Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Medicine / Development of an Alpha-synuclein Based Rat Model …
JoVE Journal
Medicine

A subscription to JoVE is required to view this content.

JoVE Journal Medicine
Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector
Biochemical Measurement of Neonatal Hypoxia
Journal (Medicine)
Biochemical Measurement of Neonatal Hypoxia
Coculture Analysis of Extracellular Protein Interactions Affecting Insulin Secretion by Pancreatic Beta Cells
Journal (Medicine)
Coculture Analysis of Extracellular Protein Interactions Affecting Insulin Secretion by Pancreatic Beta Cells
 

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

Article DOI: 10.3791/53670-v • 08:33 min • February 28th, 2016
February 28th, 2016 •
1, 2, 2, 3,4, 1,4, 1
1Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, 2Division of Nuclear Medicine, Leuven University Hospital - KU Leuven, 3Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 4Leuven Viral Vector Core, KU Leuven

Chapters

Summary
Automatic Translation

This manuscript describes how viral vector-mediated local gene delivery provides an attractive way to express transgenes in the central nervous system. The protocol outlines all crucial steps to perform a viral vector injection in the substantia nigra of the rat to develop a viral vector-based animal model for Parkinson's disease.

Tags

Alpha-synuclein Rat Model Parkinson's Disease Stereotactic Injection Recombinant Adeno-associated Viral Vector Animal Model Pre-clinical Drug Testing Molecular Mechanism Neurodegenerative Disorders Brain Regions Vector System Gene Expression Bio-safety Issues Anesthesia Wistar Rat
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter