Robyn M. Murphy Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment La Trobe University Biography Publications Institution JoVE Articles Robyn M. Murphy has not added a biography. If you are Robyn M. Murphy and would like to personalize this page please email our Author Liaison for assistance. Publications Slow or Fast: Implications of Myofibre Type and Associated Differences for Manifestation of Neuromuscular Disorders Acta Physiologica (Oxford, England). Aug, 2023 | Pubmed ID: 37306196 Calpain-3 Is Not a Sodium Dependent Protease and Simply Requires Calcium for Activation International Journal of Molecular Sciences. May, 2023 | Pubmed ID: 37298357 Evolutionary Isolation of Ryanodine Receptor Isoform 1 for Muscle-based Thermogenesis in Mammals Proceedings of the National Academy of Sciences of the United States of America. Jan, 2023 | Pubmed ID: 36649401 Dysferlin Deficiency Results in Myofiber-Type Specific Differences in Abundances of Calcium-Handling and Glycogen Metabolism Proteins International Journal of Molecular Sciences. Dec, 2022 | Pubmed ID: 36613515 Tiny Changes in Cytoplasmic [Ca] Cause Large Changes in Mitochondrial Ca: What Are the Triggers and Functional Implications? American Journal of Physiology. Cell Physiology. Oct, 2022 | Pubmed ID: 36094438 Muscle Fiber Type-specific Autophagy Responses Following an Overnight Fast and Mixed Meal Ingestion in Human Skeletal Muscle American Journal of Physiology. Endocrinology and Metabolism. Sep, 2022 | Pubmed ID: 35793481 Time Course and Fibre Type-dependent Nature of Calcium-handling Protein Responses to Sprint Interval Exercise in Human Skeletal Muscle The Journal of Physiology. Jun, 2022 | Pubmed ID: 35556249 Skeletal Muscle Cell-specific Differences in Type 2 Diabetes Cellular and Molecular Life Sciences : CMLS. Apr, 2022 | Pubmed ID: 35460430 Ryanodine Receptor Leak Triggers Fiber Ca Redistribution to Preserve Force and Elevate Basal Metabolism in Skeletal Muscle Science Advances. Oct, 2021 | Pubmed ID: 34705503 Nuclei Isolation Methods Fail to Accurately Assess the Subcellular Localization and Behaviour of Proteins in Skeletal Muscle Acta Physiologica (Oxford, England). Nov, 2021 | Pubmed ID: 34492163 Human Skeletal Muscle Fiber Type-specific Responses to Sprint Interval and Moderate-intensity Continuous Exercise: Acute and Training-induced Changes Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2021 | Pubmed ID: 33630680 Expression of Titin-linked Putative Mechanosensing Proteins in Skeletal Muscle After Power Resistance Exercise in Resistance-trained Men Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2021 | Pubmed ID: 33356984 Autophagy is Not Involved in Lipid Accumulation and the Development of Insulin Resistance in Skeletal Muscle Biochemical and Biophysical Research Communications. Jan, 2021 | Pubmed ID: 33261883 Effects of Voluntary Wheel Running on Mitochondrial Content and Dynamics in Rat Skeletal Muscle Journal of Muscle Research and Cell Motility. Mar, 2021 | Pubmed ID: 32441024 Metabolic Communication During Exercise Nature Metabolism. Sep, 2020 | Pubmed ID: 32747791 MicroRNA-99b-5p Downregulates Protein Synthesis in Human Primary Myotubes American Journal of Physiology. Cell Physiology. Aug, 2020 | Pubmed ID: 32608991 Elevated MMP2 Abundance and Activity in Mdx Mice Are Alleviated by Prenatal Taurine Supplementation American Journal of Physiology. Cell Physiology. Jun, 2020 | Pubmed ID: 32208990 Controversies in TWEAK-Fn14 Signaling in Skeletal Muscle Atrophy and Regeneration Cellular and Molecular Life Sciences : CMLS. Sep, 2020 | Pubmed ID: 32200423 Effects of Intrauterine Growth Restriction on Ca-activated Force and Contractile Protein Expression in the Mesenteric Artery of 1-year-old Wistar-Kyoto Rats