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Bacteriële Levering van RNAi effectors
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Bacteriële Levering van RNAi effectors: Transkingdom RNAi

Article DOI: 10.3791/2099-v • 07:57 min • August 18th, 2010
August 18th, 2010 •
1, 1
1Institute of Pathology, Charité Campus Mitte

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Voor de ontwikkeling van RNA-interferentie (RNAi)-gebaseerde therapieën, was een nieuwe strategie ontwikkeld, transkingdom RNAi (tkRNAi). Deze technologie maakt gebruik van niet-pathogene bacteriën te produceren en therapeutische short hairpin RNA (shRNA) leveren in doelcellen. Hier werd tkRNAi met succes toegepast voor omkering van de klassieke ABCB1-gemedieerde multidrug resistance (MDR) van kankercellen.

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Microbiologie Transkingdom RNAi shRNA gentherapie kanker multidrug resistance bacteriën
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