Robert M. Graham Molecular Cardiology and Biophysics Division Victor Chang Cardiac Research Institute Biography Publications Institution JoVE Articles Robert M. Graham has not added a biography. If you are Robert M. Graham and would like to personalize this page please email our Author Liaison for assistance. Publications Standardised Method for Cardiomyocyte Isolation and Purification from Individual Murine Neonatal, Infant, and Adult Hearts Journal of Molecular and Cellular Cardiology. May, 2022 | Pubmed ID: 35644482 Adverse Events After Spontaneous Coronary Artery Dissection Heart (British Cardiac Society). May, 2022 | Pubmed ID: 35641180 Cardiovascular Magnetic Resonance for Rejection Surveillance After Cardiac Transplantation Circulation. May, 2022 | Pubmed ID: 35621277 Remuscularization with Triiodothyronine and β-blocker Therapy Reverses Post-ischemic Left Ventricular Dysfunction and Adverse Remodeling Scientific Reports. May, 2022 | Pubmed ID: 35614155 Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing Circulation. Genomic and Precision Medicine. May, 2022 | Pubmed ID: 35583931 Accuracy of Vascular Tortuosity Measures Using Computational Modelling Scientific Reports. 01, 2022 | Pubmed ID: 35039557 Vascular Stiffness in Aging and Disease Frontiers in Physiology. 2021 | Pubmed ID: 34950048 Mechanism-Based Cardiac Regeneration Strategies in Mammals Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 34708043 Involvement of GPR37L1 in Murine Blood Pressure Regulation and Human Cardiac Disease Pathophysiology American Journal of Physiology. Heart and Circulatory Physiology. 10, 2021 | Pubmed ID: 34533400 The Ca-activated Cation Channel TRPM4 is a Positive Regulator of Pressure Overload-induced Cardiac Hypertrophy ELife. 06, 2021 | Pubmed ID: 34190686 Everolimus for the Prevention of Calcineurin-Inhibitor-Induced Left Ventricular Hypertrophy After Heart Transplantation (RADTAC Study) JACC. Heart Failure. 04, 2021 | Pubmed ID: 33795116 Thyroid Hormone Plus Dual-specificity Phosphatase-5 SiRNA Increases the Number of Cardiac Muscle Cells and Improves Left Ventricular Contractile Function in Chronic Doxorubicin-injured Hearts Theranostics. 2021 | Pubmed ID: 33754028 Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 33659256 Retraction Note: Orphan Receptor Ligand Discovery by Pickpocketing Pharmacological Neighbors Nature Chemical Biology. Apr, 2021 | Pubmed ID: 33649604 Adaptation to Exercise-induced Stress is Not Dependent on Cardiomyocyte α-adrenergic Receptors Journal of Molecular and Cellular Cardiology. 06, 2021 | Pubmed ID: 33647309 Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women Heart, Lung & Circulation. Jan, 2021 | Pubmed ID: 32713767 Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner Frontiers in Pharmacology. 2020 | Pubmed ID: 33633567 DUSP5 Expression in Left Ventricular Cardiomyocytes of Young Hearts Regulates Thyroid Hormone (T3)-induced Proliferative ERK1/2 Signaling Scientific Reports. 12, 2020 | Pubmed ID: 33318551 The N-terminus of GPR37L1 is Proteolytically Processed by Matrix Metalloproteases Scientific Reports. 11, 2020 | Pubmed ID: 33203955 Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation From Genome Sequencing Circulation. Genomic and Precision Medicine. 12, 2020 | Pubmed ID: 33125268 Pressure Overload by Suprarenal Aortic Constriction in Mice Leads to Left Ventricular Hypertrophy Without C-Kit Expression in Cardiomyocytes Scientific Reports. 09, 2020 | Pubmed ID: 32948799 Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation Frontiers in Immunology. 2020 | Pubmed ID: 32793209 Platelet-derived Growth Factor-AB Improves Scar Mechanics and Vascularity After Myocardial Infarction Science Translational Medicine. 01, 2020 | Pubmed ID: 31894101 Redox Activation of JNK2α2 Mediates Thyroid Hormone-stimulated Proliferation of Neonatal Murine Cardiomyocytes Scientific Reports. 11, 2019 | Pubmed ID: 31776360 Generation of VCCRIi001-A, a Human Induced Pluripotent Stem Cell Line, from a Patient with Spontaneous Coronary Artery Dissection Stem Cell Research. 12, 2019 | Pubmed ID: 31707208 A Vascular Smooth Muscle Cell X-box Binding Protein 1 and Transglutaminase 2 Regulatory Circuit Limits Neointimal Hyperplasia PloS One. 2019 | Pubmed ID: 30943188 The Australian Cardiovascular Alliance-Towards an Integrated Whole-of-Nation Strategy to Address Our Major Health Burden Heart, Lung & Circulation. Feb, 2019 | Pubmed ID: 30654944 Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection Journal of the American College of Cardiology. 