Roosmarijn E. Vandenbroucke VIB Center for Inflammation Research VIB Biography Publications Institution JoVE Articles Roosmarijn E. Vandenbroucke has not added a biography. If you are Roosmarijn E. Vandenbroucke and would like to personalize this page please email our Author Liaison for assistance. Publications Choroid Plexus-derived Extracellular Vesicles Exhibit Brain Targeting Characteristics Biomaterials. Nov, 2022 | Pubmed ID: 36302306 A Mouse Model of Hepatic Encephalopathy: Bile Duct Ligation Induces Brain Ammonia Overload, Glial Cell Activation and Neuroinflammation Scientific Reports. Oct, 2022 | Pubmed ID: 36266427 Differential Plasticity and Fate of Brain-resident and Recruited Macrophages During the Onset and Resolution of Neuroinflammation Immunity. Nov, 2022 | Pubmed ID: 36228615 Recent Insights into Viral Infections As a Trigger and Accelerator in Alzheimer's Disease Drug Discovery Today. Aug, 2022 | Pubmed ID: 35987492 Biomarker and Therapeutic Potential of Peripheral Extracellular Vesicles in Alzheimer's Disease Advanced Drug Delivery Reviews. Nov, 2022 | Pubmed ID: 35952829 Targeting Gliovascular Connexins Prevents Inflammatory Blood-brain Barrier Leakage and Astrogliosis JCI Insight. Aug, 2022 | Pubmed ID: 35881483 High-Precision Isotopic Analysis of Cu and Fe Multi-Collector Inductively Coupled Plasma-Mass Spectrometry Reveals Lipopolysaccharide-Induced Inflammatory Effects in Blood Plasma and Brain Tissues Frontiers in Chemistry. 2022 | Pubmed ID: 35783204 Astrocyte-targeted Gene Delivery of Interleukin 2 Specifically Increases Brain-resident Regulatory T Cell Numbers and Protects Against Pathological Neuroinflammation Nature Immunology. Jun, 2022 | Pubmed ID: 35618831 The Tremendous Biomedical Potential of Bacterial Extracellular Vesicles Trends in Biotechnology. Oct, 2022 | Pubmed ID: 35581020 Fighting Fire with Fire: The Immune System Might Be Key in Our Fight Against Alzheimer's Disease Drug Discovery Today. May, 2022 | Pubmed ID: 35032668 The Impact of Systemic Inflammation on Alzheimer's Disease Pathology Frontiers in Immunology. 2021 | Pubmed ID: 35069578 Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann-Pick Type C Disease Biomedicines. Dec, 2021 | Pubmed ID: 34944681 Special DelEVery: Extracellular Vesicles As Promising Delivery Platform to the Brain Biomedicines. Nov, 2021 | Pubmed ID: 34829963 Gastric Infection Partially Protects Against Neurotoxicity in A 6-OHDA Parkinson's Disease Mouse Model International Journal of Molecular Sciences. Oct, 2021 | Pubmed ID: 34768765 Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C Frontiers in Cellular Neuroscience. 2021 | Pubmed ID: 34720883 Low-grade Peripheral Inflammation Affects Brain Pathology in the Appmouse Model of Alzheimer's Disease Acta Neuropathologica Communications. Oct, 2021 | Pubmed ID: 34620254 Amelioration of Systemic Inflammation Via the Display of Two Different Decoy Protein Receptors on Extracellular Vesicles Nature Biomedical Engineering. Sep, 2021 | Pubmed ID: 34616047 The Neurogliovascular Unit in Hepatic Encephalopathy JHEP Reports : Innovation in Hepatology. Oct, 2021 | Pubmed ID: 34611619 Extracellular Vesicles: A Double-Edged Sword in Sepsis Pharmaceuticals (Basel, Switzerland). Aug, 2021 | Pubmed ID: 34451925 The Power of Imaging to Understand Extracellular Vesicle Biology in Vivo Nature Methods. Sep, 2021 | Pubmed ID: 34446922 Importance of Extracellular Vesicle Secretion at the Blood-cerebrospinal Fluid Interface in the Pathogenesis of Alzheimer's Disease Acta Neuropathologica Communications. Aug, 2021 | Pubmed ID: 34425919 Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg Isotopic Composition of Biofluids and Tissues in Mice Frontiers in Medicine. 