Suzanne Jackowski Department of Infectious Diseases St. Jude Children's Research Hospital Biography Publications Institution JoVE Articles Suzanne Jackowski has not added a biography. If you are Suzanne Jackowski and would like to personalize this page please email our Author Liaison for assistance. Publications Antimalarial Pantothenamide Metabolites Target Acetyl-coenzyme A Biosynthesis in Science Translational Medicine. Sep, 2019 | Pubmed ID: 31534021 Proposed Therapies for Pantothenate-Kinase-Associated Neurodegeneration Journal of Experimental Neuroscience. 2019 | Pubmed ID: 31205425 Human Pantothenate Kinase 4 is a Pseudo-pantothenate Kinase Protein Science : a Publication of the Protein Society. Jun, 2019 | Pubmed ID: 30927326 A Therapeutic Approach to Pantothenate Kinase Associated Neurodegeneration Nature Communications. 10, 2018 | Pubmed ID: 30352999 Excess Coenzyme A Reduces Skeletal Muscle Performance and Strength in Mice Overexpressing Human PANK2 Molecular Genetics and Metabolism. 04, 2017 | Pubmed ID: 28189602 T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions The Journal of Biological Chemistry. Jan, 2017 | Pubmed ID: 27903651 Allosteric Regulation of Mammalian Pantothenate Kinase The Journal of Biological Chemistry. Oct, 2016 | Pubmed ID: 27555321 Correction of a Genetic Deficiency in Pantothenate Kinase 1 Using Phosphopantothenate Replacement Therapy Molecular Genetics and Metabolism. Dec, 2015 | Pubmed ID: 26549575 Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice PloS One. 2015 | Pubmed ID: 26052948 The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis Without Altering Insulin Sensitivity Cell Metabolism. May, 2015 | Pubmed ID: 25955207 A High-throughput Screen Reveals New Small-molecule Activators and Inhibitors of Pantothenate Kinases Journal of Medicinal Chemistry. Feb, 2015 | Pubmed ID: 25569308 Deregulated Coenzyme A, Loss of Metabolic Flexibility and Diabetes Biochemical Society Transactions. Aug, 2014 | Pubmed ID: 25110012 Physiological Roles of the Pantothenate Kinases Biochemical Society Transactions. Aug, 2014 | Pubmed ID: 25109998 Coenzyme A and Its Derivatives: Renaissance of a Textbook Classic Biochemical Society Transactions. Aug, 2014 | Pubmed ID: 25109997 Pank1 Deletion in Leptin-deficient Mice Reduces Hyperglycaemia and Hyperinsulinaemia and Modifies Global Metabolism Without Affecting Insulin Resistance Diabetologia. Jul, 2014 | Pubmed ID: 24781151 Preface: Phospholipids and Phospholipid Metabolism Biochimica Et Biophysica Acta. Mar, 2013 | Pubmed ID: 23369660 Phosphatidylcholine and the CDP-choline Cycle Biochimica Et Biophysica Acta. Mar, 2013 | Pubmed ID: 23010477 Compartmentalization of Mammalian Pantothenate Kinases PloS One. 2012 | Pubmed ID: 23152917 Germline Deletion of Pantothenate Kinases 1 and 2 Reveals the Key Roles for CoA in Postnatal Metabolism PloS One. 2012 | Pubmed ID: 22815849 The Specialized Unfolded Protein Response of B Lymphocytes: ATF6α-independent Development of Antibody-secreting B Cells Molecular Immunology. Jul, 2012 | Pubmed ID: 22555069 Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22442146 UPR-Mediated Membrane Biogenesis in B Cells Biochemistry Research International. 2012 | Pubmed ID: 22110962 The Unfolded Protein Response Transducer IRE1α Prevents ER Stress-induced Hepatic Steatosis The EMBO Journal. Apr, 2011 | Pubmed ID: 21407177 Modulation of Pantothenate Kinase 3 Activity by Small Molecules That Interact with the Substrate/allosteric Regulatory Domain Chemistry & Biology. Aug, 2010 | Pubmed ID: 20797618 Pantothenate Kinase 1 is Required to Support the Metabolic Transition from the Fed to the Fasted State PloS One. Jun, 2010 | Pubmed ID: 20559429 Phosphatidylcholine Biosynthesis During Neuronal Differentiation and Its Role in Cell Fate Determination The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20525991 Pantothenate Kinase from the Thermoacidophilic Archaeon Picrophilus Torridus Journal of Bacteriology. Jan, 2010 | Pubmed ID: 19854913 Elimination of the CDP-ethanolamine Pathway Disrupts Hepatic Lipid Homeostasis The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19666474 ATF6alpha Induces XBP1-independent Expansion of the Endoplasmic Reticulum Journal of Cell Science. May, 2009 | Pubmed ID: 19420237 CTP:phosphocholine Cytidylyltransferase Alpha is Required for B-cell Proliferation and Class Switch Recombination The Journal of Biological Chemistry. Mar, 2009 | Pubmed ID: 19139091 Membrane Phospholipid Synthesis and Endoplasmic Reticulum Function Journal of Lipid Research. Apr, 2009 | Pubmed ID: 18952570 Cytokine Secretion Requires Phosphatidylcholine Synthesis The Journal of Cell Biology. Jun, 2008 | Pubmed ID: 18559668 Biosynthesis of Pantothenic Acid and Coenzyme A EcoSal Plus. Apr, 2007 | Pubmed ID: 26443589 Localization and Regulation of Mouse Pantothenate Kinase 2 FEBS Letters. Oct, 2007 | Pubmed ID: 17825826 Probucol Therapy Overcomes the Reproductive Defect in CTP: Phosphocholine Cytidylyltransferase Beta2 Knockout Mice Biochimica Et Biophysica Acta. Jul, 2007 | Pubmed ID: 17560827 Chemical Knockout of Pantothenate Kinase Reveals the Metabolic and Genetic Program Responsible for Hepatic Coenzyme A Homeostasis Chemistry & Biology. Mar, 2007 | Pubmed ID: 17379144 Structure of the Type III Pantothenate Kinase from Bacillus Anthracis at 2.0 A Resolution: Implications for Coenzyme A-dependent Redox Biology Biochemistry. Mar, 2007 | Pubmed ID: 17323930 Activation of Human Mitochondrial Pantothenate Kinase 2 by Palmitoylcarnitine Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17242360 Phospholipid Biosynthesis Program Underlying Membrane Expansion During B-lymphocyte Differentiation The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17213195 Role of Phosphocholine Cytidylyltransferase Alpha in Lung Development Molecular and Cellular Biology. Feb, 2007 | Pubmed ID: 17130238 Placental Thrombosis and Spontaneous Fetal Death in Mice Deficient in Ethanolamine Kinase 2 The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16861741 Biochemical Properties of Human Pantothenate Kinase 2 Isoforms and Mutations Linked to Pantothenate Kinase-associated Neurodegeneration The Journal of Biological Chemistry. Jan, 2006 | Pubmed ID: 16272150 Feedback Regulation of Murine Pantothenate Kinase 3 by Coenzyme A and Coenzyme A Thioesters The Journal of Biological Chemistry. Sep, 2005 | Pubmed ID: 16040613 Coenzyme A: Back in Action Progress in Lipid Research. Mar-May, 2005 | Pubmed ID: 15893380 Early Embryonic Lethality in Mice with Targeted Deletion of the CTP:phosphocholine Cytidylyltransferase Alpha Gene (Pcyt1a) Molecular and Cellular Biology. Apr, 2005 | Pubmed ID: 15798219 A Pantothenate Kinase from Staphylococcus Aureus Refractory to Feedback Regulation by Coenzyme A The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15548531 CTP: Phosphocholine Cytidylyltransferase: Paving the Way from Gene to Membrane The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15536089 XBP1: a Link Between the Unfolded Protein Response, Lipid Biosynthesis, and Biogenesis of the Endoplasmic Reticulum The Journal of Cell Biology. Oct, 2004 | Pubmed ID: 15466483 Acyl Carrier Protein is a Cellular Target for the Antibacterial Action of the Pantothenamide Class of Pantothenate Antimetabolites The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15459190 Bacterial Inhibition of Phosphatidylcholine Synthesis Triggers Apoptosis in the Brain The Journal of Experimental Medicine. Jul, 2004 | Pubmed ID: 15238609 Disruption of CCTbeta2 Expression Leads to Gonadal Dysfunction Molecular and Cellular Biology. Jun, 2004 | Pubmed ID: 15143167 The Structure of the Pantothenate Kinase.ADP.pantothenate Ternary Complex Reveals the Relationship Between the Binding Sites for Substrate, Allosteric Regulator, and Antimetabolites The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15136582 PPARalpha Controls the Intracellular Coenzyme A Concentration Via Regulation of PANK1alpha Gene Expression Journal of Lipid Research. Jan, 2004 | Pubmed ID: 14523052 Gene Structure, Expression and Identification of a New CTP:phosphocholine Cytidylyltransferase Beta Isoform Biochimica Et Biophysica Acta. Jul, 2003 | Pubmed ID: 12842190 Role of Feedback Regulation of Pantothenate Kinase (CoaA) in Control of Coenzyme A Levels in Escherichia Coli Journal of Bacteriology. Jun, 2003 | Pubmed ID: 12754240 The Murine Pantothenate Kinase (Pank1) Gene Encodes Two Differentially Regulated Pantothenate Kinase Isozymes Gene. May, 2002 | Pubmed ID: 12095677 Forty Years of Bacterial Fatty Acid Synthesis Biochemical and Biophysical Research Communications. Apr, 2002 | Pubmed ID: 11969206 A Missense Mutation in the FabB (beta-ketoacyl-acyl Carrier Protein Synthase I) Gene Confers Tiolactomycin Resistance to Escherichia Coli Antimicrobial Agents and Chemotherapy. May, 2002 | Pubmed ID: 11959552 Structure and Mechanism of CTP:phosphocholine Cytidylyltransferase (LicC) from Streptococcus Pneumoniae The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11706035 The LicC Gene of Streptococcus Pneumoniae Encodes a CTP:phosphocholine Cytidylyltransferase Journal of Bacteriology. Aug, 2001 | Pubmed ID: 11466299 Modulation of CTP:phosphocholine Cytidylyltransferase by Membrane Curvature Elastic Stress Proceedings of the National Academy of Sciences of the United States of America. Aug, 2000 | Pubmed ID: 10908674 Activity of the Phosphatidylcholine Biosynthetic Pathway Modulates the Distribution of Fatty Acids into Glycerolipids in Proliferating Cells Biochimica Et Biophysica Acta. Jan, 2000 | Pubmed ID: 10666565 Quantificação da coenzima A em células e tecidos Matthew W. Frank1, Chitra Subramanian1, Charles O. Rock1, Suzanne Jackowski1 1Department of Infectious Diseases, St. Jude Children's Research Hospital JoVE 60182 Biochemistry
Quantificação da coenzima A em células e tecidos Matthew W. Frank1, Chitra Subramanian1, Charles O. Rock1, Suzanne Jackowski1 1Department of Infectious Diseases, St. Jude Children's Research Hospital JoVE 60182 Biochemistry