Vincent Poitout

Publications

• Per-Arnt-Sim Kinase Regulates Pancreatic Duodenal Homeobox-1 Protein Stability Via Phosphorylation of Glycogen Synthase Kinase 3 Beta in Pancreatic Beta Cells
  The Journal of Biological Chemistry. Jul, 2013  |   Pubmed ID: 23853095
• Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic β-Cells
  Diabetes. Aug, 2013  |   Pubmed ID: 23656887
• The Fatty Acid Receptor FFA1/GPR40 a Decade Later: How Much Do We Know?
  Trends in Endocrinology and Metabolism: TEM. Aug, 2013  |   Pubmed ID: 23631851
• Fatty Acid Receptor Gpr40 Mediates Neuromicrovascular Degeneration Induced by Transarachidonic Acids in Rodents
  Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2013  |   Pubmed ID: 23520164
• Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats
  Diabetes. Jun, 2013  |   Pubmed ID: 23378607
• The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss Through Inhibition of Osteoclast Differentiation
  The Journal of Biological Chemistry. Mar, 2013  |   Pubmed ID: 23335512
• Discovery of Novel Glucose-regulated Proteins in Isolated Human Pancreatic Islets Using LC-MS/MS-based Proteomics
  Journal of Proteome Research. Jul, 2012  |   Pubmed ID: 22578083
• Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans Via Toll-Like Receptor-4 and NF-κB Signalling
  PloS One. 2012  |   Pubmed ID: 22558381
• Glucose Activates Free Fatty Acid Receptor 1 Gene Transcription Via Phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of Pancreas-duodenum Homeobox-1
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012  |   Pubmed ID: 22308370
• Human Mutation Within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion
  The Journal of Biological Chemistry. Dec, 2011  |   Pubmed ID: 22065581
• Binding of Activating Transcription Factor 6 to the A5/Core of the Rat Insulin II Gene Promoter Does Not Mediate Its Transcriptional Repression
  Journal of Molecular Endocrinology. Dec, 2011  |   Pubmed ID: 21821716
• Lack of Preservation of Insulin Gene Expression by a Glucagon-like Peptide 1 Agonist or a Dipeptidyl Peptidase 4 Inhibitor in an in Vivo Model of Glucolipotoxicity
  Diabetes Research and Clinical Practice. Mar, 2010  |   Pubmed ID: 20092903
• Lack of TXNIP Protects Against Mitochondria-mediated Apoptosis but Not Against Fatty Acid-induced ER Stress-mediated Beta-cell Death
  Diabetes. Feb, 2010  |   Pubmed ID: 19875615
• Glucolipotoxicity of the Pancreatic Beta Cell
  Biochimica Et Biophysica Acta. Mar, 2010  |   Pubmed ID: 19715772
• Cystic Fibrosis-related Diabetes: from CFTR Dysfunction to Oxidative Stress
  The Clinical Biochemist. Reviews / Australian Association of Clinical Biochemists. Nov, 2009  |   Pubmed ID: 20011209
• Deletion of GPR40 Impairs Glucose-induced Insulin Secretion in Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets
  Diabetes. Nov, 2009  |   Pubmed ID: 19720802
• Involvement of Per-Arnt-Sim Kinase and Extracellular-regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic Beta-cells
  Diabetes. Sep, 2009  |   Pubmed ID: 19502418
• Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic Beta-cell at Submaximal Glucose Concentrations
  Endocrinology. Aug, 2009  |   Pubmed ID: 19406947
• GPR40: Good Cop, Bad Cop?
  Diabetes. May, 2009  |   Pubmed ID: 19401432
• Adipose Triglyceride Lipase is Implicated in Fuel- and Non-fuel-stimulated Insulin Secretion
  The Journal of Biological Chemistry. Jun, 2009  |   Pubmed ID: 19389712
• The Stability and Transactivation Potential of the Mammalian MafA Transcription Factor Are Regulated by Serine 65 Phosphorylation
  The Journal of Biological Chemistry. Jan, 2009  |   Pubmed ID: 19004825
• Glucolipotoxicity of the Pancreatic Beta-cell: Myth or Reality?