01, 2019 | Pubmed ID: 30621952 Identification of Clinically Actionable Variants from Genome Sequencing of Families with Congenital Heart Disease Genetics in Medicine : Official Journal of the American College of Medical Genetics. 05, 2019 | Pubmed ID: 30293987 Cardiac Hypertrophy Limits Infarct Expansion After Myocardial Infarction in Mice Scientific Reports. 04, 2018 | Pubmed ID: 29666426 Orphan Receptor GPR37L1 Contributes to the Sexual Dimorphism of Central Cardiovascular Control Biology of Sex Differences. 04, 2018 | Pubmed ID: 29625592 A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data Circulation. Genomic and Precision Medicine. 03, 2018 | Pubmed ID: 29555671 The Mystery and Enigma of Spontaneous Coronary Artery Dissection Heart, Lung & Circulation. Apr, 2018 | Pubmed ID: 29501270 Orphan Receptor Ligand Discovery by Pickpocketing Pharmacological Neighbors Nature Chemical Biology. 02, 2017 | Pubmed ID: 27992882 Pathophysiological Trends During Withdrawal of Life Support: Implications for Organ Donation After Circulatory Death Transplantation. Dec, 2016 | Pubmed ID: 27861290 Angiotensin Type 2-receptor (AT2R) Activation Induces Hypotension in Apolipoprotein E-deficient Mice by Activating Peroxisome Proliferator-activated Receptor-γ American Journal of Cardiovascular Disease. 2016 | Pubmed ID: 27679746 Outcomes of Patients with Spontaneous Coronary Artery Dissection Open Heart. 2016 | Pubmed ID: 27621835 Gestational Stress Induces the Unfolded Protein Response, Resulting in Heart Defects Development (Cambridge, England). 07, 2016 | Pubmed ID: 27436040 IGF-1 Degradation by Mouse Mast Cell Protease 4 Promotes Cell Death and Adverse Cardiac Remodeling Days After a Myocardial Infarction Proceedings of the National Academy of Sciences of the United States of America. 06, 2016 | Pubmed ID: 27274047 Metalloprotease Cleavage of the N Terminus of the Orphan G Protein-coupled Receptor GPR37L1 Reduces Its Constitutive Activity Science Signaling. Apr, 2016 | Pubmed ID: 27072655 Targeted Doxorubicin Delivery to Brain Tumors Via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors As a Model PloS One. 2016 | Pubmed ID: 27050167 Ablation of Cardiac Myosin Binding Protein-C Disrupts the Super-relaxed State of Myosin in Murine Cardiomyocytes Journal of Molecular and Cellular Cardiology. 05, 2016 | Pubmed ID: 27021517 Identifying Ligands at Orphan GPCRs: Current Status Using Structure-based Approaches British Journal of Pharmacology. 10, 2016 | Pubmed ID: 26837045 Heterologously-expressed and Liposome-reconstituted Human Transient Receptor Potential Melastatin 4 Channel (TRPM4) is a Functional Tetramer Scientific Reports. Jan, 2016 | Pubmed ID: 26785754 Cardiac Regeneration Therapies - Targeting Neuregulin 1 Signalling Heart, Lung & Circulation. Jan, 2016 | Pubmed ID: 26476583 Cardiomyocytes Replicate and Their Numbers Increase in Young Hearts Cell. Nov, 2015 | Pubmed ID: 26544928 Overexpression of Cardiomyocyte α1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2015 | Pubmed ID: 26338300 Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study Frontiers in Endocrinology. 2015 | Pubmed ID: 26175717 Irreversible Triggers for Hypertrophic cardiomyopathy Are Established in the Early Postnatal Period Journal of the American College of Cardiology. Feb, 2015 | Pubmed ID: 25677315 Introduction to the Special Issue on Heart Regeneration and Rejuvenation Stem Cell Research. Nov, 2014 | Pubmed ID: 25459518 Thyroid Hormone Action in Postnatal Heart Development Stem Cell Research. Nov, 2014 | Pubmed ID: 25087894 RhoA/ROCK Signaling and Pleiotropic α1A-adrenergic Receptor Regulation of Cardiac Contractility PloS One. 2014 | Pubmed ID: 24919197 A Proliferative Burst During Preadolescence Establishes the Final Cardiomyocyte Number Cell. May, 2014 | Pubmed ID: 24813607 Glucose Homeostasis in Mice is Transglutaminase 2 Independent PloS One. 2013 | Pubmed ID: 23717413 Functional Characterization of a Novel Mutation in NKX2-5 Associated with Congenital Heart Disease and Adult-Onset Cardiomyopathy Circulation. Cardiovascular Genetics. May, 2013 | Pubmed ID: 23661673 Granulocyte Colony Stimulating Factor in Chronic Angina to Stimulate Neovascularisation: a Placebo Controlled