Robert E. Hawkins Manchester Cancer Research Centre Building, Department Cancer Sciences University of Manchester Biography Publications Institution JoVE Articles Robert E. Hawkins has not added a biography. If you are Robert E. Hawkins and would like to personalize this page please email our Author Liaison for assistance. Publications Ex Vivo Expanded Tumour-infiltrating Lymphocytes from Ovarian Cancer Patients Release Anti-tumour Cytokines in Response to Autologous Primary Ovarian Cancer Cells Cancer Immunology, Immunotherapy : CII. Oct, 2018 | Pubmed ID: 30039427 The Clinical Efficacy of First-generation Carcinoembryonic Antigen (CEACAM5)-specific CAR T Cells is Limited by Poor Persistence and Transient Pre-conditioning-dependent Respiratory Toxicity Cancer Immunology, Immunotherapy : CII. Nov, 2017 | Pubmed ID: 28660319 Adjuvant Weekly Girentuximab Following Nephrectomy for High-Risk Renal Cell Carcinoma: The ARISER Randomized Clinical Trial JAMA Oncology. Jul, 2017 | Pubmed ID: 27787547 Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 05, 2016 | Pubmed ID: 26951309 Integrating Radiation Therapy with Emerging Systemic Therapies: Lessons from a Patient with Cerebral Radionecrosis, Spinal Cord Myelopathy, and Radiation Pneumonitis Practical Radiation Oncology. Mar-Apr, 2016 | Pubmed ID: 26723549 Immunological Response and Overall Survival in a Subset of Advanced Renal Cell Carcinoma Patients from a Randomized Phase 2/3 Study of Naptumomab Estafenatox Plus IFN-α Versus IFN-α Oncotarget. Feb, 2015 | Pubmed ID: 25669986 Immunohistochemical Assessment of NY-ESO-1 Expression in Esophageal Adenocarcinoma Resection Specimens World Journal of Gastroenterology. Apr, 2014 | Pubmed ID: 24744590 Differential Role of Th1 and Th2 Cytokines in Autotoxicity Driven by CD19-specific Second-generation Chimeric Antigen Receptor T Cells in a Mouse Model Journal of Immunology (Baltimore, Md. : 1950). Apr, 2014 | Pubmed ID: 24623129 CAR T Cells: Driving the Road from the Laboratory to the Clinic Immunological Reviews. Jan, 2014 | Pubmed ID: 24329792 Isolation of Tumor Antigen-specific Single-chain Variable Fragments Using a Chimeric Antigen Receptor Bicistronic Retroviral Vector in a Mammalian Screening Protocol Human Gene Therapy Methods. Dec, 2013 | Pubmed ID: 24028672 Potential Limitations of the NSG Humanized Mouse As a Model System to Optimize Engineered Human T Cell Therapy for Cancer Human Gene Therapy Methods. Oct, 2013 | Pubmed ID: 23931270 CAR-T Cells and Solid Tumors: Tuning T Cells to Challenge an Inveterate Foe Trends in Molecular Medicine. Jul, 2012 | Pubmed ID: 22613370 Targeted Immunotherapy of Cancer with CAR T Cells: Achievements and Challenges Cancer Immunology, Immunotherapy : CII. Jul, 2012 | Pubmed ID: 22527245 Tremelimumab (anti-CTLA4) Mediates Immune Responses Mainly by Direct Activation of T Effector Cells Rather Than by Affecting T Regulatory Cells Clinical Immunology (Orlando, Fla.). Jan, 2011 | Pubmed ID: 21056008 Gene Delivery of a Mutant TGFβ3 Reduces Markers of Scar Tissue Formation After Cutaneous Wounding Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 20736928 Functional Expression of Secreted Proteins from a Bicistronic Retroviral Cassette Based on Foot-and-mouth Disease Virus 2A Can Be Position Dependent Human Gene Therapy. Nov, 2010 | Pubmed ID: 20528679 Development of Adoptive Cell Therapy for Cancer: a Clinical Perspective Human Gene Therapy. Jun, 2010 | Pubmed ID: 20408760 Modulation of Lymphocyte Regulation for Cancer Therapy: a Phase II Trial of Tremelimumab in Advanced Gastric and Esophageal Adenocarcinoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2010 | Pubmed ID: 20179239 Natural Expression of the CD19 Antigen Impacts the Long-term Engraftment but Not Antitumor Activity of CD19-specific Engineered T Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2010 | Pubmed ID: 20089697 Development of a Flow Cytometric Co-immunoprecipitation Technique for the Study of Multiple Protein-protein Interactions and Its Application to T-cell Receptor