Vincent Poitout Montreal Diabetes Research Center CRCHUM Biography Publications Institution JoVE Articles Vincent Poitout has not added a biography. If you are Vincent Poitout and would like to personalize this page please email our Author Liaison for assistance. Publications Per-Arnt-Sim Kinase Regulates Pancreatic Duodenal Homeobox-1 Protein Stability Via Phosphorylation of Glycogen Synthase Kinase 3 Beta in Pancreatic Beta Cells The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23853095 Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic β-Cells Diabetes. Aug, 2013 | Pubmed ID: 23656887 The Fatty Acid Receptor FFA1/GPR40 a Decade Later: How Much Do We Know? Trends in Endocrinology and Metabolism: TEM. Aug, 2013 | Pubmed ID: 23631851 Fatty Acid Receptor Gpr40 Mediates Neuromicrovascular Degeneration Induced by Transarachidonic Acids in Rodents Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2013 | Pubmed ID: 23520164 Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats Diabetes. Jun, 2013 | Pubmed ID: 23378607 The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss Through Inhibition of Osteoclast Differentiation The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23335512 Discovery of Novel Glucose-regulated Proteins in Isolated Human Pancreatic Islets Using LC-MS/MS-based Proteomics Journal of Proteome Research. Jul, 2012 | Pubmed ID: 22578083 Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans Via Toll-Like Receptor-4 and NF-κB Signalling PloS One. 2012 | Pubmed ID: 22558381 Glucose Activates Free Fatty Acid Receptor 1 Gene Transcription Via Phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of Pancreas-duodenum Homeobox-1 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22308370 Human Mutation Within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 22065581 Binding of Activating Transcription Factor 6 to the A5/Core of the Rat Insulin II Gene Promoter Does Not Mediate Its Transcriptional Repression Journal of Molecular Endocrinology. Dec, 2011 | Pubmed ID: 21821716 Lack of Preservation of Insulin Gene Expression by a Glucagon-like Peptide 1 Agonist or a Dipeptidyl Peptidase 4 Inhibitor in an in Vivo Model of Glucolipotoxicity Diabetes Research and Clinical Practice. Mar, 2010 | Pubmed ID: 20092903 Lack of TXNIP Protects Against Mitochondria-mediated Apoptosis but Not Against Fatty Acid-induced ER Stress-mediated Beta-cell Death Diabetes. Feb, 2010 | Pubmed ID: 19875615 Glucolipotoxicity of the Pancreatic Beta Cell Biochimica Et Biophysica Acta. Mar, 2010 | Pubmed ID: 19715772 Cystic Fibrosis-related Diabetes: from CFTR Dysfunction to Oxidative Stress The Clinical Biochemist. Reviews / Australian Association of Clinical Biochemists. Nov, 2009 | Pubmed ID: 20011209 Deletion of GPR40 Impairs Glucose-induced Insulin Secretion in Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets Diabetes. Nov, 2009 | Pubmed ID: 19720802 Involvement of Per-Arnt-Sim Kinase and Extracellular-regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic Beta-cells Diabetes. Sep, 2009 | Pubmed ID: 19502418 Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic Beta-cell at Submaximal Glucose Concentrations Endocrinology. Aug, 2009 | Pubmed ID: 19406947 GPR40: Good Cop, Bad Cop? Diabetes. May, 2009 | Pubmed ID: 19401432 Adipose Triglyceride Lipase is Implicated in Fuel- and Non-fuel-stimulated Insulin Secretion The Journal of Biological Chemistry. Jun, 2009 | Pubmed ID: 19389712 The Stability and Transactivation Potential of the Mammalian MafA Transcription Factor Are Regulated by Serine 65 Phosphorylation The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 19004825 Glucolipotoxicity of the Pancreatic Beta-cell: Myth or Reality? Biochemical Society Transactions. Oct, 2008 | Pubmed ID: 18793158 The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion in Vivo After High-fat Feeding Diabetes. Sep, 