Stephen Wheatcroft

Publications

• Sodium-glucose Cotransporter 2 Inhibitors Influence Skeletal Muscle Pathology in Patients with Heart Failure and Reduced Ejection Fraction
  European Journal of Heart Failure. Mar, 2024  |   Pubmed ID: 38468429
• Coronary Guidewires in Temporary Cardiac Pacing and Assessment of Myocardial Viability: Current Perspectives and Future Directions
  Journal of Clinical Medicine. Nov, 2023  |   Pubmed ID: 38002591
• Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention on Medium-Term Outcomes: A Contemporary Meta-Analysis of Randomized Controlled Trials
  The American Journal of Cardiology. Sep, 2023  |   Pubmed ID: 37481812
• Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study
  Diabetes Care. Aug, 2023  |   Pubmed ID: 37368983
• Loss of IGFBP2 Mediates Alveolar Type 2 Cell Senescence and Promotes Lung Fibrosis
  Cell Reports. Medicine. Mar, 2023  |   Pubmed ID: 36787736
• Transcoronary Electrophysiological Parameters in Patients Undergoing Elective and Acute Coronary Intervention
  PloS One. 2023  |   Pubmed ID: 36745641
• Improving the Management of Left Ventricular Thrombus in a Tertiary Cardiology Centre: a Quality Improvement Project
  BMJ Open Quality. Jan, 2023  |   Pubmed ID: 36631136
• Imaging Real-Time Coronary Anatomy Using a Three-Dimensional Electrophysiology Mapping System
  Journal of Cardiovascular Translational Research. Jun, 2023  |   Pubmed ID: 36414925
• Fractional Flow Reserve Versus Angiography-Guided Management of Coronary Artery Disease: A Meta-Analysis of Contemporary Randomised Controlled Trials
  Journal of Clinical Medicine. Nov, 2022  |   Pubmed ID: 36498667
• Management of Non-ST-segment Elevation Myocardial Infarction in Patients Aged ≥ 80 Years: a Meta-analysis of Randomized Controlled Trials
  Journal of Geriatric Cardiology : JGC. Oct, 2022  |   Pubmed ID: 36338285
• Safety and Efficacy of Interrupting Dual Antiplatelet Therapy One Month Following Percutaneous Coronary Intervention: a Meta-analysis of Randomized Controlled Trials
  BMC Cardiovascular Disorders. Oct, 2022  |   Pubmed ID: 36307769
• Association Between Operator Volume and Mortality in Primary Percutaneous Coronary Intervention
  Open Heart. Oct, 2022  |   Pubmed ID: 36192035
• Meta-Analysis Comparing Clinical Outcomes of Fractional-Flow-Reserve- and Angiography-Guided Multivessel Percutaneous Coronary Intervention
  The American Journal of Cardiology. Dec, 2022  |   Pubmed ID: 36184352
• Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarction: Results of REAL-TIMI 63B
  Circulation. Sep, 2022  |   Pubmed ID: 36039762
• Cixutumumab Reveals a Critical Role for IGF-1 in Adipose and Hepatic Tissue Remodelling During the Development of Diet-induced Obesity
  Adipocyte. Dec, 2022  |   Pubmed ID: 35734881
• Meta-Analysis Comparing 10-Year Mortality Following Percutaneous Coronary Intervention or Coronary Artery Bypass Grafting in Left Main Stem or Multivessel Coronary Artery Disease
  The American Journal of Cardiology. Jul, 2022  |   Pubmed ID: 35504742
• Clinical Validation and Evaluation of a Novel Six-lead Handheld Electrocardiogram Recorder Compared to the 12-lead Electrocardiogram in Unselected Cardiology Patients (EVALECG Cardio)
  European Heart Journal. Digital Health. Dec, 2021  |   Pubmed ID: 36713105
• Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling
  Endocrinology. Nov, 2021  |   Pubmed ID: 34460911
• Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat
  Circulation Research. Sep, 2021  |   Pubmed ID: 34420367