Analysis Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Apr, 2010 | Pubmed ID: 20033991 Cytokine Stimulation and the Choice of Promoter Are Critical Factors for the Efficient Transduction of Mouse T Cells with HIV-1 Vectors The Journal of Gene Medicine. Feb, 2010 | Pubmed ID: 20033928 The Second Cellular Therapy of Cancer Symposium, 27-29 March 2009, Milan, Italy Cancer Immunology, Immunotherapy : CII. Jun, 2010 | Pubmed ID: 19669146 T Cell-based Immunotherapy of Metastatic Renal Cell Carcinoma: Modest Success and Future Perspective Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2009 | Pubmed ID: 19843660 Vaccination of Patients with Metastatic Renal Cancer with Modified Vaccinia Ankara Encoding the Tumor Antigen 5T4 (TroVax) Given Alongside Interferon-alpha Journal of Immunotherapy (Hagerstown, Md. : 1997). May, 2009 | Pubmed ID: 19342962 Immune Evasion Mechanisms in Colorectal Cancer Liver Metastasis Patients Vaccinated with TroVax (MVA-5T4) Cancer Immunology, Immunotherapy : CII. Oct, 2009 | Pubmed ID: 19221742 An MVA-based Vaccine Targeting the Oncofetal Antigen 5T4 in Patients Undergoing Surgical Resection of Colorectal Cancer Liver Metastases Journal of Immunotherapy (Hagerstown, Md. : 1997). Nov-Dec, 2008 | Pubmed ID: 18833005 The Combination of Cyclophosphamide and Human T Cells Genetically Engineered to Target CD19 Can Eradicate Established B-cell Lymphoma British Journal of Haematology. Jul, 2008 | Pubmed ID: 18477047 Immunotherapy for Gastrointestinal Cancer: Current Status and Strategies for Improving Efficacy Expert Opinion on Biological Therapy. Apr, 2008 | Pubmed ID: 18352844 CD4+ T-cell Recognition of Human 5T4 Oncofoetal Antigen: Implications for Initial Depletion of CD25+ T Cells Cancer Immunology, Immunotherapy : CII. Jun, 2008 | Pubmed ID: 18004564 Adoptive Transfer of T(reg) Depleted Autologous T Cells in Advanced Renal Cell Carcinoma Cancer Immunology, Immunotherapy : CII. May, 2008 | Pubmed ID: 17899077 Eotaxin-2 and Colorectal Cancer: a Potential Target for Immune Therapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2007 | Pubmed ID: 17908961 Cellular Therapy of Cancer Symposium December 2nd-3rd 2006 Manchester, UK Cancer Immunology, Immunotherapy : CII. Jun, 2007 | Pubmed ID: 17333180 Combination of Vaccination and Chimeric Receptor Expressing T Cells Provides Improved Active Therapy of Tumors Journal of Immunology (Baltimore, Md. : 1950). Oct, 2006 | Pubmed ID: 16982863 Killing of Non-Hodgkin Lymphoma Cells by Autologous CD19 Engineered T Cells British Journal of Haematology. May, 2005 | Pubmed ID: 15842655 The Role of Extracellular Spacer Regions in the Optimal Design of Chimeric Immune Receptors: Evaluation of Four Different ScFvs and Antigens Journal of Immunotherapy (Hagerstown, Md. : 1997). May-Jun, 2005 | Pubmed ID: 15838376 Retroviral Transduction with SOX9 Enhances Re-expression of the Chondrocyte Phenotype in Passaged Osteoarthritic Human Articular Chondrocytes Osteoarthritis and Cartilage. Jan, 2005 | Pubmed ID: 15639641 Gene Therapy of Patient-derived T Lymphocytes to Target and Eradicate Colorectal Hepatic Metastases Diseases of the Colon and Rectum. Jun, 2003 | Pubmed ID: 12794582 Cancer Vaccines and Immunotherapy British Medical Bulletin. 2002 | Pubmed ID: 12176857 Primary Polyclonal Human T Lymphocytes Targeted to Carcino-embryonic Antigens and Neural Cell Adhesion Molecule Tumor Antigens by CD3zeta-based Chimeric Immune Receptors Journal of Immunotherapy (Hagerstown, Md. : 1997). Mar-Apr, 2002 | Pubmed ID: 12074044 A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells Gray Kueberuwa1, Weiming Zheng1, Milena Kalaitsidou1, David E. Gilham1,2, Robert E. Hawkins1 1Manchester Cancer Research Centre Building, Department Cancer Sciences, University of Manchester, 2Celyad JoVE 58492 Cancer Research
A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells Gray Kueberuwa1, Weiming Zheng1, Milena Kalaitsidou1, David E. Gilham1,2, Robert E. Hawkins1 1Manchester Cancer Research Centre Building, Department Cancer Sciences, University of Manchester, 2Celyad JoVE 58492 Cancer Research