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Consent Forms: Documents describing a medical treatment or research project, including proposed procedures, risks, and alternatives, that are to be signed by an individual, or the individual's proxy, to indicate his/her understanding of the document and a willingness to undergo the treatment or to participate in the research.
 JoVE Medicine

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

1Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, 2Center for Brain Health, Cleveland Clinic Foundation, 3Quantitative Health Sciences, Cleveland Clinic Foundation, 4Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation


JoVE 51318

 Science Education: Essentials of Experimental Psychology

The Simple Experiment: Two-group Design

JoVE Science Education

Source: Laboratories of Gary Lewandowski, Dave Strohmetz, and Natalie Ciarocco—Monmouth University

A two-group design is the simplest way to establish a cause-effect relationship between two variables. This video demonstrates a simple experiment (two-group design).  In providing an overview of how a researcher conducts a simple experiment (two-group design), this video shows viewers the process of turning ideas into testable ideas and forming hypothesis, the identification and effect of experiment variables, the formation of experimental conditions and controls, the process of conducting the study, the collection of results, and the consideration their implications. This research technique is demonstration in the context of answering the research question: “How does physiological arousal/excitement influence perceived attraction?”

 Science Education: Essentials of Neuropsychology

Anterograde Amnesia

JoVE Science Education

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California

Anterograde amnesia is the loss of the ability to form new memories. This can be distinguished from retrograde amnesia, which is the loss of old memories. Anterograde amnesia can result from damage to structures in the brain that are involved in the formation of new memories. Patients who have damage to the structures of the medial temporal lobe, including the hippocampus, amygdala, and the surrounding cortices, often have severe deficits in the formation of certain kinds of memories. These cases can be informative as to how memory is organized in the brain, and how different systems support different kinds of memories. In this video, we will test a patient with medial temporal lobe damage on a series of memory tasks designed to distinguish between different forms of memory. First, we will test short-term or working memory, which is the process we use to keep information in mind temporarily. Next, we will test two different forms of long-term memory: explicit and implicit memory. Explicit memories are conscious and easy to verbalize. For example, memories of facts or episodes from our lives are explicit memories. We can easily tell someone what we ate for breakfast, or what city is the capital of

 JoVE Medicine

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

1Chemical and Physical Biology Program, Vanderbilt University, 2Department of Physical Medicine and Rehabilitation, Vanderbilt University School of Medicine, 3Radiology & Radiological Sciences, Vanderbilt University Medical Center, 4Department of Pharmacology, Vanderbilt University


JoVE 52415

 Science Education: Essentials of Experimental Psychology

Ethics in Psychology Research

JoVE Science Education

Source: Laboratories of Gary Lewandowski, Dave Strohmetz, and Natalie Ciarocco—Monmouth University

When a researcher finds an interesting topic to study such as aggression, the goal is often to study it in a way that is as true to life as possible. However, researchers must act in an ethical manner.  To do this, they must balance their research goals with the best interests of the participants. Ethics often enter into the planning process when researchers identify all of the ways they can manipulate or measure a variable, but then make their final decision based on how they should manipulate or measure a variable. After receiving a poor grade on a test or paper, a college student may appear to take it out on (i.e., act in an aggressive manner toward) their roommates by being mean or nasty, screaming, throwing things, or even becoming physically violent. Aggression is an important human behavior to study and understand due to the implications it has for interpersonal violence. However, for safety reasons, a study cannot expose participants to the risk that serious types of violence presents. As a result, researchers must identify similar but benign behaviors that can help us understand more aggressive behaviors without harming participants.

 Science Education: Essentials of Experimental Psychology

The Multi-group Experiment

JoVE Science Education

Source: Laboratories of Gary Lewandowski, Dave Strohmetz, and Natalie Ciarocco—Monmouth University

A multi-group design is an experimental design that has 3 or more conditions/groups of the same independent variable. This video demonstrates a multi-group experiment that examines how different interethnic ideologies (multiculturalism and color-blind) influence feelings about diversity and actions toward and out-group member. In providing an overview of how a researcher conducts a multi-group experiment, this video shows viewers how to distinguish levels in variables, common types of conditions/groups to use (including placebo and empty-control conditions/groups), the process of conducting the study, the collection of results, and the consideration of their implications.   

