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Screening of β2 Integrin Activation Inhibitors in Human Neutrophils

February 2nd, 2024

Development of a Method for Identifying Small Molecular Antagonists of Î²2 Integrin Activation (Video) | JoVE

Development of a Method for Identifying Small Molecular Antagonists of Î²2 Integrin Activation (Video) | JoVE

00:45 min

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High-Throughput Screening of Compounds Using Neutrophils Isolated from Human Blood in a 384-Well Plate Format (Video) | JoVE

High-Throughput Screening of Compounds Using Neutrophils Isolated from Human Blood in a 384-Well Plate Format (Video) | JoVE

02:35 min

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Neutrophils Screening Assay Using Flow Cytometry (Video) | JoVE

Neutrophils Screening Assay Using Flow Cytometry (Video) | JoVE

01:03 min

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Ziming Cao¹, Matthew J. Garcia², Larry A. Sklar^2,3,4,5, Angela Wandinger-Ness^3,4, Zhichao Fan¹

¹Department of Immunology, School of Medicine, UConn Health, ²Center for Molecular Discovery, University of New Mexico Health Sciences Center, ³Comprehensive Cancer Center, University of New Mexico Health Sciences Center, ⁴Department of Pathology, University of New Mexico Health Sciences Center, ⁵Autophagy, Inflammation, & Metabolism (AIM) Center, University of New Mexico

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このプロトコルは人間の好中球のβ2インテグリンの活発化を禁じる低分子薬剤を識別するために流れのcytometryベースの、ハイスループットのスクリーニング方法を記述する。

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