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JoVE Journal Bioengineering
Drug-induceret sensibilisering af adenylylcyclase
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Drug-induceret sensibilisering af adenylylcyclase: Assay Strømlining og Minituriasering for Small Molecule og siRNA Screening Applications

Article DOI: 10.3791/51218-v • 09:39 min • January 27th, 2014
January 27th, 2014 •
1, 1, 1, 2, 1
1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 2Quantitative Biology, Eli Lilly and Company

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Vedvarende aktivering af hæmmende G-protein-koblede receptorer resulterer i sensibilisering af adenylylcyclase signalering. At identificere de væsentlige molekylære veje, er det nødvendigt nonbiased tilgange, men denne strategi kræver udvikling af en skalerbar celle-baserede cAMP sensibilisering assay. Heri beskriver vi en sensibilisering assay for lille molekyle og siRNA screening.

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Bioengineering adenylylcyclase cAMP heterologt sensibilisering superactivation D2 dopamin μ opioid siRNA
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