Journal of Visualized Experiments

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Keyword Search: Neuroscience

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Video Articles

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This protocol utilizes a pull down assay to determine the levels of active RhoC GTPase within cells.
Launch Video

    Published: 08/22/2010

Michelle Lucey
Heather Unger
Kenneth L. van Golen

Department of Biological Sciences, The Center for Translational Cancer Research, University of Delaware

 

Operant drug self-administration and conditioned place preference (CPP) procedures are expansively used in research to model various components of drug reinforcement, consumption, and addiction in humans. In this report, we combined traditional CPP and self-administration methods as a novel approach to studying drug reinforcement and addiction in rats.
Launch Video

    Published: 08/20/2010

Allison A. Feduccia
Christine L. Duvauchelle

College of Pharmacy, Division of Pharmacology and Toxicology, University of Texas, Austin

 

We have developed a method for simultaneous functional magnetic resonance imaging and electrophysiological recording in the rodent brain, providing a platform for the investigation of the relationship between neural activity and the blood oxygenation level dependent (BOLD) MRI signal.
Launch Video

    Published: 08/19/2010

Wen-ju Pan1, 2
Garth Thompson1, 2
Matthew Magnuson1, 2
Waqas Majeed1, 2
Dieter Jaeger3
Shella Keilholz1, 2

1Biomedical Engineering, Emory University

2Biomedical Engineering, Georgia Institute of Technology

3Biology, Emory University

 

Thorough preclinical testing of drugs that act in the central nervous system often involves assessing and comparing drug biodistribution in association with specific routes of administration. Here, three commonly used methods of systemic delivery (intravenous, intraperitoneal, and oral) as well as a method for local delivery (convection-enhanced delivery) are demonstrated in mice.
Launch Video

    Published: 08/16/2010

Laura Serwer
Rintaro Hashizume
Tomoko Ozawa
C. David James

Department of Neurological Surgery, University of California, San Francisco

 

Eye movement monitoring (or eye tracking) reveals where in space the eyes linger, when and for how long. Here, we demonstrate how eye tracking can be used to investigate the integrity of memory in multiple participant populations, without requiring verbal, or otherwise explicit, reports.
Launch Video

    Published: 08/15/2010

Jennifer D. Ryan1, 2, 3
Lily Riggs1, 3
Doug McQuiggan1

1Rotman Research Institute

2Department of Psychiatry, University of Toronto

3Department of Psychology, University of Toronto

 

This protocol involves a non-radioactive in-situ hybridization procedure that enables the simultaneous identification of two transcript species, at a single cell resolution, in thin sections of the vertebrate brain.
Launch Video

    Published: 08/14/2010

Jin Kwon Jeong1
Zhuoxun Chen1
Liisa A. Tremere1
Raphael Pinaud1, 2

1Department of Brain and Cognitive Sciences, University of Rochester

2Center for Visual Science, University of Rochester

 

Classical fear conditioning paradigm was adapted for human participants in a fully immersive virtual reality setting. Using a discrimination paradigm, conditioned fear, cue and context memory retention, and extinction was measured with skin conductance response to dynamic virtual snakes and spiders (the conditioned stimuli) in two distinct virtual contexts.
Launch Video

    Published: 08/09/2010

Nicole C. Huff1
David J. Zeilinski2
Matthew E. Fecteau1
Rachael Brady2
Kevin S. LaBar1

1Center for Cognitive Neuroscience, Duke University

2Pratt School of Engineering, Duke University

 

Key to understanding the morphogenetic processes that shape the early embryo is the ability to image cells at high resolution. We describe here a technique for labeling single cells or small clusters of cells in whole zebrafish embryos with membrane-targeted Green Fluorescent Protein.
Launch Video

    Published: 07/25/2010

Pradeepa Jayachandran1
Elim Hong2
Rachel Brewster2

1Center for Neuroscience, Children’s National Medical Center

2Department of Biological Sciences, University of Maryland Baltimore County

 

The current article describes the basics of multivariate analysis and contrasts it to the more commonly used voxel-wise univariate analysis. Both types of analysis are applied to a clinical-neuroscience data set. Supplementary split-half simulations show better replication of the multivariate results in independent data sets.
Launch Video

    Published: 07/24/2010

Christian Georg Habeck

Department of Neurology, Columbia University

 

Drug self-administration and ultrasonic vocalizations (USV) are used as behavioral assessments in animal research, but rarely in combination. The purpose of this article is to describe the advantages of recording USVs during drug self-administration procedures to assess affective responses to drug experience.
Launch Video

    Published: 07/22/2010

Esther Y. Maier1, 2
Sean T. Ma3
Allison Ahrens2, 4
Timothy J. Schallert2, 4, 5
Christine L. Duvauchelle1, 2, 4

1College of Pharmacy, Division of Pharmacology and Toxicology, University of Texas at Austin

2The Waggoner Center of Addiction and Alcohol Research, University of Texas at Austin

3Department of Psychology, University of Michigan

4Institute for Neuroscience, University of Texas at Austin

5Department of Psychology, University of Texas at Austin

 

 

Page:1 10 

 

Total: 176 articles.

 

Search results for 9/2/2010 11:05:35 AM

 

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Journal of Visualized Experiments (JoVE) is an online research journal employing visualization to increase reproducibility and transparency in biological sciences.

 

ISSN 1940-087X

 

 

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