  Biochemical Society Transactions. Oct, 2008  |   Pubmed ID: 18793158
• The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion in Vivo After High-fat Feeding
  Diabetes. Sep, 2008  |   Pubmed ID: 18559658
• Glucolipotoxicity: Fuel Excess and Beta-cell Dysfunction
  Endocrine Reviews. May, 2008  |   Pubmed ID: 18048763
• Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets
  Diabetes. Feb, 2008  |   Pubmed ID: 17991758
• Phospholipid Hydrolysis and Insulin Secretion: a Step Toward Solving the Rubik's Cube
  American Journal of Physiology. Endocrinology and Metabolism. Feb, 2008  |   Pubmed ID: 17925452
• G Protein-coupled Receptors and Insulin Secretion: 119 and Counting
  Endocrinology. Jun, 2007  |   Pubmed ID: 17507578
• GPR40 is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion in Vivo
  Diabetes. Apr, 2007  |   Pubmed ID: 17395749
• Characterization of the Human Pancreatic Islet Proteome by Two-dimensional LC/MS/MS
  Journal of Proteome Research. Dec, 2006  |   Pubmed ID: 17137336
• Regulation of the Insulin Gene by Glucose and Fatty Acids
  The Journal of Nutrition. Apr, 2006  |   Pubmed ID: 16549443
• Palmitate Inhibits Insulin Gene Expression by Altering PDX-1 Nuclear Localization and Reducing MafA Expression in Isolated Rat Islets of Langerhans
  The Journal of Biological Chemistry. Sep, 2005  |   Pubmed ID: 15944145
• Pancreatic Islet Response to Hyperglycemia is Dependent on Peroxisome Proliferator-activated Receptor Alpha (PPARalpha)
  FEBS Letters. Apr, 2005  |   Pubmed ID: 15848159
• The Islet Beta Cell-enriched MafA Activator is a Key Regulator of Insulin Gene Transcription
  The Journal of Biological Chemistry. Mar, 2005  |   Pubmed ID: 15665000
• Elevated Glucose Attenuates Human Insulin Gene Promoter Activity in INS-1 Pancreatic Beta-cells Via Reduced Nuclear Factor Binding to the A5/core and Z Element
  Molecular Endocrinology (Baltimore, Md.). May, 2005  |   Pubmed ID: 15650027
• Evidence Against the Involvement of Oxidative Stress in Fatty Acid Inhibition of Insulin Secretion
  Diabetes. Oct, 2004  |   Pubmed ID: 15448091
• Beta-cell Lipotoxicity: Burning Fat into Heat?
  Endocrinology. Aug, 2004  |   Pubmed ID: 15265823
• A Role for the Malonyl-CoA/long-chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli
  Diabetes. Apr, 2004  |   Pubmed ID: 15047616
• Beta-cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes
  Diabetes. Feb, 2004  |   Pubmed ID: 14749276
• The Ins and Outs of Fatty Acids on the Pancreatic Beta Cell
  Trends in Endocrinology and Metabolism: TEM. Jul, 2003  |   Pubmed ID: 12826323
• Palmitate Inhibition of Insulin Gene Expression is Mediated at the Transcriptional Level Via Ceramide Synthesis
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12771145
• Insulin Secretory Deficiency and Glucose Intolerance in Rab3A Null Mice
  The Journal of Biological Chemistry. Mar, 2003  |   Pubmed ID: 12510060
• Effect of the Two-layer (University of Wisconsin Solution-perfluorochemical Plus O2) Method of Pancreas Preservation on Human Islet Isolation, As Assessed by the Edmonton Isolation Protocol
  Transplantation. Nov, 2002  |   Pubmed ID: 12451242
• Increasing Triglyceride Synthesis Inhibits Glucose-induced Insulin Secretion in Isolated Rat Islets of Langerhans: a Study Using Adenoviral Expression of Diacylglycerol Acyltransferase
  Endocrinology. Sep, 2002  |   Pubmed ID: 12193544
• Differential Effects of Hyperlipidemia on Insulin Secretion in Islets of Langerhans from Hyperglycemic Versus Normoglycemic Rats
  Diabetes. Mar, 2002  |   Pubmed ID: 11872664
• Minireview: Secondary Beta-cell Failure in Type 2 Diabetes--a Convergence of Glucotoxicity and Lipotoxicity
  Endocrinology. Feb, 2002  |   Pubmed ID: 11796484