Toshifumi Yokota Department of Medical Genetics University of Alberta Faculty of Medicine and Dentistry Biography Publications Institution JoVE Articles Toshifumi Yokota has not added a biography. If you are Toshifumi Yokota and would like to personalize this page please email our Author Liaison for assistance. Publications Skipping Multiple Exons to Treat DMD-Promises and Challenges Biomedicines. Jan, 2018 | Pubmed ID: 29301272 Designing Effective Antisense Oligonucleotides for Exon Skipping Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29067661 Exon Skipping Therapy Using Phosphorodiamidate Morpholino Oligomers in the Mdx52 Mouse Model of Duchenne Muscular Dystrophy Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29067660 Immortalized Muscle Cell Model to Test the Exon Skipping Efficacy for Duchenne Muscular Dystrophy Journal of Personalized Medicine. Oct, 2017 | Pubmed ID: 29035327 Quantitative Antisense Screening and Optimization for Exon 51 Skipping in Duchenne Muscular Dystrophy Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2017 | Pubmed ID: 28865998 LNA/DNA Mixmer-based Antisense Oligonucleotides Correct Alternative Splicing of The SMN2 Gene and Restore SMN Protein Expression in Type 1 SMA Fibroblasts Scientific Reports. Jun, 2017 | Pubmed ID: 28623256 Effects of Systemic Multiexon Skipping with Peptide-conjugated Morpholinos in the Heart of a Dog Model of Duchenne Muscular Dystrophy Proceedings of the National Academy of Sciences of the United States of America. Apr, 2017 | Pubmed ID: 28373570 Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28364245 Impaired Regenerative Capacity and Lower Revertant Fibre Expansion in Dystrophin-deficient Mdx Muscles on DBA/2 Background Scientific Reports. Dec, 2016 | Pubmed ID: 27924830 Current Translational Research and Murine Models For Duchenne Muscular Dystrophy Journal of Neuromuscular Diseases. Mar, 2016 | Pubmed ID: 27854202 Deletion of Exons 3-9 Encompassing a Mutational Hot Spot in the DMD Gene Presents an Asymptomatic Phenotype, Indicating a Target Region for Multiexon Skipping Therapy Journal of Human Genetics. Mar, 2016 | Pubmed ID: 27009627 Antisense Oligonucleotide Drugs for Duchenne Muscular Dystrophy: How Far Have We Come and What Does the Future Hold? Future Medicinal Chemistry. Sep, 2015 | Pubmed ID: 26423833 Dystrophin-deficient Large Animal Models: Translational Research and Exon Skipping American Journal of Translational Research. 2015 | Pubmed ID: 26396664 Muscular Dystrophy: Disease Mechanisms and Therapies BioMed Research International. 2015 | Pubmed ID: 26380274 Nonmechanical Roles of Dystrophin and Associated Proteins in Exercise, Neuromuscular Junctions, and Brains Brain Sciences. 2015 | Pubmed ID: 26230713 In Silico Screening Based on Predictive Algorithms As a Design Tool for Exon Skipping Oligonucleotides in Duchenne Muscular Dystrophy PloS One. 2015 | Pubmed ID: 25816009 Long-term Efficacy of Systemic Multiexon Skipping Targeting Dystrophin Exons 45-55 with a Cocktail of Vivo-morpholinos in Mdx52 Mice Molecular Therapy. Nucleic Acids. 2015 | Pubmed ID: 25647512 New Developments in Exon Skipping and Splice Modulation Therapies for Neuromuscular Diseases Expert Opinion on Biological Therapy. Jun, 2014 | Pubmed ID: 24620745 Skipping Multiple Exons of Dystrophin Transcripts Using Cocktail Antisense Oligonucleotides Nucleic Acid Therapeutics. Feb, 2014 | Pubmed ID: 24380394 Morpholino Treatment Improves Muscle Function and Pathology of Pitx1 Transgenic Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2014 | Pubmed ID: 24232919 α1-Syntrophin-deficient Mice Exhibit Impaired Muscle Force Recovery After Osmotic Shock Muscle & Nerve. May, 2014 | Pubmed ID: 24037898 Antisense Therapy in Neurology Journal of Personalized Medicine. 2013 | Pubmed ID: 25562650 Development of Multiexon Skipping Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy BioMed Research International. 