 Science Education: Essentials of Experimental Psychology

Self-report vs. Behavioral Measures of Recycling

JoVE Science Education

Source: Laboratories of Gary Lewandowski, Dave Strohmetz, and Natalie Ciarocco—Monmouth University

One of the challenges in measuring an experimental variable is identifying the technique that will produce the more accurate measurement. The most common way to measure a dependent variable is self-report—asking the participant to describe his/her feelings, thoughts, or behaviors. Yet, people may not be honest. To truly know something about a participant, it may be necessary to see what they actually do in a situation. This video uses a multi-group experiment to see if feeling close to others results in more favorable attitudes toward environmental consciousness measured both by self-report and behavioral observation. Psychological studies often use higher sample sizes than studies in other sciences. A large number of participants helps to better ensure that the population under study is better represented, i.e., the margin of error accompanied by studying human behavior is sufficiently accounted for. In this video, we demonstrate this experiment using just one participant. However, as represented in the results, we used a total of 186 participants to reach the experiment’s conclusions.

 Science Education: Essentials of Neuropsychology

Using Diffusion Tensor Imaging in Traumatic Brain Injury

JoVE Science Education

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California

Traditional brain imaging techniques using MRI are very good at visualizing the gross structures of the brain. A structural brain image made with MRI provides high contrast of the borders between gray and white matter, and information about the size and shape of brain structures. However, these images do not detail the underlying structure and integrity of white matter networks in the brain, which consist of axon bundles that interconnect local and distant brain regions. Diffusion MRI uses pulse sequences that are sensitive to the diffusion of water molecules. By measuring the direction of diffusion, it is possible to make inferences about the structure of white matter networks in the brain. Water molecules within an axon are constrained in their movements by the cell membrane; instead of randomly moving in every direction with equal probability (isotropic movement), they are more likely to move in certain directions, in parallel with the axon (anisotropic movement; Figure 1). Therefore, measures of diffusion anisotropy are thought to reflect properties of the white matter such as fiber density, axon thickness, and degree of myelination. One common measure is fractional anisotropy

 Science Education: Essentials of Neuropsychology

The Split Brain

JoVE Science Education

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California

The study of how damage to the brain affects cognitive functioning has historically been one of the most important tools for cognitive neuroscience. While the brain is one of the most well protected parts of the body, there are many events that can affect the functioning of the brain. Vascular issues, tumors, degenerative diseases, infections, blunt force traumas, and neurosurgery are just some of the underlying causes of brain damage, all of which may produce different patterns of tissue damage that affect brain functioning in different ways. The history of neuropsychology is marked by several well-known cases that led to advances in the understanding of the brain. For instance, in 1861 Paul Broca observed how damage to the left frontal lobe resulted in aphasia, an acquired language disorder. As another example, a great deal about memory has been learned from patients with amnesia, such as the famous case of Henry Molaison, known for many years in the neuropsychology literature as "H.M.," whose temporal lobe surgery led to a profound deficit in forming certain kinds of new memories. While the observation and testing of patients with focal brain damage has provi