• Endothelial Insulin Receptors Promote VEGF-A Signaling Via ERK1/2 and Sprouting Angiogenesis
  Endocrinology. Aug, 2021  |   Pubmed ID: 34037749
• Endothelial IGF-1 Receptor Mediates Crosstalk with the Gut Wall to Regulate Microbiota in Obesity
  EMBO Reports. May, 2021  |   Pubmed ID: 33934497
• Advantages of CEMiTool for Gene Co-expression Analysis of RNA-seq Data
  Computers in Biology and Medicine. Oct, 2020  |   Pubmed ID: 32911277
• Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy
  Journal of the American Heart Association. Sep, 2020  |   Pubmed ID: 32892688
• Direct Oral Anticoagulants Compared to Vitamin K Antagonist for the Management of Left Ventricular Thrombus
  ESC Heart Failure. Oct, 2020  |   Pubmed ID: 32583975
• Divergent Effects of Genetic and Pharmacological Inhibition of Nox2 NADPH Oxidase on Insulin Resistance-related Vascular Damage
  American Journal of Physiology. Cell Physiology. Jul, 2020  |   Pubmed ID: 32401607
• IGFBP-1 in Cardiometabolic Pathophysiology-Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice
  Journal of the Endocrine Society. Jan, 2020  |   Pubmed ID: 32190801
• Prescribing Diabetes Medication for Cardiovascular Risk Reduction in Patients Admitted with Acute Coronary Syndromes: a Survey of Cardiologists' Attitudes and Practice
  European Heart Journal. Cardiovascular Pharmacotherapy. Jul, 2020  |   Pubmed ID: 31702003
• Real-world Comparison of Clopidogrel, Prasugrel and Ticagrelor in Patients Undergoing Primary Percutaneous Coronary Intervention
  Open Heart. 2019  |   Pubmed ID: 31328001
• Tpl2 is Required for VEGF-A-stimulated Signal Transduction and Endothelial Cell Function
  Biology Open. May, 2019  |   Pubmed ID: 31072823
• Insulin-like Growth Factor Binding Proteins and Angiogenesis: from Cancer to Cardiovascular Disease
  Cytokine & Growth Factor Reviews. Apr, 2019  |   Pubmed ID: 30954375
• TRPC5 Ion Channel Permeation Promotes Weight Gain in Hypercholesterolaemic Mice
  Scientific Reports. 01, 2019  |   Pubmed ID: 30692584
• The Insulin Like Growth Factor and Binding Protein Family: Novel Therapeutic Targets in Obesity & Diabetes
  Molecular Metabolism. Jan, 2019  |   Pubmed ID: 30392760
• Clinical Outcomes Following Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction According to Sex and Race
  European Heart Journal. Acute Cardiovascular Care. Apr, 2019  |   Pubmed ID: 28980483
• Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice
  Endocrinology. Aug, 2018  |   Pubmed ID: 29796592
• Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance
  Endocrinology. Feb, 2018  |   Pubmed ID: 29186427
• Piezo1 Channels Sense Whole Body Physical Activity to Reset Cardiovascular Homeostasis and Enhance Performance
  Nature Communications. 08, 2017  |   Pubmed ID: 28839146
• Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance
  Diabetes. Nov, 2017  |   Pubmed ID: 28830894
• Ubiquitination of Basal VEGFR2 Regulates Signal Transduction and Endothelial Function
  Biology Open. Oct, 2017  |   Pubmed ID: 28798148
• Assessing Coronary Blood Flow Physiology in the Cardiac Catheterisation Laboratory
  Current Cardiology Reviews. 2017  |   Pubmed ID: 28545351
• Inhibition of Plasmin-mediated TAFI Activation May Affect Development but Not Progression of Abdominal Aortic Aneurysms
  PloS One. 2017  |   Pubmed ID: 28472123
• Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain
  Diabetes. Feb, 2017  |   Pubmed ID: 28108607
• Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop
  Circulation Research. Mar, 2017  |   Pubmed ID: 27920123
• How We Measure Heart Rate: Does It Matter?
