Suzanne M Ponik Department of Cell and Regenerative Biology University of Wisconsin - Madison Biography Publications Institution JoVE Articles Suzanne M Ponik Dr. Suzanne Ponik is an Assistant Professor in the Department of Cell and Regenerative Biology at the University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin. She received her undergraduate degree in Biology from St. Norbert College in DePere, WI, and her Ph.D. in Cell Biology and Biophysics from Indiana University-Purdue University at Indianapolis. Dr. Ponik completed her post-doctoral training with Dr. Patricia Keely at UW-Madison. She served as a lead scientist and project manager for over over 10 years in the Keely Lab, gaining valuable experience in both lab and grants management.The long-term goal of Dr. Ponik's research program is to understand the regulation of breast cancer progression through biomechanical cues from the extracellular matrix. Particularly, her lab is interested in defining how the organization and composition of the extracellular matrix is deposited in tumors and how it initiates immune infiltration, influences cancer and immune cell function, and impacts tumor cell dissemination and metastatic outgrowth. Improving the basic biological understanding of the ECM in tumor progression will lead to the ultimate goal of developing therapies that target the ECM to improve breast cancer outcome. To accomplish these goals her research integrates cell biology and advanced imaging techniques using 3D cell culture and murine tumor models to address the following unanswered questions related to pathophysiologic changes in the ECM of the breast tumor microenvironment. 1) What are the mechanisms regulating the assembly and organization of the ECM in the breast tumor microenvironment? 2) How do cells, including macrophages and fibroblasts, sense and respond to changes in the ECM? 3) How do changes in the ECM within the primary tumor microenvironment impact tumor cell seeding and outgrowth in the metastatic niche? 4) Can we therapeutically target the ECM as an effective anti-cancer therapy? Publications 유방 종양 미세환경의 생체 내 이미징을 위한 라벨 없는 세분화 접근법 Brian M. Burkel1, David R. Inman1, María Virumbrales-Muñoz1,2, Erica J. Hoffmann1, Suzanne M. Ponik1,3 1Department of Cell and Regenerative Biology, University of Wisconsin-Madison, 2Department of Pathology, University of Wisconsin-Madison, 3Carbone Cancer Center, University of Wisconsin-Madison JoVE 63413 Cancer Research 3D 상호 작용의 연구에 대한 3D 콜라겐 젤과 마이크로 채널 준비 Brian Burkel1,2, Brett A. Morris1, Suzanne M. Ponik1, Kristin M. Riching1, Kevin W. Eliceiri2,3,4, Patricia J. Keely1,2,5 1Department of Cell and Regenerative Biology, University of Wisconsin-Madison, 2Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, 3Department of Biomedical Engineering, University of Wisconsin-Madison, 4Morgridge Institute for Research, University of Wisconsin-Madison, 5Paul P. Carbone Comprehensive Cancer center, University of Wisconsin-Madison JoVE 53989 Bioengineering
유방 종양 미세환경의 생체 내 이미징을 위한 라벨 없는 세분화 접근법 Brian M. Burkel1, David R. Inman1, María Virumbrales-Muñoz1,2, Erica J. Hoffmann1, Suzanne M. Ponik1,3 1Department of Cell and Regenerative Biology, University of Wisconsin-Madison, 2Department of Pathology, University of Wisconsin-Madison, 3Carbone Cancer Center, University of Wisconsin-Madison JoVE 63413 Cancer Research
3D 상호 작용의 연구에 대한 3D 콜라겐 젤과 마이크로 채널 준비 Brian Burkel1,2, Brett A. Morris1, Suzanne M. Ponik1, Kristin M. Riching1, Kevin W. Eliceiri2,3,4, Patricia J. Keely1,2,5 1Department of Cell and Regenerative Biology, University of Wisconsin-Madison, 2Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, 3Department of Biomedical Engineering, University of Wisconsin-Madison, 4Morgridge Institute for Research, University of Wisconsin-Madison, 5Paul P. Carbone Comprehensive Cancer center, University of Wisconsin-Madison JoVE 53989 Bioengineering