Yuuki Imai Division of Integrative Pathophysiology, Proteo-Science Center Ehime University Biography Publications Institution JoVE Articles Yuuki Imai has not added a biography. If you are Yuuki Imai and would like to personalize this page please email our Author Liaison for assistance. Publications Periostin Increased by Mechanical Stress Upregulates Interleukin-6 Expression in the Ligamentum Flavum FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2023 | Pubmed ID: 36583686 Effect of Hormonal Therapy on the Otoconial Changes Caused by Estrogen Deficiency Scientific Reports. Dec, 2022 | Pubmed ID: 36585504 Deletion of Tfam in Prx1-Cre Expressing Limb Mesenchyme Results in Spontaneous Bone Fractures Journal of Bone and Mineral Metabolism. Sep, 2022 | Pubmed ID: 35947192 Induction of IPSC-derived Prg4-positive Cells with Characteristics of Superficial Zone Chondrocytes and Fibroblast-like Synovial Cells BMC Molecular and Cell Biology. Jul, 2022 | Pubmed ID: 35870887 Reduced Dynamic Loads Due to Hip Dislocation Induce Acetabular Cartilage Degeneration by IL-6 and MMP3 Via the STAT3/periostin/NF-κB Axis Scientific Reports. Jul, 2022 | Pubmed ID: 35842459 Epigenetic Regulator UHRF1 Orchestrates Proinflammatory Gene Expression in Rheumatoid Arthritis in a Suppressive Manner The Journal of Clinical Investigation. Jun, 2022 | Pubmed ID: 35472067 Uhrf1 Governs the Proliferation and Differentiation of Muscle Satellite Cells IScience. Mar, 2022 | Pubmed ID: 35243267 Novel Animal Model of Soft Tissue Tumor Due to Aberrant Hedgehog Signaling Activation in Pericyte Lineage Cell and Tissue Research. Apr, 2022 | Pubmed ID: 35072792 Histone H3K27 Demethylase, Utx, Regulates Osteoblast-to-osteocyte Differentiation Biochemical and Biophysical Research Communications. Jan, 2022 | Pubmed ID: 34974301 Macrophages Are Requisite for Angiogenesis of Type H Vessels During Bone Regeneration in Mice Bone. Jan, 2022 | Pubmed ID: 34534711 Estrogen Receptor α in Mature Osteoblasts Regulates the Late Stage of Bone Regeneration Biochemical and Biophysical Research Communications. Jun, 2021 | Pubmed ID: 33964733 Myofiber Androgen Receptor Increases Muscle Strength Mediated by a Skeletal Muscle Splicing Variant of Mylk4 IScience. Apr, 2021 | Pubmed ID: 33870126 Topical Co-administration of Zoledronate with Recombinant Human Bone Morphogenetic Protein-2 Can Induce and Maintain Bone Formation in the Bone Marrow Environment BMC Musculoskeletal Disorders. Jan, 2021 | Pubmed ID: 33472600 DNA Maintenance Methylation Enzyme Dnmt1 in Satellite Cells is Essential for Muscle Regeneration Biochemical and Biophysical Research Communications. Jan, 2021 | Pubmed ID: 33310192 Reprogramming of Synovial Macrophage Metabolism by Synovial Fibroblasts Under Inflammatory Conditions Cell Communication and Signaling : CCS. Nov, 2020 | Pubmed ID: 33256735 Estrogen Receptor β Controls Muscle Growth and Regeneration in Young Female Mice Stem Cell Reports. Sep, 2020 | Pubmed ID: 32822588 The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Sep, 2020 | Pubmed ID: 32777102 Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss International Journal of Molecular Sciences. Apr, 2020 | Pubmed ID: 32326611 Evaluation of the Structure of the Otoconial Layer Using Micro-computed Tomography Auris, Nasus, Larynx. Oct, 2020 | Pubmed ID: 32173170 GPRC5A Facilitates Cell Proliferation Through Cell Cycle Regulation and Correlates with Bone Metastasis in Prostate Cancer International Journal of Cancer. Mar, 2020 | Pubmed ID: 31276604 Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate International Journal of Molecular Sciences. Nov, 2019 | Pubmed ID: 31757091 Micro-CT Imaging Analysis for the Effects of Ibandronate and Eldecalcitol on Secondary Osteoporosis and Arthritis in Adjuvant-induced Arthritis Rats Biomedical Research (Tokyo, Japan). 2019 | Pubmed ID: 31597905 The E3 Ubiquitin Ligase MIB2 Enhances Inflammation by Degrading the Deubiquitinating Enzyme CYLD The Journal of Biological Chemistry. Sep, 2019 | Pubmed ID: 31366726 A Simple Mouse Model of Pericardial Adhesions Journal of Cardiothoracic Surgery. Jun, 2019 | Pubmed ID: 31253183 Fibroblast Growth Factor 9 Is Upregulated Upon Intervertebral Mechanical Stress-Induced Ligamentum Flavum Hypertrophy in a Rabbit Model Spine. Oct, 2019 | Pubmed ID: 31022154 The Effects of Resistance Training on Bone Mineral Density and Bone Quality in Type 2 Diabetic Rats Physiological Reports. 03, 2019 | Pubmed ID: 30916457 Zscan10 Suppresses Osteoclast Differentiation by Regulating Expression of Haptoglobin Bone. May, 2019 | Pubmed ID: 30771488 Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8 T Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2019 | Pubmed ID: 30626691 [ASBMR 2018 Report on Basic Research.] Clinical Calcium. 