Microarray Analysis of Corneal Fibroblast Gene Expression After Interleukin-1 Treatment

Investigative Ophthalmology & Visual Science. Jul, 2002  |  Pubmed ID: 12091409

To identify changes in gene expression in human corneal fibroblasts after exposure to interleukin-1alpha.

Tissue-specific Gene Expression of Head and Neck Squamous Cell Carcinoma in Vivo by Complementary DNA Microarray Analysis

Archives of Otolaryngology--head & Neck Surgery. Jul, 2003  |  Pubmed ID: 12874079

To identify distinct gene expression profiles of human head and neck squamous cell carcinomas (HNSCCAs) using complementary DNA (cDNA) microarray analysis and to create a preliminary, comprehensive database of HNSCCA gene expression.

Estrogen Receptor Alpha and Matrix Metalloproteinase 2 Polymorphisms and Age-related Maculopathy in Older Women

American Journal of Epidemiology. May, 2008  |  Pubmed ID: 18359774

In this study, the authors sought to determine whether single nucleotide polymorphisms in the estrogen receptor alpha (ESR1) and matrix metalloproteinase 2 (MMP2) genes are associated with age-related maculopathy (ARM) in older women. Subjects comprised a random sample of Caucasian women aged > or =74 years participating in the Study of Osteoporotic Fractures year 10 follow-up (n = 906) in 1997-1998. Fundus photographs were graded for ARM using a modification of the Wisconsin Age-Related Maculopathy Grading System. The prevalences of early ARM and late ARM were 46% and 4%, respectively. The MMP2 rs2287074 single nucleotide polymorphism (G-->A) was associated with ARM. The A allele was present in 47%, 43%, and 30% of subjects with no, early, and late ARM, respectively (p = 0.01), and was associated with lower odds of any ARM (for AG vs. GG, odds ratio = 0.80, 95% confidence interval: 0.65, 0.99; for AA vs. GG, odds ratio = 0.64, 95% confidence interval: 0.42, 0.98). An interaction with use of postmenopausal hormone therapy was significant (p = 0.02). The MMP2 rs2287074 A allele may be associated with a lower likelihood of ARM in older Caucasian women, particularly those who have never used hormone therapy. The role of MMP2 rs2287074 in ARM should be further elucidated.

A Head-tilt Test for Hypopyon After Intravitreal Triamcinolone

Retina (Philadelphia, Pa.). Apr, 2009  |  Pubmed ID: 19092731

Management of Sympathetic Ophthalmia with the Fluocinolone Acetonide Implant

Ophthalmology. Mar, 2009  |  Pubmed ID: 19147232

We examined whether implantation of the fluocinolone acetonide (Retisert) implant achieved control of inflammation and a reduced need for oral corticosteroids or immunosuppressives in patients with sympathetic ophthalmia (SO).

A New Macular Dystrophy with Anomalous Vascular Development, Pigment Spots, Cystic Spaces, and Neovascularization

Archives of Ophthalmology. Nov, 2009  |  Pubmed ID: 19901210

To clinically phenotype an inherited macular dystrophy with peculiar intraretinal pigment spots, cysts, and hemorrhage in a 24-year-old female proband and her family.

Erythropoetin Receptor Expression in the Human Diabetic Retina

BMC Research Notes. 2009  |  Pubmed ID: 19930719

Recent evidence suggests erythropoietin (EPO) and the erythropoietin receptor (EPOR) may play a direct role in the pathogenesis of diabetic retinopathy. Better characterization of the EPO-EPOR signaling system in the ischemic retina may offer a new therapeutic modality for ischemic ophthalmic diseases. This study was performed to identify EPOR mRNA expression in the human diabetic eye.

Effects of Vitrectomy on Age-related Macular Degeneration

Ophthalmology. Jul, 2010  |  Pubmed ID: 20176401

To determine whether vitrectomy alters the long-term progression of age-related macular degeneration (AMD).

Automated Early Detection of Diabetic Retinopathy

Ophthalmology. Jun, 2010  |  Pubmed ID: 20399502

To compare the performance of automated diabetic retinopathy (DR) detection, using the algorithm that won the 2009 Retinopathy Online Challenge Competition in 2009, the Challenge2009, against that of the one currently used in EyeCheck, a large computer-aided early DR detection project.

T-cell Infiltration in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy

Molecular Vision. 2010  |  Pubmed ID: 20596252

Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a familial blinding disease of unknown pathophysiology. The eyes and sera from patients with ADNIV were studied to understand the immune response in this condition.

Patients with an Acute Zonal Occult Outer Retinopathy-like Illness Rapidly Improve with Valacyclovir Treatment

American Journal of Ophthalmology. Oct, 2010  |  Pubmed ID: 20691421

To describe 3 cases of an acute zonal occult outer retinopathy-like illness responsive to valacyclovir hydrochloride.

Collagen XVIII Mutation in Knobloch Syndrome with Acute Lymphoblastic Leukemia

American Journal of Medical Genetics. Part A. Nov, 2010  |  Pubmed ID: 20799329

Knobloch syndrome (KNO) is caused by mutations in the collagen XVIII gene (COL18A1) and patients develop encephalocele and vitreoretinal degeneration. Here, we report an El Salvadorian family where two sisters showed features of KNO. One of the siblings also developed acute lymphoblastic leukemia. DNA sequencing of COL18A1 revealed a homozygous, 2-bp deletion (c3514-3515delCT) in exon 41, which leads to abnormal collagen XVIII and deficiency of its proteolytic cleavage product endostatin. KNO patients with mutations in COL18A1 may be at risk for endostatin-related conditions including malignancy.

