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In JoVE (1)
Other Publications (3)
Articles by Robert Mannino in JoVE
Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
David R. Myers*1,2,3,4, Yumiko Sakurai*1,2,3,4, Reginald Tran1,2,3,4, Byungwook Ahn1,2,3,4, Elaissa Trybus Hardy1,2,3,4, Robert Mannino1,2,3,4, Ashley Kita1,2,3,4, Michelle Tsai1,2,3,4, Wilbur A. Lam1,2,3,4
1Department of Pediatrics, Emory University School of Medicine, 2Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 3Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, 4Winship Cancer Institute of Emory University
A method to culture an endothelial cell monolayer throughout the entire inner 3D surface of a microfluidic device with microvascular-sized channels (<30 μm) is described. This in vitro microvasculature model enables the study of biophysical interactions between blood cells, endothelial cells, and soluble factors in hematologic diseases.
Other articles by Robert Mannino on PubMed
Chest. Jun, 2006 | Pubmed ID: 16778259
To evaluate the longitudinal epidemiology of sepsis in patients with a history of cancer and to specifically examine sepsis-related disparities in risk or outcome.
Critical Care Medicine. Oct, 2006 | Pubmed ID: 16915108
Large healthcare disparities exist in the incidence of sepsis based on both race and gender. We sought to determine factors that may influence the occurrence of these healthcare disparities, with respect to the source of infection, causal organisms, and chronic comorbid medical conditions.
The Role of Body Mass Index and Diabetes in the Development of Acute Organ Failure and Subsequent Mortality in an Observational Cohort
Critical Care (London, England). 2006 | Pubmed ID: 16999863
Several studies have shown a correlation between body mass index (BMI) and both the development of critical illness and adverse outcomes in critically ill patients. The goal of our study was to examine this relationship prospectively with particular attention to the influence of concomitant diabetes mellitus (DM).