Ray-Jade Chen Department of Surgery, School of Medicine, College of Medicine Taipei Medical University Biography Publications Institution JoVE Articles Ray-Jade Chen has not added a biography. If you are Ray-Jade Chen and would like to personalize this page please email our Author Liaison for assistance. Publications An Integrated Influenza Surveillance Framework Based on National Influenza-Like Illness Incidence and Multiple Hospital Electronic Medical Records for Early Prediction of Influenza Epidemics: Design and Evaluation Journal of Medical Internet Research. Feb, 2019 | Pubmed ID: 30707099 New Therapeutic Strategy of Hinokitiol in Haemorrhagic Shock-induced Liver Injury Journal of Cellular and Molecular Medicine. Mar, 2019 | Pubmed ID: 30548082 Overexpression of IGF-IIRα Regulates Cardiac Remodeling and Aggravates High Salt Induced Apoptosis and Fibrosis in Transgenic Rats Environmental Toxicology. Feb, 2019 | Pubmed ID: 30450786 Protective Effect of Fisetin Against Angiotensin II-induced Apoptosis by Activation of IGF-IR-PI3K-Akt Signaling in H9c2 Cells and Spontaneous Hypertension Rats Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Sep, 2018 | Pubmed ID: 30668312 Exercise Training Augments Sirt1-signaling and Attenuates Cardiac Inflammation in D-galactose Induced-aging Rats Aging. Dec, 2018 | Pubmed ID: 30582744 Alpinate Oxyphyllae Extracts Enhance the Longevity and Homing of Mesenchymal Stem Cells and Augment Their Protection Against Senescence in H9c2 Cells Journal of Cellular Physiology. Dec, 2018 | Pubmed ID: 30515824 Tumorous Imaginal Disc 1 (TID1) Inhibits Isoproterenol-induced Cardiac Hypertrophy and Apoptosis by Regulating C-terminus of Hsc70-interacting Protein (CHIP) Mediated Degradation of Gαs International Journal of Medical Sciences. 2018 | Pubmed ID: 30443176 An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets Journal of Clinical Medicine. Nov, 2018 | Pubmed ID: 30441821 Licochalcone A Attenuates Glioma Cell Growth in Vitro and in Vivo Through Cell Cycle Arrest Food & Function. Aug, 2018 | Pubmed ID: 30083664 Machine Learning-Based Radiomics for Molecular Subtyping of Gliomas Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2018 | Pubmed ID: 29789422 GABA Tea Attenuates Cardiac Apoptosis in Spontaneously Hypertensive Rats (SHR) by Enhancing PI3K/Akt-mediated Survival Pathway and Suppressing Bax/Bak Dependent Apoptotic Pathway Environmental Toxicology. Jul, 2018 | Pubmed ID: 29708300 Lupeol Alters ER Stress-signaling Pathway by Downregulating ABCG2 Expression to Induce Oxaliplatin-resistant LoVo Colorectal Cancer Cell Apoptosis Environmental Toxicology. May, 2018 | Pubmed ID: 29436100 A Clinical Decision Support Engine Based on a National Medication Repository for the Detection of Potential Duplicate Medications: Design and Evaluation JMIR Medical Informatics. Jan, 2018 | Pubmed ID: 29351893 E4BP4 Inhibits AngII-induced Apoptosis in H9c2 Cardiomyoblasts by Activating the PI3K-Akt Pathway and Promoting Calcium Uptake Experimental Cell Research. 02, 2018 | Pubmed ID: 29331388 The Multifaceted Link Between Inflammation and Human Diseases Journal of Cellular Physiology. Sep, 2018 | Pubmed ID: 29323719 Predicted Coronary Heart Disease Risk Decreases in Obese Patients After Laparoscopic Sleeve Gastrectomy World Journal of Surgery. 07, 2018 | Pubmed ID: 29282509 Data Supporting the Angiotensin II Activates MEL18 to DeSUMOylate HSF2 for Hypertension-related Heart Failure Data in Brief. Feb, 2018 | Pubmed ID: 29270451 Inhibition of HSF2 SUMOylation Via MEL18 Upregulates IGF-IIR and Leads to Hypertension-induced Cardiac Hypertrophy International Journal of Cardiology. 