Crossover Trial Heart (British Cardiac Society). Feb, 2012 | Pubmed ID: 22115984 The Ontogeny of Cardiac Regeneration Circulation Research. May, 2011 | Pubmed ID: 21617133 Regulation of Murine Cardiac Contractility by Activation of α(1A)-adrenergic Receptor-operated Ca(2+) Entry Cardiovascular Research. Jul, 2011 | Pubmed ID: 21546445 A Recombinant Human Neuregulin-1 Peptide Improves Preservation of the Rodent Heart After Prolonged Hypothermic Storage Transplantation. May, 2011 | Pubmed ID: 21364498 The Elusive π-helix Journal of Structural Biology. Jan, 2011 | Pubmed ID: 20828621 Reproducibility of Adenosine Stress Cardiovascular Magnetic Resonance in Multi-vessel Symptomatic Coronary Artery Disease Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance. Jul, 2010 | Pubmed ID: 20663155 Transglutaminases and Disease: Lessons from Genetically Engineered Mouse Models and Inherited Disorders Physiological Reviews. Jul, 2009 | Pubmed ID: 19584319 Safety and Efficacy of Consecutive Cycles of Granulocyte-colony Stimulating Factor, and an Intracoronary CD133+ Cell Infusion in Patients with Chronic Refractory Ischemic Heart Disease: the G-CSF in Angina Patients with IHD to Stimulate Neovascularization (GAIN I) Trial American Heart Journal. Nov, 2008 | Pubmed ID: 19061712 Wide Turn Diversity in Protein Transmembrane Helices Implications for G-protein-coupled Receptor and Other Polytopic Membrane Protein Structure and Function Molecular Pharmacology. Apr, 2008 | Pubmed ID: 18202304 Actions and Therapeutic Potential of G-CSF and GM-CSF in Cardiovascular Disease Journal of Molecular and Cellular Cardiology. Jan, 2007 | Pubmed ID: 17109881 Profound Thrombocytopenia Related to G-CSF American Journal of Hematology. Mar, 2007 | Pubmed ID: 17034024 Mechanism of Allosteric Regulation of Transglutaminase 2 by GTP Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17179049 Cross-linking Transglutaminases with G Protein-coupled Receptor Signaling Science's STKE : Signal Transduction Knowledge Environment. Sep, 2006 | Pubmed ID: 16985237 Mutation of a Critical Arginine in the GTP-binding Site of Transglutaminase 2 Disinhibits Intracellular Cross-linking Activity The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16522628 The Alpha(1D)-adrenergic Receptor: Cinderella or Ugly Stepsister Molecular Pharmacology. Jan, 2006 | Pubmed ID: 16246907 Molecular Basis of Exopeptidase Activity in the C-terminal Domain of Human Angiotensin I-converting Enzyme: Insights into the Origins of Its Exopeptidase Activity The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15615692 Involvement of Chymase-mediated Angiotensin II Generation in Blood Pressure Regulation The Journal of Clinical Investigation. Jul, 2004 | Pubmed ID: 15232618 Evolutionary Specialization of a Tryptophan Indole Group for Transition-state Stabilization by Eukaryotic Transglutaminases Proceedings of the National Academy of Sciences of the United States of America. Oct, 2003 | Pubmed ID: 14566064 Molecular Mechanisms of Inherited Cardiomyopathies Physiological Reviews. Oct, 2002 | Pubmed ID: 12270949 Mutation of a Single TMVI Residue, Phe(282), in the Beta(2)-adrenergic Receptor Results in Structurally Distinct Activated Receptor Conformations Biochemistry. May, 2002 | Pubmed ID: 11993999 Phe(303) in TMVI of the Alpha(1B)-adrenergic Receptor is a Key Residue Coupling TM Helical Movements to G-protein Activation Biochemistry. Jan, 2002 | Pubmed ID: 11781098 Анестезия и интубация предподростков мышиных щенков для кардиоторакальной хирургии Jianxin Wu*1, Amy M. Nicks1,2, Justin J. Skowno3,4, Michael P. Feneley1,2, Robert M. Graham1,2, Siiri E. Iismaa*1,2 1Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, 2St Vincent’s Clinical School, University of New South Wales Sydney, 3Department of Anaesthesia, The Children’s Hospital at Westmead, 4School of Child and Adolescent Health, University of Sydney JoVE 64004 Biology
Анестезия и интубация предподростков мышиных щенков для кардиоторакальной хирургии Jianxin Wu*1, Amy M. Nicks1,2, Justin J. Skowno3,4, Michael P. Feneley1,2, Robert M. Graham1,2, Siiri E. Iismaa*1,2 1Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, 2St Vincent’s Clinical School, University of New South Wales Sydney, 3Department of Anaesthesia, The Children’s Hospital at Westmead, 4School of Child and Adolescent Health, University of Sydney JoVE 64004 Biology