Intravitreal Bevacizumab During Pregnancy

Retina (Philadelphia, Pa.). Oct, 2010  |  Pubmed ID: 20924262

To report the clinical course of four women treated with intravitreal bevacizumab during pregnancy.

Bilateral Intravitreal Injection of Antivascular Endothelial Growth Factor Therapy

Retina (Philadelphia, Pa.). Jan, 2011  |  Pubmed ID: 21187731

The purpose of this study was to review adverse events and patient preference after bilateral intravitreal injection of antibodies to vascular endothelial growth factor.

Intraoperative Choroidal Detachment During 23-gauge Vitrectomy

Retina (Philadelphia, Pa.). May, 2011  |  Pubmed ID: 21273944

To review intraoperative choroidal detachments during 23-gauge vitrectomy and examine possible mechanism(s) involved.

Mutations in Prickle Orthologs Cause Seizures in Flies, Mice, and Humans

American Journal of Human Genetics. Feb, 2011  |  Pubmed ID: 21276947

Epilepsy is heritable, yet few causative gene mutations have been identified, and thus far no human epilepsy gene mutations have been found to produce seizures in invertebrates. Here we show that mutations in prickle genes are associated with seizures in humans, mice, and flies. We identified human epilepsy patients with heterozygous mutations in either PRICKLE1 or PRICKLE2. In overexpression assays in zebrafish, prickle mutations resulted in aberrant prickle function. A seizure phenotype was present in the Prickle1-null mutant mouse, two Prickle1 point mutant (missense and nonsense) mice, and a Prickle2-null mutant mouse. Drosophila with prickle mutations displayed seizures that were responsive to anti-epileptic medication, and homozygous mutant embryos showed neuronal defects. These results suggest that prickle mutations have caused seizures throughout evolution.

Seroreactivity Against Aqueous-soluble and Detergent-soluble Retinal Proteins in Posterior Uveitis

Archives of Ophthalmology. Apr, 2011  |  Pubmed ID: 21482867

To characterize the seroreactivity against retinal proteins in patients with posterior uveitis, retinal disease of noninflammatory origin, and healthy controls.

Sutureless Triplanar Sclerotomy for 23-gauge Vitrectomy

Archives of Ophthalmology. May, 2011  |  Pubmed ID: 21555611

To describe and test the intraoperative integrity of triplanar sclerotomies.

Intravitreal Bevacizumab for Treatment of Proliferative and Nonproliferative Type 2 Idiopathic Macular Telangiectasia

Retina (Philadelphia, Pa.). Oct, 2011  |  Pubmed ID: 21610563

To determine the effect of treatment with intravitreal bevacizumab on retinal thickness and visual acuity in the nonproliferative and proliferative forms of Type 2 idiopathic macular telangiectasia.

Uveitis Following Intravitreal Bevacizumab: a Non-infectious Cluster

Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye. Jul-Aug, 2011  |  Pubmed ID: 21800802

In this retrospective case series, the authors report seven cases of bevacizumab-related uveitis that occurred within a 4-month period.

Automated Discovery and Quantification of Image-based Complex Phenotypes: a Twin Study of Drusen Phenotypes in Age-related Macular Degeneration

Investigative Ophthalmology & Visual Science. 2011  |  Pubmed ID: 22039249

Determining the relationships between phenotype and genotype of many disorders can improve clinical diagnoses, identify disease mechanisms, and enhance therapy. Most genetic disorders result from interaction of many genes that obscure the discovery of such relationships. The hypothesis for this study was that image analysis has the potential to enable formalized discovery of new visible phenotypes. It was tested in twins affected with age-related macular degeneration (AMD).

Correspondence

Retina (Philadelphia, Pa.). Feb, 2012  |  Pubmed ID: 22222759

Infrared Imaging and Optical Coherence Tomography Reveal Early-Stage Astrocytic Hamartomas Not Detectable by Fundoscopy

American Journal of Ophthalmology. Feb, 2012  |  Pubmed ID: 22310082

PURPOSE: To describe and correlate the features of astrocytic hamartomas using multimodal imaging. DESIGN: Prospective, noncomparative, observational case series. METHODS: This was a single-center study of 4 patients (8 eyes) with tuberous sclerosis complex. A complete ophthalmologic examination, fundus photography, fundus autofluorescence (FAF), infrared imaging, and spectral-domain optical coherence tomography (SD-OCT) were performed for each patient. Images from each modality were analyzed and compared. RESULTS: In 2 patients, infrared imaging and SD-OCT detected occult retinal astrocytic hamartomas that were not observed on clinical examination or color fundus photography. FAF demonstrated the greatest contrast between lesions and surrounding retina but failed to identify 1 occult lesion that was detected with infrared imaging and SD-OCT. SD-OCT revealed lesions arising from the retinal nerve fiber layer with overlying vitreous adhesions, hyperreflective dots, and optically empty spaces at all depths of the tumor. Hamartomas were hyporeflective on infrared imaging and hypoautofluorescent on FAF. FAF of some lesions demonstrated hyperautofluorescent spots. CONCLUSIONS: Infrared imaging and SD-OCT aid in the detection of astrocytic hamartomas that are not visible on clinical examination or color fundus photography. SD-OCT enhances visualization of structural details. FAF is a useful adjunctive test to obtain greater contrast between lesions and surrounding retina. The ability to monitor structural changes over time in astrocytic hamartomas using SD-OCT may be beneficial for monitoring the success of systemic chemotherapy in the treatment of various tuberous sclerosis tumors.