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 JoVE Medicine

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

1The Perinatal Research Unit, Department of Pediatrics, Institute of Clinical Medicine, Aarhus University Hospital, 2Department of Otorhinolaryngology and Head & Neck Surgery, Institute of Clinical Medicine, Aarhus University Hospital


JoVE 52454

Hypoxic-ischemic encephalopathy following perinatal asphyxia can be studied using animal models. We demonstrate the procedures necessary for establishing a piglet model of neonatal hypoxic-ischemic encephalopathy.

 JoVE Biology

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia

1Department of Neurology and Neurological Sciences, Stanford University School of Medicine


JoVE 955

The postnatal rat model for hypoxic-ischemic brain injury is a well-established model of human neonatal hypoxic ischemic encephalopathy (HIE). In this article, we describe the model of HIE in post-natal rat pups.

 JoVE Medicine

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

1Department of Pediatrics, Division of Neurology, The Emory University School of Medicine


JoVE 52978

Thromboembolic stroke models are vital tools for optimizing the recanalization therapy. Here we report a murine thrombotic stroke model based on transient cerebral hypoxic-ischemic (tHI) insult, which triggers thrombosis and infarction, and responds favorably to tissue plasminogen activator (tPA)-mediated fibrinolysis in a therapeutic window similar to those in stroke patients.

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