  The American Journal of Medicine. Sep, 2016  |   Pubmed ID: 27554964
• VEGF-A Isoforms Program Differential VEGFR2 Signal Transduction, Trafficking and Proteolysis
  Biology Open. May, 2016  |   Pubmed ID: 27044325
• Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance
  Trends in Endocrinology and Metabolism: TEM. Feb, 2016  |   Pubmed ID: 26712712
• VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8
  Traffic (Copenhagen, Denmark). Jan, 2016  |   Pubmed ID: 26459808
• Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics
  Journal of Cardiovascular Translational Research. Nov, 2015  |   Pubmed ID: 26385009
• Detection and Quantification of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases in Primary Human Endothelial Cells
  Methods in Molecular Biology (Clifton, N.J.). 2015  |   Pubmed ID: 26285745
• Scavenger Receptor Structure and Function in Health and Disease
  Cells. May, 2015  |   Pubmed ID: 26010753
• VEGF-A Isoform-specific Regulation of Calcium Ion Flux, Transcriptional Activation and Endothelial Cell Migration
  Biology Open. Apr, 2015  |   Pubmed ID: 25910937
• Vascular Endothelial Growth Factors: Multitasking Functionality in Metabolism, Health and Disease
  Journal of Inherited Metabolic Disease. Jul, 2015  |   Pubmed ID: 25868665
• Oxidized LDL Activates Blood Platelets Through CD36/NOX2-mediated Inhibition of the CGMP/protein Kinase G Signaling Cascade
  Blood. Apr, 2015  |   Pubmed ID: 25710879
• In Silico Design and Biological Evaluation of a Dual Specificity Kinase Inhibitor Targeting Cell Cycle Progression and Angiogenesis
  PloS One. 2014  |   Pubmed ID: 25393739
• Haploinsufficiency of the Insulin-like Growth Factor-1 Receptor Enhances Endothelial Repair and Favorably Modifies Angiogenic Progenitor Cell Phenotype
  Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2014  |   Pubmed ID: 25012136
• VEGF-A Isoforms Differentially Regulate ATF-2-dependent VCAM-1 Gene Expression and Endothelial-leukocyte Interactions
  Molecular Biology of the Cell. Aug, 2014  |   Pubmed ID: 24966171
• Restoring Akt1 Activity in Outgrowth Endothelial Cells from South Asian Men Rescues Vascular Reparative Potential
  Stem Cells (Dayton, Ohio). Oct, 2014  |   Pubmed ID: 24916783
• Vascular Endothelial Growth Factor A-stimulated Signaling from Endosomes in Primary Endothelial Cells
  Methods in Enzymology. 2014  |   Pubmed ID: 24377929
• Endothelium-specific Insulin Resistance Leads to Accelerated Atherosclerosis in Areas with Disturbed Flow Patterns: a Role for Reactive Oxygen Species
  Atherosclerosis. Sep, 2013  |   Pubmed ID: 23958265
• Ankle Pressures in UK South Asians with Diabetes Mellitus: a Case Control Study
  Heart (British Cardiac Society). May, 2013  |   Pubmed ID: 23442538
• Teaching an Old Drug New Tricks: Can Paroxetine Ease the Burden of Cardiovascular Disease in Diabetes?