2019 | Pubmed ID: 30590367 Raman Spectroscopic Analysis to Detect Reduced Bone Quality After Sciatic Neurectomy in Mice Molecules (Basel, Switzerland). Nov, 2018 | Pubmed ID: 30477282 The Tumor Suppressor Menin Prevents Effector CD8 T-cell Dysfunction by Targeting MTORC1-dependent Metabolic Activation Nature Communications. Aug, 2018 | Pubmed ID: 30120246 Growth Plate-derived Hedgehog-signal-responsive Cells Provide Skeletal Tissue Components in Growing Bone Histochemistry and Cell Biology. Apr, 2018 | Pubmed ID: 29356962 DANFIN Functions As an Inhibitor of Transcription Factor NF-κB and Potentiates the Antitumor Effect of Bortezomib in Multiple Myeloma Biochemical and Biophysical Research Communications. 01, 2018 | Pubmed ID: 29284118 Uhrf1 is Indispensable for Normal Limb Growth by Regulating Chondrocyte Differentiation Through Specific Gene Expression Development (Cambridge, England). Jan, 2018 | Pubmed ID: 29180567 The HIV Co-receptor CCR5 Regulates Osteoclast Function Nature Communications. Dec, 2017 | Pubmed ID: 29263385 Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head Scientific Reports. Nov, 2017 | Pubmed ID: 29118346 [Calcium and Bone Metabolism Across Women's Life Stages. Molecular Mechanisms Underlying Bone Metabolism by Estrogen.] Clinical Calcium. 2017 | Pubmed ID: 28439051 The CUL3-SPOP-DAXX Axis is a Novel Regulator of VEGFR2 Expression in Vascular Endothelial Cells Scientific Reports. Feb, 2017 | Pubmed ID: 28216678 Hydroxylation of Methylated DNA by TET1 in Chondrocyte Differentiation of C3H10T1/2 Cells Biochemistry and Biophysics Reports. Mar, 2016 | Pubmed ID: 28955815 Local Co-application of Zoledronate Promotes Long-term Maintenance of Newly Formed Bone Induced by Recombinant Human Bone Morphogenetic Protein 2 Biochemical and Biophysical Research Communications. Nov, 2016 | Pubmed ID: 27746180 [Epigenetic Regulation by Androgen Receptor and Possible Function in Bone Metabolism] Clinical Calcium. Jul, 2016 | Pubmed ID: 27346313 Identification of Nedd9 As a TGF-β-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis PloS One. 2016 | Pubmed ID: 27336669 SFRP4-dependent Wnt Signal Modulation is Critical for Bone Remodeling During Postnatal Development and Age-related Bone Loss Scientific Reports. Apr, 2016 | Pubmed ID: 27117872 [Application of Big Data Analyses for Musculoskeletal Cell Differentiation] Clinical Calcium. Apr, 2016 | Pubmed ID: 27013628 Fatostatin, an SREBP Inhibitor, Prevented RANKL-induced Bone Loss by Suppression of Osteoclast Differentiation Biochimica Et Biophysica Acta. Nov, 2015 | Pubmed ID: 26319416 [Analysis of Musculoskeletal Systems and Their Diseases. Sex Hormone Receptors Dependent Gene Expression Mechanisms in Locomotive Tissues] Clinical Calcium. Aug, 2015 | Pubmed ID: 26224671 Aryl Hydrocarbon Receptor Catabolic Activity in Bone Metabolism is Osteoclast Dependent in Vivo Biochemical and Biophysical Research Communications. Jul, 2014 | Pubmed ID: 24938130 Pctaire1/Cdk16 Promotes Skeletal Myogenesis by Inducing Myoblast Migration and Fusion FEBS Letters. Aug, 2014 | Pubmed ID: 24931367 [Bone Metabolism by Sex Hormones and Gonadotropins] Clinical Calcium. Jun, 2014 | Pubmed ID: 24870831 Netrin-4 Derived from Murine Vascular Endothelial Cells Inhibits Osteoclast Differentiation in Vitro and Prevents Bone Loss in Vivo FEBS Letters. Jun, 2014 | Pubmed ID: 24846137 Nonmyocytic Androgen Receptor Regulates the Sexually Dimorphic Development of the Embryonic Bulbocavernosus Muscle Endocrinology. Jul, 2014 | Pubmed ID: 24742196 Identification of Novel Transcription Factors in Osteoclast Differentiation Using Genome-wide Analysis of Open Chromatin Determined by DNase-seq Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Aug, 2014 | Pubmed ID: 24677342 Estrogen Receptor α in Osteocytes Regulates Trabecular Bone Formation in Female Mice Bone. Mar, 2014 | Pubmed ID: 24333171 [Regulation of Bone Metabolisms by Estrogen/estrogen Receptors Signaling] Clinical Calcium. Nov, 2013 | Pubmed ID: 24162602 Novel Insights into Histone Modifiers in Adipogenesis Adipocyte. Oct, 2013 | Pubmed ID: 24052908 Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue (Video) | JoVE Noritaka Saeki1,2, Yuuki Imai2,3 1Division of Medical Research Support, Advanced Research Support Center, Ehime University, 2Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, 3Department of Pathophysiology, Graduate School of Medicine, Ehime University JoVE 65196 Biology
Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue (Video) | JoVE Noritaka Saeki1,2, Yuuki Imai2,3 1Division of Medical Research Support, Advanced Research Support Center, Ehime University, 2Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, 3Department of Pathophysiology, Graduate School of Medicine, Ehime University JoVE 65196 Biology