2013 | Pubmed ID: 23984357 Mutation Types and Aging Differently Affect Revertant Fiber Expansion in Dystrophic Mdx and Mdx52 Mice PloS One. 2013 | Pubmed ID: 23894429 Highly Efficient in Vivo Delivery of PMO into Regenerating Myotubes and Rescue in Laminin-α2 Chain-null Congenital Muscular Dystrophy Mice Human Molecular Genetics. Dec, 2013 | Pubmed ID: 23882132 Extensive and Prolonged Restoration of Dystrophin Expression with Vivo-morpholino-mediated Multiple Exon Skipping in Dystrophic Dogs Nucleic Acid Therapeutics. Oct, 2012 | Pubmed ID: 22888777 Bodywide Skipping of Exons 45-55 in Dystrophic Mdx52 Mice by Systemic Antisense Delivery Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22869723 Exon Skipping for Nonsense Mutations in Duchenne Muscular Dystrophy: Too Many Mutations, Too Few Patients? Expert Opinion on Biological Therapy. Sep, 2012 | Pubmed ID: 22650324 Pathogenic Exon-trapping by SVA Retrotransposon and Rescue in Fukuyama Muscular Dystrophy Nature. Oct, 2011 | Pubmed ID: 21979053 Restoring Dystrophin Expression in Duchenne Muscular Dystrophy Muscle Progress in Exon Skipping and Stop Codon Read Through The American Journal of Pathology. Jul, 2011 | Pubmed ID: 21703390 Antisense Oligo-mediated Multiple Exon Skipping in a Dog Model of Duchenne Muscular Dystrophy Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21194037 The Status of Exon Skipping As a Therapeutic Approach to Duchenne Muscular Dystrophy Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2011 | Pubmed ID: 20978473 In-frame Dystrophin Following Exon 51-skipping Improves Muscle Pathology and Function in the Exon 52-deficient Mdx Mouse Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2010 | Pubmed ID: 20823833 Antisense PMO Found in Dystrophic Dog Model Was Effective in Cells from Exon 7-deleted DMD Patient PloS One. 2010 | Pubmed ID: 20805873 Efficacy of Systemic Morpholino Exon-skipping in Duchenne Dystrophy Dogs Annals of Neurology. Jun, 2009 | Pubmed ID: 19288467 A Renaissance for Antisense Oligonucleotide Drugs in Neurology: Exon Skipping Breaks New Ground Archives of Neurology. Jan, 2009 | Pubmed ID: 19139297 Potential of Oligonucleotide-mediated Exon-skipping Therapy for Duchenne Muscular Dystrophy Expert Opinion on Biological Therapy. Jun, 2007 | Pubmed ID: 17555369 Expansion of Revertant Fibers in Dystrophic Mdx Muscles Reflects Activity of Muscle Precursor Cells and Serves As an Index of Muscle Regeneration Journal of Cell Science. Jul, 2006 | Pubmed ID: 16757519 Systemic Delivery of Antisense Oligoribonucleotide Restores Dystrophin Expression in Body-wide Skeletal Muscles Proceedings of the National Academy of Sciences of the United States of America. Jan, 2005 | Pubmed ID: 15608067 Alpha1-syntrophin Modulates Turnover of ABCA1 The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14722086 Alpha1-syntrophin-deficient Skeletal Muscle Exhibits Hypertrophy and Aberrant Formation of Neuromuscular Junctions During Regeneration The Journal of Cell Biology. Sep, 2002 | Pubmed ID: 12221071 Micro-dystrophin CDNA Ameliorates Dystrophic Phenotypes when Introduced into Mdx Mice As a Transgene Biochemical and Biophysical Research Communications. May, 2002 | Pubmed ID: 12054513 ब्याह द्वारा प्रेरित एक्सॉन शामिल करने का मूल्यांकन स्विचिंग Antisense Oligonucleotides में SMA रोगी Fibroblasts Rika Maruyama1, Aleksander Touznik1, Toshifumi Yokota1,2 1Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry, 2Muscular Dystrophy Canada Research Chair, Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry JoVE 57530 Medicine सेल झिल्ली की मरंमत परख एक दो फोटॉन लेजर माइक्रोस्कोप का उपयोग Joshua J. A. Lee1, Rika Maruyama1, Hidetoshi Sakurai2, Toshifumi Yokota1 1Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry, 2Center for iPS Cell Research and Application, Kyoto University JoVE 56999 Immunology and Infection मल्टी एक्सॉन कुत्ते एक्स से जुड़े पेशी Dystrophy में कॉकटेल antisense oligonucleotides का प्रयोग लंघन Bailey Miskew Nichols*1, Yoshitsugu Aoki*2, Mutsuki Kuraoka2, Joshua J.A. Lee1, Shin'ichi Takeda2, Toshifumi Yokota1 1Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry, 2Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry JoVE 53776 Medicine
ब्याह द्वारा प्रेरित एक्सॉन शामिल करने का मूल्यांकन स्विचिंग Antisense Oligonucleotides में SMA रोगी Fibroblasts Rika Maruyama1, Aleksander Touznik1, Toshifumi Yokota1,2 1Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry, 2Muscular Dystrophy Canada Research Chair, Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry JoVE 57530 Medicine
सेल झिल्ली की मरंमत परख एक दो फोटॉन लेजर माइक्रोस्कोप का उपयोग Joshua J. A. Lee1, Rika Maruyama1, Hidetoshi Sakurai2, Toshifumi Yokota1 1Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry, 2Center for iPS Cell Research and Application, Kyoto University JoVE 56999 Immunology and Infection
मल्टी एक्सॉन कुत्ते एक्स से जुड़े पेशी Dystrophy में कॉकटेल antisense oligonucleotides का प्रयोग लंघन Bailey Miskew Nichols*1, Yoshitsugu Aoki*2, Mutsuki Kuraoka2, Joshua J.A. Lee1, Shin'ichi Takeda2, Toshifumi Yokota1 1Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry, 2Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry JoVE 53776 Medicine
