Xin Hu Group of "Biohybrid Neuroelectronics (BIONICS)" German Center for Neurodegenerative Diseases (DZNE) Biography Publications Institution JoVE Articles Xin Hu has not added a biography. If you are Xin Hu and would like to personalize this page please email our Author Liaison for assistance. Publications High-resolution CMOS-based Biosensor for Assessing Hippocampal Circuit Dynamics in Experience-dependent Plasticity Biosensors & Bioelectronics. Oct, 2023 | Pubmed ID: 37379793 Implementation of Biohybrid Olfactory Bulb on a High-density CMOS-chip to Reveal Large-scale Spatiotemporal Circuit Information Biosensors & Bioelectronics. Feb, 2022 | Pubmed ID: 34852985 Therapeutic Effects of a Small Molecule Agonist of the Relaxin Receptor ML290 in Liver Fibrosis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2019 | Pubmed ID: 31419161 Lead Optimization and Efficacy Evaluation of Quinazoline-based BET Family Inhibitors for Potential Treatment of Cancer and Inflammatory Diseases Bioorganic & Medicinal Chemistry Letters. May, 2019 | Pubmed ID: 30905542 Discovery of Novel Inhibitors of Human Galactokinase by Virtual Screening Journal of Computer-aided Molecular Design. Apr, 2019 | Pubmed ID: 30806949 A Large Scale High-throughput Screen Identifies Chemical Inhibitors of Phosphatidylinositol 4-kinase Type II Alpha Journal of Lipid Research. Mar, 2019 | Pubmed ID: 30626625 Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions Cell Chemical Biology. 02, 2019 | Pubmed ID: 30554914 Structure-Based Engineering of Irreversible Inhibitors Against Histone Lysine Demethylase KDM5A Journal of Medicinal Chemistry. 12, 2018 | Pubmed ID: 30392349 Discovery and Lead Identification of Quinazoline-based BRD4 Inhibitors Bioorganic & Medicinal Chemistry Letters. 11, 2018 | Pubmed ID: 30268702 KDM5 Histone Demethylases Repress Immune Response Via Suppression of STING PLoS Biology. 08, 2018 | Pubmed ID: 30080846 Optimization of the First Small-molecule Relaxin/insulin-like Family Peptide Receptor (RXFP1) Agonists: Activation Results in an Antifibrotic Gene Expression Profile European Journal of Medicinal Chemistry. Aug, 2018 | Pubmed ID: 30006176 Emetine Inhibits Zika and Ebola Virus Infections Through Two Molecular Mechanisms: Inhibiting Viral Replication and Decreasing Viral Entry Cell Discovery. 2018 | Pubmed ID: 29872540 High-throughput Screening Identified Selective Inhibitors of Exosome Biogenesis and Secretion: A Drug Repurposing Strategy for Advanced Cancer Scientific Reports. 05, 2018 | Pubmed ID: 29802284 In Vivo CRISPR Screening Unveils Histone Demethylase UTX As an Important Epigenetic Regulator in Lung Tumorigenesis Proceedings of the National Academy of Sciences of the United States of America. 04, 2018 | Pubmed ID: 29632194 Insights into the Action of Inhibitor Enantiomers Against Histone Lysine Demethylase 5A Journal of Medicinal Chemistry. 04, 2018 | Pubmed ID: 29537847 Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro The Journal of Pharmacology and Experimental Therapeutics. 01, 2018 | Pubmed ID: 29089368 Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH) Journal of Medicinal Chemistry. 11, 2017 | Pubmed ID: 29120638 Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus NsP2 Cysteine Protease Leads to a Self-Inhibited State Biochemistry. 11, 2017 | Pubmed ID: 29064679 Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle Journal of Medicinal Chemistry. 07, 2017 | Pubmed ID: 28636348 Synthetic Non-peptide Low Molecular Weight Agonists of the Relaxin Receptor 1 British Journal of Pharmacology. 05, 2017 | Pubmed ID: 27771940 High Throughput Cell-based Assay for Identification of Glycolate Oxidase Inhibitors As a Potential Treatment for Primary Hyperoxaluria Type 1 Scientific Reports. Sep, 2016 | Pubmed ID: 27670739 Cell-based High-throughput Screening Identifies Galactocerebrosidase Enhancers As Potential Small-molecule Therapies for Krabbe's Disease Journal of Neuroscience Research. 11, 2016 | Pubmed ID: 27638606 Efficacy and Mechanism of Action of Low Dose Emetine Against Human Cytomegalovirus PLoS Pathogens. 06, 2016 | Pubmed ID: 27336364 Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2016 | Pubmed ID: 27267852 CERAPP: Collaborative Estrogen Receptor Activity Prediction Project Environmental Health Perspectives. 07, 2016 | Pubmed ID: 26908244 Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists Biochemistry. Mar, 2016 | Pubmed ID: 26866459 Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection Journal of Medicinal Chemistry. Feb, 2016 | Pubmed ID: 26599718 Identification of Novel Anti-hepatitis C Virus Agents by a Quantitative High Throughput Screen in a Cell-based Infection Assay Antiviral Research. Dec, 2015 | Pubmed ID: 26515788 Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290 Frontiers in Endocrinology. 