Takashi Koyama Department of Cardiology Saitama Municipal Hospital Biography Publications Institution JoVE Articles Takashi KoyamaVice Director Dr. Koyama is a vice director of the Saitama Municipal Hospital near Tokyo, Japan. He graduated from the Keio University School of Medicine, Tokyo in 1985 and received a Ph.D. there in 1997. His Ph.D. was based on his experimental studies around 1990, during his early clinical career, investigating the mechanism of ischemia-reperfusion injury. He is a clinical cardiologist, who received his training at Keio University Hospital and its affiliated local community hospitals, including the Saitama Municipal Hospital. In 1992, he suspended his clinical career and moved to the University of Utah in Utah, USA (Prof. William H. Barry), where he worked as a research fellow in the department of cardiology for further experimental investigation on the mechanism of ischemia-reperfusion injury. After returning to Japan in 1994, he then devoted himself mostly to clinical works in affiliated hospitals of Keio University including percutaneous coronary intervention for patients with coronary artery disease. Later in life, his experiences in reperfusion therapy for many patients with ST-segment elevation myocardial infarction (STEMI) and in his past experimental research investigating the mechanism of ischemia-reperfusion injury inspired him to develop a new treatment strategy for myocardial reperfusion injury in patients with STEMI undergoing reperfusion therapy (postconditioning with lactate-enriched blood [PCLeB]). This new method for cardioprotection in humans emerged from his earlier experimental study using guinea-pig myocytes, published in 1991 (Am J Physiol 1991;261; H1115–22). The first paper on this new approach, i.e., PCLeB, was published in 2013 (Cardiology 2013:125:92-3). Therefore, it took decades for him to translate the results of his experimental studies into clinical practice. Publications Reperfusion-induced contracture develops with a decreasing [Ca2+]i in single heart cells American Journal of Physiology. Oct,1991 | Pubmed ID: 1928393Usefulness of accelerated diastolic reversed flow along the left ventricular posterior wall in aortic regurgitation for estimating left ventricular function American Journal of Cardiology. Oct,1992 | Pubmed ID: 1529953Survival of metabolically inhibited ventricular myocytes is enhanced by inhibition of rigor and SR Ca2+ cycling American Journal of Physiology. Aug,1996 | Pubmed ID: 8770107Effects of early reperfusion on creatine kinase release in patients with acute myocardial infarction: Implications for reperfusion injury International Journal of Cardiology. Mar,2012 | Pubmed ID: 22240752Ischemic postconditioning with lactate-enriched blood in patients with acute myocardial infarction Cardiology. ,2013 | Pubmed ID: 23711672Shifting calcium plaque in progressive aortic dissection Circulation. Oct,2013 | Pubmed ID: 24126326Impact of ischemic postconditioning with lactate-enriched blood on early inflammation after myocardial infarction International Journal of Cardiology: Metabolic & Endocrine. Mar,2014 | Pubmed ID: nonePossible creatine kinase washout mechanism revealed by postconditioning with lactate-enriched blood in patients experiencing ST-elevation myocardial infarctions International Journal of Cardiology. Dec,2014 | Pubmed ID: 25172968Muscle squeezing of the culprit coronary artery in a patient with ST-elevation myocardial infarction after postconditioning with lactate-enriched blood International Journal of Cardiology. Mar,2015 | Pubmed ID: 25576726An extensive discrepancy in myocardial uptake of thallium-201 and iodine-123 BMIPP in a patient with ST-segment elevation myocardial infarction treated using postconditioning with lactate-enriched blood International Journal of Cardiology. Nov,2015 | Pubmed ID: 26151721Minimum ischemia-reperfusion injury in a STEMI patient treated using postconditioning with lactate-enriched blood International Journal of Cardiology. Jan,2016 | Pubmed ID: 26408841Impact of postconditioning with lactate-enriched blood on in-hospital outcomes in patients with ST-segment elevation myocardial infarction International Journal of Cardiology. Oct,2016 | Pubmed ID: 27379916Absence of reperfusion-induced arrhythmia in patients with ST-segment elevation myocardial infarction treated using postconditioning with lactate-enriched blood International Journal of Cardiology. Nov,2016 | Pubmed ID: 27521558Lactated Ringer's solution for preventing myocardial reperfusion injury International Journal of Cardiology: Heart & Vasculature. Apr,2017 | Pubmed ID: 28616565Muscle squeezing immediately after coronary reperfusion therapy using postconditioning with lactate-enriched blood International Journal of Cardiology. Jan,2019 | Pubmed ID: 30309681Postconditioning with lactate-enriched blood in patients with ST-segment elevation myocardial infarction Cardiology. Apr,2019 | Pubmed ID: 30999290 Postacondicionamiento con Sangre Enriquecida con Lactato para Cardioprotección en el infarto de miocardio de elevación del segmento ST Takashi Koyama1, Masahito Munakata1, Takashi Akima1, Kazutaka Miyamoto1, Hideaki Kanki1, Shiro Ishikawa1 1Department of Cardiology, Saitama Municipal Hospital JoVE 59672 Medicine
Postacondicionamiento con Sangre Enriquecida con Lactato para Cardioprotección en el infarto de miocardio de elevación del segmento ST Takashi Koyama1, Masahito Munakata1, Takashi Akima1, Kazutaka Miyamoto1, Hideaki Kanki1, Shiro Ishikawa1 1Department of Cardiology, Saitama Municipal Hospital JoVE 59672 Medicine