Tuomas P. J. Knowles Centre for Misfolding Diseases, Department of Chemistry University of Cambridge Biography Publications Institution JoVE Articles Tuomas P. J. Knowles has not added a biography. If you are Tuomas P. J. Knowles and would like to personalize this page please email our Author Liaison for assistance. Publications Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification ACS Central Science. Aug, 2019 | Pubmed ID: 31482124 Soluble Aggregates Present in Cerebrospinal Fluid Change in Size and Mechanism of Toxicity During Alzheimer's Disease Progression Acta Neuropathologica Communications. Jul, 2019 | Pubmed ID: 31349874 Universality of Filamentous Aggregation Phenomena Physical Review. E. Jun, 2019 | Pubmed ID: 31330719 Analysis of αB-crystallin Polydispersity in Solution Through Native Microfluidic Electrophoresis The Analyst. Jul, 2019 | Pubmed ID: 31215547 Programmable On-Chip Artificial Cell Producing Post-Translationally Modified Ubiquitinated Protein Small (Weinheim an Der Bergstrasse, Germany). Aug, 2019 | Pubmed ID: 31207024 Direct Observation of Prion Protein Oligomer Formation Reveals an Aggregation Mechanism with Multiple Conformationally Distinct Species Chemical Science. May, 2019 | Pubmed ID: 31123569 Secondary Nucleation and Elongation Occur at Different Sites on Alzheimer's Amyloid-β Aggregates Science Advances. Apr, 2019 | Pubmed ID: 31001578 Different Soluble Aggregates of Aβ42 Can Give Rise to Cellular Toxicity Through Different Mechanisms Nature Communications. 04, 2019 | Pubmed ID: 30948723 The Amyloid Phenomenon and Its Significance in Biology and Medicine Cold Spring Harbor Perspectives in Biology. Apr, 2019 | Pubmed ID: 30936117 Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation Angewandte Chemie (International Ed. in English). May, 2019 | Pubmed ID: 30897271 A Method of Predicting the in Vitro Fibril Formation Propensity of Aβ40 Mutants Based on Their Inclusion Body Levels in E. Coli Scientific Reports. Mar, 2019 | Pubmed ID: 30842594 Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules Macromolecular Rapid Communications. Apr, 2019 | Pubmed ID: 30840348 Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42 ACS Chemical Neuroscience. May, 2019 | Pubmed ID: 30793584 Atomic Force Microscopy for Single Molecule Characterisation of Protein Aggregation Archives of Biochemistry and Biophysics. Mar, 2019 | Pubmed ID: 30742801 Trodusquemine Enhances Aβ Aggregation but Suppresses Its Toxicity by Displacing Oligomers from Cell Membranes Nature Communications. 01, 2019 | Pubmed ID: 30644384 Physical Determinants of Amyloid Assembly in Biofilm Formation MBio. 01, 2019 | Pubmed ID: 30622185 Resolving Protein Mixtures Using Microfluidic Diffusional Sizing Combined with Synchrotron Radiation Circular Dichroism Lab on a Chip. 12, 2018 | Pubmed ID: 30515508 Mechanobiology of Protein Droplets: Force Arises from Disorder Cell. 11, 2018 | Pubmed ID: 30500530 Quantifying Co-Oligomer Formation by α-Synuclein ACS Nano. Nov, 2018 | Pubmed ID: 30371053 Direct Observation of Murine Prion Protein Replication in Vitro Journal of the American Chemical Society. Nov, 2018 | Pubmed ID: 30351023 Statistical Mechanics of Globular Oligomer Formation by Protein Molecules The Journal of Physical Chemistry. B. Oct, 2018 | Pubmed ID: 30336667 Observation of Molecular Self-assembly Events in Massively Parallel Microdroplet Arrays Lab on a Chip. Oct, 2018 | Pubmed ID: 30270398 SAR by Kinetics for Drug Discovery in Protein Misfolding Diseases Proceedings of the National Academy of Sciences of the United States of America. 