 Science Education: Essentials of Neuropsychology

Executive Function in Autism Spectrum Disorder

JoVE Science Education

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California

Attention, working-memory, planning, impulse control, inhibition, and mental flexibility are important components of human cognition that are often referred to as executive functions. Autism spectrum disorder is a developmental disorder that is characterized by impairments in social interaction, communication, and repetitive behaviors. It is a disorder that lasts a lifetime, and is thought to affect 0.6% of the population. The symptoms of autism suggest a deficit in executive function, which may be assessed by specialized neuropsychological tests. By employing several tests that each emphasize different aspects of executive function, we can gain a more complete picture of the cognitive profile of the disorder. One such task, known as the Wisconsin Card Sorting Test (WCST), is a cognitively complex task used widely in research and clinical studies as a highly sensitive measure of deficits in executive function. It tests a person's ability to shift attention and tests their flexibility with changing rules and reinforcement.1 In the WCST, a participant is presented with four stimulus cards, incorporating three stimulus parameters: color, shape, and number. The participant is asked to sort

 Science Education: Essentials of Neuropsychology

Measuring Grey Matter Differences with Voxel-based Morphometry: The Musical Brain

JoVE Science Education

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California

Experience shapes the brain. It is well understood that our brains are different as a result of learning. While many experience-related changes manifest themselves at the microscopic level, for example by neurochemical adjustments in the behavior of individual neurons, we may also examine anatomical changes to the structure of the brain at a macroscopic level. One famous example of this kind of change comes from the case of the London taxi drivers, who along with learning the complex routes of the city show larger volume in the hippocampus, a brain structure known to play a role in navigational memory.1 Many traditional methods of examining brain anatomy require painstaking tracing of anatomical regions of interest in order to measure their size. However, using modern neuroimaging techniques, we can now compare the anatomy of the brains across groups of people using automated algorithms. While these techniques do not avail themselves of the sophisticated knowledge that human neuroanatomists may bring to the task, they are quick, and sensitive to very small differences in anatomy. In a structural magnetic resonance image of the brain, the intensity of each volumetric pixel, or voxel, relat

 JoVE Medicine

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

1iC42 Clinical Research and Development, University of Colorado, Anschutz Medical Campus, 2Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, 3Food and Drug Administration (FDA), Center of Drug Evaluation Research - Office of Generic Drugs, 4Transplant Clinical Research, University of Cincinnati


JoVE 52424

 Science Education: Essentials of Neuropsychology

Visual Attention: fMRI Investigation of Object-based Attentional Control

JoVE Science Education

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel— University of Southern California

The human visual system is incredibly sophisticated and capable of processing large amounts of information very quickly. However, the brain's capacity to process information is not an unlimited resource. Attention, the ability to selectively process information that is relevant to current goals and to ignore information that is not, is therefore an essential part of visual perception. Some aspects of attention are automatic, while others are subject to voluntary, conscious control. In this experiment we explore the mechanisms of voluntary, or "top-down" attentional control on visual processing. This experiment leverages the orderly organization of visual cortex to examine how top-down attention can selectively modulate the processing of visual stimuli. Certain regions of the visual cortex appear to be specialized for processing specific visual items. Specifically, work by Kanwisher et al.1 has identified an area in the fusiform gyrus of the inferior temporal lobe that is significantly more active when subjects view faces compared to when they observe other common objects. This area has come to be known as the Fusiform Face Area (FFA). Another brain region, known as the Para

 Science Education: Essentials of Neuropsychology

Event-related Potentials and the Oddball Task

JoVE Science Education

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California

Given the overwhelming amount of information captured by the sensory organs, it is crucial that the brain is able to prioritize the processing of certain stimuli, to spend less effort on what might not be currently important and to attend to what is. One heuristic the brain uses is to ignore stimuli that are frequent or constant in favor of stimuli that are unexpected or unique. Therefore, rare events tend to be more salient and capture our attention. Furthermore, stimuli that are relevant to our current behavioral goals are prioritized over those that are irrelevant. The neurophysiological correlates of attention have been experimentally examined through the use of the oddball paradigm. Originally introduced in 1975, the oddball task presents the participant with a sequence of repetitive audio or visual stimuli, infrequently interrupted by an unexpected stimulus.1 This interruption by a target stimulus has been shown to elicit specific electrical events that are recordable at the scalp known as event-related potentials (ERPs). An ERP is the measured brain response resulting from a specific sensory, cognitive, or motor event. ERPs are measured using electroencephalography (EEG), a noninv

