JoVE Clinical and Translational Medicine
Michael P. Hutchens1, Richard J. Traystman2, Tetsuhiro Fujiyoshi1, Shin Nakayama1, Paco S. Herson1
1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Sciences University, 2Department of Pharmacology, University of Colorado Denver
A powerful model for perioperative and critical care related acute kidney injury is presented. Using whole body hypoperfusion induced by cardiac arrest it is possible to nearly replicate the histologic and functional changes of clinical AKI.
Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2007 | Pubmed ID: 17272753
Plasmin is a key enzyme in fibrinolysis. We attempted to determine the possible role of plasmin in the regulation of vascular tone, while also investigating the mechanism of plasmin-induced vasorelaxation.