JoVE Behavior documents observational and experimental techniques that seek to understand human and animal behavior. Work in this field includes analysis of genetic causes and physiological responses to internal or external stimuli as well as the implicated brain regions.
1Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz
Persistent practice improves the precision of coordinated movements. Here we introduce a single-pellet reaching task, which is designed to assess the learning and memory of forelimb skill in mice.
Published March 4, 2014. Keywords: Behavior, mouse, neuroscience, motor skill learning, single-pellet reaching, forelimb movements, Learning and Memory
1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 2Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 3Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences
This article presents a protocol for a contextual and cued fear conditioning test using a video analyzing system to assess fear learning and memory in mice.
Published March 1, 2014. Keywords: Behavior, Fear, Learning, Memory, ImageFZ program, Mouse, contextual fear, cued fear
1Biomedical Sciences and Bond Life Sciences Center, University of Missouri, 2Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration
The dry-land Barnes maze is widely used to measure spatial navigation ability in response to mildly aversive stimuli. Over consecutive days, performance (e.g. latency to locate escape cage) of control subjects improves, indicative of normal learning and memory. Differences between rats and mice necessitate apparatus and methodology changes that are detailed here.
Published February 26, 2014. Keywords: Behavior, spatial navigation, rats, Peromyscus, mice, intra- and extra-maze cues, learning, memory, latency, search strategy, escape motivation
1Department of Psychology, Rutgers University, 2Department of Psychology, Koç University, 3Center for Neural Science, New York University, 4Department of Mathematics & Computer Science, Fairfield University
Fully automated system for measuring physiologically meaningful properties of the mechanisms mediating spatial localization, temporal localization, duration, rate and probability estimation, risk assessment, impulsivity, and the accuracy and precision of memory, in order to assess the effects of genetic and pharmacological manipulations on foundational mechanisms of cognition in mice.
Published February 26, 2014. Keywords: Behavior, genetics, cognitive mechanisms, behavioral screening, learning, memory, timing
1Department of Cognitive, Linguistic & Psychological Sciences, Brown University, 2Department of Neuroscience, Brown University
We describe protocols for training rats for chronic electrophysiological recordings in fully automated cognitive tasks on a Floor Projection Maze.
Published February 20, 2014. Keywords: Neurobiology, Rat behavioral tasks, visual discrimination, chronic electrophysiological recordings, Floor Projection Maze, neuropsychology, learning, memory
1Brain and Cognition, University of Amsterdam
Reading in color is a new method for training letter-color associations that are typically found only in grapheme-color synesthetes. It involves an implicit form of training that has potential for long-term associative training methods because the training is a byproduct of reading and any text can be colored.
Published February 20, 2014. Keywords: Behavior, synesthesia, training, learning, reading, vision, memory, cognition
1Friedrich Miescher Institute for Biomedical Research, 2Max Planck Institute of Neurobiology, 3Department of Biosystems Science and Engineering, ETH Zurich
Here we describe the experimental procedures involved in two-photon imaging of mouse cortex during behavior in a virtual reality environment.
Published February 20, 2014. Keywords: Behavior, Two-photon imaging, Virtual Reality, mouse behavior, adeno-associated virus, genetically encoded calcium indicators
1Department of Psychology, Rutgers, the State University of New Jersey, 2Neuronal Networks Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse
Implanting organized arrays of microwires for use in single-unit electrophysiological recordings presents a number of technical challenges. Methods for performing this technique and the equipment necessary are described. Also, the beneficial use of organized microwire arrays to record from distinct neural subregions with high spatial selectivity is discussed.
Published February 14, 2014. Keywords: Behavior, Single-unit Recordings, Electrophysiology, Microwire, Neurophysiology, Neural signaling
1Cluster of Excellence "Languages of Emotion", Freie Universität Berlin, 2Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 3Dahlem Institute for Neuroimaging of Emotion, Freie Universität Berlin, 4Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich
We tested the usability of a tablet-computer-based application (EmoCogMeter) in investigating the effects of age on cognition. Results show an age-related cognitive decline, thereby proving the usability of our application. Findings underline the great clinical and practical potential of a tablet-based application for detection and monitoring of cognitive dysfunction.
Published February 14, 2014. Keywords: Behavior, Neuropsychological Testing, cognitive decline, age, tablet-computer, memory, attention, executive functions
1Department of Psychology, University of Guelph
The current study evaluates a novel procedure for assessing the reinforcing effects of palatable solutions in laboratory rats: intraoral self-administration. To this end, operant responding (i.e. lever pressing) for intraoral infusions of sweet solutions at different concentrations was measured on continuous and progressive ratios schedules of reinforcement.
Published February 6, 2014. Keywords: Behavior, Administration, Oral, Conditioning, Operant, Reinforcement (Psychology), Reinforcement Schedule, Taste, Neurosciences, Intraoral infusions, operant chambers, self-administration, high fructose corn syrup, progressive ratio, breakpoint, addiction