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Automated Processor for Clinical-Scale CAR-T Cell Manufacturing

August 18th, 2023
1, 1, 2, 2, 2,3, 1,2,3, 1,3,4, 1,3,4
1Cell and Gene Therapy Laboratory, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, 2Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia, 3Perelman School of Medicine at the University of Pennsylvania, 4Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia

Summary
Automatic Translation

本文详细介绍了临床使用的嵌合抗原受体T细胞的制造过程，特别是使用能够进行病毒转导和T细胞培养的自动化细胞处理器。我们提供建议并描述在早期临床试验的工艺开发和实施过程中应考虑的陷阱。

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