2021 | Pubmed ID: 34368182 Profiling of Extracellular Small RNAs Highlights a Strong Bias Towards Non-Vesicular Secretion Cells. Jun, 2021 | Pubmed ID: 34207405 Single-cell Profiling of Myeloid Cells in Glioblastoma Across Species and Disease Stage Reveals Macrophage Competition and Specialization Nature Neuroscience. Apr, 2021 | Pubmed ID: 33782623 and the Potential Role in Neurological Disorders: There Is More Than Frontiers in Immunology. 2020 | Pubmed ID: 33633723 Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences Cells. Nov, 2020 | Pubmed ID: 33203181 High-precision Isotopic Analysis of Mg and Ca in Biological Samples Using Multi-collector ICP-mass Spectrometry After Their Sequential Chromatographic Isolation - Application to the Characterization of the Body Distribution of Mg and Ca Isotopes in Mice Analytica Chimica Acta. Sep, 2020 | Pubmed ID: 32892933 Tightening the Retinal Glia Limitans Attenuates Neuroinflammation After Optic Nerve Injury Glia. Dec, 2020 | Pubmed ID: 32645232 Microglial Activation Arises After Aggregation of Phosphorylated-tau in a Neuron-specific P301S Tauopathy Mouse Model Neurobiology of Aging. May, 2020 | Pubmed ID: 32008854 A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice Frontiers in Immunology. 2019 | Pubmed ID: 31787972 Biological Membranes in EV Biogenesis, Stability, Uptake, and Cargo Transfer: an ISEV Position Paper Arising from the ISEV Membranes and EVs Workshop Journal of Extracellular Vesicles. 2019 | Pubmed ID: 31762963 Blocking Connexin43 Hemichannels Protects Mice Against Tumour Necrosis Factor-induced Inflammatory Shock Scientific Reports. 11, 2019 | Pubmed ID: 31719598 Interferons: A Molecular Switch Between Damage and Repair in Ageing and Alzheimer's Disease Mechanisms of Ageing and Development. Oct, 2019 | Pubmed ID: 31541624 Immunogenicity and Protection Efficacy of a Naked Self-Replicating MRNA-Based Zika Virus Vaccine Vaccines. Aug, 2019 | Pubmed ID: 31450775 Choroid Plexus-derived MiR-204 Regulates the Number of Quiescent Neural Stem Cells in the Adult Brain The EMBO Journal. Sep, 2019 | Pubmed ID: 31304985 A Single-cell Atlas of Mouse Brain Macrophages Reveals Unique Transcriptional Identities Shaped by Ontogeny and Tissue Environment Nature Neuroscience. Jun, 2019 | Pubmed ID: 31061494 Choroid Plexus Tumor Necrosis Factor Receptor 1: A New Neuroinflammatory Piece of the Complex Alzheimer's Disease Puzzle Neural Regeneration Research. Jul, 2019 | Pubmed ID: 30804238 The N-terminal P.(Ser38Cys) TIMP3 Mutation Underlying Sorsby Fundus Dystrophy is a Founder Mutation Disrupting an Intramolecular Disulfide Bond Human Mutation. May, 2019 | Pubmed ID: 30668888 Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis Shock (Augusta, Ga.). Aug, 2019 | Pubmed ID: 30124596 A New Venue of TNF Targeting International Journal of Molecular Sciences. May, 2018 | Pubmed ID: 29751683 Glucocorticoid Receptor Dimers Control Intestinal STAT1 and TNF-induced Inflammation in Mice The Journal of Clinical Investigation. Aug, 2018 | Pubmed ID: 29746256 Counteracting the Effects of TNF Receptor-1 Has Therapeutic Potential in Alzheimer's Disease EMBO Molecular Medicine. Apr, 2018 | Pubmed ID: 29472246 Correction To: Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017 Fluids and Barriers of the CNS. 01, 2018 | Pubmed ID: 29329565 The Choroid Plexus Epithelium As a Novel Player in the Stomach-brain Axis During Helicobacter Infection Brain, Behavior, and Immunity. Mar, 2018 | Pubmed ID: 