10, 2018 | Pubmed ID: 30257937 Microfluidic Deposition for Resolving Single-molecule Protein Architecture and Heterogeneity Nature Communications. Sep, 2018 | Pubmed ID: 30250131 Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy International Journal of Molecular Sciences. Aug, 2018 | Pubmed ID: 30200270 DNA-Coated Functional Oil Droplets Langmuir : the ACS Journal of Surfaces and Colloids. 08, 2018 | Pubmed ID: 30086643 Self-Assembly-Mediated Release of Peptide Nanoparticles Through Jets Across Microdroplet Interfaces ACS Applied Materials & Interfaces. Aug, 2018 | Pubmed ID: 30080033 Origin of Metastable Oligomers and Their Effects on Amyloid Fibril Self-assembly Chemical Science. Jul, 2018 | Pubmed ID: 30079208 Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing Analytical Chemistry. Sep, 2018 | Pubmed ID: 30070105 C-terminal Truncation of α-synuclein Promotes Amyloid Fibril Amplification at Physiological PH Chemical Science. Jul, 2018 | Pubmed ID: 30061982 Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution Analytical Chemistry. Sep, 2018 | Pubmed ID: 30059210 Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions ACS Chemical Neuroscience. Aug, 2018 | Pubmed ID: 29986583 Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine ACS Chemical Biology. Aug, 2018 | Pubmed ID: 29953201 Oligomer Diversity During the Aggregation of the Repeat Region of Tau ACS Chemical Neuroscience. Jul, 2018 | Pubmed ID: 29953200 Kinetic Barriers to α-synuclein Protofilament Formation and Conversion into Mature Fibrils Chemical Communications (Cambridge, England). Jul, 2018 | Pubmed ID: 29951679 Identification and Nanomechanical Characterization of the Fundamental Single-strand Protofilaments of Amyloid α-synuclein Fibrils Proceedings of the National Academy of Sciences of the United States of America. 07, 2018 | Pubmed ID: 29941606 Enhancing the Resolution of Micro Free Flow Electrophoresis Through Spatially Controlled Sample Injection Analytical Chemistry. Aug, 2018 | Pubmed ID: 29938505 Determination of Polypeptide Conformation with Nanoscale Resolution in Water ACS Nano. Jul, 2018 | Pubmed ID: 29932670 On the Role of Sidechain Size and Charge in the Aggregation of A42 with Familial Mutations Proceedings of the National Academy of Sciences of the United States of America. 06, 2018 | Pubmed ID: 29895690 Kinetic Analysis of Amyloid Formation Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29886534 Budding-like Division of All-aqueous Emulsion Droplets Modulated by Networks of Protein Nanofibrils Nature Communications. 05, 2018 | Pubmed ID: 29844310 On-chip Measurements of Protein Unfolding from Direct Observations of Micron-scale Diffusion Chemical Science. Apr, 2018 | Pubmed ID: 29780480 Rapid Growth of Acetylated Aβ(16-20) into Macroscopic Crystals ACS Nano. May, 2018 | Pubmed ID: 29771495 Cooperative Assembly of Hsp70 Subdomain Clusters Biochemistry. Jul, 2018 | Pubmed ID: 29763298 Cholesterol Catalyses Aβ42 Aggregation Through a Heterogeneous Nucleation Pathway in the Presence of Lipid Membranes Nature Chemistry. Jun, 2018 | Pubmed ID: 29736006 Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion Advanced Healthcare Materials. Jun, 2018 | Pubmed ID: 29635761 Distinct Thermodynamic Signatures of Oligomer Generation in the Aggregation of the Amyloid-β Peptide Nature Chemistry. May, 2018 | Pubmed ID: 29581486 Microfluidic Approaches for Probing Amyloid Assembly and Behaviour Lab on a Chip. 03, 2018 | Pubmed ID: 29527600 Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation Annual Review of Physical Chemistry. 04, 2018 | Pubmed ID: 29490200 Massively Parallel C. Elegans Tracking Provides Multi-dimensional Fingerprints for Phenotypic Discovery Journal of Neuroscience Methods. Aug, 2018 | Pubmed ID: 29452179 Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices Analytical Chemistry. Mar, 2018 | Pubmed ID: 29451779 Biophotonics of Native Silk Fibrils Macromolecular Bioscience. Apr, 2018 | Pubmed ID: 29377575 Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2 Journal of the American Chemical Society. 