schizophrenia and Bipolar Disorder Pharmacogenomics. Apr, 2017 | Pubmed ID: 28346060 Unbiased Metabolite Profiling of Schizophrenia Fibroblasts Under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines Journal of Proteome Research. 02, 2017 | Pubmed ID: 28152600 Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate As a Potential Biomarker for Bipolar Disorder Molecular Neuropsychiatry. Jul, 2016 | Pubmed ID: 27606323 Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 As a Neuroprotective Agent ACS Chemical Neuroscience. 07, 2016 | Pubmed ID: 27270122 Stem Cell Models of Neuropsychiatric Disorders Molecular and Cellular Neurosciences. 06, 2016 | Pubmed ID: 27013423 Disease Signatures for Schizophrenia and Bipolar Disorder Using Patient-derived Induced Pluripotent Stem Cells Molecular and Cellular Neurosciences. 06, 2016 | Pubmed ID: 26777134 Effects of LEP, LEPR, ADIPOQ, MC4R and FTO Polymorphisms on Dyslipidemia in Korean Patients with Schizophrenia Who Are Taking Clozapine Psychiatry Research. Jul, 2015 | Pubmed ID: 25841316 Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors Cell Reports. Feb, 2015 | Pubmed ID: 25660025 HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-catenin in Human IPSC-derived Neuronal Cells ACS Chemical Biology. Mar, 2015 | Pubmed ID: 25546293 Principles and Neurobiological Correlates of Concentrative, Diffuse, and Insight Meditation Harvard Review of Psychiatry. Jul-Aug, 2013 | Pubmed ID: 24651509 Co-Culturing Microglia and Cortical Neurons Differentiated from Human Induced Pluripotent Stem Cells Kara Lopez-Lengowski1,2, Annie Kathuria1,2,3, Kaia Gerlovin1,2, Rakesh Karmacharya1,2,3,4,5,6,7 1Center for Genomic Medicine, Massachusetts General Hospital, 2Chemical Biology Program, Broad Institute of MIT & Harvard, 3Department of Psychiatry, Harvard Medical School, 4Schizophrenia and Bipolar Disorder Program, McLean Hospital, 5Program in Neuroscience, Harvard University, 6Program in Chemical Biology, Harvard University, 7Harvard Stem Cell Institute JoVE 62480 Neuroscience Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells Sovannarath Pong1,2,3, Paulo Lizano1,2,3,4, Rakesh Karmacharya1,3,4,5 1Center for Genomic Medicine, Massachusetts General Hospital, 2Department of Psychiatry, Beth Israel Deaconess Medical Center, 3Chemical Biology and Therapeutic Science Program, Broad Institute of MIT and Harvard, 4Department of Psychiatry, Harvard Medical School, 5Schizophrenia and Bipolar Disorder Program, McLean Hospital JoVE 61629 Neuroscience
Co-Culturing Microglia and Cortical Neurons Differentiated from Human Induced Pluripotent Stem Cells Kara Lopez-Lengowski1,2, Annie Kathuria1,2,3, Kaia Gerlovin1,2, Rakesh Karmacharya1,2,3,4,5,6,7 1Center for Genomic Medicine, Massachusetts General Hospital, 2Chemical Biology Program, Broad Institute of MIT & Harvard, 3Department of Psychiatry, Harvard Medical School, 4Schizophrenia and Bipolar Disorder Program, McLean Hospital, 5Program in Neuroscience, Harvard University, 6Program in Chemical Biology, Harvard University, 7Harvard Stem Cell Institute JoVE 62480 Neuroscience
Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells Sovannarath Pong1,2,3, Paulo Lizano1,2,3,4, Rakesh Karmacharya1,3,4,5 1Center for Genomic Medicine, Massachusetts General Hospital, 2Department of Psychiatry, Beth Israel Deaconess Medical Center, 3Chemical Biology and Therapeutic Science Program, Broad Institute of MIT and Harvard, 4Department of Psychiatry, Harvard Medical School, 5Schizophrenia and Bipolar Disorder Program, McLean Hospital JoVE 61629 Neuroscience