  Diabetes. Mar, 2013  |   Pubmed ID: 23431014
• Diurnal Variation in Vascular and Metabolic Function in Diet-induced Obesity: Divergence of Insulin Resistance and Loss of Clock Rhythm
  Diabetes. Jun, 2013  |   Pubmed ID: 23382450
• Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance-related Endothelial Cell Dysfunction
  Diabetes. Jun, 2013  |   Pubmed ID: 23349484
• Diabetes Mellitus is Associated with Adverse Prognosis in Chronic Heart Failure of Ischaemic and Non-ischaemic Aetiology
  Diabetes & Vascular Disease Research. Jul, 2013  |   Pubmed ID: 23349368
• A Heat-shock Protein Axis Regulates VEGFR2 Proteolysis, Blood Vessel Development and Repair
  PloS One. 2012  |   Pubmed ID: 23139789
• The S100A6 Calcium-binding Protein Regulates Endothelial Cell-cycle Progression and Senescence
  The FEBS Journal. Dec, 2012  |   Pubmed ID: 23095053
• Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-targeted IGF-1 Receptor Transgenic Mice
  Diabetes. Sep, 2012  |   Pubmed ID: 22733797
• Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis
  Diabetes. Apr, 2012  |   Pubmed ID: 22357965
• The Insulin-like Growth Factor-1 Receptor is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium
  Diabetes. Aug, 2011  |   Pubmed ID: 21677284
• Changing Characteristics and Mode of Death Associated with Chronic Heart Failure Caused by Left Ventricular Systolic Dysfunction: a Study Across Therapeutic Eras
  Circulation. Heart Failure. Jul, 2011  |   Pubmed ID: 21562056
• OBTAIN: a Study of the Occurrence of Bleeding and Thrombosis During Anti-platelet Therapy in Non-cardiac Surgery
  European Journal of Anaesthesiology. Jun, 2011  |   Pubmed ID: 21544024
• Insulin Resistance Impairs Circulating Angiogenic Progenitor Cell Function and Delays Endothelial Regeneration
  Diabetes. Apr, 2011  |   Pubmed ID: 21317296
• Scavenger Receptors and Their Potential As Therapeutic Targets in the Treatment of Cardiovascular Disease
  International Journal of Hypertension. Aug, 2010  |   Pubmed ID: 20981357
• Pregnenolone Sulphate- and Cholesterol-regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction
  Circulation Research. May, 2010  |   Pubmed ID: 20360246
• Human Exercise-induced Circulating Progenitor Cell Mobilization is Nitric Oxide-dependent and is Blunted in South Asian Men
  Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2010  |   Pubmed ID: 20110574
• Effects of Insulin Resistance on Endothelial Progenitor Cells and Vascular Repair
  Clinical Science (London, England : 1979). Aug, 2009  |   Pubmed ID: 19630751
• Vascular Insulin-like Growth Factor-I Resistance and Diet-induced Obesity
  Endocrinology. Oct, 2009  |   Pubmed ID: 19608653
• IGF-dependent and IGF-independent Actions of IGF-binding Protein-1 and -2: Implications for Metabolic Homeostasis
  Trends in Endocrinology and Metabolism: TEM. May, 2009  |   Pubmed ID: 19349193
• Diabetes Mellitus and Mortality After Acute Coronary Syndrome As a First or Recurrent Cardiovascular Event
  PloS One. 2008  |   Pubmed ID: 18941531
• Effect of Endothelium-specific Insulin Resistance on Endothelial Function in Vivo
  Diabetes. Dec, 2008  |   Pubmed ID: 18835939
• Insulin Resistance and Endothelial Cell Dysfunction: Studies in Mammalian Models
  Experimental Physiology. Jan, 2008  |   Pubmed ID: 17933859
• The Impact of Insulin Resistance on Endothelial Function, Progenitor Cells and Repair
  Diabetes & Vascular Disease Research. Jun, 2007  |   Pubmed ID: 17654443
• Inter-subject Differences in Constitutive Expression Levels of the Clock Gene in Man
  Diabetes & Vascular Disease Research. Mar, 2007  |   Pubmed ID: 17469042
• IGF-binding Protein-2 Protects Against the Development of Obesity and Insulin Resistance
  Diabetes. Feb, 2007  |   Pubmed ID: 17259371