Journal of Physiology and Biochemistry. Feb, 2020 | Pubmed ID: 31927696 Distribution and Activation of Matrix Metalloproteinase-2 in Skeletal Muscle Fibers American Journal of Physiology. Cell Physiology. Sep, 2019 | Pubmed ID: 31241984 A Fast, Reliable and Sample-sparing Method to Identify Fibre Types of Single Muscle Fibres Scientific Reports. Apr, 2019 | Pubmed ID: 31019216 Dysferlin-deficiency Has Greater Impact on Function of Slow Muscles, Compared with Fast, in Aged BLAJ Mice PloS One. 2019 | Pubmed ID: 30970035 The Effect of Intrauterine Growth Restriction on Ca -activated Force and Contractile Protein Expression in the Mesenteric Artery of Adult (6-month-old) Male and Female Wistar-Kyoto Rats Physiological Reports. Dec, 2018 | Pubmed ID: 30592188 Taurine and Methylprednisolone Administration at Close Proximity to the Onset of Muscle Degeneration Is Ineffective at Attenuating Force Loss in the Hind-Limb of 28 Days Mice Sports (Basel, Switzerland). Sep, 2018 | Pubmed ID: 30274388 Junctional Membrane Ca Dynamics in Human Muscle Fibers Are Altered by Malignant Hyperthermia Causative RyR Mutation Proceedings of the National Academy of Sciences of the United States of America. Aug, 2018 | Pubmed ID: 30038012 Physiological and Biochemical Characteristics of Skeletal Muscles in Sedentary and Active Rats Journal of Muscle Research and Cell Motility. Apr, 2018 | Pubmed ID: 29948664 Cold-water Immersion After Training Sessions: Effects on Fiber Type-specific Adaptations in Muscle K Transport Proteins to Sprint-interval Training in Men Journal of Applied Physiology (Bethesda, Md. : 1985). Aug, 2018 | Pubmed ID: 29745801 Abundance of ClC-1 Chloride Channel in Human Skeletal Muscle: Fiber Type Specific Differences and Effect of Training Journal of Applied Physiology (Bethesda, Md. : 1985). Aug, 2018 | Pubmed ID: 29722626 Elevated GLUT4 and Glycogenin Protein Abundance Correspond to Increased Glycogen Content in the Soleus Muscle of Mdx Mice with No Benefit Associated with Taurine Supplementation Physiological Reports. Mar, 2018 | Pubmed ID: 29484837 Mitochondrial Content is Preserved Throughout Disease Progression in the Mdx Mouse Model of Duchenne Muscular Dystrophy, Regardless of Taurine Supplementation American Journal of Physiology. Cell Physiology. Apr, 2018 | Pubmed ID: 29351413 Effect of Androgen Deprivation Therapy on the Contractile Properties of Type I and Type II Skeletal Muscle Fibres in Men with Non-metastatic Prostate Cancer Clinical and Experimental Pharmacology & Physiology. Feb, 2018 | Pubmed ID: 29044613 Benefits of Prenatal Taurine Supplementation in Preventing the Onset of Acute Damage in the Mdx Mouse PLoS Currents. Sep, 2017 | Pubmed ID: 29188135 Changes in Contractile and Metabolic Parameters of Skeletal Muscle As Rats Age from 3 to 12 Months Journal of Muscle Research and Cell Motility. Dec, 2017 | Pubmed ID: 29185184 Reply to "Letter to the Editor: Comments on Wette Et Al. (2017): 'Characterization of Muscle Ankyrin Repeat Proteins in Human Skeletal Muscle'" American Journal of Physiology. Cell Physiology. Oct, 2017 | Pubmed ID: 28993324 Preaged Remodeling of Myofibrillar Cytoarchitecture in Skeletal Muscle Expressing R349P Mutant Desmin Neurobiology of Aging. Oct, 2017 | Pubmed ID: 28715662 Characterization of Muscle Ankyrin Repeat Proteins in Human Skeletal Muscle American Journal of Physiology. Cell Physiology. Sep, 2017 | Pubmed ID: 28615162 Intense Interval Training in Healthy Older Adults Increases Skeletal Muscle [H]ouabain-binding Site Content and Elevates Na,K-ATPase α Isoform Abundance in Type II Fibers Physiological Reports. Apr, 2017 | Pubmed ID: 28373411 Preservation of Skeletal Muscle Mitochondrial Content in Older Adults: Relationship Between Mitochondria, Fibre