Robert J. Vassar

Publications

• The Case for Low-level BACE1 Inhibition for the Prevention of Alzheimer Disease
  Nature Reviews. Neurology. 11, 2021  |   Pubmed ID: 34548654
• A Promising New γ-secretase Modulator for Alzheimer's Disease
  The Journal of Experimental Medicine. 04, 2021  |   Pubmed ID: 33683299
• Early Detection and Personalized Medicine: Future Strategies Against Alzheimer's Disease
  Progress in Molecular Biology and Translational Science. 2021  |   Pubmed ID: 33453940
• Aβ-accelerated Neurodegeneration Caused by Alzheimer's-associated Variant R1279Q is Rescued by Angiotensin System Inhibition in Mice
  Science Translational Medicine. 09, 2020  |   Pubmed ID: 32998969
• Death by Microglia
  The Journal of Experimental Medicine. 11, 2019  |   Pubmed ID: 31645368
• Editorial: Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus
  The Journal of Prevention of Alzheimer's Disease. 2019  |   Pubmed ID: 30756113
• A Promising, Novel, and Unique BACE1 Inhibitor Emerges in the Quest to Prevent Alzheimer's Disease
  EMBO Molecular Medicine. 11, 2018  |   Pubmed ID: 30322841
• ER Stress is Not Elevated in the 5XFAD Mouse Model of Alzheimer's Disease
  The Journal of Biological Chemistry. 11, 2018  |   Pubmed ID: 30315100
• Axonal Organization Defects in the Hippocampus of Adult Conditional BACE1 Knockout Mice
  Science Translational Medicine. 09, 2018  |   Pubmed ID: 30232227
• Seeds of Destruction: New Mechanistic Insights into the Role of Apolipoprotein E4 in Alzheimer's Disease
  Neuron. 12, 2017  |   Pubmed ID: 29216455
• Inhibiting BACE1 to Reverse Synaptic Dysfunctions in Alzheimer's Disease
  Neuroscience and Biobehavioral Reviews. Jun, 2016  |   Pubmed ID: 27044452
• Presynaptic Dystrophic Neurites Surrounding Amyloid Plaques Are Sites of Microtubule Disruption, BACE1 Elevation, and Increased Aβ Generation in Alzheimer's Disease
  Acta Neuropathologica. 08, 2016  |   Pubmed ID: 26993139
• Aβ Reduction in BACE1 Heterozygous Null 5XFAD Mice is Associated with Transgenic APP Level
  Molecular Neurodegeneration. Jan, 2015  |   Pubmed ID: 25567526
• Molecular Neurodegeneration: Basic Biology and Disease Pathways
  Molecular Neurodegeneration. Sep, 2014  |   Pubmed ID: 25248568
• The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1
  Current Alzheimer Research. 2014  |   Pubmed ID: 24893886
• Increased MtDNA Mutations with Aging Promotes Amyloid Accumulation and Brain Atrophy in the APP/Ld Transgenic Mouse Model of Alzheimer's Disease
  Molecular Neurodegeneration. May, 2014  |   Pubmed ID: 24885175
• Targeting the β Secretase BACE1 for Alzheimer's Disease Therapy
  The Lancet. Neurology. Mar, 2014  |   Pubmed ID: 24556009
• ADAM10 Prodomain Mutations Cause Late-onset Alzheimer's Disease: Not Just the Latest FAD
  Neuron. Oct, 2013  |   Pubmed ID: 24139026
• Elevated Aβ42 in Aged, Non-demented Individuals with Cerebral Atherosclerosis
  Current Alzheimer Research. Oct, 2013  |   Pubmed ID: 23919773
• The β-secretase Enzyme BACE1 As a Therapeutic Target for Alzheimer's Disease
  Alzheimer's Research & Therapy. May, 2011  |   Pubmed ID: 21639952
• BACE1-/- Mice Exhibit Seizure Activity That Does Not Correlate with Sodium Channel Level or Axonal Localization
  Molecular Neurodegeneration. Aug, 2010  |   Pubmed ID: 20731874
• The Beta-secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009  |   Pubmed ID: 19828790