02, 2018 | Pubmed ID: 29357227 Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions Analytical Chemistry. Mar, 2018 | Pubmed ID: 29313342 Microfluidics for Protein Biophysics Journal of Molecular Biology. Mar, 2018 | Pubmed ID: 29289566 Secondary Nucleation of Monomers on Fibril Surface Dominates α-synuclein Aggregation and Provides Autocatalytic Amyloid Amplification Quarterly Reviews of Biophysics. 01, 2017 | Pubmed ID: 29233218 On-chip Label-free Protein Analysis with Downstream Electrodes for Direct Removal of Electrolysis Products Lab on a Chip. 12, 2017 | Pubmed ID: 29192926 Mechanism of Biosurfactant Adsorption to Oil/water Interfaces from Millisecond Scale Tensiometry Measurements Interface Focus. Dec, 2017 | Pubmed ID: 29147556 Scaling Behaviour and Rate-determining Steps in Filamentous Self-assembly Chemical Science. Oct, 2017 | Pubmed ID: 29147538 Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit Journal of the American Chemical Society. 11, 2017 | Pubmed ID: 28994295 Nanoscale Click-reactive Scaffolds from Peptide Self-assembly Journal of Nanobiotechnology. Oct, 2017 | Pubmed ID: 28985740 Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems Analytical Chemistry. Nov, 2017 | Pubmed ID: 28984439 Modulation of Electrostatic Interactions to Reveal a Reaction Network Unifying the Aggregation Behaviour of the Aβ42 Peptide and Its Variants Chemical Science. Jun, 2017 | Pubmed ID: 28979758 Absolute Quantification of Amyloid Propagons by Digital Microfluidics Analytical Chemistry. Nov, 2017 | Pubmed ID: 28972786 Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry Biomacromolecules. Nov, 2017 | Pubmed ID: 28959882 Kinetic Constraints on Self-assembly into Closed Supramolecular Structures Scientific Reports. Sep, 2017 | Pubmed ID: 28947758 Gradient-free Determination of Isoelectric Points of Proteins on Chip Physical Chemistry Chemical Physics : PCCP. Aug, 2017 | Pubmed ID: 28817152 Sequential Release of Proteins from Structured Multishell Microcapsules Biomacromolecules. Oct, 2017 | Pubmed ID: 28792742 Silk Micrococoons for Protein Stabilisation and Molecular Encapsulation Nature Communications. 07, 2017 | Pubmed ID: 28722016 Monomeric and Fibrillar α-synuclein Exert Opposite Effects on the Catalytic Cycle That Promotes the Proliferation of Aβ42 Aggregates Proceedings of the National Academy of Sciences of the United States of America. 07, 2017 | Pubmed ID: 28698377 Selective Targeting of Primary and Secondary Nucleation Pathways in Aβ42 Aggregation Using a Rational Antibody Scanning Method Science Advances. Jun, 2017 | Pubmed ID: 28691099 Nanobodies Raised Against Monomeric ɑ-synuclein Inhibit Fibril Formation and Destabilize Toxic Oligomeric Species BMC Biology. 07, 2017 | Pubmed ID: 28673288 Phage Display and Kinetic Selection of Antibodies That Specifically Inhibit Amyloid Self-replication Proceedings of the National Academy of Sciences of the United States of America. 06, 2017 | Pubmed ID: 28584111 Ultrasensitive Measurement of Ca Influx into Lipid Vesicles Induced by Protein Aggregates Angewandte Chemie (International Ed. in English). Jun, 2017 | Pubmed ID: 28474754 Acceleration of α-synuclein Aggregation Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 03, 2017 | Pubmed ID: 28434341 Intra-chain Organisation of Hydrophobic Residues Controls Inter-chain Aggregation Rates of Amphiphilic Polymers The Journal of Chemical Physics. Apr, 2017 | Pubmed ID: 28390364 Microfluidic Devices Fabricated Using Fast Wafer-scale LED-lithography Patterning Biomicrofluidics. Jan, 2017 | Pubmed ID: 28289484 Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition Between α-Synuclein Species Biochemistry. 