Type and High-intensity Exercise Training The Journal of Physiology. Jun, 2017 | Pubmed ID: 28251664 Human Skeletal Muscle Plasmalemma Alters Its Structure to Change Its Ca-handling Following Heavy-load Resistance Exercise Nature Communications. Feb, 2017 | Pubmed ID: 28193999 Insights into the Role and Regulation of TCTP in Skeletal Muscle Oncotarget. Mar, 2017 | Pubmed ID: 27813490 Superior Mitochondrial Adaptations in Human Skeletal Muscle After Interval Compared to Continuous Single-leg Cycling Matched for Total Work The Journal of Physiology. May, 2017 | Pubmed ID: 27396440 Store-Operated Ca Entry (SOCE) and Purinergic Receptor-Mediated Ca Homeostasis in Murine Bv2 Microglia Cells: Early Cellular Responses to ATP-Mediated Microglia Activation Frontiers in Molecular Neuroscience. 2016 | Pubmed ID: 27840602 Dissociation Between Short-term Unloading and Resistance Training Effects on Skeletal Muscle Na+,K+-ATPase, Muscle Function, and Fatigue in Humans Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2016 | Pubmed ID: 27633740 The Effect of Taurine and β-alanine Supplementation on Taurine Transporter Protein and Fatigue Resistance in Skeletal Muscle from Mdx Mice Amino Acids. Nov, 2016 | Pubmed ID: 27444300 Perilipin 5 is Dispensable for Normal Substrate Metabolism and in the Adaptation of Skeletal Muscle to Exercise Training American Journal of Physiology. Endocrinology and Metabolism. Jul, 2016 | Pubmed ID: 27189934 When Phosphorylated at Thr148, the β2-subunit of AMP-activated Kinase Does Not Associate with Glycogen in Skeletal Muscle American Journal of Physiology. Cell Physiology. Jul, 2016 | Pubmed ID: 27099349 A Quantitative Description of Tubular System Ca(2+) Handling in Fast- and Slow-twitch Muscle Fibres The Journal of Physiology. Jun, 2016 | Pubmed ID: 26775687 Cell Specific Differences in the Protein Abundances of GAPDH and Na(+),K(+)-ATPase in Skeletal Muscle from Aged Individuals Experimental Gerontology. Mar, 2016 | Pubmed ID: 26747222 Maternal Nutrient Restriction Alters Ca2+ Handling Properties and Contractile Function of Isolated Left Ventricle Bundles in Male But Not Female Juvenile Rats PloS One. 2015 | Pubmed ID: 26406887 Rat Skeletal Muscle Glycogen Degradation Pathways Reveal Differential Association of Glycogen-related Proteins with Glycogen Granules Journal of Physiology and Biochemistry. Jun, 2015 | Pubmed ID: 25875859 Clarity for 5'-AMP-activated Protein Kinase--dissecting out Human Skeletal Muscle Responses to Exercise The Journal of Physiology. Apr, 2015 | Pubmed ID: 25871559 Glucose Uptake During Contraction in Isolated Skeletal Muscles from Neuronal Nitric Oxide Synthase μ Knockout Mice Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2015 | Pubmed ID: 25749441 Skeletal Muscle Atrophy in Sedentary Zucker Obese Rats is Not Caused by Calpain-mediated Muscle Damage or Lipid Peroxidation Induced by Oxidative Stress Journal of Negative Results in Biomedicine. Dec, 2014 | Pubmed ID: 25547587 Comparative Analysis of Caveolins in Mouse and Tammar Wallaby: Role in Regulating Mammary Gland Function Gene. Nov, 2014 | Pubmed ID: 25200498 Small Heat Shock Proteins Translocate to the Cytoskeleton in Human Skeletal Muscle Following Eccentric Exercise Independently of Phosphorylation Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2014 | Pubmed ID: 24699855 Subcellular Fractionation Reveals HSP72 Does Not Associate with SERCA in Human Skeletal Muscle Following Damaging Eccentric and Concentric Exercise Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2014 | Pubmed ID: 23620494 Important Considerations for Protein Analyses Using Antibody Based Techniques: Down-sizing Western Blotting Up-sizes Outcomes The Journal of Physiology. Dec, 2013 | Pubmed ID: 24127618 