 Science Education: Essentials of Neuropsychology

Language: The N400 in Semantic Incongruity

JoVE Science Education

Source: Laboratories of Sarah I. Gimbel and Jonas T. Kaplan— University of Southern California

Understanding language is one of the most complex cognitive tasks that humans are capable of. Given the incredible amount of possible choices when combining individual words to form meaning in sentences, it is crucial that the brain is able to identify when words form coherent combinations and when an anomaly appears that undermines meaning. Extensive research has shown that certain scalp-recorded electrical events are sensitive to deviations in this kind of expectation. Importantly, these electrical signatures of incongruity are specific to unexpected meanings, and are therefore different from the brain's general responses to other kinds of anomalies. The neurophysiological correlates of semantic incongruity have been experimentally examined through the use of paradigms that present semantically congruent and incongruent ends to sentences. Originally introduced in 1980, the semantic incongruity task presents the participant with a series of sentences that end with either a congruent or incongruent word. To test that the response is from semantic incongruity and not more generally due to surprise, some sentences included words presented in a different size.1 The semantically incongrue

 JoVE Medicine

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

1Department of Cancer Biology, Dana-Farber Cancer Institute, 2Department of Pediatrics, Children's Hospital, 3Department of Biostatistics & Computational Biology, Dana-Farber Cancer Institute, 4Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem, 5Department of Neurosurgery, Children's Hospital, 6Center for Molecular Oncologic Pathology, Department of Medical Oncology, Dana-Farber Cancer Institute


JoVE 53304

 Science Education: Essentials of Neuropsychology

Decoding Auditory Imagery with Multivoxel Pattern Analysis

JoVE Science Education

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California

Imagine the sound of a bell ringing. What is happening in the brain when we conjure up a sound like this in the "mind's ear?" There is growing evidence that the brain uses the same mechanisms for imagination that it uses for perception.1 For example, when imagining visual images, the visual cortex becomes activated, and when imagining sounds, the auditory cortex is engaged. However, to what extent are these activations of sensory cortices specific to the content of our imaginations? One technique that can help to answer this question is multivoxel pattern analysis (MPVA), in which functional brain images are analyzed using machine-learning techniques.2-3 In an MPVA experiment, we train a machine-learning algorithm to distinguish among the various patterns of activity evoked by different stimuli. For example, we might ask if imagining the sound of a bell produces different patterns of activity in auditory cortex compared with imagining the sound of a chainsaw, or the sound of a violin. If our classifier learns to tell apart the brain activity patterns produced by these three stimuli, then we can conclude that the auditory cortex is activated in a distinct

 Science Education: Essentials of Experimental Psychology

Manipulating an Independent Variable through Embodiment

JoVE Science Education

Source: Laboratories of Gary Lewandowski, Dave Strohmetz, and Natalie Ciarocco—Monmouth University

In any experiment, the researcher attempts to manipulate participants in one group to have different thoughts, experiences, or feelings than the other groups in the study.  Some manipulations are overt, while others can be quite subtle. Embodiment is a growing research area focused on the theory that subtle physical experiences can unconsciously influence a person’s thoughts. For example if a person physically smiles, it often leads to elevated mood. That is, the physical experience of smiling changes the way a person feels. This video uses a two-group experiment to see if the physical sensation of weight will lead people to be stricter by giving harsher forms of discipline to fellow students who violated campus policies. 