03, 2017 | Pubmed ID: 28230968 Physical Principles of Filamentous Protein Self-assembly Kinetics Journal of Physics. Condensed Matter : an Institute of Physics Journal. Apr, 2017 | Pubmed ID: 28170349 A Natural Product Inhibits the Initiation of α-synuclein Aggregation and Suppresses Its Toxicity Proceedings of the National Academy of Sciences of the United States of America. 02, 2017 | Pubmed ID: 28096355 Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Aβ42 Aggregation in Alzheimer's Disease Proceedings of the National Academy of Sciences of the United States of America. 01, 2017 | Pubmed ID: 28011763 Physical Determinants of the Self-replication of Protein Fibrils Nature Physics. Sep, 2016 | Pubmed ID: 31031819 Kinetics of Spontaneous Filament Nucleation Via Oligomers: Insights from Theory and Simulation The Journal of Chemical Physics. Dec, 2016 | Pubmed ID: 28799382 Dynamics of Heteromolecular Filament Formation The Journal of Chemical Physics. Nov, 2016 | Pubmed ID: 27825219 β-Synuclein Suppresses Both the Initiation and Amplification Steps of α-synuclein Aggregation Via Competitive Binding to Surfaces Scientific Reports. 11, 2016 | Pubmed ID: 27808107 Dynamic Microfluidic Control of Supramolecular Peptide Self-assembly Nature Communications. 10, 2016 | Pubmed ID: 27779182 Fabrication of Fibrillosomes from Droplets Stabilized by Protein Nanofibrils at All-aqueous Interfaces Nature Communications. Oct, 2016 | Pubmed ID: 27725629 Mutations Associated with Familial Parkinson's Disease Alter the Initiation and Amplification Steps of α-synuclein Aggregation Proceedings of the National Academy of Sciences of the United States of America. 09, 2016 | Pubmed ID: 27573854 Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation Chembiochem : a European Journal of Chemical Biology. 10, 2016 | Pubmed ID: 27472818 Fluctuations in the Kinetics of Linear Protein Self-Assembly Physical Review Letters. Jun, 2016 | Pubmed ID: 27391756 Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform Journal of the American Chemical Society. 08, 2016 | Pubmed ID: 27387359 Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly ACS Nano. 08, 2016 | Pubmed ID: 27351519 Quantitative Analysis of Co-oligomer Formation by Amyloid-beta Peptide Isoforms Scientific Reports. 06, 2016 | Pubmed ID: 27346247 A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions Biophysical Journal. 05, 2016 | Pubmed ID: 27166804 Amyloid Fibrils As Building Blocks for Natural and Artificial Functional Materials Advanced Materials (Deerfield Beach, Fla.). Aug, 2016 | Pubmed ID: 27165397 The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model Molecular Cell. Apr, 2016 | Pubmed ID: 27151442 Self-assembly of MPG1, a Hydrophobin Protein from the Rice Blast Fungus That Forms Functional Amyloid Coatings, Occurs by a Surface-driven Mechanism Scientific Reports. 05, 2016 | Pubmed ID: 27142249 Electrostatically-guided Inhibition of Curli Amyloid Nucleation by the CsgC-like Family of Chaperones Scientific Reports. Apr, 2016 | Pubmed ID: 27098162 Analysis of the Length Distribution of Amyloid Fibrils by Centrifugal Sedimentation Analytical Biochemistry. 07, 2016 | Pubmed ID: 27033008 Kinetic Analysis Reveals the Diversity of Microscopic Mechanisms Through Which Molecular Chaperones Suppress Amyloid Formation Nature Communications. Mar, 2016 | Pubmed ID: 27009901 Quantitative Thermophoretic Study of Disease-related Protein Aggregates Scientific Reports. Mar, 2016 | Pubmed ID: 26984748 Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation Physical Review Letters. Feb, 2016 | Pubmed ID: 26943560 Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions Analytical Chemistry. Apr, 2016 | Pubmed ID: 26940224 An Anticancer Drug Suppresses the Primary Nucleation Reaction That Initiates the