JoVE Behavior documents observational and experimental techniques that seek to understand human and animal behavior. Work in this field includes analysis of genetic causes and physiological responses to internal or external stimuli as well as the implicated brain regions.
1Graduate Program in Neuroscience, Rutgers University, 2Department of Biomedical Engineering, Rutgers University, 3Center for Cognitive Science, Rutgers University, 4Department of Psychology, Rutgers University, 5Department of Computer Science, Rutgers University
It is unclear how top-down signals from the ventral visual stream affect movement. We developed a paradigm to test motor behavior towards a target on a 3D depth inversion illusion. Significant differences are reported in both deliberate, goal-directed movements and automatic actions under illusory and veridical viewing conditions.
Published April 16, 2014. Keywords: Behavior, vision for action, vision for perception, motor control, reach, grasp, visuomotor, ventral stream, dorsal stream, illusion, space perception, depth inversion
1Electrical and Computer Engineering, Michigan State University, 2Neuroscience Program, Michigan State University, 3Cognitive Science Program, Michigan State University
A fully automated protocol for rodent operant conditioning is proposed. The protocol relies on precise temporal control of behavioral events to investigate the extent to which this control influences neural activity underlying sensorimotor integration and cognitive control experiments.
Published April 15, 2014. Keywords: Behavior, operant conditioning, cognitive function, sensorimotor integration, decision making, Neurophysiology
1Department of Human Genetics, Leiden University Medical Center
The primary outcome measure in clinical trials for neuromuscular disorders is generally improved muscle function. Therefore, assessing the effect of potential therapeutic compounds on muscle performance pre clinically in mouse models is of great importance. We here describe several functional tests to address this.
Published March 27, 2014. Keywords: Behavior, Duchenne muscular dystrophy, neuromuscular disorders, outcome measures, functional testing, mouse model, grip strength, hanging test wire, hanging test grid, rotarod running, treadmill running
1Department of Psychology and Neuroscience, Baylor University, 2Institute of Biomedical Studies, Baylor University
In the following experiment we describe a protocol for trace fear conditioning in mice. This type of associative memory includes a trace period that separates the neutral stimulus and the unconditioned stimulus.
Published March 20, 2014. Keywords: Behavior, fear conditioning, learning, trace conditioning, memory, conditioned and unconditioned stimulus, neutral stimulus, amygdala-dependent learning
1Department of Psychiatry, University of Cambridge, 2Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, 3Cambridgeshire & Peterborough NHS Foundation Trust, University of Cambridge, 4West Anglia Comprehensive Local Research Network, Addenbrooke's Hospital
This article describes a set of methods for the measurement of food related motivation and food related goal values in humans.
Published March 19, 2014. Keywords: Behavior, Food reward, motivation, grip force, willingness to pay, subliminal motivation
1Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz
Persistent practice improves the precision of coordinated movements. Here we introduce a single-pellet reaching task, which is designed to assess the learning and memory of forelimb skill in mice.
Published March 4, 2014. Keywords: Behavior, mouse, neuroscience, motor skill learning, single-pellet reaching, forelimb movements, Learning and Memory
1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 2Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 3Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences
This article presents a protocol for a contextual and cued fear conditioning test using a video analyzing system to assess fear learning and memory in mice.
Published March 1, 2014. Keywords: Behavior, Fear, Learning, Memory, ImageFZ program, Mouse, contextual fear, cued fear
1Biomedical Sciences and Bond Life Sciences Center, University of Missouri, 2Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration
The dry-land Barnes maze is widely used to measure spatial navigation ability in response to mildly aversive stimuli. Over consecutive days, performance (e.g. latency to locate escape cage) of control subjects improves, indicative of normal learning and memory. Differences between rats and mice necessitate apparatus and methodology changes that are detailed here.
Published February 26, 2014. Keywords: Behavior, spatial navigation, rats, Peromyscus, mice, intra- and extra-maze cues, learning, memory, latency, search strategy, escape motivation
1Department of Psychology, Rutgers University, 2Department of Psychology, Koç University, 3Center for Neural Science, New York University, 4Department of Mathematics & Computer Science, Fairfield University
Fully automated system for measuring physiologically meaningful properties of the mechanisms mediating spatial localization, temporal localization, duration, rate and probability estimation, risk assessment, impulsivity, and the accuracy and precision of memory, in order to assess the effects of genetic and pharmacological manipulations on foundational mechanisms of cognition in mice.
Published February 26, 2014. Keywords: Behavior, genetics, cognitive mechanisms, behavioral screening, learning, memory, timing
1Department of Cognitive, Linguistic & Psychological Sciences, Brown University, 2Department of Neuroscience, Brown University
We describe protocols for training rats for chronic electrophysiological recordings in fully automated cognitive tasks on a Floor Projection Maze.
Published February 20, 2014. Keywords: Neurobiology, Rat behavioral tasks, visual discrimination, chronic electrophysiological recordings, Floor Projection Maze, neuropsychology, learning, memory