04, 2018 | Pubmed ID: 29180262 Oolong Tea Prevents Cardiomyocyte Loss Against Hypoxia by Attenuating P-JNK Mediated Hypertrophy and Enhancing P-IGF1R, P-akt, and P-Bad Activity and by Fortifying NRF2 Antioxidation System Environmental Toxicology. Feb, 2018 | Pubmed ID: 29139225 Cardiac Apoptosis Induced Under High Glucose Condition Involves Activation of IGF2R Signaling in H9c2 Cardiomyoblasts and Streptozotocin-induced Diabetic Rat Hearts Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Jan, 2018 | Pubmed ID: 29136764 Fenofibrate Induced PPAR Alpha Expression Was Attenuated by Oestrogen Receptor Alpha Overexpression in Hep3B Cells Environmental Toxicology. Feb, 2018 | Pubmed ID: 29134746 Acute Hypoxic Preconditioning Prevents Palmitic Acid-induced Cardiomyocyte Apoptosis Via Switching Metabolic GLUT4-glucose Pathway Back to CD36-fatty Acid Dependent Journal of Cellular Biochemistry. 04, 2018 | Pubmed ID: 29130531 Epithelioid Angiomyolipoma of the Liver Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract. 01, 2018 | Pubmed ID: 29110191 The Preventive Effects of Edible Folic Acid on Cardiomyocyte Apoptosis and Survival in Early Onset Triple-transgenic Alzheimer's Disease Model Mice Environmental Toxicology. Jan, 2018 | Pubmed ID: 29068127 Synergistic Effect of HIF-1α and FoxO3a Trigger Cardiomyocyte Apoptosis Under Hyperglycemic Ischemia Condition Journal of Cellular Physiology. 04, 2018 | Pubmed ID: 29030976 Lipoteichoic Acid Upregulates Plasminogen Activator Inhibitor-1 Expression in Parapneumonic Effusions Respirology (Carlton, Vic.). 01, 2018 | Pubmed ID: 28836366 Topical Diltiazem Ointment in Post-hemorrhoidectomy Pain Relief: A Meta-analysis of Randomized Controlled Trials Asian Journal of Surgery. Sep, 2018 | Pubmed ID: 28698000 HSF1 Phosphorylation by ERK/GSK3 Suppresses RNF126 to Sustain IGF-IIR Expression for Hypertension-induced Cardiomyocyte Hypertrophy Journal of Cellular Physiology. Feb, 2018 | Pubmed ID: 28383811 Elevated Phosphate Levels Trigger Autophagy-Mediated Cellular Apoptosis in H9c2 Cardiomyoblasts Cardiorenal Medicine. Dec, 2017 | Pubmed ID: 29344024 Identification of Epidermal Growth Factor Receptor-positive Glioblastoma Using Lipid-encapsulated Targeted Superparamagnetic Iron Oxide Nanoparticles in Vitro Journal of Nanobiotechnology. Nov, 2017 | Pubmed ID: 29166921 Tanshinone IIA Inhibits β-Catenin Nuclear Translocation and IGF-2R Activation Via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis International Journal of Medical Sciences. 2017 | Pubmed ID: 29104486 Trends in Diagnostic Approaches for Pediatric Appendicitis: Nationwide Population-based Study BMC Pediatrics. Nov, 2017 | Pubmed ID: 29100501 Lactobacillus Paracasei GMNL-32 Exerts a Therapeutic Effect on Cardiac Abnormalities in NZB/W F1 Mice PloS One. 2017 | Pubmed ID: 28934296 Risk Factors for 14-day Rehospitalization Following Trauma with New Traumatic Spinal Cord Injury Diagnosis: A 10-year Nationwide Study in Taiwan PloS One. 2017 | Pubmed ID: 28863195 Development of Benzimidazole Derivatives As Novel Anti-platelet Drugs Current Pharmaceutical Biotechnology. 2017 | Pubmed ID: 28828982 Tanshinone-induced ERs Suppresses IGFII Activation to Alleviate Ang II-mediated Cardiac Hypertrophy Journal of Receptor and Signal Transduction Research. Oct, 2017 | Pubmed ID: 28812967 Increased β-catenin Accumulation and Nuclear Translocation Are Associated with Concentric Hypertrophy in Cardiomyocytes Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. Nov - Dec, 2017 | Pubmed ID: 28802159 Licochalcone A Prevents Platelet Activation and Thrombus Formation Through the Inhibition of PLCγ2-PKC, Akt, and MAPK Pathways International Journal of Molecular Sciences. Jul, 2017 | Pubmed ID: 28704925 Protective Effect of HDL on NADPH Oxidase-derived Super Oxide Anion Mediates Hypoxia-induced Cardiomyocyte Apoptosis PloS One. 