Production of the Toxic Aβ42 Aggregates Linked with Alzheimer's Disease Science Advances. Feb, 2016 | Pubmed ID: 26933687 Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function PLoS Computational Biology. Feb, 2016 | Pubmed ID: 26928170 A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins ACS Combinatorial Science. Mar, 2016 | Pubmed ID: 26923286 Kinetic Model of the Aggregation of Alpha-synuclein Provides Insights into Prion-like Spreading Proceedings of the National Academy of Sciences of the United States of America. Mar, 2016 | Pubmed ID: 26884195 An Environmentally Sensitive Fluorescent Dye As a Multidimensional Probe of Amyloid Formation The Journal of Physical Chemistry. B. Mar, 2016 | Pubmed ID: 26865546 Hamiltonian Dynamics of Protein Filament Formation Physical Review Letters. Jan, 2016 | Pubmed ID: 26849615 Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform Biophysical Journal. Feb, 2016 | Pubmed ID: 26840721 Quantitative Analysis of Intrinsic and Extrinsic Factors in the Aggregation Mechanism of Alzheimer-associated Aβ-peptide Scientific Reports. Jan, 2016 | Pubmed ID: 26758487 Molecular Mechanisms of Protein Aggregation from Global Fitting of Kinetic Models Nature Protocols. Feb, 2016 | Pubmed ID: 26741409 Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins Under Native Solution Conditions ACS Nano. Jan, 2016 | Pubmed ID: 26678709 Single-molecule FRET Studies on Alpha-synuclein Oligomerization of Parkinson's Disease Genetically Related Mutants Scientific Reports. Nov, 2015 | Pubmed ID: 26582456 The Length Distribution of Frangible Biofilaments The Journal of Chemical Physics. Oct, 2015 | Pubmed ID: 26520548 Latent Analysis of Unmodified Biomolecules and Their Complexes in Solution with Attomole Detection Sensitivity Nature Chemistry. Oct, 2015 | Pubmed ID: 26391079 Biophysical Approaches for the Study of Interactions Between Molecular Chaperones and Protein Aggregates Chemical Communications (Cambridge, England). Oct, 2015 | Pubmed ID: 26328629 Fast Flow Microfluidics and Single-molecule Fluorescence for the Rapid Characterization of α-synuclein Oligomers Analytical Chemistry. Sep, 2015 | Pubmed ID: 26258431 Dynamics of Protein Aggregation and Oligomer Formation Governed by Secondary Nucleation The Journal of Chemical Physics. Aug, 2015 | Pubmed ID: 26254664 Force Generation by the Growth of Amyloid Aggregates Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26195762 Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation The Journal of Physical Chemistry. B. Aug, 2015 | Pubmed ID: 26192338 A High Power-Density, Mediator-Free, Microfluidic Biophotovoltaic Device for Cyanobacterial Cells Advanced Energy Materials. Jan, 2015 | Pubmed ID: 26190957 Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry ACS Nano. Jun, 2015 | Pubmed ID: 26030507 Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale Under Mildly Acidic Conditions Chembiochem : a European Journal of Chemical Biology. Jun, 2015 | Pubmed ID: 25989377 A Mechanistic Model of Tau Amyloid Aggregation Based on Direct Observation of Oligomers Nature Communications. Apr, 2015 | Pubmed ID: 25926130 Preventing Peptide and Protein Misbehavior Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25902542 A Microfluidic Platform for Quantitative Measurements of Effective Protein Charges and Single Ion Binding in Solution Physical Chemistry Chemical Physics : PCCP. May, 2015 | Pubmed ID: 25880209 Structural Characterization of Toxic Oligomers That Are Kinetically Trapped During α-synuclein Fibril Formation Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25855634 On the Lag Phase in Amyloid Fibril Formation Physical Chemistry Chemical Physics : PCCP. Mar, 2015 | Pubmed ID: 25719972 A Molecular Chaperone Breaks the Catalytic Cycle That Generates