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Medicine

כימות decrements קוגניטיבי נגרמת על ידי הקרנות גולגולתי

Published: October 18, 2011 doi: 10.3791/3108

References

  1. Abayomi, O. K. Pathogenesis of irradiation-induced cognitive dysfunction. Acta. Oncol. 35, 659-663 (1996).
  2. Anderson, V. A., Godber, T., Smibert, E., Weiskop, S., Ekert, H. Cognitive and academic outcome following cranial irradiation and chemotherapy in children: a longitudinal study. Br. J. Cancer. 82, 255-262 (2000).
  3. Acharya, M. M. Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 106, 19150-19155 (2009).
  4. Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., Lehmann, H. Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. Learn. Mem. 9, 49-57 (2002).
  5. Walf, A. A. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat. Protoc. 2, 322-328 (2007).
  6. Macleod, J. E. Cancer chemotherapy impairs contextual but not cue-specific fear memory. Behav Brain Res. 181, 168-172 (2007).
  7. Schafe, G. E., Nadel, N. V., Sullivan, G. M., Harris, A. Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase. Learn. Mem. 6, 97-110 (1999).
  8. Winocur, G., Wojtowicz, J. M., Sekeres, M., Snyder, J. S., Wang, S. Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus. 16, 296-304 (2006).
  9. Phillips, R. G., LeDoux, J. E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106, 274-285 (1992).
  10. D'Hooge, R., De Deyn, P. P. Applications of the Morris water maze in the study of learning and memory. Brain. Res. Brain. Res. Rev. 36, 60-90 (2001).
  11. Morris, R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods. 11, 47-60 (1984).
  12. Meyers, C. A., Brown, P. D. Role and relevance of neurocognitive assessment in clinical trials of patients with CNS tumors. J. Clin. Oncol. 24, 1305-1309 (2006).
  13. de Ruiter, M. B. Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer. Hum. Brain. Mapp. , (2010).
  14. Hess, D. C., Borlongan, C. V. Cell-based therapy in ischemic stroke. Expert. Rev. Neurother. 8, 1193-1201 (2008).
כימות decrements קוגניטיבי נגרמת על ידי הקרנות גולגולתי
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Christie, L. A., Acharya, M. M.,More

Christie, L. A., Acharya, M. M., Limoli, C. L. Quantifying Cognitive Decrements Caused by Cranial Radiotherapy. J. Vis. Exp. (56), e3108, doi:10.3791/3108 (2011).

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