 JoVE Neuroscience

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

1Department of Neurosurgery, Columbia University Medical Center, New York Presbyterian Hospital, 2Department of Neurology, Columbia University Medical Center, New York Presbyterian Hospital, 3Columbia University Medical Center, New York Presbyterian Hospital, 4School of Medicine, King's College London


JoVE 52773

 JoVE In-Press

Measurement of Differentially Methylated INS DNA Species in Human Serum Samples As a Biomarker of Islet β Cell Death

1Department of Pediatrics, IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine, 2Department of Pediartics, Omaha Children's Hospital and Medical Center, University of Nebraska Medical Center, 3Departments of Biochemistry and Molecular Biology, Medicine, and Cellular and Integrative Physiology, IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine, 4Indiana Biosciences Research Institute

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JoVE 54838

 JoVE Cancer Research

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

1Department of Surgery and Translational Medicine (DCMT), University of Florence, 2Neurofarba Department, University of Florence, 3Department of Traumatology and General Orthopedics, Azienda Ospedaliera Universitaria Careggi


JoVE 53884

 JoVE Behavior

Using Fiberless, Wearable fNIRS to Monitor Brain Activity in Real-world Cognitive Tasks

1Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, University College London, 2Infrared Imaging Lab, Institute for Advanced Biomedical Technology (ITAB), Department of Neuroscience, Imaging and Clinical Sciences, University of Chieti-Pescara, 3Institute of Cognitive Neuroscience, Alexandra House, University College London


JoVE 53336

 JoVE Immunology and Infection

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

1Charité Center for Internal Medicine and Dermatology, Division General Internal and Psychosomatic Medicine, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, 2Department of Internal Medicine, Institute of Neurogastroenterology and Motility, Martin-Luther Hospital, Academic Teaching Institution of Charité Universitätsmedizin Berlin, 3Department of Hepatology and Gastroenterology, Molecular Cancer Research Center (MKFZ), Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin


JoVE 53959

 Science Education: Essentials of Experimental Psychology

Realism in Experimentation

JoVE Science Education

Source: Laboratories of Gary Lewandowski, Dave Strohmetz, and Natalie Ciarocco—Monmouth University

In an ideal world researchers would conduct their studies in real world settings where behaviors naturally happen. For example, if you want to see what influences individuals’ voting behavior, it would be best to watch them vote. However, research in these settings is not always ethical or even practical. Further, a researcher may want more control over the setting to better pinpoint the exact variables that are influencing an outcome.  When researchers need to conduct studies in a lab, they try to optimize mundane realism, which means that they do everything they can to make the lab feel like a real-life experience. This video demonstrates a two-group design that examines how researchers use mundane realism in a lab to determine whether positive restaurant reviews are connected to diners’ level of tipping. Psychological studies often use higher sample sizes than studies in other sciences. A large number of participants helps to ensure that the population under study is better represented and the margin of error accompanied by studying human behavior is sufficiently accounted for. In this vid

 Science Education: Essentials of Experimental Psychology

Observational Research

JoVE Science Education

Source: Laboratories of Gary Lewandowski, Dave Strohmetz, and Natalie Ciarocco—Monmouth University

If you want to know how someone thinks or feels, you can ask that person questions.  Another approach is to observe how the person is acting or look for indicators of how they acted in the past. While observations may seem revealing, it isn’t always easy to know if they are truly accurate. For instance, you may see a person smiling and assume they are happy, when in reality they are annoyed and merely being polite. The purpose of science is to move beyond an individual’s own views of the self because they are inherently skewed by that individual’s expectations, previous experience, personal biases, motivations, emotions, etc. While a person may have unique insight into one’s self, these insight may not accurately represent reality. Put more simply, what a person says, does not always match up well with what they actually do. For this reason, researchers should incorporate a variety of measures (e.g., asking participants to report how they feel, but also observing actual behavior) in order to more accurately capture how the person truly feels. This video demonstrates a correlational des

 JoVE Behavior

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

1Institute of Statistical Science, Academia Sinica, 2Max Planck Institute for Human Cognitive and Brain Sciences, 3Department of Psychology, Fo Guang University, 4Department of Electrical Engineering, Fu Jen Catholic University, 5State Research Institute of Physiology and Basic Medicine, 6Novosibirsk State University, 7Imaging Research Center, Taipei Medical University


JoVE 53962

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