Toxic Aβ Oligomers Nature Structural & Molecular Biology. Mar, 2015 | Pubmed ID: 25686087 Lipid Vesicles Trigger α-synuclein Aggregation by Stimulating Primary Nucleation Nature Chemical Biology. Mar, 2015 | Pubmed ID: 25643172 Protein Microgels from Amyloid Fibril Networks ACS Nano. Jan, 2015 | Pubmed ID: 25469621 Tetracycline Nanoparticles As Antibacterial and Gene-silencing Agents Advanced Healthcare Materials. Apr, 2015 | Pubmed ID: 25425122 Multiphase Protein Microgels Macromolecular Bioscience. Apr, 2015 | Pubmed ID: 25407891 Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems The Journal of Physical Chemistry Letters. Feb, 2014 | Pubmed ID: 26270839 Self-Assembly of Amyloid Fibrils That Display Active Enzymes ChemCatChem. Jul, 2014 | Pubmed ID: 25937845 Crucial Role of Nonspecific Interactions in Amyloid Nucleation Proceedings of the National Academy of Sciences of the United States of America. Dec, 2014 | Pubmed ID: 25453085 Ostwald's Rule of Stages Governs Structural Transitions and Morphology of Dipeptide Supramolecular Polymers Nature Communications. Nov, 2014 | Pubmed ID: 25391268 Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation The Journal of Biological Chemistry. Nov, 2014 | Pubmed ID: 25217638 The Physical Chemistry of the Amyloid Phenomenon: Thermodynamics and Kinetics of Filamentous Protein Aggregation Essays in Biochemistry. 2014 | Pubmed ID: 25131584 Differences in Nucleation Behavior Underlie the Contrasting Aggregation Kinetics of the Aβ40 and Aβ42 Peptides Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 24938782 Role of Filament Annealing in the Kinetics and Thermodynamics of Nucleated Polymerization The Journal of Chemical Physics. Jun, 2014 | Pubmed ID: 24908038 The Amyloid State and Its Association with Protein Misfolding Diseases Nature Reviews. Molecular Cell Biology. Jun, 2014 | Pubmed ID: 24854788 Asymptotic Solutions of the Oosawa Model for the Length Distribution of Biofilaments The Journal of Chemical Physics. May, 2014 | Pubmed ID: 24852562 Solution Conditions Determine the Relative Importance of Nucleation and Growth Processes in α-synuclein Aggregation Proceedings of the National Academy of Sciences of the United States of America. May, 2014 | Pubmed ID: 24817693 Nucleation-conversion-polymerization Reactions of Biological Macromolecules with Prenucleation Clusters Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Mar, 2014 | Pubmed ID: 24730879 Density-gradient-free Microfluidic Centrifugation for Analytical and Preparative Separation of Nanoparticles Nano Letters. May, 2014 | Pubmed ID: 24611748 Chemical Kinetics for Drug Discovery to Combat Protein Aggregation Diseases Trends in Pharmacological Sciences. Mar, 2014 | Pubmed ID: 24560688 Targeting the Intrinsically Disordered Structural Ensemble of α-synuclein by Small Molecules As a Potential Therapeutic Strategy for Parkinson's Disease PloS One. 2014 | Pubmed ID: 24551051 Nanoscale Spatially Resolved Infrared Spectra from Single Microdroplets Lab on a Chip. Apr, 2014 | Pubmed ID: 24519414 Expanding the Solvent Chemical Space for Self-assembly of Dipeptide Nanostructures ACS Nano. Feb, 2014 | Pubmed ID: 24422499 Quantification of the Concentration of Aβ42 Propagons During the Lag Phase by an Amyloid Chain Reaction Assay Journal of the American Chemical Society. Jan, 2014 | Pubmed ID: 24313551 Single Point Mutations Induce a Switch in the Molecular Mechanism of the Aggregation of the Alzheimer's Disease Associated Aβ42 Peptide ACS Chemical Biology. Feb, 2014 | Pubmed ID: 24199868 A Clear View of Polymorphism, Twist, and Chirality in Amyloid Fibril Formation ACS Nano. Dec, 2013 | Pubmed ID: 24359171 Single-molecule Measurements of Transient Biomolecular Complexes Through Microfluidic Dilution Analytical Chemistry. Jul, 