29258921 Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis Critical Care Medicine. Jan, 2018 | Pubmed ID: 29095202 Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017 Fluids and Barriers of the CNS. Nov, 2017 | Pubmed ID: 29110676 TNFR1 Inhibition with a Nanobody Protects Against EAE Development in Mice Scientific Reports. Oct, 2017 | Pubmed ID: 29057962 Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor Gastroenterology. Oct, 2017 | Pubmed ID: 28642198 A Hidden Epithelial Barrier in the Brain with a Central Role in Regulating Brain Homeostasis. Implications for Aging Annals of the American Thoracic Society. Dec, 2016 | Pubmed ID: 28005425 MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment International Journal of Molecular Sciences. Nov, 2016 | Pubmed ID: 27809288 Mouse Models of Ageing and Their Relevance to Disease Mechanisms of Ageing and Development. Dec, 2016 | Pubmed ID: 27717883 Sizing Nanomaterials in Bio-fluids by CFRAP Enables Protein Aggregation Measurements and Diagnosis of Bio-barrier Permeability Nature Communications. Sep, 2016 | Pubmed ID: 27653841 Identification of a Novel Mechanism of Blood-brain Communication During Peripheral Inflammation Via Choroid Plexus-derived Extracellular Vesicles EMBO Molecular Medicine. Oct, 2016 | Pubmed ID: 27596437 With Mouse Age Comes Wisdom: A Review and Suggestions of Relevant Mouse Models for Age-related Conditions Mechanisms of Ageing and Development. Dec, 2016 | Pubmed ID: 27450180 Caloric Restriction: Beneficial Effects on Brain Aging and Alzheimer's Disease Mammalian Genome : Official Journal of the International Mammalian Genome Society. Aug, 2016 | Pubmed ID: 27240590 The Choroid Plexus-cerebrospinal Fluid Interface in Alzheimer's Disease: More Than Just a Barrier Neural Regeneration Research. Apr, 2016 | Pubmed ID: 27212900 Efficient Analysis of Mouse Genome Sequences Reveal Many Nonsense Variants Proceedings of the National Academy of Sciences of the United States of America. May, 2016 | Pubmed ID: 27147605 The Effect of Aging on Brain Barriers and the Consequences for Alzheimer's Disease Development Mammalian Genome : Official Journal of the International Mammalian Genome Society. Aug, 2016 | Pubmed ID: 27143113 Nanobodies As Therapeutics: Big Opportunities for Small Antibodies Drug Discovery Today. Jul, 2016 | Pubmed ID: 27080147 Comparing Exosome-like Vesicles with Liposomes for the Functional Cellular Delivery of Small RNAs Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2016 | Pubmed ID: 27072025 Into Rather Unexplored Terrain-transcellular Transport Across the Blood-brain Barrier Glia. Jul, 2016 | Pubmed ID: 26852907 Topical Imiquimod Yields Systemic Effects Due to Unintended Oral Uptake Scientific Reports. Jan, 2016 | Pubmed ID: 26818707 Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8 Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2016 | Pubmed ID: 26775809 Endothelial LRP1 Transports Amyloid-β(1-42) Across the Blood-brain Barrier The Journal of Clinical Investigation. Jan, 2016 | Pubmed ID: 26619118 Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases Mediators of Inflammation. 2015 | Pubmed ID: 26538832 Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 As TNF Sheddase Mediators of Inflammation. 