2017 | Pubmed ID: 28617849 Prostaglandin E2-Induced COX-2 Expressions Via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells International Journal of Molecular Sciences. May, 2017 | Pubmed ID: 28587064 High Density Lipoprotein (HDL) Reverses Palmitic Acid Induced Energy Metabolism Imbalance by Switching CD36 and GLUT4 Signaling Pathways in Cardiomyocyte Journal of Cellular Physiology. Nov, 2017 | Pubmed ID: 28500736 Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Treatment Evidence-based Complementary and Alternative Medicine : ECAM. 2017 | Pubmed ID: 28479925 E2/ER β Enhances Calcineurin Protein Degradation and PI3K/Akt/MDM2 Signal Transduction to Inhibit ISO-Induced Myocardial Cell Apoptosis International Journal of Molecular Sciences. Apr, 2017 | Pubmed ID: 28441761 Alpinia Oxyphylla Miq. Fruit Extract Activates IGFR-PI3K/Akt Signaling to Induce Schwann Cell Proliferation and Sciatic Nerve Regeneration BMC Complementary and Alternative Medicine. Mar, 2017 | Pubmed ID: 28359314 Corrigendum to "Rates of Susceptibility of Carbapenems, Ceftobiprole, and Colistin Against Clinically Important Bacteria Collected from Intensive Care Units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)" [J Microbiol Immunol Infect 49 (2016) 969-976] Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi. Mar, 2017 | Pubmed ID: 28325540 Major Pancreatic Duct Continuity is the Crucial Determinant in the Management of Blunt Pancreatic Injury: a Pancreatographic Classification Surgical Endoscopy. 10, 2017 | Pubmed ID: 28281124 Relation of Polymorphism of Arsenic Metabolism Genes to Arsenic Methylation Capacity and Developmental Delay in Preschool Children in Taiwan Toxicology and Applied Pharmacology. 04, 2017 | Pubmed ID: 28235556 Interleukin 15 Activates Akt to Protect Astrocytes from Oxygen Glucose Deprivation-induced Cell Death Cytokine. 04, 2017 | Pubmed ID: 28110119 Impact of Beta-Blocker Initiation Timing on Mortality Risk in Patients With Diabetes Mellitus Undergoing Noncardiac Surgery: A Nationwide Population-Based Cohort Study Journal of the American Heart Association. 01, 2017 | Pubmed ID: 28073770 Corrigendum to "Carbapenem Susceptibility Among Escherichia Coli, Klebsiella Pneumoniae, and Enterobacter Cloacae Isolates Obtained from Patients in Intensive Care Units in Taiwan in 2005, 2007, and 2009" [Diagn Microbiol Infect Dis 2015;81(4):290-295] Diagnostic Microbiology and Infectious Disease. Mar, 2017 | Pubmed ID: 27993423 Taiwanin E Inhibits Cell Migration in Human LoVo Colon Cancer Cells by Suppressing MMP-2/9 Expression Via P38 MAPK Pathway Environmental Toxicology. Aug, 2017 | Pubmed ID: 27807932 How Motorcycle Helmets Affect Trauma Mortality: Clinical and Policy Implications Traffic Injury Prevention. 08, 2017 | Pubmed ID: 27715312 Inhibition of NF-κB and Metastasis in Irinotecan (CPT-11)-resistant LoVo Colon Cancer Cells by Thymoquinone Via JNK and P38 Environmental Toxicology. Feb, 2017 | Pubmed ID: 27060453 Bevacizumab and Cetuximab with Conventional Chemotherapy Reduced Pancreatic Tumor Weight in Mouse Pancreatic Cancer Xenografts Clinical and Experimental Medicine. May, 2017 | Pubmed ID: 26995061 Contrast-Enhanced Ultrasound and Computed Tomography Assessment of Hepatocellular Carcinoma After Transcatheter Arterial Chemo-Embolization: A Systematic Review Journal of Gastrointestinal and Liver Diseases : JGLD. Dec, 2016 | Pubmed ID: 27981306 Suppression of Isoproterenol-induced Apoptosis in H9c2 Cardiomyoblast Cells by Daidzein Through Activation of Akt The Chinese Journal of Physiology. Dec, 2016 | Pubmed ID: 27817194 Therapeutic Effectiveness of Percutaneous Drainage and Factors for Performing an Interval Appendectomy in Pediatric Appendiceal Abscess BMC Surgery. Oct, 2016 | Pubmed ID: 27756361 Palmitic Acid Interferes with Energy Metabolism Balance by Adversely Switching the SIRT1-CD36-fatty Acid Pathway to the PKC Zeta-GLUT4-glucose Pathway in Cardiomyoblasts The Journal of Nutritional Biochemistry. 