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Keyword Search: Neuroscience

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RhoC GTPase Activation Assay

This protocol utilizes a pull down assay to determine the levels of active RhoC GTPase within cells.

Launch Video

Published: 08/22/2010

Michelle Lucey
Heather Unger
Kenneth L. van Golen

Department of Biological Sciences, The Center for Translational Cancer Research, University of Delaware

neuroscience, Issue 42, brain, mouse, transplantation, labeling

Novel Apparatus and Method for Drug Reinforcement

Operant drug self-administration and conditioned place preference (CPP) procedures are expansively used in research to model various components of drug reinforcement, consumption, and addiction in humans. In this report, we combined traditional CPP and self-administration methods as a novel approach to studying drug reinforcement and addiction in rats.

Launch Video

Published: 08/20/2010

Allison A. Feduccia
Christine L. Duvauchelle

College of Pharmacy, Division of Pharmacology and Toxicology, University of Texas, Austin

Neuroscience, Issue 42, conditioned place preference (CPP), self-administration, rat, behavioral neuroscience, drug reinforcement, cocaine, animal models

Simultaneous fMRI and Electrophysiology in the Rodent Brain

We have developed a method for simultaneous functional magnetic resonance imaging and electrophysiological recording in the rodent brain, providing a platform for the investigation of the relationship between neural activity and the blood oxygenation level dependent (BOLD) MRI signal.

Launch Video

Published: 08/19/2010

Wen-ju Pan^{1, 2}
Garth Thompson^{1, 2}
Matthew Magnuson^{1, 2}
Waqas Majeed^{1, 2}
Dieter Jaeger³
Shella Keilholz^{1, 2}

¹Biomedical Engineering, Emory University

²Biomedical Engineering, Georgia Institute of Technology

³Biology, Emory University

Neuroscience, Issue 42, fMRI, electrophysiology, rat, BOLD, brain, resting state

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Thorough preclinical testing of drugs that act in the central nervous system often involves assessing and comparing drug biodistribution in association with specific routes of administration. Here, three commonly used methods of systemic delivery (intravenous, intraperitoneal, and oral) as well as a method for local delivery (convection-enhanced delivery) are demonstrated in mice.

Launch Video

Published: 08/16/2010

Laura Serwer
Rintaro Hashizume
Tomoko Ozawa
C. David James

Department of Neurological Surgery, University of California, San Francisco

Neuroscience, Issue 42, mouse, in vivo optical imaging, preclinical, central nervous system, fluorescent imaging, convection-enhanced delivery, oral gavage, intravenous injection, intraperitoneal injection

Eye Movement Monitoring of Memory

Eye movement monitoring (or eye tracking) reveals where in space the eyes linger, when and for how long. Here, we demonstrate how eye tracking can be used to investigate the integrity of memory in multiple participant populations, without requiring verbal, or otherwise explicit, reports.

Launch Video

Published: 08/15/2010

Jennifer D. Ryan^{1, 2, 3}
Lily Riggs^{1, 3}
Doug McQuiggan¹

¹Rotman Research Institute

²Department of Psychiatry, University of Toronto

³Department of Psychology, University of Toronto

Neuroscience, Issue 42, eye movement monitoring, eye tracking, memory, aging, amnesia, visual processing

Double Fluorescence in situ Hybridization in Fresh Brain Sections

This protocol involves a non-radioactive in-situ hybridization procedure that enables the simultaneous identification of two transcript species, at a single cell resolution, in thin sections of the vertebrate brain.

Launch Video

Published: 08/14/2010

Jin Kwon Jeong¹
Zhuoxun Chen¹
Liisa A. Tremere¹
Raphael Pinaud^{1, 2}

¹Department of Brain and Cognitive Sciences, University of Rochester

²Center for Visual Science, University of Rochester

Neuroscience, Issue 42, Fluorescence in situ hybridization (FISH), double FISH (dFISH), digoxigenin, biotin, non-radioactive riboprobes, vertebrate brain

Human Fear Conditioning Conducted in Full Immersion 3-Dimensional Virtual Reality

Classical fear conditioning paradigm was adapted for human participants in a fully immersive virtual reality setting. Using a discrimination paradigm, conditioned fear, cue and context memory retention, and extinction was measured with skin conductance response to dynamic virtual snakes and spiders (the conditioned stimuli) in two distinct virtual contexts.

Launch Video

Published: 08/09/2010

Nicole C. Huff¹
David J. Zeilinski²
Matthew E. Fecteau¹
Rachael Brady²
Kevin S. LaBar¹

¹Center for Cognitive Neuroscience, Duke University

²Pratt School of Engineering, Duke University

JoVE Neuroscience, Issue 42, fear conditioning, virtual reality, human memory, skin conductance response, context learning

Labeling and Imaging Cells in the Zebrafish Hindbrain

Key to understanding the morphogenetic processes that shape the early embryo is the ability to image cells at high resolution. We describe here a technique for labeling single cells or small clusters of cells in whole zebrafish embryos with membrane-targeted Green Fluorescent Protein.

Launch Video

Published: 07/25/2010

Pradeepa Jayachandran¹
Elim Hong²
Rachel Brewster²

¹Center for Neuroscience, Children’s National Medical Center

²Department of Biological Sciences, University of Maryland Baltimore County

JoVE Neuroscience, Issue 41, development, zebrafish, embryo, brain, neural tube, microinjection, sectioning, time-lapse microscopy, confocal microscopy

Basics of Multivariate Analysis in Neuroimaging Data

The current article describes the basics of multivariate analysis and contrasts it to the more commonly used voxel-wise univariate analysis. Both types of analysis are applied to a clinical-neuroscience data set. Supplementary split-half simulations show better replication of the multivariate results in independent data sets.

Launch Video

Published: 07/24/2010

Christian Georg Habeck

Department of Neurology, Columbia University

JoVE Neuroscience, Issue 41, fMRI, PET, multivariate analysis, cognitive neuroscience, clinical neuroscience

Assessment of Ultrasonic Vocalizations During Drug Self-administration in Rats

Drug self-administration and ultrasonic vocalizations (USV) are used as behavioral assessments in animal research, but rarely in combination. The purpose of this article is to describe the advantages of recording USVs during drug self-administration procedures to assess affective responses to drug experience.

Launch Video

Published: 07/22/2010

Esther Y. Maier^{1, 2}
Sean T. Ma³
Allison Ahrens^{2, 4}
Timothy J. Schallert^{2, 4, 5}
Christine L. Duvauchelle^{1, 2, 4}

¹College of Pharmacy, Division of Pharmacology and Toxicology, University of Texas at Austin

²The Waggoner Center of Addiction and Alcohol Research, University of Texas at Austin

³Department of Psychology, University of Michigan

⁴Institute for Neuroscience, University of Texas at Austin

⁵Department of Psychology, University of Texas at Austin

JoVE Neuroscience, Issue 41, ultrasound, behavior, self-administration, emotionality, anticipation, reward

Page:1 2 3 4 5 6 7 8 9 10

Total: 176 articles.

Search results for 9/2/2010 11:05:35 AM

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Journal of Visualized Experiments (JoVE) is an online research journal employing visualization to increase reproducibility and transparency in biological sciences.

ISSN 1940-087X

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