2015 | Pubmed ID: 26451076 Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2015 | Pubmed ID: 26377465 Hematopoietic Plakophilin-3 Regulates Acute Tissue-specific and Systemic Inflammation in Mice European Journal of Immunology. Oct, 2015 | Pubmed ID: 26173741 Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice Immunity. Jul, 2015 | Pubmed ID: 26163370 Therapeutic Implications of the Choroid Plexus-cerebrospinal Fluid Interface in Neuropsychiatric Disorders Brain, Behavior, and Immunity. Nov, 2015 | Pubmed ID: 26116435 Glucocorticoid-induced MicroRNA-511 Protects Against TNF by Down-regulating TNFR1 EMBO Molecular Medicine. Aug, 2015 | Pubmed ID: 25995337 Clinical Implications of Leukocyte Infiltration at the Choroid Plexus in (neuro)inflammatory Disorders Drug Discovery Today. Aug, 2015 | Pubmed ID: 25979470 Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice Journal of Immunology (Baltimore, Md. : 1950). Jun, 2015 | Pubmed ID: 25911755 Generation and Characterization of Small Single Domain Antibodies Inhibiting Human Tumor Necrosis Factor Receptor 1 The Journal of Biological Chemistry. Feb, 2015 | Pubmed ID: 25538244 An Inflammatory Triangle in Psoriasis: TNF, Type I IFNs and IL-17 Cytokine & Growth Factor Reviews. Feb, 2015 | Pubmed ID: 25434285 Is There New Hope for Therapeutic Matrix Metalloproteinase Inhibition? Nature Reviews. Drug Discovery. Dec, 2014 | Pubmed ID: 25376097 Tauroursodeoxycholic Acid Inhibits Experimental Colitis by Preventing Early Intestinal Epithelial Cell Death Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2014 | Pubmed ID: 25310532 Choose Your Models Wisely: How Different Murine Bone Marrow-derived Dendritic Cell Protocols Influence the Success of Nanoparticulate Vaccines in Vitro Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2014 | Pubmed ID: 24960224 A New Angle on Blood-CNS Interfaces: a Role for Connexins? FEBS Letters. Apr, 2014 | Pubmed ID: 24631535 An Acute Phase Protein Ready to Go Therapeutic for Sepsis EMBO Molecular Medicine. Jan, 2014 | Pubmed ID: 24408964 Antisense Oligonucleotides Against TNFR1 Prevent Toxicity of TNF/IFNγ Treatment in Mouse Tumor Models International Journal of Cancer. Aug, 2014 | Pubmed ID: 24382818 Mice Overexpressing β-1,4-Galactosyltransferase I Are Resistant to TNF-induced Inflammation and DSS-induced Colitis PloS One. 2013 | Pubmed ID: 24339869 Matrix Metalloproteinase 13 Modulates Intestinal Epithelial Barrier Integrity in Inflammatory Diseases by Activating TNF EMBO Molecular Medicine. Jul, 2013 | Pubmed ID: 23723167 Safe TNF-based Antitumor Therapy Following P55TNFR Reduction in Intestinal Epithelium The Journal of Clinical Investigation. Jun, 2013 | Pubmed ID: 23676465 Treatment of TNF Mediated Diseases by Selective Inhibition of Soluble TNF or TNFR1 Cytokine & Growth Factor Reviews. 2011 | Pubmed ID: 21962830 Matrix Metalloproteinases As Drug Targets in Ischemia/reperfusion Injury Drug Discovery Today. Sep, 2011 | Pubmed ID: 21745586 The First MMP in Sepsis EMBO Molecular Medicine. Jul, 2011 | Pubmed ID: 21591260 Matrix Metalloproteinase8 Has a Central Role in Inflammatory Disorders and Cancer Progression Cytokine & Growth Factor Reviews. Apr, 2011 | Pubmed ID: 21388856 The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2010 | Pubmed ID: 20010917 Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus Elien Van Wonterghem*1,2, Lien Van Hoecke*1,2, Griet Van Imschoot1,2, Daan Verhaege1,2, Marlies Burgelman1,2, Roosmarijn E. Vandenbroucke1,2 1VIB Center for Inflammation Research, VIB, 2Department of Biomedical Molecular Biology, Ghent University JoVE 64733 Neuroscience
Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus Elien Van Wonterghem*1,2, Lien Van Hoecke*1,2, Griet Van Imschoot1,2, Daan Verhaege1,2, Marlies Burgelman1,2, Roosmarijn E. Vandenbroucke1,2 1VIB Center for Inflammation Research, VIB, 2Department of Biomedical Molecular Biology, Ghent University JoVE 64733 Neuroscience