05, 2016 | Pubmed ID: 27133433 Combination of Two Targeted Medications (Bevacizumab Plus Cetuximab) Improve the Therapeutic Response of Pancreatic Carcinoma Medicine. Apr, 2016 | Pubmed ID: 27082562 Anti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a D-Galactose-Induced Aging Heart International Journal of Molecular Sciences. Mar, 2016 | Pubmed ID: 27043531 Alpinate Oxyphyllae Fructus Inhibits IGFII-Related Signaling Pathway to Attenuate Ang II-Induced Pathological Hypertrophy in H9c2 Cardiomyoblasts Journal of Medicinal Food. Mar, 2016 | Pubmed ID: 26987022 Mechanism of Taiwan Mingjian Oolong Tea to Inhibit Isoproterenol-Induced Hypertrophy and Apoptosis in Cardiomyoblasts The American Journal of Chinese Medicine. 2016 | Pubmed ID: 26916915 Andrographolide Stimulates P38 Mitogen-activated Protein Kinase-nuclear Factor Erythroid-2-related Factor 2-heme Oxygenase 1 Signaling in Primary Cerebral Endothelial Cells for Definite Protection Against Ischemic Stroke in Rats Translational Research : the Journal of Laboratory and Clinical Medicine. Apr, 2016 | Pubmed ID: 26746802 Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration Via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways Phytotherapy Research : PTR. Feb, 2016 | Pubmed ID: 26560814 Rates of Susceptibility of Carbapenems, Ceftobiprole, and Colistin Against Clinically Important Bacteria Collected from Intensive Care Units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi. Dec, 2016 | Pubmed ID: 25661253 Leclercia Adecarboxylata Bacteremia in a Patient with Long-term Use of Nonsteroidal Anti-inflammatory Drugs Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi. Jun, 2016 | Pubmed ID: 24183991 Evaluation of Safety and Efficacy of Salvage Therapy With Sunitinib, Docetaxel (Tyxan) and Cisplatinum Followed by Maintenance Vinorelbine for Unresectable/Metastatic Nonsmall Cell Lung Cancer: Stage 1 of a Simon 2 Stage Clinical Trial. [Corrected] Medicine. Dec, 2015 | Pubmed ID: 26717366 Heat Killed Lactobacillus Reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters Via TGF-β Suppression International Journal of Molecular Sciences. Oct, 2015 | Pubmed ID: 26516851 Moderate Exercise Training Attenuates Aging-induced Cardiac Inflammation, Hypertrophy and Fibrosis Injuries of Rat Hearts Oncotarget. Nov, 2015 | Pubmed ID: 26496028 Mycobacterium Tuberculosis Upregulates TNF-α Expression Via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells PloS One. 2015 | Pubmed ID: 26367274 National Trends in Therapeutic Approaches and Outcomes for Pediatric Appendicitis: a Taiwanese Nationwide Cohort Study Pediatric Surgery International. Jul, 2015 | Pubmed ID: 25985878 Carbapenemase-producing Gram-negative Bacteria: Current Epidemics, Antimicrobial Susceptibility and Treatment Options Future Microbiology. 2015 | Pubmed ID: 25812463 Carbapenem Susceptibility Among Escherichia Coli, Klebsiella Pneumoniae, and Enterobacter Cloacae Isolates Obtained from Patients in Intensive Care Units in Taiwan in 2005, 2007, and 2009 Diagnostic Microbiology and Infectious Disease. Apr, 2015 | Pubmed ID: 25600841 Early Changes of the Anemia Phenomenon in Male 100-km Ultramarathoners Journal of the Chinese Medical Association : JCMA. Feb, 2015 | Pubmed ID: 25456038 Empyema Necessitatis Due to Mycobacterium Tuberculosis Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi. Aug, 2015 | Pubmed ID: 24560698 Relationship Between the Distribution of Cefepime Minimum Inhibitory Concentrations and Detection of Extended-spectrum β-lactamase Production