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Heterotop Mucosal transplantere Procedure for direkte Drug Delivery til Brain i mus
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Heterotop Mucosal transplantere Procedure for direkte Drug Delivery til Brain i mus

Article DOI: 10.3791/51452-v • 08:25 min • July 16th, 2014
July 16th, 2014 •
1, 1, 2
1Department of Biomedical Engineering, Boston University, 2Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School

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En musemodel af human endoskopisk cranii genopbygning er blevet udviklet, der skaber en semipermeabel grænseflade mellem hjernen og næsen ved hjælp af nasal slimhinde-podninger. Denne metode gør det muligt for forskere at undersøge levering til centralnervesystemet af højmolekylære terapeutika, der ellers er udelukket af blod-hjerne-barrieren, når de indgives systemisk.

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Medicine drug delivery slimhinde membran blod-hjerne-barrieren neurokirurgi transnasal musemodel
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