2013 | Pubmed ID: 23782428 Proliferation of Amyloid-β42 Aggregates Occurs Through a Secondary Nucleation Mechanism Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23703910 Influence of Specific HSP70 Domains on Fibril Formation of the Yeast Prion Protein Ure2 Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. May, 2013 | Pubmed ID: 23530260 Atomic Structure and Hierarchical Assembly of a Cross-β Amyloid Fibril Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23513222 Electrostatic Effects in Filamentous Protein Aggregation Biophysical Journal. Mar, 2013 | Pubmed ID: 23473495 Twisting Transition Between Crystalline and Fibrillar Phases of Aggregated Peptides Physical Review Letters. Oct, 2012 | Pubmed ID: 23102370 Connecting Macroscopic Observables and Microscopic Assembly Events in Amyloid Formation Using Coarse Grained Simulations PLoS Computational Biology. 2012 | Pubmed ID: 23071427 Role of Elongation and Secondary Pathways in S6 Amyloid Fibril Growth Biophysical Journal. May, 2012 | Pubmed ID: 22824281 Direct Observation of the Interconversion of Normal and Toxic Forms of α-synuclein Cell. May, 2012 | Pubmed ID: 22632969 Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth Angewandte Chemie (International Ed. in English). May, 2012 | Pubmed ID: 22489083 From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation Journal of Molecular Biology. Aug, 2012 | Pubmed ID: 22406275 Inversion of the Balance Between Hydrophobic and Hydrogen Bonding Interactions in Protein Folding and Aggregation PLoS Computational Biology. Oct, 2011 | Pubmed ID: 22022239 Nucleated Polymerisation in the Presence of Pre-formed Seed Filaments International Journal of Molecular Sciences. 2011 | Pubmed ID: 22016630 Probing Small Molecule Binding to Amyloid Fibrils Physical Chemistry Chemical Physics : PCCP. Dec, 2011 | Pubmed ID: 22006124 Binding of the Molecular Chaperone αB-crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation Biophysical Journal. Oct, 2011 | Pubmed ID: 21961594 Observation of Spatial Propagation of Amyloid Assembly from Single Nuclei Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21876182 Nucleated Polymerization with Secondary Pathways. III. Equilibrium Behavior and Oligomer Populations The Journal of Chemical Physics. Aug, 2011 | Pubmed ID: 21842956 Nucleated Polymerization with Secondary Pathways. II. Determination of Self-consistent Solutions to Growth Processes Described by Non-linear Master Equations The Journal of Chemical Physics. Aug, 2011 | Pubmed ID: 21842955 Nucleated Polymerization with Secondary Pathways. I. Time Evolution of the Principal Moments The Journal of Chemical Physics. Aug, 2011 | Pubmed ID: 21842954 Protein Solubility and Protein Homeostasis: a Generic View of Protein Misfolding Disorders Cold Spring Harbor Perspectives in Biology. Dec, 2011 | Pubmed ID: 21825020 Nanomechanics of Functional and Pathological Amyloid Materials Nature Nanotechnology. Jul, 2011 | Pubmed ID: 21804553 Probing Protein Aggregation with Quartz Crystal Microbalances Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21713635 Conserved C-terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-synuclein Journal of Molecular Biology. Aug, 2011 | Pubmed ID: 21689664 Metastability of Native Proteins and the Phenomenon of Amyloid Formation Journal of the American Chemical Society. Sep, 2011 | Pubmed ID: 21650202 Perturbation of the Stability of Amyloid Fibrils Through Alteration of Electrostatic Interactions Biophysical Journal. Jun, 2011 | Pubmed ID: 21641324 Population of Nonnative States of Lysozyme Variants Drives Amyloid Fibril Formation Journal of the American Chemical Society. May, 2011 | Pubmed ID: 21528861 Relationship Between Prion Propensity and the Rates of Individual Molecular Steps of Fibril Assembly