Among Clinically Important Enterobacteriaceae Isolates Obtained from Patients in Intensive Care Units in Taiwan: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) in 2007 Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi. Feb, 2015 | Pubmed ID: 23973410 Implementation of the Acute Care Surgery Model Provides Benefits in the Surgical Treatment of the Acute Appendicitis American Journal of Surgery. Nov, 2014 | Pubmed ID: 25441600 Emergency Department Utilization Can Indicate Early Diagnosis of Digestive Tract Cancers: A Population-based Study in Taiwan Computer Methods and Programs in Biomedicine. Jul, 2014 | Pubmed ID: 24835615 Genistein Suppresses the Isoproterenol-treated H9c2 Cardiomyoblast Cell Apoptosis Associated with P-38, Erk1/2, JNK, and NFκB Signaling Protein Activation The American Journal of Chinese Medicine. 2013 | Pubmed ID: 24117073 Carbapenem Susceptibilities and Non-susceptibility Concordance to Different Carbapenems Amongst Clinically Important Gram-negative Bacteria Isolated from Intensive Care Units in Taiwan: Results from the Surveillance of Multicentre Antimicrobial Resistance in Taiwan (SMART) in 2009 International Journal of Antimicrobial Agents. May, 2013 | Pubmed ID: 23507415 Whether Intravenous Contrast is Necessary for CT Diagnosis of Acute Appendicitis in Adult ED Patients? Academic Radiology. Jan, 2013 | Pubmed ID: 22951113 Lodox/Statscan Facilitates the Early Detection of Commonly Overlooked Extracranial Injuries in Patients with Traumatic Brain Injury European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society. Jun, 2012 | Pubmed ID: 26815965 Conservative Treatment of Concomitant Extraperitoneal Bladder Rupture and Intrabladder Blood Clot Formation: Case Report of Application of Ureteral Catheterization Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada. Dec, 2012 | Pubmed ID: 23283098 The Effects of Repeat Laparoscopic Surgery on the Treatment of Complications Resulting from Laparoscopic Surgery The American Surgeon. Sep, 2012 | Pubmed ID: 22964198 Selective Computed Tomography and Angioembolization Provide Benefits in the Management of Patients with Concomitant Unstable Hemodynamics and Negative Sonography Results World Journal of Surgery. Apr, 2012 | Pubmed ID: 22350476 Comparison Between Laparoscopic and Open Repair of Perforated Peptic Ulcer Disease in the Elderly The American Surgeon. Jun, 2011 | Pubmed ID: 21679660 脑缺血再灌注的双血管闭塞小鼠模型 Cheng-Yu Chen*1,2,3,4,5, Ray-Jade Chen*6,7, Gilbert Aaron Lee5 1Research Center of Translational Imaging, College of Medicine, Taipei Medical University, 2Radiogenomic Research Center, Taipei Medical University Hospital, Taipei Medical University, 3Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, 4Department of Medical Imaging, Taipei Medical University Hospital, Taipei Medical University, 5Department of Medical Research, Taipei Medical University Hospital, Taipei Medical University, 6Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, 7Division of General Surgery, Department of Surgery, Taipei Medical University Hospital JoVE 59078 Medicine
脑缺血再灌注的双血管闭塞小鼠模型 Cheng-Yu Chen*1,2,3,4,5, Ray-Jade Chen*6,7, Gilbert Aaron Lee5 1Research Center of Translational Imaging, College of Medicine, Taipei Medical University, 2Radiogenomic Research Center, Taipei Medical University Hospital, Taipei Medical University, 3Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, 4Department of Medical Imaging, Taipei Medical University Hospital, Taipei Medical University, 5Department of Medical Research, Taipei Medical University Hospital, Taipei Medical University, 6Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, 7Division of General Surgery, Department of Surgery, Taipei Medical University Hospital JoVE 59078 Medicine