Single Fiber Analyses of Glycogen-related Proteins Reveal Their Differential Association with Glycogen in Rat Skeletal Muscle American Journal of Physiology. Cell Physiology. Dec, 2012 | Pubmed ID: 23015546 Absolute Amounts and Diffusibility of HSP72, HSP25, and αB-crystallin in Fast- and Slow-twitch Skeletal Muscle Fibers of Rat American Journal of Physiology. Cell Physiology. Jan, 2012 | Pubmed ID: 21975426 Activation of Skeletal Muscle Calpain-3 by Eccentric Exercise in Humans Does Not Result in Its Translocation to the Nucleus or Cytosol Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2011 | Pubmed ID: 21836041 On the Localization of ClC-1 in Skeletal Muscle Fibers The Journal of General Physiology. Mar, 2011 | Pubmed ID: 21357735 Quantification of Calsequestrin 2 (CSQ2) in Sheep Cardiac Muscle and Ca2+-binding Protein Changes in CSQ2 Knockout Mice American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2011 | Pubmed ID: 21131479 Enhanced Technique to Measure Proteins in Single Segments of Human Skeletal Muscle Fibers: Fiber-type Dependence of AMPK-alpha1 and -beta1 Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2011 | Pubmed ID: 21088205 Calpains, Skeletal Muscle Function and Exercise Clinical and Experimental Pharmacology & Physiology. Mar, 2010 | Pubmed ID: 19793101 Taurine Supplementation Increases Skeletal Muscle Force Production and Protects Muscle Function During and After High-frequency in Vitro Stimulation Journal of Applied Physiology (Bethesda, Md. : 1985). Jul, 2009 | Pubmed ID: 19423840 Involvement of Calpains in Ca2+-induced Disruption of Excitation-contraction Coupling in Mammalian Skeletal Muscle Fibers American Journal of Physiology. Cell Physiology. May, 2009 | Pubmed ID: 19295178 Are Genuine Changes in Protein Expression Being Overlooked? Reassessing Western Blotting Analytical Biochemistry. Mar, 2009 | Pubmed ID: 19161968 Endogenous Calpain-3 Activation is Primarily Governed by Small Increases in Resting Cytoplasmic [Ca2+] and is Not Dependent on Stretch The Journal of Biological Chemistry. Mar, 2009 | Pubmed ID: 19144634 Plasma Membrane Removal in Rat Skeletal Muscle Fibers Reveals Caveolin-3 Hot-spots at the Necks of Transverse Tubules Experimental Cell Research. Apr, 2009 | Pubmed ID: 19101541 Calsequestrin Content and SERCA Determine Normal and Maximal Ca2+ Storage Levels in Sarcoplasmic Reticulum of Fast- and Slow-twitch Fibres of Rat The Journal of Physiology. Jan, 2009 | Pubmed ID: 19029185 Calpain-3 is Autolyzed and Hence Activated in Human Skeletal Muscle 24 H Following a Single Bout of Eccentric Exercise Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2007 | Pubmed ID: 17585039 Ca2+ Activation of Diffusible and Bound Pools of Mu-calpain in Rat Skeletal Muscle The Journal of Physiology. Oct, 2006 | Pubmed ID: 16857710 Disruption of Excitation-contraction Coupling and Titin by Endogenous Ca2+-activated Proteases in Toad Muscle Fibres The Journal of Physiology. May, 2005 | Pubmed ID: 15746171 Effect of Creatine on Contractile Force and Sensitivity in Mechanically Skinned Single Fibers from Rat Skeletal Muscle American Journal of Physiology. Cell Physiology. Dec, 2004 | Pubmed ID: 15282195 Deciphering the Mysteries of Skeletal Muscle Fiber Types Using the MyDoBID Technique (Video) | JoVE Heidy K. Latchman*1, Stefan G. Wette*1, Dion J. Ellul1, Robyn M. Murphy1, Noni T. Frankenberg1 1Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University JoVE 65750 Biochemistry
Deciphering the Mysteries of Skeletal Muscle Fiber Types Using the MyDoBID Technique (Video) | JoVE Heidy K. Latchman*1, Stefan G. Wette*1, Dion J. Ellul1, Robyn M. Murphy1, Noni T. Frankenberg1 1Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University JoVE 65750 Biochemistry