The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21233211 Interactions Between Amyloidophilic Dyes and Their Relevance to Studies of Amyloid Inhibitors Biophysical Journal. Nov, 2010 | Pubmed ID: 21081099 Frequency Factors in a Landscape Model of Filamentous Protein Aggregation Physical Review Letters. Jun, 2010 | Pubmed ID: 20873942 Stabilization of Neurotoxic Alzheimer Amyloid-beta Oligomers by Protein Engineering Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20713699 Surface Attachment of Protein Fibrils Via Covalent Modification Strategies The Journal of Physical Chemistry. B. Sep, 2010 | Pubmed ID: 20695458 Protein Aggregation in Crowded Environments Journal of the American Chemical Society. Apr, 2010 | Pubmed ID: 20334356 The Interaction of AlphaB-crystallin with Mature Alpha-synuclein Amyloid Fibrils Inhibits Their Elongation Biophysical Journal. Mar, 2010 | Pubmed ID: 20197038 Nanostructured Films from Hierarchical Self-assembly of Amyloidogenic Proteins Nature Nanotechnology. Mar, 2010 | Pubmed ID: 20190750 Fabrication and Characterisation of Protein Fibril-elastomer Composites Acta Biomaterialia. Apr, 2010 | Pubmed ID: 19836000 An Analytical Solution to the Kinetics of Breakable Filament Assembly Science (New York, N.Y.). Dec, 2009 | Pubmed ID: 20007899 Biosensor-based Label-free Assays of Amyloid Growth FEBS Letters. Aug, 2009 | Pubmed ID: 19523953 Position-dependent Electrostatic Protection Against Protein Aggregation Chembiochem : a European Journal of Chemical Biology. May, 2009 | Pubmed ID: 19415709 Label-free Detection of Amyloid Growth with Microcantilever Sensors Nanotechnology. Sep, 2008 | Pubmed ID: 21832567 Chemical and Biophysical Insights into the Propagation of Prion Strains HFSP Journal. Dec, 2008 | Pubmed ID: 19436493 Highly Specific Label-free Protein Detection from Lysed Cells Using Internally Referenced Microcantilever Sensors Biosensors & Bioelectronics. Oct, 2008 | Pubmed ID: 18495468 Measurement of Amyloid Fibril Length Distributions by Inclusion of Rotational Motion in Solution NMR Diffusion Measurements Angewandte Chemie (International Ed. in English). 2008 | Pubmed ID: 18350531 Characterisation of Amyloid Fibril Formation by Small Heat-shock Chaperone Proteins Human AlphaA-, AlphaB- and R120G AlphaB-crystallins Journal of Molecular Biology. Sep, 2007 | Pubmed ID: 17662998 Kinetics and Thermodynamics of Amyloid Formation from Direct Measurements of Fluctuations in Fibril Mass Proceedings of the National Academy of Sciences of the United States of America. Jun, 2007 | Pubmed ID: 17540728 Characterization of the Nanoscale Properties of Individual Amyloid Fibrils Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17038504 Spatial Persistence of Angular Correlations in Amyloid Fibrils Physical Review Letters. Jun, 2006 | Pubmed ID: 16803412 The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner Journal of Molecular Biology. Jul, 2006 | Pubmed ID: 16774767 इन्फ्रारेड नैनोस्पेक्ट्रोस्कोपी और परमाणु बल माइक्रोस्कोपी द्वारा व्यक्तिगत प्रोटीन सकल की विशेषता Francesco Simone Ruggeri1, Tomas Šneideris1,2, Sean Chia1, Michele Vendruscolo1, Tuomas P. J. Knowles1,3 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2Institute of Biotechnology, Life Sciences Center, Vilnius University, 3Cavendish Laboratory, Department of Physics, University of Cambridge JoVE 60108 Biochemistry
इन्फ्रारेड नैनोस्पेक्ट्रोस्कोपी और परमाणु बल माइक्रोस्कोपी द्वारा व्यक्तिगत प्रोटीन सकल की विशेषता Francesco Simone Ruggeri1, Tomas Šneideris1,2, Sean Chia1, Michele Vendruscolo1, Tuomas P. J. Knowles1,3 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2Institute of Biotechnology, Life Sciences Center, Vilnius University, 3Cavendish Laboratory, Department of Physics, University of Cambridge JoVE 60108 Biochemistry