2008 | Pubmed ID: 18559658 Glucolipotoxicity: Fuel Excess and Beta-cell Dysfunction Endocrine Reviews. May, 2008 | Pubmed ID: 18048763 Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets Diabetes. Feb, 2008 | Pubmed ID: 17991758 Phospholipid Hydrolysis and Insulin Secretion: a Step Toward Solving the Rubik's Cube American Journal of Physiology. Endocrinology and Metabolism. Feb, 2008 | Pubmed ID: 17925452 G Protein-coupled Receptors and Insulin Secretion: 119 and Counting Endocrinology. Jun, 2007 | Pubmed ID: 17507578 GPR40 is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion in Vivo Diabetes. Apr, 2007 | Pubmed ID: 17395749 Characterization of the Human Pancreatic Islet Proteome by Two-dimensional LC/MS/MS Journal of Proteome Research. Dec, 2006 | Pubmed ID: 17137336 Regulation of the Insulin Gene by Glucose and Fatty Acids The Journal of Nutrition. Apr, 2006 | Pubmed ID: 16549443 Palmitate Inhibits Insulin Gene Expression by Altering PDX-1 Nuclear Localization and Reducing MafA Expression in Isolated Rat Islets of Langerhans The Journal of Biological Chemistry. Sep, 2005 | Pubmed ID: 15944145 Pancreatic Islet Response to Hyperglycemia is Dependent on Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) FEBS Letters. Apr, 2005 | Pubmed ID: 15848159 The Islet Beta Cell-enriched MafA Activator is a Key Regulator of Insulin Gene Transcription The Journal of Biological Chemistry. Mar, 2005 | Pubmed ID: 15665000 Elevated Glucose Attenuates Human Insulin Gene Promoter Activity in INS-1 Pancreatic Beta-cells Via Reduced Nuclear Factor Binding to the A5/core and Z Element Molecular Endocrinology (Baltimore, Md.). May, 2005 | Pubmed ID: 15650027 Evidence Against the Involvement of Oxidative Stress in Fatty Acid Inhibition of Insulin Secretion Diabetes. Oct, 2004 | Pubmed ID: 15448091 Beta-cell Lipotoxicity: Burning Fat into Heat? Endocrinology. Aug, 2004 | Pubmed ID: 15265823 A Role for the Malonyl-CoA/long-chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli Diabetes. Apr, 2004 | Pubmed ID: 15047616 Beta-cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes Diabetes. Feb, 2004 | Pubmed ID: 14749276 The Ins and Outs of Fatty Acids on the Pancreatic Beta Cell Trends in Endocrinology and Metabolism: TEM. Jul, 2003 | Pubmed ID: 12826323 Palmitate Inhibition of Insulin Gene Expression is Mediated at the Transcriptional Level Via Ceramide Synthesis The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12771145 Insulin Secretory Deficiency and Glucose Intolerance in Rab3A Null Mice The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12510060 Effect of the Two-layer (University of Wisconsin Solution-perfluorochemical Plus O2) Method of Pancreas Preservation on Human Islet Isolation, As Assessed by the Edmonton Isolation Protocol Transplantation. Nov, 2002 | Pubmed ID: 12451242 Increasing Triglyceride Synthesis Inhibits Glucose-induced Insulin Secretion in Isolated Rat Islets of Langerhans: a Study Using Adenoviral Expression of Diacylglycerol Acyltransferase Endocrinology. Sep, 2002 | Pubmed ID: 12193544 Differential Effects of Hyperlipidemia on Insulin Secretion in Islets of Langerhans from Hyperglycemic Versus Normoglycemic Rats Diabetes. Mar, 2002 | Pubmed ID: 11872664 Minireview: Secondary Beta-cell Failure in Type 2 Diabetes--a Convergence of Glucotoxicity and Lipotoxicity Endocrinology. Feb, 2002 | Pubmed ID: 11796484 Модели хронического Питательные инфузии у крыс Grace Fergusson1, Mélanie Ethier1, Bader Zarrouki1,2, Ghislaine Fontés1, Vincent Poitout1,2 1Montreal Diabetes Research Center, CRCHUM, 2Department of Medicine, University of Montreal JoVE 50267 Medicine
Модели хронического Питательные инфузии у крыс Grace Fergusson1, Mélanie Ethier1, Bader Zarrouki1,2, Ghislaine Fontés1, Vincent Poitout1,2 1Montreal Diabetes Research Center, CRCHUM, 2Department of Medicine, University of Montreal JoVE 50267 Medicine