2015 | Pubmed ID: 26347712 High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors ACS Combinatorial Science. Oct, 2015 | Pubmed ID: 26332742 Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) Journal of Medicinal Chemistry. Aug, 2015 | Pubmed ID: 26207746 Repurposing of the Antihistamine Chlorcyclizine and Related Compounds for Treatment of Hepatitis C Virus Infection Science Translational Medicine. Apr, 2015 | Pubmed ID: 25855495 Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression Journal of Biomolecular Screening. Jun, 2015 | Pubmed ID: 25477201 Structural Insight into Exosite Binding and Discovery of Novel Exosite Inhibitors of Botulinum Neurotoxin Serotype A Through in Silico Screening Journal of Computer-aided Molecular Design. Jul, 2014 | Pubmed ID: 24958623 Discovery and Characterization of a G Protein-biased Agonist That Inhibits β-arrestin Recruitment to the D2 Dopamine Receptor Molecular Pharmacology. Jul, 2014 | Pubmed ID: 24755247 Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Cell Migration The Journal of Biological Chemistry. Jun, 2014 | Pubmed ID: 24755226 A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of Gsp PloS One. 2014 | Pubmed ID: 24667240 Discovery, Optimization, and Characterization of Novel D2 Dopamine Receptor Selective Antagonists Journal of Medicinal Chemistry. Apr, 2014 | Pubmed ID: 24666157 Structure-activity Relationship Studies and Biological Characterization of Human NAD(+)-dependent 15-hydroxyprostaglandin Dehydrogenase Inhibitors Bioorganic & Medicinal Chemistry Letters. Jan, 2014 | Pubmed ID: 24360556 Novel Cell-based Hepatitis C Virus Infection Assay for Quantitative High-throughput Screening of Anti-hepatitis C Virus Compounds Antimicrobial Agents and Chemotherapy. 2014 | Pubmed ID: 24277038 Disrupting Malaria Parasite AMA1-RON2 Interaction with a Small Molecule Prevents Erythrocyte Invasion Nature Communications. 2013 | Pubmed ID: 23907321 Identification and Optimization of Small-molecule Agonists of the Human Relaxin Hormone Receptor RXFP1 Nature Communications. 2013 | Pubmed ID: 23764525 Inhibitors of the Yersinia Protein Tyrosine Phosphatase Through High Throughput and Virtual Screening Approaches Bioorganic & Medicinal Chemistry Letters. Feb, 2013 | Pubmed ID: 23294700 Synthesis and Biological Evaluation of Analogues of the Kinase Inhibitor Nilotinib As Abl and Kit Inhibitors Bioorganic & Medicinal Chemistry Letters. Feb, 2013 | Pubmed ID: 23273517 Identification of Small-molecule Agonists of Human Relaxin Family Receptor 1 (RXFP1) by Using a Homogenous Cell-based CAMP Assay Journal of Biomolecular Screening. Jul, 2013 | Pubmed ID: 23212924 A High-throughput Screening Assay Using Krabbe Disease Patient Cells Analytical Biochemistry. Mar, 2013 | Pubmed ID: 23138179 Discovery of a Novel Noniminosugar Acid α Glucosidase Chaperone Series Journal of Medicinal Chemistry. Sep, 2012 | Pubmed ID: 22834902 Probing the Donor and Acceptor Substrate Specificity of the γ-Glutamyl Transpeptidase Biochemistry. Feb, 2012 | Pubmed ID: 22257032 Novel Patient Cell-based HTS Assay for Identification of Small Molecules for a Lysosomal Storage Disease PloS One. 2011 | Pubmed ID: 22216298 H4R3 Methylation Facilitates Beta-globin Transcription by Regulating Histone Acetyltransferase Binding and H3 Acetylation Blood. Mar, 2010 | Pubmed ID: 20068219 LSD1-mediated Epigenetic Modification is Required for TAL1 Function and Hematopoiesis Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19497860 Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology Brett Addison Emery*1, Shahrukh Khanzada*1, Xin Hu*1, Diana Klütsch1, Hayder Amin1,2,3 1Group of "Biohybrid Neuroelectronics (BIONICS)", German Center for Neurodegenerative Diseases (DZNE), 2Faculty of Medicine Carl Gustav Carus, Technical University Dresden, 3Dresden Center for Intelligent Materials (DCIM), Technical University Dresden JoVE 66473 Neuroscience Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods Xin Hu1, Jaimee R. Compton2, Patricia M. Legler2 1National Center for Advancing Translational Sciences, National Institutes of Health, 2United States Naval Research Laboratory JoVE 60421 Immunology and Infection
Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology Brett Addison Emery*1, Shahrukh Khanzada*1, Xin Hu*1, Diana Klütsch1, Hayder Amin1,2,3 1Group of "Biohybrid Neuroelectronics (BIONICS)", German Center for Neurodegenerative Diseases (DZNE), 2Faculty of Medicine Carl Gustav Carus, Technical University Dresden, 3Dresden Center for Intelligent Materials (DCIM), Technical University Dresden JoVE 66473 Neuroscience
Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods Xin Hu1, Jaimee R. Compton2, Patricia M. Legler2 1National Center for Advancing Translational Sciences, National Institutes of Health, 2United States Naval Research Laboratory JoVE 60421 Immunology and Infection
